Novel mediators and mechanisms in the resolution of infectious inflammation: evidence for vagus regulation

Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration

(2018) Xavier de la Rosa et al.   AMERICAN JOURNAL OF PATHOLOGY

New maresin conjugates in tissue regeneration pathway counters leukotriene D4–stimulated vascular responses

(2018) Nan Chiang et al.   FASEB JOURNAL

Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37

(2018) Lintao Qu et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Frontline Science: Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation

(2018) Jeremy W. Winkler et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Heart rate variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations

(2018) P S Matusik et al.   LUPUS

Resolvin D1 Halts Remote Neuroinflammation and Improves Functional Recovery after Focal Brain Damage Via ALX/FPR2 Receptor-Regulated MicroRNAs

(2018) Elisa Bisicchia et al.   MOLECULAR NEUROBIOLOGY

Splenic leukocytes define the resolution of inflammation in heart failure

(2018) Ganesh V. Halade et al.   Science Signaling

Relationship Between Fish Consumption and Disease Activity in Rheumatoid Arthritis

(2018) Sara K. Tedeschi et al.   ARTHRITIS CARE & RESEARCH

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

(2018) Ju Youn Lee et al.   Nature Communications

Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2

(2018) A. Gaudin et al.   Scientific Reports

Dementia and vagotomy in Taiwan: a population-based cohort study

(2018) Shih-Yi Lin et al.   BMJ Open

Resolvin D2 protects against cerebral ischemia/reperfusion injury in rats

(2018) Gang Zuo et al.   Molecular Brain

Splenic leukocytes define the resolution of inflammation in heart failure

(2018) Ganesh V. Halade et al.   Science Signaling

The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review

(2018) Marijke De Couck et al.   Journal of Oncology

Clarification of the Mechanism Involved in Orexigenic Action by Oral Zinc Ingestion

(2018) Michio Komai et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Cutting Edge: Human Vagus Produces Specialized Proresolving Mediators of Inflammation with Electrical Stimulation Reducing Proinflammatory Eicosanoids

(2018) Charles N. Serhan et al.   JOURNAL OF IMMUNOLOGY

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution

(2017) Jesmond Dalli et al.   IMMUNITY

Resolvin D1 and D2 Reverse Lipopolysaccharide-Induced Depression-Like Behaviors Through the mTORC1 Signaling Pathway

(2017) Satoshi Deyama et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection

(2017) Aram Asatryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury

(2017) Izhar Livne-Bar et al.   JOURNAL OF CLINICAL INVESTIGATION

Frontline Science: Aspirin-triggered resolvin D1 controls herpes simplex virus-induced corneal immunopathology

(2017) Naveen K. Rajasagi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury

(2017) Isaac Francos-Quijorna et al.   JOURNAL OF NEUROSCIENCE

Maresin 1 induces a novel pro-resolving phenotype in human platelets

(2017) K. L. Lannan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

(2017) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

How does parkinson's disease begin? Perspectives on neuroanatomical pathways, prions, and histology

(2017) Per Borghammer   MOVEMENT DISORDERS

The novel lipid mediator PD1 n-3 DPA : An overview of the structural elucidation, synthesis, biosynthesis and bioactions

(2017) Trond Vidar Hansen et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics

(2017) Justin T. English et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

A cluster of immunoresolvents links coagulation to innate host defense in human blood

(2017) Paul C. Norris et al.   Science Signaling

A cluster of immunoresolvents links coagulation to innate host defense in human blood

(2017) Paul C. Norris et al.   Science Signaling

Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain

(2017) Junting Huang et al.   Arthritis & Rheumatology

Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans

(2017) Ana M. Valdes et al.   Scientific Reports

The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation

(2016) Sesquile Ramon et al.   AMERICAN JOURNAL OF PATHOLOGY

Phagocytosis: An Immunobiologic Process

(2016) Siamon Gordon   IMMUNITY

Novel Resolvin D2 Receptor Axis in Infectious Inflammation

(2016) Nan Chiang et al.   JOURNAL OF IMMUNOLOGY

Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation

(2016) Hildur H. Arnardottir et al.   JOURNAL OF IMMUNOLOGY

Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation

(2016) Romain A. Colas et al.   JOURNAL OF IMMUNOLOGY

Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

(2016) Alessandra Cadete Martini et al.   Journal of Neuroinflammation

Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models

(2016) Pongsatorn Meesawatsom et al.   Journal of Neuroinflammation

Resolvin E1 Inhibits Substance P-Induced Potentiation of TRPV1 in Primary Sensory Neurons

(2016) Youn Yi Jo et al.   MEDIATORS OF INFLAMMATION

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

(2016) Frieda A. Koopman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D3 multi-level proresolving actions are host protective during infection

(2016) Paul C. Norris et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Specialised pro-resolving mediators of inflammation in inflammatory arthritis

(2016) Anne E. Barden et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution

(2016) Bangwei Luo et al.   Nature Communications

Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia

(2016) Mette M. B. Nielsen et al.   Scientific Reports

Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

(2016) Jeremy W. Winkler et al.   Scientific Reports

Resolution of inflammation is altered in Alzheimer's disease

(2015) Xiuzhe Wang et al.   Alzheimers & Dementia

n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats

(2015) Michio Hashimoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

(2015) Charles N. Serhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse

(2015) Jordan L. Harrison et al.   BRAIN BEHAVIOR AND IMMUNITY

Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration

(2015) Ahmed I. Mahmoud et al.   DEVELOPMENTAL CELL

Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

(2015) Jesmond Dalli et al.   FASEB JOURNAL

Neural circuitry and immunity

(2015) Valentin A. Pavlov et al.   IMMUNOLOGIC RESEARCH

Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses

(2015) Yu Sawada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4

(2015) Xiaohui Fang et al.   JOURNAL OF IMMUNOLOGY

A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation

(2015) Kathy Stein et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins

(2015) Phillip J. White et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

(2015) Mingqin Zhu et al.   MOLECULAR NEUROBIOLOGY

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Vagotomy prevents the effect of probiotics on caspase activity in a model of postmyocardial infarction depression

(2015) M. Malick et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats

(2015) Masanori Katakura et al.   PLoS One

Inflammation's stop signals

(2015) M. Leslie   SCIENCE

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

(2014) Romain A. Colas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages

(2014) Antonio Recchiuti et al.   FASEB JOURNAL

Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis

(2014) Joanne C Masterson et al.   GUT

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Vagus nerve controls resolution and pro-resolving mediators of inflammation

(2014) Valbona Mirakaj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling

(2014) Jin Endo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in Resolution

(2014) K. Kasuga et al.   JOURNAL OF IMMUNOLOGY

Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nano-Proresolving Medicines

(2014) Hildur H. Arnardottir et al.   JOURNAL OF IMMUNOLOGY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages

(2014) Bin Deng et al.   PLoS One

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment

(2013) James F. Markworth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

(2013) Jesmond Dalli et al.   CHEMISTRY & BIOLOGY

15-Epi-lipoxin A4 inhibits human neutrophil superoxide anion generation by regulating polyisoprenyl diphosphate phosphatase 1

(2013) Troy Carlo et al.   FASEB JOURNAL

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

Inhaled Carbon Monoxide Accelerates Resolution of Inflammation via Unique Proresolving Mediator-Heme Oxygenase-1 Circuits

(2013) N. Chiang et al.   JOURNAL OF IMMUNOLOGY

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid mediators in immune dysfunction after severe inflammation

(2013) James N. Fullerton et al.   TRENDS IN IMMUNOLOGY

Novel n-3 Immunoresolvents: Structures and Actions

(2013) Jesmond Dalli et al.   Scientific Reports

Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci

(2012) Lucy V. Norling et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma

(2012) Jun Miyata et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of Basic Science in the Development of New Medicines: Examples from the Eicosanoid Field

(2012) Bengt Samuelsson   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid

(2012) Yosuke Isobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neural reflexes in inflammation and immunity

(2012) Ulf Andersson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resolvin E2 Formation and Impact in Inflammation Resolution

(2012) S. F. Oh et al.   JOURNAL OF IMMUNOLOGY

Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury

(2012) O Eickmeier et al.   Mucosal Immunology

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

(2012) Janine M van Gils et al.   NATURE IMMUNOLOGY

The vagus nerve and the inflammatory reflex—linking immunity and metabolism

(2012) Valentin A. Pavlov et al.   Nature Reviews Endocrinology

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA

(2012) Gabrielle Fredman et al.   Scientific Reports

Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution

(2011) Gabrielle Fredman et al.   BIOCHEMICAL JOURNAL

The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats

(2011) JF Lima-Garcia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resolvins and Protectins in Inflammation Resolution

(2011) Charles N. Serhan et al.   CHEMICAL REVIEWS

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Novel Proresolving Aspirin-Triggered DHA Pathway

(2011) Charles N. Serhan et al.   CHEMISTRY & BIOLOGY

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

Resolving TRPV1- and TNF- -Mediated Spinal Cord Synaptic Plasticity and Inflammatory Pain with Neuroprotectin D1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Emerging roles of resolvins in the resolution of inflammation and pain

(2011) Ru-Rong Ji et al.   TRENDS IN NEUROSCIENCES

Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice

(2010) Tomohiro Yamada et al.   FASEB JOURNAL

Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1

(2010) Nicolas G. Bazan et al.   JOURNAL OF LIPID RESEARCH

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets

(2008) M. Dona et al.   BLOOD

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

(2008) Aksam J. Merched et al.   FASEB JOURNAL

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation

(2008) Oliver Haworth et al.   NATURE IMMUNOLOGY

Anesthetics Impact the Resolution of Inflammation

(2008) Nan Chiang et al.   PLoS One

Tonic inhibition of chemotaxis in human plasma

(2008) S. E. Malawista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA