NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming

In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury

(2021) Wenjiao Tai et al.   Cell Stem Cell

Revisiting astrocyte to neuron conversion with lineage tracing in vivo

(2021) Lei-Lei Wang et al.   CELL

Improved tools to study astrocytes

(2020) Xinzhu Yu et al.   NATURE REVIEWS NEUROSCIENCE

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Efficient Strategies for Microglia Replacement in the Central Nervous System

(2020) Zhen Xu et al.   Cell Reports

Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury

(2019) Tian Zhou et al.   NATURE NEUROSCIENCE

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

(2019) Taito Matsuda et al.   NEURON

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

(2019) Lihong Zhan et al.   PLOS BIOLOGY

A phase I study of pexidartinib, a colony-stimulating factor 1 receptor inhibitor, in Asian patients with advanced solid tumors

(2019) Jih-Hsiang Lee et al.   INVESTIGATIONAL NEW DRUGS

Conditional ablation of reactive astrocytes to dissect their roles in spinal cord injury and repair

(2019) Yakun Gu et al.   BRAIN BEHAVIOR AND IMMUNITY

Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreERT2 lines

(2019) A. Álvarez-Aznar et al.   TRANSGENIC RESEARCH

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease

(2019) Joshua D Crapser et al.   BRAIN

Ablation of reactive astrocytes exacerbates disease pathology in a model of Alzheimer's disease

(2019) Loukia Katsouri et al.   GLIA

Sources of off-target expression from recombinase-dependent AAV vectors and mitigation with cross-over insensitive ATG-out vectors

(2019) Kyle B. Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression Patterns of Inducible Cre Recombinase Driven by Differential Astrocyte-Specific Promoters in Transgenic Mouse Lines

(2019) Neng-Yuan Hu et al.   Neuroscience Bulletin

Intestinal Neurod1 expression impairs paneth cell differentiation and promotes enteroendocrine lineage specification

(2019) Hui Joyce Li et al.   Scientific Reports

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

(2018) Jillian C. Nissen et al.   EXPERIMENTAL NEUROLOGY

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

(2018) Justyna Sosna et al.   Molecular Neurodegeneration

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

(2018) Yubin Huang et al.   NATURE NEUROSCIENCE

Dual extra-retinal origins of microglia in the model of retinal microglia repopulation

(2018) Yubin Huang et al.   Cell Discovery

Microglia ablation alleviates myelin-associated catatonic signs in mice

(2017) Hana Janova et al.   JOURNAL OF CLINICAL INVESTIGATION

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation

(2017) Sarah Jäkel et al.   Frontiers in Cellular Neuroscience

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

(2017) Michael A. Cannarile et al.   Journal for ImmunoTherapy of Cancer

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

(2016) Sergio Gascón et al.   Cell Stem Cell

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain

(2015) Wenze Niu et al.   Stem Cell Reports

Suppression of Microglial Activation Is Neuroprotective in a Mouse Model of Human Retinitis Pigmentosa

(2014) B. Peng et al.   JOURNAL OF NEUROSCIENCE

Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1

(2014) Soham Chanda et al.   Stem Cell Reports

Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

(2014) Christophe Heinrich et al.   Stem Cell Reports

Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke

(2013) Ting Li et al.   BRAIN

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Adjuvant effect of diphtheria toxin after mucosal administration in both wild type and diphtheria toxin receptor engineered mouse strains

(2013) Timothy J. Chapman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

Preferential Lentiviral Targeting of Astrocytes in the Central Nervous System

(2013) Michael Fassler et al.   PLoS One

Visualization and genetic modification of resident brain microglia using lentiviral vectors regulated by microRNA-9

(2013) Malin Åkerblom et al.   Nature Communications

Efficient gene expression from integration-deficient lentiviral vectors in the spinal cord

(2012) H Peluffo et al.   GENE THERAPY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis

(2010) Yujin E Kim et al.   Nature Protocols

Tamoxifen-Independent Recombination in the RIP-CreER Mouse

(2010) Yanmei Liu et al.   PLoS One

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Neurod1 is essential for the survival and maturation of adult-born neurons

(2009) Zhengliang Gao et al.   NATURE NEUROSCIENCE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis

(2009) C. Boutin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA