Mechanochemical C−X/C−H Functionalization: An Alternative Strategic Access to Pharmaceuticals

Liquid‐Assisted Grinding Mechanochemistry in the Synthesis of Pharmaceuticals

(2021) Ping Ying et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Developments in Z‐Selective Olefin Metathesis Reactions by Molybdenum, Tungsten, Ruthenium, and Vanadium Catalysts

(2021) Kamal M. Dawood et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Advances in Cross‐Dehydrogenative Couplings (CDC) of C‐H Bond in Aqueous Media

(2021) Zhi-Bing Dong et al.   ADVANCED SYNTHESIS & CATALYSIS

Nickel-Catalyzed Cross-Electrophile Coupling of the Difluoromethyl Group for Fluorinated Cyclopropane Synthesis

(2021) Elizabeth R. Jarvo et al.   SYNLETT

Solvent-less Dehydrogenative C–H Etherification with Alcohols Using Mechanochemistry

(2021) Kun Zhou et al.   ACS Sustainable Chemistry & Engineering

The many flavours of mechanochemistry and its plausible conceptual underpinnings

(2021) Robert T. O’Neill et al.   Nature Reviews Chemistry

Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry

(2021) Karen J. Ardila‐Fierro et al.   ChemSusChem

Tackling Solubility Issues in Organic Synthesis: Solid-State Cross-Coupling of Insoluble Aryl Halides

(2021) Tamae Seo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ullmann‐Goldberg and Buchwald‐Hartwig C−N Cross Couplings: Synthetic Methods to Pharmaceutically Potential N‐Heterocycles

(2021) Behnoush Seifinoferest et al.   Asian Journal of Organic Chemistry

A Solid‐Phase Assisted Flow Approach to In Situ Wittig‐Type Olefination Coupling

(2021) Joseph Tadros et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Mechanochemical Rearrangements

(2021) David Virieux et al.   JOURNAL OF ORGANIC CHEMISTRY

Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties

(2021) Vittorio Canale et al.   MOLECULES

Mechanochemical Magnesium-Mediated Minisci C–H Alkylation of Pyrimidines with Alkyl Bromides and Chlorides

(2021) Chongyang Wu et al.   ORGANIC LETTERS

A Ball-Milling-Enabled Cross-Electrophile Coupling

(2021) Andrew C. Jones et al.   ORGANIC LETTERS

Mechanochemical Synthesis of 1,2-Diketoindolizine Derivatives from Indolizines and Epoxides Using Piezoelectric Materials

(2021) Yumei Wang et al.   ORGANIC LETTERS

Tribochemistry, Mechanical Alloying, Mechanochemistry: What is in a Name?

(2021) Adam A. L. Michalchuk et al.   Frontiers in Chemistry

Late-stage C–H functionalization offers new opportunities in drug discovery

(2021) Lucas Guillemard et al.   Nature Reviews Chemistry

Mechanochemical Iridium(III)-Catalyzed B-Amidation of o-Carboranes with Dioxazolones

(2021) Gi Uk Han et al.   ORGANIC LETTERS

Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis

(2021) Rina Takahashi et al.   Nature Communications

Palladium-Catalyzed Solid-State Polyfluoroarylation of Aryl Halides Using Mechanochemistry

(2021) Rikuro Takahashi et al.   ACS Catalysis

Immobilized Pd on a NHC functionalized metal–organic framework MIL‐101(Cr): an efficient heterogeneous catalyst in Suzuki−Miyaura coupling reaction in water

(2020) Esmaeil Niknam et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Effect of stressing conditions on mechanochemical Knoevenagel synthesis

(2020) Christine Friederike Burmeister et al.   CHEMICAL ENGINEERING JOURNAL

Nickel-Catalyzed Alkyl–Alkyl Cross-Electrophile Coupling Reaction of 1,3-Dimesylates for the Synthesis of Alkylcyclopropanes

(2020) Amberly B. Sanford et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reductive sp3–sp2 Coupling Reactions Enable Late-Stage Modification of Pharmaceuticals

(2020) Katrina M. Mennie et al.   ORGANIC LETTERS

Redox reactions of small organic molecules using ball milling and piezoelectric materials

(2020) Koji Kubota et al.   SCIENCE

The Mizoroki‐Heck Reaction with Internal Olefins: Reactivities and Stereoselectivities

(2020) Yusei Nakashima et al.   Asian Journal of Organic Chemistry

Nickel‐Catalyzed Synthesis of Dialkyl Ketones from the Coupling of N‐Alkyl Pyridinium Salts with Activated Carboxylic Acids

(2020) Jiang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Cross-Electrophile Reductive Couplings of Neopentyl Bromides with Aryl Bromides

(2020) Soumik Biswas et al.   JOURNAL OF ORGANIC CHEMISTRY

Selective Mechanochemical Monoarylation of Unbiased Dibromoarenes by in Situ Crystallization

(2020) Tamae Seo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Chlorides with Primary Alkyl Chlorides

(2020) Seoyoung Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-Mediated and Metal-Catalyzed Reactions Under Mechanochemical Conditions

(2020) Andrea Porcheddu et al.   ACS Catalysis

Advanced Mechanochemistry Device for Sustainable Synthetic Processes

(2020) Carla Gomes et al.   ACS Omega

A Review on the Latest Progress of Chan‐Lam Coupling Reaction

(2020) Jin‐Quan Chen et al.   ADVANCED SYNTHESIS & CATALYSIS

Electro‐Mechanochemical Atom Transfer Radical Cyclizations using Piezoelectric BaTiO 3

(2020) Christian Schumacher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanochemical Synthesis of Corannulene‐Based Curved Nanographenes

(2020) Gábor Báti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Impact of Cross-Coupling Reactions in Drug Discovery and Development

(2020) Melissa J. Buskes et al.   MOLECULES

Novel Methodologies for Chemical Activation in Organic Synthesis under Solvent-Free Reaction Conditions

(2020) Claudia Gabriela Avila-Ortiz et al.   MOLECULES

Mechanochemical and Mechanoenzymatic Synthesis of Pharmacologically Active Compounds: A Green Perspective

(2020) Mario Pérez-Venegas et al.   ACS Sustainable Chemistry & Engineering

Solvent-Free, Continuous Synthesis of Hydrazone-Based Active Pharmaceutical Ingredients by Twin-Screw Extrusion

(2020) Deborah E. Crawford et al.   ACS Sustainable Chemistry & Engineering

Solid‐State Radical C−H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials

(2020) Yadong Pang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium‐catalyzed cross‐coupling reactions of coumarin derivatives: An overview

(2020) U.S. Kanchana et al.   APPLIED ORGANOMETALLIC CHEMISTRY

A Robust Pd-Catalyzed C–S Cross-Coupling Process Enabled by Ball-Milling

(2020) Andrew C. Jones et al.   ORGANIC LETTERS

A Glove-Box- and Schlenk-Line-Free Protocol for Solid-State C–N Cross-Coupling Reactions Using Mechanochemistry

(2020) Koji Kubota et al.   ACS Sustainable Chemistry & Engineering

Cytotoxicity of Mechanochemically Prepared Cu(II) Complexes

(2020) Aaron S. McCalmont et al.   ACS Sustainable Chemistry & Engineering

Mn(I)-Catalyzed Mechanochemical C–H Bond Activation: C-2 Selective Alkenylation of Indoles

(2020) Dharmendra Das et al.   ACS Sustainable Chemistry & Engineering

Olefin-accelerated solid-state C–N cross-coupling reactions using mechanochemistry

(2019) Koji Kubota et al.   Nature Communications

Introducing Students to Mechanochemistry via Environmentally Friendly Organic Synthesis Using a Solvent-Free Mechanochemical Preparation of the Antidiabetic Drug Tolbutamide

(2019) Evelina Colacino et al.   JOURNAL OF CHEMICAL EDUCATION

Iridium(I)‐Catalyzed C−H Borylation in Air by Using Mechanochemistry

(2019) Yadong Pang et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Ball‐Milling Enabled Reformatsky Reaction

(2019) Qun Cao et al.   ChemSusChem

Mechanochemistry for Synthesis

(2019) Tomislav Friscic et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Buchwald-Hartwig Amination after 25 Years

(2019) Ruth Dorel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The 25th Anniversary of the Buchwald–Hartwig Amination: Development, Applications, and Outlook

(2019) Paola A. Forero-Cortés et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Recent applications of mechanochemistry in enantioselective synthesis

(2019) C. Gabriela Avila-Ortiz et al.   TETRAHEDRON LETTERS

Approaches to Obtaining Fluorinated α-Amino Acids

(2019) Johann Moschner et al.   CHEMICAL REVIEWS

The symbiotic relationship between drug discovery and organic chemistry

(2019) Oleksandr O Grygorenko et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanochemical Pd(II)-Catalyzed Direct and C-2-Selective Arylation of Indoles

(2019) Dharmendra Das et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanochemical Oxidative Heck Coupling of Activated and Unactivated Alkenes: A Chemo‐, Regio‐ and Stereo‐Controlled Synthesis of Alkenylbenzenes

(2019) Jingbo Yu et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct Mechanocatalysis: Palladium as Milling Media and Catalyst in the Mechanochemical Suzuki Polymerization

(2019) Christian G. Vogt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phenomenological Inferences on the Kinetics of a Mechanically Activated Knoevenagel Condensation: Understanding the “Snowball” Kinetic Effect in Ball Milling

(2019) Maria Carta et al.   MOLECULES

Mechanochemical Asymmetric Cross‐Dehydrogenative Coupling Reaction: Liquid‐Assisted Grinding Enables Reaction Acceleration and Enantioselectivity Control

(2019) Jingbo Yu et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium-Catalyzed C–H/C–H Cross-Coupling by Mechanochemistry: Direct Alkenylation and Heteroarylation of N1-Protected 1H-Indazoles

(2019) Jingbo Yu et al.   JOURNAL OF ORGANIC CHEMISTRY

Engaging Sulfonamides: Intramolecular Cross-Electrophile Coupling Reaction of Sulfonamides with Alkyl Chlorides

(2019) Erika L. Lucas et al.   JOURNAL OF ORGANIC CHEMISTRY

Increasing Catalyst Efficiency in C−H Activation Catalysis

(2018) Tobias Gensch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling

(2018) Qun Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late-Stage Peptide Diversification by Position-Selective C-H Activation

(2018) Wei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanochemical Rhodium(III)- and Gold(I)-Catalyzed C−H Bond Alkynylations of Indoles under Solventless Conditions in Mixer Mills

(2018) Gary N. Hermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Altering Copper-Catalyzed A3 Couplings by Mechanochemistry: One-Pot Synthesis of 1,4-Diamino-2-butynes from Aldehydes, Amines, and Calcium Carbide

(2018) Mathias Turberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Catalyzed Cross-Couplings in the Synthesis of Pharmaceuticals: In Pursuit of Sustainability

(2018) Aleksandra Piontek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bromide-assisted chemoselective Heck reaction of 3-bromoindazoles under high-speed ball-milling conditions: synthesis of axitinib

(2018) Jingbo Yu et al.   Beilstein Journal of Organic Chemistry

High throughput mechanochemistry: application to parallel synthesis of benzoxazines

(2018) K. Martina et al.   CHEMICAL COMMUNICATIONS

Green and Sustainable Solvents in Chemical Processes

(2018) Coby J. Clarke et al.   CHEMICAL REVIEWS

Catalyst- and Reagent-free Electrochemical Azole C-H Amination

(2018) Youai Qiu et al.   CHEMISTRY-A EUROPEAN JOURNAL

From Synthesis of Amino Acids and Peptides to Enzymatic Catalysis: A Bottom-Up Approach in Mechanochemistry

(2018) Carsten Bolm et al.   ChemSusChem

Mechanochemistry and organic synthesis: from mystical to practical

(2018) J. Andersen et al.   GREEN CHEMISTRY

Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene

(2018) Evelina Colacino et al.   GREEN CHEMISTRY

One-Pot Multicomponent Mechanosynthesis of Polysubstituted trans-2,3-Dihydropyrroles and Pyrroles from Amines, Alkyne Esters, and Chalcones

(2018) Hui Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

Organic synthesis provides opportunities to transform drug discovery

(2018) David C. Blakemore et al.   Nature Chemistry

Chemical probes and drug leads from advances in synthetic planning and methodology

(2018) Christopher J. Gerry et al.   NATURE REVIEWS DRUG DISCOVERY

Solvent-free mechanochemical Buchwald-Hartwig amination of aryl chlorides without inert gas protection

(2018) Qiao-Ling Shao et al.   TETRAHEDRON LETTERS

Recent advances in mechanochemical C–H functionalization reactions

(2018) Shujuan Zhao et al.   TETRAHEDRON LETTERS

Ligand-enabled ortho-C–H olefination of phenylacetic amides with unactivated alkenes

(2018) Ming-Zhu Lu et al.   Chemical Science

Mechanochemistry as an emerging tool for molecular synthesis: what can it offer?

(2018) Joseph L. Howard et al.   Chemical Science

Synthesis and characterisation of new sulfonamide chalcones containing an azo group

(2018) Tayfun Arslan   JOURNAL OF CHEMICAL RESEARCH

Electrocatalytic C–H Activation

(2018) Nicolas Sauermann et al.   ACS Catalysis

Mechanochemical Cobalt-Catalyzed C−H Bond Functionalizations by Ball Milling

(2018) Hanchao Cheng et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent advances in the electrochemical α-C-H bonds functionalization of carbonyl compounds

(2018) Sen Liang et al.   ADVANCED SYNTHESIS & CATALYSIS

Radicals in natural product synthesis

(2018) Kevin J. Romero et al.   CHEMICAL SOCIETY REVIEWS

Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

(2018) Qun Cao et al.   GREEN CHEMISTRY

Palladium-Catalyzed Cross-Coupling Reactions: A Powerful Tool for the Synthesis of Agrochemicals

(2018) Ponnam Devendar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Palladium-Catalyzed C3 Arylations of 1H and 2H Pyrazolo[4,3-b]pyridines on Water

(2018) Soukaina Faarasse et al.   JOURNAL OF ORGANIC CHEMISTRY

Robust Buchwald–Hartwig amination enabled by ball-milling

(2018) Qun Cao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mechanoenzymatic resolution of racemic chiral amines, a green technique for the synthesis of pharmaceutical building blocks

(2018) Mario Pérez-Venegas et al.   TETRAHEDRON

Switching Chemoselectivity: Using Mechanochemistry to Alter Reaction Kinetics

(2018) Joseph L. Howard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanochemistry of Gaseous Reactants

(2018) Carsten Bolm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ni-Catalyzed Reductive Coupling of Electron-Rich Aryl Iodides with Tertiary Alkyl Halides

(2018) Xuan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zn-Mediated Fragmentation of Tertiary Alkyl Oxalates Enabling Formation of Alkylated and Arylated Quaternary Carbon Centers

(2018) Yang Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives

(2018) Tomislav Portada et al.   MOLECULES

Mechanochemistry for Organic Chemists: An Update

(2017) Davin Tan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Fast, solvent-free and highly enantioselective fluorination of β-keto esters catalyzed by chiral copper complexes in a ball mill

(2017) Yifeng Wang et al.   GREEN CHEMISTRY

Mechanochemical indole synthesis by rhodium-catalysed oxidative coupling of acetanilides and alkynes under solventless conditions in a ball mill

(2017) Gary N. Hermann et al.   GREEN CHEMISTRY

Mechanochemical Suzuki polycondensation – from linear to hyperbranched polyphenylenes

(2017) S. Grätz et al.   GREEN CHEMISTRY

Controlling reactivity through liquid assisted grinding: the curious case of mechanochemical fluorination

(2017) Joseph L. Howard et al.   GREEN CHEMISTRY

Long-term survival in patients treated with ruxolitinib for myelofibrosis: COMFORT-I and -II pooled analyses

(2017) Srdan Verstovsek et al.   Journal of Hematology & Oncology

The Necessary Nitrogen Atom: A Versatile High-Impact Design Element for Multiparameter Optimization

(2017) Lewis D. Pennington et al.   JOURNAL OF MEDICINAL CHEMISTRY

Altering Product Selectivity by Mechanochemistry

(2017) José G. Hernández et al.   JOURNAL OF ORGANIC CHEMISTRY

Cobalt(III)-Catalyzed Fast and Solvent-Free C–H Allylation of Indoles Using Mechanochemistry

(2017) Xinpeng Jiang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling

(2017) Julie L. Hofstra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strategies to diversify natural products for drug discovery

(2017) Gang Li et al.   MEDICINAL RESEARCH REVIEWS

Introducing unactivated acyclic internal aliphatic olefins into a cobalt catalyzed allylic selective dehydrogenative Heck reaction

(2017) Soham Maity et al.   Chemical Science

Incorporating Unbiased, Unactivated Aliphatic Alkenes in Pd(II)-Catalyzed Olefination of Benzyl Phosphonamide

(2017) Kapileswar Seth et al.   ACS Catalysis

Beyond C2 and C3: Transition-Metal-Catalyzed C–H Functionalization of Indole

(2017) Jamie A. Leitch et al.   ACS Catalysis

Mechanochemical Rhodium(III)-Catalyzed C–H Bond Amidation of Arenes with Dioxazolones under Solventless Conditions in a Ball Mill

(2017) Gary N. Hermann et al.   ACS Catalysis

1,1′-Carbonyldiimidazole and Mechanochemistry: A Shining Green Combination

(2017) Thomas-Xavier Métro et al.   ACS Sustainable Chemistry & Engineering

N-Acyl Benzotriazole Derivatives for the Synthesis of Dipeptides and Tripeptides and Peptide Biotinylation by Mechanochemistry

(2017) Lori Gonnet et al.   ACS Sustainable Chemistry & Engineering

Mechanochemical Iridium(III)-Catalyzed C−H Bond Amidation of Benzamides with Sulfonyl Azides under Solvent-Free Conditions in a Ball Mill

(2016) Gary N. Hermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The First Synthesis of the Sterically Encumbered Adamantoid Phosphazane P4 (N t Bu)6 : Enabled by Mechanochemistry

(2016) Yan X. Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Randomized Trial of Food Effect on Pharmacokinetic Parameters of ABX464 Administered Orally to Healthy Male Subjects

(2016) Didier Scherrer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)

(2016) Davin Tan et al.   CHEMICAL COMMUNICATIONS

Fluorine and Gold: A Fruitful Partnership

(2016) Javier Miró et al.   CHEMICAL REVIEWS

Hypervalent iodine(iii) fluorinations of alkenes and diazo compounds: new opportunities in fluorination chemistry

(2016) Stefanie V. Kohlhepp et al.   CHEMICAL SOCIETY REVIEWS

La vortioxétine : un nouvel antidépresseur pour traiter les épisodes dépressifs caractérisés

(2016) R. Colle et al.   ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE

Mechanochemical Oxidative Mannich Reaction: Evaluation of Chemical and Mechanical Parameters for the Mild and Chemoselective Coupling ofN-tert-butoxycarbonyltetrahydroquinolines and Ketones

(2016) Jing-Bo Yu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Emergence of Unactivated Olefins for the Synthesis of Olefinated Arenes

(2016) Arghya Deb et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Effective Monitoring of Fluxapyroxad and Its Three Biologically Active Metabolites in Vegetables, Fruits, and Cereals by Optimized QuEChERS Treatment Based on UPLC-MS/MS

(2016) Xixi Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

The Suzuki–Miyaura Cross-Coupling Reaction of Halogenated Aminopyrazoles: Method Development, Scope, and Mechanism of Dehalogenation Side Reaction

(2016) Lukáš Jedinák et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanically Induced Fe(III) Catalysis at Room Temperature: Solvent-Free Cross-Dehydrogenative Coupling of 3-Benzylic Indoles with Methylenes/Indoles

(2016) Jing-Bo Yu et al.   JOURNAL OF ORGANIC CHEMISTRY

Liquid-Assisted Grinding Accelerating: Suzuki–Miyaura Reaction of Aryl Chlorides under High-Speed Ball-Milling Conditions

(2016) Zhi-Jiang Jiang et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanochemically Activated Oxidative Coupling of Indoles with Acrylates through C–H Activation: Synthesis of 3-Vinylindoles and β,β-Diindolyl Propionates and Study of the Mechanism

(2016) Kan-Yan Jia et al.   JOURNAL OF ORGANIC CHEMISTRY

A Practical Solution to Stereodefined Tetrasubstituted Olefins

(2016) Jianxin Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Enabled, Copper-Catalyzed Regio- and Stereoselective Synthesis of Trialkylsubstituted Alkenylboronates from Unactivated Internal Alkynes

(2016) Taisuke Itoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of acceptor strength on OFET properties of small molecular organic semiconducting materials with D-A-D architecture

(2016) M. Sasikumar et al.   SYNTHETIC METALS

The Choice Is Yours: Using Liquid-Assisted Grinding To Choose between Products in the Palladium-Catalyzed Dimerization of Terminal Alkynes

(2016) Longrui Chen et al.   ACS Catalysis

Fast and Selective Dehydrogenative C–H/C–H Arylation Using Mechanochemistry

(2016) Shao-Jie Lou et al.   ACS Catalysis

Mechanochemistry: A Force of Synthesis

(2016) Jean-Louis Do et al.   ACS Central Science

Fe-Catalyzed Cross-Dehydrogenative Coupling Reactions

(2016) Leiyang Lv et al.   Topics in Current Chemistry

Iron-Catalyzed C–H Functionalization Processes

(2016) Gianpiero Cera et al.   Topics in Current Chemistry

Transition Metal-Catalyzed CH Activation of Indoles

(2015) Alexander H. Sandtorv   ADVANCED SYNTHESIS & CATALYSIS

Mechanochemical Rhodium(III)-Catalyzed CH Bond Functionalization of Acetanilides under Solventless Conditions in a Ball Mill

(2015) Gary N. Hermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Synthesis of Atropisomeric Vinyl Arene Compounds by Palladium Catalysis: A Carbene Strategy

(2015) Jia Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

[Cp*RhCl2]2: mechanosynthesis and applications in C–H bond functionalisations under ball-milling conditions

(2015) José G. Hernández et al.   CHEMICAL COMMUNICATIONS

Electrochemical Intramolecular CH Amination: Synthesis of Benzoxazoles and Benzothiazoles

(2015) Tatsuya Morofuji et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of indazole motifs and their medicinal importance: An overview

(2015) Digambar D. Gaikwad et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effective Laboratory-Scale Preparation of Axitinib by Two CuI-Catalyzed Coupling Reactions

(2015) Li-Hai Zhai et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

An Improved Synthesis of 4-(1-Piperazinyl)benzo[b]thiophene Dihydrochloride

(2015) Chunhui Wu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Mechanically activated ring-opening reactions of N-acyl-1,2,3,4-tetrahydroisoquinolines derived from the synthesis of praziquantel intermediate

(2015) Jingbo Yu et al.   TETRAHEDRON

Metal-catalyzed organic reactions using mechanochemistry

(2015) José G. Hernández et al.   TETRAHEDRON LETTERS

Cobalt-Catalyzed C–H Activation

(2015) Marc Moselage et al.   ACS Catalysis

Negishi coupling in the synthesis of advanced electronic, optical, electrochemical, and magnetic materials

(2015) Shouquan Huo et al.   Organic Chemistry Frontiers

Radical CH Functionalization of Heteroarenes under Electrochemical Control

(2014) Alexander G. O'Brien et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ceritinib

(2014) Maryann R. Cooper et al.   ANNALS OF PHARMACOTHERAPY

Mechanochemical C–H bond activation: rapid and regioselective double cyclopalladation monitored by in situ Raman spectroscopy

(2014) Marina Juribašić et al.   CHEMICAL COMMUNICATIONS

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development

(2014) Carlo Sambiagio et al.   CHEMICAL SOCIETY REVIEWS

CuI/Pd0Cooperative Dual Catalysis: Tunable Stereoselective Construction of Tetra-Substituted Alkenes

(2014) Sébastien Vercruysse et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanochemical Preparation of Hydantoins from Amino Esters: Application to the Synthesis of the Antiepileptic Drug Phenytoin

(2014) Laure Konnert et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of Tetracyclic 3-Spirooxindole through Cross-Dehydrogenation of Pyridinium: Applications in Facile Synthesis of (±)-Corynoxine and (±)-Corynoxine B

(2014) Jun Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aerobic Direct C–H Arylation of Nonbiased Olefins

(2014) Nicolas Gigant et al.   ORGANIC LETTERS

Amidation and N-Boc Deprotection Process Improvement for the Preparation of 5-(1-Piperazinyl)benzofuran-2-carboxamide, a Key Intermediate of Vilazodone

(2014) Prasenjit Das et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Pd- and Ni-catalyzed cross-coupling reactions in the synthesis of organic electronic materials

(2014) Shiqing Xu et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

A novel approach for the synthesis of Crizotinib through the key chiral alcohol intermediate by asymmetric hydrogenation using highly active Ir-Spiro-PAP catalyst

(2014) Jian-Qiang Qian et al.   TETRAHEDRON LETTERS

Solvent-free mechanochemical route for green synthesis of pharmaceutically attractive phenol-hydrazones

(2014) P. F. M. Oliveira et al.   RSC Advances

Concise synthesis of atorvastatin lactone under high-speed vibration milling conditions

(2014) Verónica Estévez et al.   Organic Chemistry Frontiers

Dehydrogenative Heck Reaction (Fujiwara-Moritani Reaction) of Unactivated Olefins with Simple Dihydropyrans under Aprotic Conditions

(2013) Govind Goroba Pawar et al.   ADVANCED SYNTHESIS & CATALYSIS

The Cross-Dehydrogenative Coupling of C sp 3H Bonds: A Versatile Strategy for CC Bond Formations

(2013) Simon A. Girard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal-Free Cross-Dehydrogenative Coupling of Heterocycles with Aldehydes

(2013) Kiran Matcha et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas

(2013) Davin Tan et al.   CHEMICAL COMMUNICATIONS

The historical development of mechanochemistry

(2013) Laszlo Takacs   CHEMICAL SOCIETY REVIEWS

Mechanochemistry of inorganic and organic systems: what is similar, what is different?

(2013) Elena Boldyreva   CHEMICAL SOCIETY REVIEWS

Aerobic Iron-Based Cross-Dehydrogenative Coupling Enables Efficient Diversity-Oriented Synthesis of Coumestrol-Based Selective Estrogen Receptor Modulators

(2013) Umesh A. Kshirsagar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Environmentally benign peptide synthesis using liquid-assisted ball-milling: application to the synthesis of Leu-enkephalin

(2013) Julien Bonnamour et al.   GREEN CHEMISTRY

Total Synthesis of Schizocommunin and Revision of Its Structure

(2013) Koji Uehata et al.   JOURNAL OF NATURAL PRODUCTS

Pd-Catalyzed Cyclization and Carbene Migratory Insertion: New Approach to 3-Vinylindoles and 3-Vinylbenzofurans

(2013) Zhenxing Liu et al.   ORGANIC LETTERS

Development of an Efficient Pd-Catalyzed Coupling Process for Axitinib

(2013) Brian P. Chekal et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Fast, solvent-free asymmetric alkynylation of prochiral sp3 C–H bonds in a ball mill for the preparation of optically active tetrahydroisoquinoline derivatives

(2013) Jingbo Yu et al.   TETRAHEDRON LETTERS

A robust protocol for Pd(ii)-catalyzed C-3 arylation of (1H) indazoles and pyrazoles: total synthesis of nigellidine hydrobromide

(2013) Mengchun Ye et al.   Chemical Science

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanically activated synthesis of (E)-stilbene derivatives by high-speed ball milling

(2012) Xingyi Zhu et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery

(2012) Thomas-Xavier Métro et al.   CHEMICAL COMMUNICATIONS

Poly(ethylene glycol) as reaction medium for mild Mizoroki–Heck reaction in a ball-mill

(2012) Valérie Declerck et al.   CHEMICAL COMMUNICATIONS

Solvent-assisted mechanochemistry

(2012) Graham A. Bowmaker   CHEMICAL COMMUNICATIONS

Photoredox functionalization of C–H bonds adjacent to a nitrogen atom

(2012) Lei Shi et al.   CHEMICAL SOCIETY REVIEWS

Click Mechanochemistry: Quantitative Synthesis of “Ready to Use” Chiral Organocatalysts by Efficient Two-Fold Thiourea Coupling to Vicinal Diamines

(2012) Vjekoslav Štrukil et al.   CHEMISTRY-A EUROPEAN JOURNAL

CH Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products

(2012) David Y.-K. Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalyst-Controlled Regioselectivity in the Synthesis of Branched Conjugated Dienes via Aerobic Oxidative Heck Reactions

(2012) Changwu Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Suzuki cross-couplings of (hetero)aryl chlorides in the solid-state

(2012) Giancarlo Cravotto et al.   NEW JOURNAL OF CHEMISTRY

Recent applications of the Suzuki reaction in total synthesis

(2012) Majid M. Heravi et al.   TETRAHEDRON

Conducting moisture sensitive reactions under mechanochemical conditions

(2012) Daniel C. Waddell et al.   TETRAHEDRON LETTERS

Mechanosynthesis of the Metallodrug Bismuth Subsalicylate from Bi2O3 and Structure of Bismuth Salicylate without Auxiliary Organic Ligands

(2011) Vânia André et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Overcoming hydrolytic sensitivity and low solubility of phosphitylation reagents by combining ionic liquids with mechanochemistry

(2011) Christopher Hardacre et al.   CHEMICAL COMMUNICATIONS

Tandem indole C–H alkenylation/arylation for tetra-substituted alkene synthesis

(2011) Laura Lopez Suarez et al.   CHEMICAL COMMUNICATIONS

Mechanochemistry: opportunities for new and cleaner synthesis

(2011) Stuart L. James et al.   CHEMICAL SOCIETY REVIEWS

Clinical Pharmacokinetics of Fingolimod

(2011) Olivier J. David et al.   CLINICAL PHARMACOKINETICS

Regioselective Suzuki Coupling of Dihaloheteroaromatic Compounds as a Rapid Strategy To Synthesize Potent Rigid Combretastatin Analogues

(2011) Sewan Theeramunkong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solvent-Free Cross-Dehydrogenative Coupling Reactions under High Speed Ball-Milling Conditions Applied to the Synthesis of Functionalized Tetrahydroisoquinolines

(2011) Weike Su et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Unsymmetrical Diarylureas via Pd-Catalyzed C–N Cross-Coupling Reactions

(2011) Simon Breitler et al.   ORGANIC LETTERS

A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation

(2011) Steven M. Gaulier et al.   TETRAHEDRON LETTERS

Silicon-Based Cross-Coupling Reactions in the Total Synthesis of Natural Products

(2010) Scott E. Denmark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solvent-free and time-efficient Suzuki–Miyaura reaction in a ball mill: the solid reagent system KF–Al2O3 under inspection

(2010) Franziska Bernhardt et al.   Beilstein Journal of Organic Chemistry

Enzymatic functionalization of carbon–hydrogen bonds

(2010) Jared C. Lewis et al.   CHEMICAL SOCIETY REVIEWS

Convenient synthesis of Valsartan via a Suzuki reaction

(2010) Samir Ghosh et al.   JOURNAL OF CHEMICAL RESEARCH-S

Pd-Catalyzed Reaction of Sterically Hindered Hydrazones with Aryl Halides: Synthesis of Tetra-Substituted Olefins Related toiso-Combretastatin A4

(2010) Etienne Brachet et al.   ORGANIC LETTERS

Lisdexamfetamine: A prodrug for the treatment of attention-deficit/hyperactivity disorder

(2009) B. Popovic et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Solvent-Free Synthesis of Peptides

(2009) Valérie Declerck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Levalbuterol versus albuterol

(2009) Bill T. Ameredes et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Energetic assessment of the Suzuki–Miyaura reaction: a curtate life cycle assessment as an easily understandable and applicable tool for reaction optimization

(2009) Franziska Schneider et al.   GREEN CHEMISTRY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cross-Dehydrogenative Coupling (CDC): Exploring C−C Bond Formations beyond Functional Group Transformations

(2008) Chao-Jun Li   ACCOUNTS OF CHEMICAL RESEARCH

Sitagliptin: A novel agent for the management of type 2 diabetes mellitus

(2008) D. Q. Pham et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

It All Began with an Error: The Nomofungin/Communesin Story

(2008) Peter Siengalewicz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanochemical Solid‐State Suzuki Reactions Using an In Situ Generated Base

(2008) Franziska Schneider et al.   ChemSusChem

Alkynes as Stille Reaction Pseudohalides:  Gold- and Palladium-Cocatalyzed Synthesis of Tri- and Tetra-Substituted Olefins

(2008) Yili Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Facile Total Synthesis of Imatinib Base and Its Analogues

(2008) Yi-Feng Liu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The Suzuki−Miyaura Reaction under Mechanochemical Conditions§

(2008) Franziska Schneider et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Microwave-Assisted Olefin Metathesis

(2007) Yoann Coquerel et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY