Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2

In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury

(2021) Wenjiao Tai et al.   Cell Stem Cell

Molecular Mechanisms Underlying Ascl1-Mediated Astrocyte-to-Neuron Conversion

(2021) Zhiping Rao et al.   Stem Cell Reports

Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming

(2021) Álvaro Herrero-Navarro et al.   Science Advances

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes

(2020) Qian Yi Lee et al.   NATURE CELL BIOLOGY

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion

(2020) Gianluca L. Russo et al.   Cell Stem Cell

Region-Restrict Astrocytes Exhibit Heterogeneous Susceptibility to Neuronal Reprogramming

(2019) Xin Hu et al.   Stem Cell Reports

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord

(2019) Julien Delile et al.   DEVELOPMENT

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis

(2019) Qinjie Weng et al.   Cell Stem Cell

Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

(2019) Joseph Herdy et al.   eLife

Development and Cell Biology of the Blood-Brain Barrier

(2019) Urs H. Langen et al.   Annual Review of Cell and Developmental Biology

Mediator complex interaction partners organize the transcriptional network that defines neural stem cells

(2019) Marti Quevedo et al.   Nature Communications

Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control

(2019) Rebecca A Callahan et al.   eLife

Single‐cell RNA‐Seq characterization of anatomically identified OLM interneurons in different transgenic mouse lines

(2019) Jochen Winterer et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex

(2019) Nicola Mattugini et al.   NEURON

Establishing neuronal diversity in the spinal cord: a time and a place

(2019) Andreas Sagner et al.   DEVELOPMENT

Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

(2019) Jing Ren et al.   eLife

ASCL1 regulates proliferation of NG2-glia in the embryonic and adult spinal cord

(2018) Demetra P. Kelenis et al.   GLIA

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program

(2018) Marisa Karow et al.   NATURE NEUROSCIENCE

Sensitive and powerful single-cell RNA sequencing using mcSCRB-seq

(2018) Johannes W. Bagnoli et al.   Nature Communications

Tal1, Gata2a, and Gata3 Have Distinct Functions in the Development of V2b and Cerebrospinal Fluid-Contacting KA Spinal Neurons

(2018) Livia A. Andrzejczuk et al.   Frontiers in Neuroscience

zUMIs - A fast and flexible pipeline to process RNA sequencing data with UMIs

(2018) Swati Parekh et al.   GigaScience

New approaches for brain repair—from rescue to reprogramming

(2018) Roger A. Barker et al.   NATURE

CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming

(2018) Yanxia Liu et al.   Cell Stem Cell

Assessing Transcriptome Quality in Patch-Seq Datasets

(2018) Shreejoy J. Tripathy et al.   Frontiers in Molecular Neuroscience

Anti-ACSA-2 defines a novel monoclonal antibody for prospective isolation of living neonatal and adult astrocytes

(2017) Christina G. Kantzer et al.   GLIA

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

(2017) Pia Rivetti di Val Cervo et al.   NATURE BIOTECHNOLOGY

Multimodal profiling of single-cell morphology, electrophysiology, and gene expression using Patch-seq

(2017) Cathryn R Cadwell et al.   Nature Protocols

Neurog2andAscl1together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex

(2017) Daniel J. Dennis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes

(2017) Malek Chouchane et al.   Stem Cell Reports

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq

(2016) Barbara Treutlein et al.   NATURE

A predictive computational framework for direct reprogramming between human cell types

(2016) Owen J L Rackham et al.   NATURE GENETICS

Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone

(2016) J.A. Filosa et al.   NEUROSCIENCE

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons

(2016) Csaba Földy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming

(2016) Derek K. Smith et al.   Stem Cell Reports

Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

(2015) Giacomo Masserdotti et al.   Cell Stem Cell

E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease

(2015) Lan-Hsin Wang et al.   DEVELOPMENTAL CELL

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

(2015) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Molecular and cellular development of spinal cord locomotor circuitry

(2015) Daniel C. Lu et al.   Frontiers in Molecular Neuroscience

Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the gray matter and white matter of the spinal cord

(2014) T. Y. Vue et al.   DEVELOPMENT

A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord

(2014) Mark D. Borromeo et al.   DEVELOPMENT

The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro

(2014) F. R. Ali et al.   DEVELOPMENT

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

A day in the life of the spliceosome

(2014) A. Gregory Matera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AnimalTFDB 2.0: a resource for expression, prediction and functional study of animal transcription factors

(2014) Hong-Mei Zhang et al.   NUCLEIC ACIDS RESEARCH

In vivo conversion of astrocytes to neurons in the injured adult spinal cord

(2014) Zhida Su et al.   Nature Communications

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

(2013) Orly L. Wapinski et al.   CELL

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGF  signaling to specify V2b interneurons in the spinal cord

(2013) K. Misra et al.   DEVELOPMENT

Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization

(2013) Polyxeni Philippidou et al.   NEURON

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

(2013) K. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of induced neurons via direct conversion in vivo

(2013) O. Torper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons

(2013) Meng-Lu Liu et al.   Nature Communications

Neurog2 Simultaneously Activates and Represses Alternative Gene Expression Programs in the Developing Neocortex

(2012) Christopher Kovach et al.   CEREBRAL CORTEX

Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation

(2012) C. Hindley et al.   DEVELOPMENT

Biciliated ependymal cell proliferation contributes to spinal cord growth

(2012) Clara Alfaro-Cervello et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Small molecules enable highly efficient neuronal conversion of human fibroblasts

(2012) Julia Ladewig et al.   NATURE METHODS

Induced Neuronal Cells: How to Make and Define a Neuron

(2011) Nan Yang et al.   Cell Stem Cell

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

(2011) Esther Y. Son et al.   Cell Stem Cell

Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex

(2011) Christophe Heinrich et al.   Nature Protocols

Differences in subthreshold resonance of hippocampal pyramidal cells and interneurons: the role of h-current and passive membrane characteristics

(2010) Rita Zemankovics et al.   JOURNAL OF PHYSIOLOGY-LONDON

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

(2010) Christophe Heinrich et al.   PLOS BIOLOGY

Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord

(2009) R. M. Henke et al.   DEVELOPMENT

The genetics of early telencephalon patterning: some assembly required

(2008) Jean M. Hébert et al.   NATURE REVIEWS NEUROSCIENCE