Reprogramming cellular identity in vivo

A quantitative model of cellular decision making in direct neuronal reprogramming

(2021) Adriaan Merlevede et al.   Scientific Reports

In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury

(2021) Wenjiao Tai et al.   Cell Stem Cell

CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion

(2021) Gianluca L. Russo et al.   Cell Stem Cell

Direct cell reprogramming: approaches, mechanisms and progress

(2021) Haofei Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Formation and integration of new neurons in the adult hippocampus

(2021) Annina Denoth-Lippuner et al.   NATURE REVIEWS NEUROSCIENCE

Donor cell memory confers a metastable state of directly converted cells

(2021) Kee-Pyo Kim et al.   Cell Stem Cell

The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming

(2021) Glynnis A. Garry et al.   NATURE CELL BIOLOGY

Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming

(2021) Álvaro Herrero-Navarro et al.   Science Advances

Direct reprogramming with Sendai virus vectors repaired infarct hearts at the chronic stage

(2021) Mari Isomi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Direct in vivo reprogramming with non-viral sequential targeting nanoparticles promotes cardiac regeneration

(2021) Qiaozi Wang et al.   BIOMATERIALS

Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4

(2021) Stefanie Ohlig et al.   EMBO JOURNAL

Transient astrocyte‐like NG2 glia subpopulation emerges solely following permanent brain ischemia

(2021) Denisa Kirdajova et al.   GLIA

Highly Efficient MicroRNA Delivery Using Functionalized Carbon Dots for Enhanced Conversion of Fibroblasts to Cardiomyocytes

(2021) Lei Yang et al.   International Journal of Nanomedicine

Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2

(2021) J. Kempf et al.   Cell Reports

Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

(2021) Suhong Sun et al.   eLife

Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions

(2021) Meritxell Sáez et al.   Cell Systems

Restoration of Visual Function and Cortical Connectivity After Ischemic Injury Through NeuroD1-Mediated Gene Therapy

(2021) Yu Tang et al.   Frontiers in Cell and Developmental Biology

Revisiting astrocyte to neuron conversion with lineage tracing in vivo

(2021) Lei-Lei Wang et al.   CELL

Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy

(2021) Célia Lentini et al.   Cell Stem Cell

Epigenetic memory in reprogramming

(2021) Eva Hörmanseder   CURRENT OPINION IN GENETICS & DEVELOPMENT

Delineating chromatin accessibility re-patterning at single cell level during early stage of direct cardiac reprogramming

(2021) Haofei Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming

(2021) Yanxia Rao et al.   NEURON

Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors

(2021) Levi Todd et al.   Cell Reports

STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse Retina

(2020) Nikolas L. Jorstad et al.   Cell Reports

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

REST Inhibits Direct Reprogramming of Pancreatic Exocrine to Endocrine Cells by Preventing PDX1-Mediated Activation of Endocrine Genes

(2020) Ofer Elhanani et al.   Cell Reports

A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury

(2020) Margherita Zamboni et al.   Cell Stem Cell

The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors

(2020) Kenichi Horisawa et al.   MOLECULAR CELL

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in Müller Glial regenerative potential

(2020) Leah S. VandenBosch et al.   Scientific Reports

Activation of a neural stem cell transcriptional program in parenchymal astrocytes

(2020) Jens P Magnusson et al.   eLife

Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs

(2020) Kitra Cates et al.   Cell Stem Cell

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

EpiMogrify Models H3K4me3 Data to Identify Signaling Molecules that Improve Cell Fate Control and Maintenance

(2020) Uma S. Kamaraj et al.   Cell Systems

Reprogramming to recover youthful epigenetic information and restore vision

(2020) Yuancheng Lu et al.   NATURE

Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea

(2020) Sungsu Lee et al.   Scientific Reports

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

(2019) Taito Matsuda et al.   NEURON

Adeno-associated virus vector as a platform for gene therapy delivery

(2019) Dan Wang et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs

(2019) Khatia Gabisonia et al.   NATURE

Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming

(2019) Nicole R. Stone et al.   Cell Stem Cell

Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming

(2019) Yang Zhou et al.   Cell Stem Cell

In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia

(2019) Toru Yamashita et al.   Scientific Reports

Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex

(2019) Nicola Mattugini et al.   NEURON

Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming

(2019) Kimberley N. Babos et al.   Cell Stem Cell

Properties of human astrocytes and NG2 glia

(2019) Peter Bedner et al.   GLIA

Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction

(2018) Kazutaka Miyamoto et al.   Cell Stem Cell

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

(2018) Xiangwei Xiao et al.   Cell Stem Cell

Regenerative proliferation of differentiated cells by mTORC1‐dependent paligenosis

(2018) Spencer G Willet et al.   EMBO JOURNAL

Long-Term Correction of Diabetes in Mice by In Vivo Reprogramming of Pancreatic Ducts

(2018) Yuhan Wang et al.   MOLECULAR THERAPY

Genetic determinants and epigenetic effects of pioneer-factor occupancy

(2018) Julie Donaghey et al.   NATURE GENETICS

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program

(2018) Marisa Karow et al.   NATURE NEUROSCIENCE

Pancreas regeneration

(2018) Qiao Zhou et al.   NATURE

Diverse reprogramming codes for neuronal identity

(2018) Rachel Tsunemoto et al.   NATURE

De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation

(2018) Johanna R. Schaub et al.   NATURE

High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor

(2018) Tetsuji Yamashita et al.   PLoS Genetics

Efficient in vivo direct conversion of fibroblasts into cardiomyocytes using a nanoparticle-based gene carrier

(2018) Yujung Chang et al.   BIOMATERIALS

Viral Vector Reprogramming of Adult Resident Striatal Oligodendrocytes into Functional Neurons

(2017) Marc S. Weinberg et al.   MOLECULAR THERAPY

Stimulation of functional neuronal regeneration from Müller glia in adult mice

(2017) Nikolas L. Jorstad et al.   NATURE

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

(2017) Alexander Raven et al.   NATURE

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

(2017) Pia Rivetti di Val Cervo et al.   NATURE BIOTECHNOLOGY

Redefining the identity of cardiac fibroblasts

(2017) Michelle D. Tallquist et al.   Nature Reviews Cardiology

In Vivo Interplay between p27 Kip1 , GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice

(2017) Bradley J. Walters et al.   Cell Reports

Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes

(2017) Malek Chouchane et al.   Stem Cell Reports

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons

(2017) Maria Pereira et al.   Stem Cell Reports

Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis

(2016) Guangqi Song et al.   Cell Stem Cell

In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis

(2016) Milad Rezvani et al.   Cell Stem Cell

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

A comparative view of regenerative neurogenesis in vertebrates

(2016) Alessandro Alunni et al.   DEVELOPMENT

Reprogramming Müller glia via in vivo cell fusion regenerates murine photoreceptors

(2016) Daniela Sanges et al.   JOURNAL OF CLINICAL INVESTIGATION

Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq

(2016) Barbara Treutlein et al.   NATURE

A predictive computational framework for direct reprogramming between human cell types

(2016) Owen J L Rackham et al.   NATURE GENETICS

The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord

(2016) Lei-Lei Wang et al.   Cell Reports

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

(2015) Giacomo Masserdotti et al.   Cell Stem Cell

Glia in mammalian development and disease

(2015) J. Bradley Zuchero et al.   DEVELOPMENT

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

(2015) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice

(2015) Yumi Ueki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain

(2015) Wenze Niu et al.   Stem Cell Reports

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block

(2014) Y.-F. Hu et al.   Science Translational Medicine

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

(2014) Christophe Heinrich et al.   Stem Cell Reports

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog

(2013) Swetlana Sirko et al.   Cell Stem Cell

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

(2013) Sophia Bardehle et al.   NATURE NEUROSCIENCE

Age-Dependent In Vivo Conversion of Mouse Cochlear Pillar and Deiters' Cells to Immature Hair Cells by Atoh1 Ectopic Expression

(2012) Z. Liu et al.   JOURNAL OF NEUROSCIENCE

Local generation of glia is a major astrocyte source in postnatal cortex

(2012) Woo-Ping Ge et al.   NATURE

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

(2008) A. Buffo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA