Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?

Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

(2020) Jan Borén et al.   EUROPEAN HEART JOURNAL

Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells

(2020) Anne-Cathrin Behr et al.   ARCHIVES OF TOXICOLOGY

Associations between perfluoroalkyl substances and serum lipids in a Swedish adult population with contaminated drinking water

(2020) Ying Li et al.   Environmental Health

Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells

(2020) Jochem Louisse et al.   ARCHIVES OF TOXICOLOGY

Associations between perfluoroalkyl substances and lipid profile in a highly exposed young adult population in the Veneto Region

(2020) Cristina Canova et al.   ENVIRONMENT INTERNATIONAL

Dose effects of ammonium perfluorooctanoate on lipoprotein metabolism in APOE*3-Leiden.CETP mice

(2019) Marianne G Pouwer et al.   TOXICOLOGICAL SCIENCES

Liver function biomarkers disorder is associated with exposure to perfluoroalkyl acids in adults: Isomers of C8 Health Project in China

(2019) Min Nian et al.   ENVIRONMENTAL RESEARCH

System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells

(2019) Leonore Wigger et al.   PLoS One

Interspecies differences in perfluoroalkyl substances (PFAS) toxicokinetics and application to health-based criteria

(2019) Daniella M. Pizzurro et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases

(2019) Matthew M Yeh et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods

(2019) Patrick D. McMullen et al.   TOXICOLOGY IN VITRO

Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration

(2019) Anika L. Dzierlenga et al.   XENOBIOTICA

Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice

(2019) Marianne G. Pouwer et al.   JOURNAL OF LIPID RESEARCH

Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)

(2019) Anne-Cathrin Behr et al.   TOXICOLOGY IN VITRO

The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice

(2018) Montserrat A. de la Rosa Rodriguez et al.   BMC GENOMICS

Changes in markers of liver function in relation to changes in perfluoroalkyl substances - A longitudinal study

(2018) Samira Salihovic et al.   ENVIRONMENT INTERNATIONAL

Comparing the toxic potency in vivo of long-chain perfluoroalkyl acids and fluorinated alternatives

(2018) Melissa I. Gomis et al.   ENVIRONMENT INTERNATIONAL

FXR activation by obeticholic acid or nonsteroidal agonists induces a human-like lipoprotein cholesterol change in mice with humanized chimeric liver

(2018) Romeo Papazyan et al.   JOURNAL OF LIPID RESEARCH

Stochastic Pharmacokinetic-Pharmacodynamic Modeling for Assessing the Systemic Health Risk of Perfluorooctanoate (PFOA)

(2018) Matteo Convertino et al.   TOXICOLOGICAL SCIENCES

Reverse Cholesterol Transport: Molecular Mechanisms and the Non-medical Approach to Enhance HDL Cholesterol

(2018) Leandro R. Marques et al.   Frontiers in Physiology

Application of the comparison approach to open TG-GATEs: A useful toxicogenomics tool for detecting modes of action in chemical risk assessment

(2018) Harm J. Heusinkveld et al.   FOOD AND CHEMICAL TOXICOLOGY

Plasma lipidomic analysis reveals strong similarities between lipid fingerprints in human, hamster and mouse compared to other animal species

(2018) Zied Kaabia et al.   Scientific Reports

The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk

(2018) Pratik B Sandesara et al.   ENDOCRINE REVIEWS

Selective Associations of Recent Low Concentrations of Perfluoroalkyl Substances With Liver Function Biomarkers

(2018) Ram B. Jain et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: A systematic review of epidemiologic studies

(2017) Virginia Ballesteros et al.   ENVIRONMENT INTERNATIONAL

Adverse bioeffect of perfluorooctanoic acid on liver metabolic function in mice

(2017) Xinmou Wu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

(2017) Brian A. Ference et al.   EUROPEAN HEART JOURNAL

The impact of exposure to environmental contaminant on hepatocellular lipid metabolism

(2017) Zongguang Hui et al.   GENE

Relationship between peroxisome proliferator-activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells

(2017) Anna Kjerstine Rosenmai et al.   JOURNAL OF APPLIED TOXICOLOGY

Poly- and perfluorinated compounds activate human pregnane X receptor

(2017) Yi-Ming Zhang et al.   TOXICOLOGY

Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis

(2017) Kaberi P. Das et al.   TOXICOLOGY

PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling

(2017) Mitchell B. Rosen et al.   TOXICOLOGY

Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid

(2016) Taiki Abe et al.   ARCHIVES OF TOXICOLOGY

HDL functionality in reverse cholesterol transport — Challenges in translating data emerging from mouse models to human disease

(2016) Miriam Lee-Rueckert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

2016 European Guidelines on cardiovascular disease prevention in clinical practice

(2016) Massimo F. Piepoli et al.   EUROPEAN HEART JOURNAL

Gender differences in pharmacokinetics and tissue distribution of 3 perfluoroalkyl and polyfluoroalkyl substances in rats

(2016) Sook-Jin Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Elevated levels of serum cholesterol are associated with better performance on tasks of episodic memory

(2016) Elizabeth C. Leritz et al.   METABOLIC BRAIN DISEASE

The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction

(2016) Kevin M. Beggs et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Crosstalk of HNF4 α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids

(2016) Hong Lu   Acta Pharmaceutica Sinica B

The impact of PPARα activation on whole genome gene expression in human precision cut liver slices

(2015) Aafke W.F. Janssen et al.   BMC GENOMICS

Associations of perfluorinated chemical serum concentrations and biomarkers of liver function and uric acid in the US population (NHANES), 2007–2010

(2015) Jessie A. Gleason et al.   ENVIRONMENTAL RESEARCH

Isomer-Specific Binding Affinity of Perfluorooctanesulfonate (PFOS) and Perfluorooctanoate (PFOA) to Serum Proteins

(2015) Sanjay Beesoon et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raisingA systematic review and meta-analysis of relevant preclinical studies and clinical trials

(2015) Susan Kühnast et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

Toxicokinetics of perfluoroalkyl carboxylic acids with different carbon chain lengths in mice and humans

(2015) Yukiko Fujii et al.   JOURNAL OF OCCUPATIONAL HEALTH

Na+/Taurocholate Cotransporting Polypeptide and Apical Sodium-Dependent Bile Acid Transporter Are Involved in the Disposition of Perfluoroalkyl Sulfonates in Humans and Rats

(2015) Wen Zhao et al.   TOXICOLOGICAL SCIENCES

Perfluorooctanoic acid (PFOA) affects distinct molecular signalling pathways in human primary hepatocytes

(2015) Thorsten Buhrke et al.   TOXICOLOGY

Deciphering the roles of the constitutive androstane receptor in energy metabolism

(2014) Jiong Yan et al.   ACTA PHARMACOLOGICA SINICA

Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28 days

(2014) Shengmin Yan et al.   ARCHIVES OF TOXICOLOGY

Cholesterol and Lipoprotein Metabolism

(2014) Hanrui Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Modeled PFOA Exposure and Coronary Artery Disease, Hypertension, and High Cholesterol in Community and Worker Cohorts

(2014) Andrea Winquist et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Toxicokinetics of Seven Perfluoroalkyl Sulfonic and Carboxylic Acids in Pigs Fed a Contaminated Diet

(2014) Jorge Numata et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE

(2014) Brandon Ason et al.   JOURNAL OF LIPID RESEARCH

Triglycerides and cardiovascular disease

(2014) Børge G Nordestgaard et al.   LANCET

High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways

(2014) Xiaobing Tan et al.   PLoS One

Cross-Species Gene Expression Analysis of Species Specific Differences in the Preclinical Assessment of Pharmaceutical Compounds

(2014) John Okyere et al.   PLoS One

Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-α activation

(2014) Cynthia J. Wolf et al.   TOXICOLOGY

PBPK modeling for PFOS and PFOA: Validation with human experimental data

(2014) Francesc Fàbrega et al.   TOXICOLOGY LETTERS

PFOS induced lipid metabolism disturbances in BALB/c mice through inhibition of low density lipoproteins excretion

(2014) Ling Wang et al.   Scientific Reports

Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

The association between PFOA, PFOS and serum lipid levels in adolescents

(2013) Sarah Dee Geiger et al.   CHEMOSPHERE

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

(2013) J. Christopher Corton et al.   CRITICAL REVIEWS IN TOXICOLOGY

Accumulation of perfluoroalkyl substances in human tissues

(2013) Francisca Pérez et al.   ENVIRONMENT INTERNATIONAL

Perfluoroalkyl substances and lipid concentrations in plasma during pregnancy among women in the Norwegian Mother and Child Cohort Study

(2013) Anne P. Starling et al.   ENVIRONMENT INTERNATIONAL

Serum Perfluorooctanoic Acid and Perfluorooctane Sulfonate Concentrations in Relation to Birth Outcomes in the Mid-Ohio Valley, 2005–2010

(2013) Lyndsey A. Darrow et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Reductions in Serum Lipids with a 4-year Decline in Serum Perfluorooctanoic Acid and Perfluorooctanesulfonic Acid

(2013) Nicola Fitz-Simon et al.   EPIDEMIOLOGY

Cholesteryl ester transfer proteins from different species do not have equivalent activities

(2013) Richard E. Morton et al.   JOURNAL OF LIPID RESEARCH

An integrated metabonomics and transcriptomics approach to understanding metabolic pathway disturbance induced by perfluorooctanoic acid

(2013) Siyuan Peng et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Association between Plasma PFOA and PFOS Levels and Total Cholesterol in a Middle-Aged Danish Population

(2013) Kirsten T. Eriksen et al.   PLoS One

Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism

(2013) Ewa C. S. Ellis et al.   PLoS One

Specific Accumulation of Lipid Droplets in Hepatocyte Nuclei of PFOA-exposed BALB/c Mice

(2013) Ling Wang et al.   Scientific Reports

PFOS-induced hepatic steatosis, the mechanistic actions on β-oxidation and lipid transport

(2012) H.T. Wan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Low-Density Lipoprotein Cholesterol, Apolipoprotein B, and Risk of Coronary Heart Disease: From Familial Hyperlipidemia to Genomics

(2012) C. C. Imes et al.   Biological Research for Nursing

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

PPARα/HNF4α Interplay on Diversified Responsive Elements. Relevance in the Regulation of Liver Peroxisomal Fatty Acid Catabolism

(2012) Julie Chamouton et al.   CURRENT DRUG METABOLISM

Serum Perfluorooctanoate (PFOA) and Perfluorooctane Sulfonate (PFOS) Concentrations and Liver Function Biomarkers in a Population with Elevated PFOA Exposure

(2012) Valentina Gallo et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Nuclear Receptors HNF4α and LRH-1 Cooperate in RegulatingCyp7a1 in Vivo

(2012) Serkan Kir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague–Dawley rats

(2012) John L. Butenhoff et al.   TOXICOLOGY

Chronic dietary toxicity and carcinogenicity study with potassium perfluorooctanesulfonate in Sprague Dawley rats

(2012) John L. Butenhoff et al.   TOXICOLOGY

Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR

(2012) Clifford R. Elcombe et al.   TOXICOLOGY

Perfluorooctanoic acid affects the activity of the hepatocyte nuclear factor 4 alpha (HNF4α)

(2012) E. Scharmach et al.   TOXICOLOGY LETTERS

Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice

(2011) Tomohiko Nakagawa et al.   ARCHIVES OF TOXICOLOGY

Renal Elimination of Perfluorocarboxylates (PFCAs)

(2011) Xing Han et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Peroxisome proliferator-activated receptor-α agonist, Wy 14 643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis

(2011) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys

(2011) Shu-Ching Chang et al.   REPRODUCTIVE TOXICOLOGY

Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): Further investigation of C4–C12 compounds

(2011) Cynthia J. Wolf et al.   REPRODUCTIVE TOXICOLOGY

Perfluoroalkyl Sulfonates Cause Alkyl Chain Length–Dependent Hepatic Steatosis and Hypolipidemia Mainly by Impairing Lipoprotein Production in APOE*3-Leiden CETP Mice

(2011) Silvia Bijland et al.   TOXICOLOGICAL SCIENCES

Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes

(2011) J.A. Bjork et al.   TOXICOLOGY

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Perfluorooctanoic Acid, Perfluorooctanesulfonate, and Serum Lipids in Children and Adolescents

(2010) Stephanie J. Frisbee et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

(2010) Liya Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of Peroxisome Proliferator-activated Receptor-α in Hepatobiliary Injury Induced by Ammonium Perfluorooctanoate in Mouse Liver

(2010) Mutsuko MINATA et al.   INDUSTRIAL HEALTH

Two-year follow-up biomonitoring pilot study of residents’ and controls’ PFC plasma levels after PFOA reduction in public water system in Arnsberg, Germany

(2010) Edna Brede et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Effect of Fenofibrate and Niacin on Intrahepatic Triglyceride Content, Very Low-Density Lipoprotein Kinetics, and Insulin Action in Obese Subjects with Nonalcoholic Fatty Liver Disease

(2010) Elisa Fabbrini et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Human detoxification of perfluorinated compounds

(2010) S.J. Genuis et al.   PUBLIC HEALTH

Gene Expression Profiling in Wild-Type and PPAR-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR-Independent Effects

(2010) Mitchell B. Rosen et al.   PPAR Research

Association of Perfluorooctanoic Acid and Perfluorooctane Sulfonate With Serum Lipids Among Adults Living Near a Chemical Plant

(2009) K. Steenland et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Investigation of the Associations Between Low-Dose Serum Perfluorinated Chemicals and Liver Enzymes in US Adults

(2009) Chien-Yu Lin et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Human Organic Anion Transporter hOAT4 is a Transporter of Perfluorooctanoic Acid

(2009) Hatsuki Nakagawa et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Rate of Decline in Serum PFOA Concentrations after Granular Activated Carbon Filtration at Two Public Water Systems in Ohio and West Virginia

(2009) Scott M. Bartell et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Exposure to Polyfluoroalkyl Chemicals and Cholesterol, Body Weight, and Insulin Resistance in the General U.S. Population

(2009) Jessica W. Nelson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors

(2009) M. J. Chapman et al.   EUROPEAN HEART JOURNAL

Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species

(2009) Hongzu Ren et al.   REPRODUCTIVE TOXICOLOGY

Structure-Activity Relationships and Human Relevance for Perfluoroalkyl Acid–Induced Transcriptional Activation of Peroxisome Proliferation in Liver Cell Cultures

(2009) James A. Bjork et al.   TOXICOLOGICAL SCIENCES

Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor α, but not human PPARα

(2009) Toshiki Nakamura et al.   TOXICOLOGY

Organic anion transporting polypeptide (Oatp) 1a1-mediated perfluorooctanoate transport and evidence for a renal reabsorption mechanism of Oatp1a1 in renal elimination of perfluorocarboxylates in rats

(2009) Ching-Hui Yang et al.   TOXICOLOGY LETTERS

Regulation of Bile Acid and Cholesterol Metabolism by PPARs

(2009) Tiangang Li et al.   PPAR Research

Overproduction of Very Low–Density Lipoproteins Is the Hallmark of the Dyslipidemia in the Metabolic Syndrome

(2008) Martin Adiels et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase

(2008) Russell A DeBose-Boyd   CELL RESEARCH

Immunotoxicity of Perfluorooctanoic Acid and Perfluorooctane Sulfonate and the Role of Peroxisome Proliferator-Activated Receptor Alpha

(2008) Jamie C. DeWitt et al.   CRITICAL REVIEWS IN TOXICOLOGY

EFFECTS OF PERFLUOROOCTANE SULFONATE ON RAT THYROID HORMONE BIOSYNTHESIS AND METABOLISM

(2008) Wen-Guang Yu et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Altered Fatty Acid Homeostasis and Related Toxicologic Sequelae in Rats Exposed to Dietary Potassium Perfluorooctanesulfonate (PFOS)

(2008) Ivan Curran et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Gene Profiling in the Livers of Wild-type and PPARα-Null Mice Exposed to Perfluorooctanoic Acid

(2008) Mitchell B. Rosen et al.   TOXICOLOGIC PATHOLOGY

Toxicogenomic Dissection of the Perfluorooctanoic Acid Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPARα and CAR

(2008) Mitchell B. Rosen et al.   TOXICOLOGICAL SCIENCES

Activation of Mouse and Human Peroxisome Proliferator−Activated Receptor Alpha by Perfluoroalkyl Acids of Different Functional Groups and Chain Lengths

(2008) Cynthia J. Wolf et al.   TOXICOLOGICAL SCIENCES