Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury
Authors
Keywords
PFAS toxicity, Per- and polyfluoroalkyl substances, Liver injury, Cardiometabolic disease, Hyperlipidemia, Cholesterol, Bile acids
Journal
ENVIRONMENT INTERNATIONAL
Volume 157, Issue -, Pages 106843
Publisher
Elsevier BV
Online
2021-09-01
DOI
10.1016/j.envint.2021.106843
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The Bile Salt Export Pump: Molecular Structure, Study Models and Small-Molecule Drugs for the Treatment of Inherited BSEP Deficiencies
- (2021) Muhammad Imran Sohail et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Legacy and Emerging Per- and Polyfluoroalkyl Substances: Analytical Techniques, Environmental Fate, and Health Effects
- (2021) Richard A. Brase et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inferior control of low-density lipoprotein cholesterol in women is the primary sex difference in modifiable cardiovascular risk: A large-scale, cross-sectional study in primary care
- (2021) Yael Rachamin et al. ATHEROSCLEROSIS
- Physiology and Physical Chemistry of Bile Acids
- (2021) Maria Chiara di Gregorio et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- An ‘Omics Approach to Unraveling the Paradoxical Effect of Diet on Perfluorooctanesulfonic Acid (PFOS) and Perfluorononanoic Acid (PFNA)-Induced Hepatic Steatosis
- (2021) Marisa Pfohl et al. TOXICOLOGICAL SCIENCES
- Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?
- (2021) Styliani Fragki et al. CRITICAL REVIEWS IN TOXICOLOGY
- High-Throughput Transcriptomic Analysis of Human Primary Hepatocyte Spheroids Exposed to Per- and Polyfluoroalkyl Substances as a Platform for Relative Potency Characterization
- (2021) Andrea Rowan-Carroll et al. TOXICOLOGICAL SCIENCES
- Identification and Classification of Commercially Relevant Per‐ and Poly‐fluoroalkyl Substances (PFAS)
- (2021) Robert C. Buck et al. Integrated Environmental Assessment and Management
- FXR in liver physiology: Multiple faces to regulate liver metabolism
- (2021) Katrin Panzitt et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort
- (2021) Annelise J. Blomberg et al. ENVIRONMENTAL RESEARCH
- Rapid Characterization of Per- and Polyfluoroalkyl Substances (PFAS) by Ion Mobility Spectrometry–Mass Spectrometry (IMS-MS)
- (2020) James N. Dodds et al. ANALYTICAL CHEMISTRY
- Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker
- (2020) Guido Alessandro Baselli et al. GUT
- Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells
- (2020) Anne-Cathrin Behr et al. ARCHIVES OF TOXICOLOGY
- Associations between perfluoroalkyl substances and serum lipids in a Swedish adult population with contaminated drinking water
- (2020) Ying Li et al. Environmental Health
- Enhanced Extraction of AFFF-Associated PFASs from Source Zone Soils
- (2020) Anastasia Nickerson et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina
- (2020) Nadine Kotlarz et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Per‐ and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research
- (2020) Suzanne E. Fenton et al. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
- Perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) alter the blood lipidome and the hepatic proteome in a murine model of diet-induced obesity
- (2020) Marisa Pfohl et al. TOXICOLOGICAL SCIENCES
- Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet
- (2020) J.J. Schlezinger et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults
- (2020) Zhanghua Chen et al. ENVIRONMENT INTERNATIONAL
- PFAS Exposure Pathways for Humans and Wildlife: A Synthesis of Current Knowledge and Key Gaps in Understanding
- (2020) Amila O. De Silva et al. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
- Dose effects of ammonium perfluorooctanoate on lipoprotein metabolism in APOE*3-Leiden.CETP mice
- (2019) Marianne G Pouwer et al. TOXICOLOGICAL SCIENCES
- Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid β-Oxidation Disorder, and Kidney Injury in a Manufactory in China
- (2019) Yao Lu et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- Human exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water: A review of the recent scientific literature
- (2019) José L. Domingo et al. ENVIRONMENTAL RESEARCH
- The influence of biological sex and sex hormones on bile acid synthesis and cholesterol homeostasis
- (2019) Taylor Phelps et al. Biology of Sex Differences
- Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach
- (2019) Ran Jin et al. ENVIRONMENT INTERNATIONAL
- Mechanisms and regulation of cholesterol homeostasis
- (2019) Jie Luo et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)
- (2019) Anne-Cathrin Behr et al. TOXICOLOGY IN VITRO
- FABP4 and MMP9 levels identified as predictive factors for poor prognosis in patients with nonalcoholic fatty liver using data mining approaches and gene expression analysis
- (2019) Audrey Coilly et al. Scientific Reports
- Perfluorooctane sulphonate induces oxidative hepatic damage via mitochondria-dependent and NF-κB/TNF-α-mediated pathway
- (2018) Rui Han et al. CHEMOSPHERE
- Early life exposure to per- and polyfluoroalkyl substances and mid-childhood lipid and alanine aminotransferase levels
- (2018) Ana M. Mora et al. ENVIRONMENT INTERNATIONAL
- Association among total serum isomers of perfluorinated chemicals, glucose homeostasis, lipid profiles, serum protein and metabolic syndrome in adults: NHANES, 2013–2014
- (2018) Hui-Shan Liu et al. ENVIRONMENTAL POLLUTION
- Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle
- (2018) Suzan J. G. Knottnerus et al. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
- Reverse Cholesterol Transport: Molecular Mechanisms and the Non-medical Approach to Enhance HDL Cholesterol
- (2018) Leandro R. Marques et al. Frontiers in Physiology
- Identification of metabolic profiles associated with human exposure to perfluoroalkyl substances
- (2018) Samira Salihovic et al. Journal of Exposure Science and Environmental Epidemiology
- Selective Associations of Recent Low Concentrations of Perfluoroalkyl Substances With Liver Function Biomarkers
- (2018) Ram B. Jain et al. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
- Roles of gender and obesity in defining correlations between perfluoroalkyl substances and lipid/lipoproteins
- (2018) Ram B. Jain et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Serum metabolome biomarkers associate low-level environmental perfluorinated compound exposure with oxidative /nitrosative stress in humans
- (2017) Xiaofei Wang et al. ENVIRONMENTAL POLLUTION
- Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice
- (2017) Davor Slijepcevic et al. HEPATOLOGY
- Per- and Polyfluoroalkyl Substances (PFASs) in Food and Human Dietary Intake: A Review of the Recent Scientific Literature
- (2017) José L. Domingo et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Dioxin-like PCB 126 Increases Systemic Inflammation and Accelerates Atherosclerosis in Lean LDL Receptor-Deficient Mice
- (2017) Michael C Petriello et al. TOXICOLOGICAL SCIENCES
- Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis
- (2017) Kaberi P. Das et al. TOXICOLOGY
- Modeled Perfluorooctanoic Acid (PFOA) Exposure and Liver Function in a Mid-Ohio Valley Community
- (2016) Lyndsey A. Darrow et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Absorption, distribution, metabolism, excretion, and kinetics of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid ammonium salt following a single dose in rat, mouse, and cynomolgus monkey
- (2016) Shawn A. Gannon et al. TOXICOLOGY
- Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation
- (2016) Jieun Lee et al. Cell Reports
- Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice
- (2016) Fenni Rusli et al. Scientific Reports
- Bile Acids as Hormones: The FXR-FGF15/19 Pathway
- (2015) Steven A. Kliewer et al. DIGESTIVE DISEASES
- Hazard assessment of fluorinated alternatives to long-chain perfluoroalkyl acids (PFAAs) and their precursors: Status quo, ongoing challenges and possible solutions
- (2015) Zhanyun Wang et al. ENVIRONMENT INTERNATIONAL
- Associations of perfluorinated chemical serum concentrations and biomarkers of liver function and uric acid in the US population (NHANES), 2007–2010
- (2015) Jessie A. Gleason et al. ENVIRONMENTAL RESEARCH
- Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism
- (2015) Marcus J. Miller et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Na+/Taurocholate Cotransporting Polypeptide and Apical Sodium-Dependent Bile Acid Transporter Are Involved in the Disposition of Perfluoroalkyl Sulfonates in Humans and Rats
- (2015) Wen Zhao et al. TOXICOLOGICAL SCIENCES
- Bile acid nuclear receptor FXR and digestive system diseases
- (2015) Lili Ding et al. Acta Pharmaceutica Sinica B
- HTSeq--a Python framework to work with high-throughput sequencing data
- (2014) S. Anders et al. BIOINFORMATICS
- Bile acids and the gut microbiome
- (2014) Jason M. Ridlon et al. CURRENT OPINION IN GASTROENTEROLOGY
- Modeled PFOA Exposure and Coronary Artery Disease, Hypertension, and High Cholesterol in Community and Worker Cohorts
- (2014) Andrea Winquist et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
- (2014) Dmitry B. Zorov et al. PHYSIOLOGICAL REVIEWS
- Perfluorooctanoic Acid (PFOA)–induced Liver Lesions in Two Strains of Mice Following Developmental Exposures
- (2014) Adam J. Filgo et al. TOXICOLOGIC PATHOLOGY
- PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion
- (2014) Ling Wang et al. Scientific Reports
- Narrowing Sex Differences in Lipoprotein Cholesterol Subclasses Following Mid‐Life: The Very Large Database of Lipids (VLDL‐10B)
- (2014) Kristopher J. Swiger et al. Journal of the American Heart Association
- Role of Nrf2 in Oxidative Stress and Toxicity
- (2013) Qiang Ma Annual Review of Pharmacology and Toxicology
- The association between PFOA, PFOS and serum lipid levels in adolescents
- (2013) Sarah Dee Geiger et al. CHEMOSPHERE
- Emerging role of cellular cholesterol in the pathogenesis of nonalcoholic fatty liver disease
- (2013) Amir Bashiri et al. CURRENT OPINION IN LIPIDOLOGY
- Menopause, atherosclerosis, and coronary artery disease
- (2013) Elizabeth Barrett-Connor CURRENT OPINION IN PHARMACOLOGY
- Differential regulation of bile acid and cholesterol metabolism by the farnesoid X receptor inLdlr−/−mice versus hamsters
- (2013) Christophe Gardès et al. JOURNAL OF LIPID RESEARCH
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Serum Perfluorooctanoate (PFOA) and Perfluorooctane Sulfonate (PFOS) Concentrations and Liver Function Biomarkers in a Population with Elevated PFOA Exposure
- (2012) Valentina Gallo et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- FXR signaling in the enterohepatic system
- (2012) Tsutomu Matsubara et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis
- (2012) Giovanni Musso et al. PROGRESS IN LIPID RESEARCH
- Chronic dietary toxicity and carcinogenicity study with potassium perfluorooctanesulfonate in Sprague Dawley rats
- (2012) John L. Butenhoff et al. TOXICOLOGY
- Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice
- (2011) Tomohiko Nakagawa et al. ARCHIVES OF TOXICOLOGY
- Gender, but not CYP7A1 or SLCO1B1 Polymorphism, Affects the Fasting Plasma Concentrations of Bile Acids in Human Beings
- (2011) Xiaoqiang Xiang et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Polyfluorinated Compounds: Past, Present, and Future
- (2011) Andrew B. Lindstrom et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- Polyfluorinated surfactants (PFS) in paper and board coatings for food packaging
- (2011) Xenia Trier et al. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
- Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis
- (2011) Derrick M. Van Rooyen et al. GASTROENTEROLOGY
- The Human Plasma Lipidome
- (2011) Oswald Quehenberger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): Further investigation of C4–C12 compounds
- (2011) Cynthia J. Wolf et al. REPRODUCTIVE TOXICOLOGY
- Immunotoxicity of Perfluorinated Compounds: Recent Developments
- (2011) Jamie C. DeWitt et al. TOXICOLOGIC PATHOLOGY
- Perfluoroalkyl Sulfonates Cause Alkyl Chain Length–Dependent Hepatic Steatosis and Hypolipidemia Mainly by Impairing Lipoprotein Production in APOE*3-Leiden CETP Mice
- (2011) Silvia Bijland et al. TOXICOLOGICAL SCIENCES
- Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins
- (2011) Robert C Buck et al. Integrated Environmental Assessment and Management
- Perfluorooctanoic Acid, Perfluorooctanesulfonate, and Serum Lipids in Children and Adolescents
- (2010) Stephanie J. Frisbee et al. ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
- The fatty acid composition of plasma cholesteryl esters and estimated desaturase activities in patients with nonalcoholic fatty liver disease and the effect of long-term ezetimibe therapy on these levels
- (2010) Hyohun Park et al. CLINICA CHIMICA ACTA
- Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice
- (2010) Kristiaan Wouters et al. FEBS LETTERS
- Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: An open-label, pilot study
- (2010) Masato Yoneda et al. HEPATOLOGY RESEARCH
- Dietary exposure to perfluorooctanoate or perfluorooctane sulfonate induces hypertrophy in centrilobular hepatocytes and alters the hepatic immune status in mice
- (2010) Mousumi Rahman Qazi et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Anabolic-androgenic steroids: a possible new risk factor of toxicant-associated fatty liver disease
- (2010) Paulo Adriano Schwingel et al. LIVER INTERNATIONAL
- Nuclear Receptor Regulation of the Adaptive Response of Bile Acid Transporters in Cholestasis
- (2010) Martin Wagner et al. SEMINARS IN LIVER DISEASE
- Association of Perfluorooctanoic Acid and Perfluorooctane Sulfonate With Serum Lipids Among Adults Living Near a Chemical Plant
- (2009) K. Steenland et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Investigation of the Associations Between Low-Dose Serum Perfluorinated Chemicals and Liver Enzymes in US Adults
- (2009) Chien-Yu Lin et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Exposure to Polyfluoroalkyl Chemicals and Cholesterol, Body Weight, and Insulin Resistance in the General U.S. Population
- (2009) Jessica W. Nelson et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH
- (2009) Francisco Caballero et al. JOURNAL OF HEPATOLOGY
- Thirty Years of Medical Surveillance in Perfluooctanoic Acid Production Workers
- (2009) Giovanni Costa et al. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
- Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor α, but not human PPARα
- (2009) Toshiki Nakamura et al. TOXICOLOGY
- Regulation of Bile Acid and Cholesterol Metabolism by PPARs
- (2009) Tiangang Li et al. PPAR Research
- Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice
- (2008) Shuqin Zheng et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Toxicogenomic Dissection of the Perfluorooctanoic Acid Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPARα and CAR
- (2008) Mitchell B. Rosen et al. TOXICOLOGICAL SCIENCES
- Emissions of perfluorinated alkylated substances (PFAS) from point sources—identification of relevant branches
- (2008) M. Clara et al. WATER SCIENCE AND TECHNOLOGY
- Bile acid transporters in health and disease
- (2008) A. Kosters et al. XENOBIOTICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started