High-Throughput Transcriptomic Analysis of Human Primary Hepatocyte Spheroids Exposed to Per- and Polyfluoroalkyl Substances as a Platform for Relative Potency Characterization

Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells

(2020) Jochem Louisse et al.   ARCHIVES OF TOXICOLOGY

Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet

(2020) J.J. Schlezinger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Extraction-free whole transcriptome gene expression analysis of FFPE sections and histology-directed subareas of tissue

(2019) Christy L. Trejo et al.   PLoS One

Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization

(2019) Katie Paul Friedman et al.   TOXICOLOGICAL SCIENCES

Toxicity testing in the 21st century: progress in the past decade and future perspectives

(2019) D. Krewski et al.   ARCHIVES OF TOXICOLOGY

Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach

(2019) Ran Jin et al.   ENVIRONMENT INTERNATIONAL

Accelerating the Pace of Chemical Risk Assessment

(2018) Robert J. Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) – A comparison with lysosomotropic drugs

(2018) Diana Sanchez Garcia et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics

(2018) Deepak Mav et al.   PLoS One

Nonmonotonic Dose–Response Curves Occur in Dose Ranges That Are Relevant to Regulatory Decision-Making

(2018) Corinne E. Hill et al.   Dose-Response

Selective Associations of Recent Low Concentrations of Perfluoroalkyl Substances With Liver Function Biomarkers

(2018) Ram B. Jain et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis

(2017) Kaberi P. Das et al.   TOXICOLOGY

Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides

(2017) Osamu Kimura et al.   TOXICOLOGY LETTERS

A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics

(2017) John S. House et al.   Frontiers in Genetics

Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment

(2016) Reza Farmahin et al.   ARCHIVES OF TOXICOLOGY

Perfluoroalkyl and polyfluoroalkyl substances and measures of human fertility: a systematic review

(2016) Cathrine Carlsen Bach et al.   CRITICAL REVIEWS IN TOXICOLOGY

Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach

(2016) Nanyang Yu et al.   Scientific Reports

The impact of PPARα activation on whole genome gene expression in human precision cut liver slices

(2015) Aafke W.F. Janssen et al.   BMC GENOMICS

Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates

(2015) Katrine Kielsen et al.   Journal of Immunotoxicology

Na+/Taurocholate Cotransporting Polypeptide and Apical Sodium-Dependent Bile Acid Transporter Are Involved in the Disposition of Perfluoroalkyl Sulfonates in Humans and Rats

(2015) Wen Zhao et al.   TOXICOLOGICAL SCIENCES

Incorporating High-Throughput Exposure Predictions With Dosimetry-AdjustedIn VitroBioactivity to Inform Chemical Toxicity Testing

(2015) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Transcriptomal changes and functional annotation of the developing non-human primate choroid plexus

(2015) C. Joakim Ek et al.   Frontiers in Neuroscience

A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and cancer risk in humans

(2014) Ellen T. Chang et al.   CRITICAL REVIEWS IN TOXICOLOGY

Perfluorooctanoic Acid (PFOA)–induced Liver Lesions in Two Strains of Mice Following Developmental Exposures

(2014) Adam J. Filgo et al.   TOXICOLOGIC PATHOLOGY

PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion

(2014) Ling Wang et al.   Scientific Reports

The association between PFOA, PFOS and serum lipid levels in adolescents

(2013) Sarah Dee Geiger et al.   CHEMOSPHERE

Accumulation of perfluoroalkyl substances in human tissues

(2013) Francisca Pérez et al.   ENVIRONMENT INTERNATIONAL

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population

(2013) Kirsten T. Eriksen et al.   PLoS One

Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate

(2013) John F. Wambaugh et al.   TOXICOLOGICAL SCIENCES

Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

PFOS-induced hepatic steatosis, the mechanistic actions on β-oxidation and lipid transport

(2012) H.T. Wan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Putative Mechanisms of Environmental Chemical–Induced Steatosis

(2012) J. Phillip Kaiser et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein

(2012) Carlos L. J. Vrins et al.   JOURNAL OF LIPID RESEARCH

Gene expression profiling in fetal rat lung during gestational perfluorooctane sulfonate exposure

(2012) Leping Ye et al.   TOXICOLOGY LETTERS

Transcriptional effects of perfluorinated compounds in rat hepatoma cells

(2011) Jonathan E. Naile et al.   CHEMOSPHERE

Perfluoroalkyl Sulfonates Cause Alkyl Chain Length–Dependent Hepatic Steatosis and Hypolipidemia Mainly by Impairing Lipoprotein Production in APOE*3-Leiden CETP Mice

(2011) Silvia Bijland et al.   TOXICOLOGICAL SCIENCES

Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes

(2011) J.A. Bjork et al.   TOXICOLOGY

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

(2010) David M. Reif et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Gene Expression Profiling in Wild-Type and PPAR-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR-Independent Effects

(2010) Mitchell B. Rosen et al.   PPAR Research

Association of Perfluorooctanoic Acid and Perfluorooctane Sulfonate With Serum Lipids Among Adults Living Near a Chemical Plant

(2009) K. Steenland et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Comparative Assessment of the Global Fate and Transport Pathways of Long-Chain Perfluorocarboxylic Acids (PFCAs) and Perfluorocarboxylates (PFCs) Emitted from Direct Sources

(2009) James M. Armitage et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Chronic effects of water-borne PFOS exposure on growth, survival and hepatotoxicity in zebrafish: A partial life-cycle test

(2008) Yongbing Du et al.   CHEMOSPHERE

Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPARα) in the mouse

(2008) Barbara D. Abbott et al.   REPRODUCTIVE TOXICOLOGY

Developmental toxicity in white leghorn chickens following in ovo exposure to perfluorooctane sulfonate (PFOS)

(2008) Margie M. Peden-Adams et al.   REPRODUCTIVE TOXICOLOGY

Gene Profiling in the Livers of Wild-type and PPARα-Null Mice Exposed to Perfluorooctanoic Acid

(2008) Mitchell B. Rosen et al.   TOXICOLOGIC PATHOLOGY

Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats

(2008) X HAN et al.   TOXICOLOGY LETTERS