Nuclear deformations, from signaling to perturbation and damage

Pressure sensing through Piezo channels controls whether cells migrate with blebs or pseudopods

(2020) Nishit Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

(2020) Michele M. Nava et al.   CELL

Mechano-genomic regulation of coronaviruses and its interplay with ageing

(2020) Caroline Uhler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear Membrane Rupture and Its Consequences

(2020) John Maciejowski et al.   Annual Review of Cell and Developmental Biology

Modeling of Cell Nuclear Mechanics: Classes, Components, and Applications

(2020) Chad M. Hobson et al.   Cells

Structural basis for sequestration and autoinhibition of cGAS by chromatin

(2020) Sebastian Michalski et al.   NATURE

Structural mechanism of cGAS inhibition by the nucleosome

(2020) Ganesh R. Pathare et al.   NATURE

ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

(2020) Gururaj Rao Kidiyoor et al.   Nature Communications

Nuclear Deformation Causes DNA Damage by Increasing Replication Stress

(2020) Pragya Shah et al.   CURRENT BIOLOGY

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

(2019) Matteo Gentili et al.   Cell Reports

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

(2019) Sangkyun Cho et al.   DEVELOPMENTAL CELL

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

(2019) Ashley J. Earle et al.   NATURE MATERIALS

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

(2018) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Constricted migration increases DNA damage and independently represses cell cycle

(2018) Charlotte R. Pfeifer et al.   MOLECULAR BIOLOGY OF THE CELL

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors

(2018) Yuntao Xia et al.   JOURNAL OF CELL BIOLOGY

Mechanical regulation of genome architecture and cell-fate decisions

(2018) G.V. Shivashankar   CURRENT OPINION IN CELL BIOLOGY

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb

(2017) Zhe Yang et al.   MOLECULAR CANCER RESEARCH

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

(2017) Tohru Takaki et al.   Nature Communications

Cofilin Regulates Nuclear Architecture through a Myosin-II Dependent Mechanotransduction Module

(2017) O’Neil Wiggan et al.   Scientific Reports

The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation

(2016) Balázs Enyedi et al.   CELL

Focal adhesions, stress fibers and mechanical tension

(2016) Keith Burridge et al.   EXPERIMENTAL CELL RESEARCH

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

(2016) Huy Quang Le et al.   NATURE CELL BIOLOGY

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation

(2015) Kazuya Tsujita et al.   NATURE CELL BIOLOGY

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness

(2015) Takashi Furusawa et al.   Nature Communications

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

(2015) Georgios Kanellos et al.   Cell Reports

ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

(2014) Amit Kumar et al.   CELL

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Curvature, Lipid Packing, and Electrostatics of Membrane Organelles: Defining Cellular Territories in Determining Specificity

(2012) Joëlle Bigay et al.   DEVELOPMENTAL CELL

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Use the force: membrane tension as an organizer of cell shape and motility

(2012) Alba Diz-Muñoz et al.   TRENDS IN CELL BIOLOGY

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Nuclear mechanics during cell migration

(2010) Peter Friedl et al.   CURRENT OPINION IN CELL BIOLOGY

DNA lesions sequestered in micronuclei induce a local defective-damage response

(2009) Mariona Terradas et al.   DNA REPAIR

The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

(2008) T. Shimi et al.   GENES & DEVELOPMENT

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY