HMGB2 holds the key to the senescence-associated secretory phenotype

MLL1 is essential for the senescence-associated secretory phenotype

(2016) Brian C. Capell et al.   GENES & DEVELOPMENT

HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci

(2016) Katherine M. Aird et al.   JOURNAL OF CELL BIOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

(2016) N. Tasdemir et al.   Cancer Discovery

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation

(2014) Sanghee Lee et al.   Nature Chemical Biology

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

Control of senescence by CXCR2 and its ligands

(2011) Juan C. Acosta et al.   CELL CYCLE

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT