Cellular senescence in the tumor microenvironment and context‐specific cancer treatment strategies

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

(2021) Yoshikazu Johmura et al.   SCIENCE

Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination

(2021) Tadahito Yasuda et al.   Cell Reports

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

(2021) Christopher D. Wiley et al.   Cell Metabolism

Therapy-Induced Senescence: Opportunities to Improve Anti-Cancer Therapy

(2021) Pataje G Prasanna et al.   JNCI-Journal of the National Cancer Institute

An aged immune system drives senescence and ageing of solid organs

(2021) Matthew J. Yousefzadeh et al.   NATURE

COX2 regulates senescence secretome composition and senescence surveillance through PGE2

(2021) Susana Gonçalves et al.   Cell Reports

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

(2020) Maria Grazia Vizioli et al.   GENES & DEVELOPMENT

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

(2020) Marcus Ruscetti et al.   CELL

DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS

(2020) Giulia Biffi et al.   PHYSIOLOGICAL REVIEWS

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

(2020) Masahiro Wakita et al.   Nature Communications

Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

(2020) Tareq Saleh et al.   Cancers

Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance

(2020) Tomoyuki Uchihara et al.   CANCER RESEARCH

Functional diversity of cancer‐associated fibroblasts in modulating drug resistance

(2020) Luke Bu et al.   CANCER SCIENCE

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

AP-1 imprints a reversible transcriptional programme of senescent cells

(2020) Ricardo Iván Martínez-Zamudio et al.   NATURE CELL BIOLOGY

Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics

(2020) Ariana Rostami et al.   Cell Reports

Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells

(2020) Hyun Jung Hwang et al.   CANCER LETTERS

Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo

(2020) Satotaka Omori et al.   Cell Metabolism

Cellular Senescence Variation by Metabolic and Epigenomic Remodeling

(2020) Mitsuyoshi Nakao et al.   TRENDS IN CELL BIOLOGY

Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG

(2020) Ilango Balakrishnan et al.   Cell Reports

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment

(2019) Luke Bu et al.   ONCOGENE

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3

(2019) Masahiro Maeda et al.   GUT

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Connecting cancer relapse with senescence

(2019) Olivier Pluquet et al.   CANCER LETTERS

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer

(2019) Tze Mun Loo et al.   CANCER SCIENCE

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

(2018) Akiko Takahashi et al.   Nature Communications

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

(2018) Boyi Zhang et al.   Nature Communications

Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways

(2018) Takahiro Ito et al.   Cell Reports

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

(2018) Marcus Ruscetti et al.   SCIENCE

A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal

(2018) Michalis Mastri et al.   Cell Reports

Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells

(2017) Takatsugu Ishimoto et al.   GASTROENTEROLOGY

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Senescent tumor cells lead the collective invasion in thyroid cancer

(2017) Young Hwa Kim et al.   Nature Communications

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

(2017) Masaki Takasugi et al.   Nature Communications

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression

(2017) Kévin Contrepois et al.   Nature Communications

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

(2017) Akiko Takahashi et al.   Nature Communications

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE 2 -Mediated Suppression of Antitumor Immunity

(2017) Tze Mun Loo et al.   Cancer Discovery

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

(2017) Liqin Wang et al.   Cell Reports

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Senescent endothelial cells: Potential modulators of immunosenescence and ageing

(2016) Ia Pantsulaia et al.   AGEING RESEARCH REVIEWS

A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts

(2016) Tasnuva Kabir et al.   Aging-US

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

(2016) Yingying Wang et al.   Aging-US

Senescence and Cancer: In the Name of Immunosuppression

(2016) Susana Llanos et al.   CANCER CELL

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

MLL1 is essential for the senescence-associated secretory phenotype

(2016) Brian C. Capell et al.   GENES & DEVELOPMENT

A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

(2016) Eric H. Bent et al.   GENES & DEVELOPMENT

HMGB2 holds the key to the senescence-associated secretory phenotype

(2016) Ana Guerrero et al.   JOURNAL OF CELL BIOLOGY

HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci

(2016) Katherine M. Aird et al.   JOURNAL OF CELL BIOLOGY

Senescent Carcinoma-Associated Fibroblasts Upregulate IL8 to Enhance Prometastatic Phenotypes

(2016) Tao Wang et al.   MOLECULAR CANCER RESEARCH

The Aging Epigenome

(2016) Lauren N. Booth et al.   MOLECULAR CELL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

(2016) N. Tasdemir et al.   Cancer Discovery

Evasion of Cell Senescence Leads to Medulloblastoma Progression

(2016) Lukas Tamayo-Orrego et al.   Cell Reports

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

(2015) Hongshan Chen et al.   MOLECULAR CELL

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

(2015) Maria-Giuseppina Procopio et al.   NATURE CELL BIOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion

(2014) Y Hassona et al.   BRITISH JOURNAL OF CANCER

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis

(2014) E. Alspach et al.   Cancer Discovery

Inhibition of Endothelial p53 Improves Metabolic Abnormalities Related to Dietary Obesity

(2014) Masataka Yokoyama et al.   Cell Reports

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

Chemotherapeutic Resistance: Surviving Stressful Situations

(2011) L. A. Gilbert et al.   CANCER RESEARCH

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells

(2011) Akiko Takahashi et al.   MOLECULAR CELL

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

DNA Damage-Mediated Induction of a Chemoresistant Niche

(2010) Luke A. Gilbert et al.   CELL

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Real-time in vivo imaging of p16Ink4areveals cross talk with p53

(2009) Kimi Yamakoshi et al.   JOURNAL OF CELL BIOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY