Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells

Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)

(2019) Anne-Cathrin Behr et al.   TOXICOLOGY IN VITRO

Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures

(2018) Robim M. Rodrigues et al.   ARCHIVES OF TOXICOLOGY

Direct Quantification of Cytochromes P450 and Drug Transporters—A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

(2018) Frederik Weiß et al.   DRUG METABOLISM AND DISPOSITION

Bile micro-infarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood

(2018) Ahmed Ghallab et al.   HEPATOLOGY

The ascending pathophysiology of cholestatic liver disease

(2017) Peter L.M. Jansen et al.   HEPATOLOGY

The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction

(2016) Kevin M. Beggs et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

(2016) Ahmad Sharanek et al.   Scientific Reports

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

(2015) Valentina Tremaroli et al.   Cell Metabolism

Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes

(2015) Pamela Bachour-El Azzi et al.   TOXICOLOGICAL SCIENCES

Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes

(2015) Ahmad Sharanek et al.   TOXICOLOGICAL SCIENCES

Different Dose-Dependent Mechanisms Are Involved in Early Cyclosporine A-Induced Cholestatic Effects in HepaRG Cells

(2014) Ahmad Sharanek et al.   TOXICOLOGICAL SCIENCES

PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion

(2014) Ling Wang et al.   Scientific Reports

Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

(2013) Mathieu Vinken et al.   TOXICOLOGICAL SCIENCES

Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells

(2013) Marc Le Vee et al.   TOXICOLOGY IN VITRO

Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR

(2013) Claudia Luckert et al.   TOXICOLOGY LETTERS

One-Step Sequence- and Ligation-Independent Cloning as a Rapid and Versatile Cloning Method for Functional Genomics Studies

(2012) Jae-Yeon Jeong et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells

(2012) Sébastien Anthérieu et al.   HEPATOLOGY

Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR

(2012) Clifford R. Elcombe et al.   TOXICOLOGY

Perfluorooctanoic acid affects the activity of the hepatocyte nuclear factor 4 alpha (HNF4α)

(2012) E. Scharmach et al.   TOXICOLOGY LETTERS

Organic Anion Transporting Polypeptides (OATPs): Regulation of Expression and Function

(2011) Martin Svoboda et al.   CURRENT DRUG METABOLISM

Trends in Exposure to Polyfluoroalkyl Chemicals in the U.S. Population: 1999−2008†

(2011) Kayoko Kato et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Drug-induced cholestasis

(2011) Manmeet S. Padda et al.   HEPATOLOGY

Role of Peroxisome Proliferator-activated Receptor-α in Hepatobiliary Injury Induced by Ammonium Perfluorooctanoate in Mouse Liver

(2010) Mutsuko MINATA et al.   INDUSTRIAL HEALTH

Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

(2009) S. Antherieu et al.   DRUG METABOLISM AND DISPOSITION

Hepatocyte nuclear factor 4α regulation of bile acid and drug metabolism

(2009) John YL Chiang   Expert Opinion on Drug Metabolism & Toxicology

Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification

(2009) Yazen Alnouti   TOXICOLOGICAL SCIENCES

Activation of Mouse and Human Peroxisome Proliferator−Activated Receptor Alpha by Perfluoroalkyl Acids of Different Functional Groups and Chain Lengths

(2008) Cynthia J. Wolf et al.   TOXICOLOGICAL SCIENCES