Transient disorder along pathways to amyloid

FUS and TDP-43 Phases in Health and Disease

(2021) Bede Portz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recent Developments in the Field of Intrinsically Disordered Proteins: Intrinsic Disorder–Based Emergence in Cellular Biology in Light of the Physiological and Pathological Liquid–Liquid Phase Transitions

(2021) Vladimir N. Uversky   Annual Review of Biophysics

Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis

(2021) Lynn Radamaker et al.   Nature Communications

AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils

(2021) Akanksha Bansal et al.   Nature Communications

MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in routine clinical practice: a cross-sectional study of 6315 patients

(2021) Patrick W. Mellors et al.   Blood Cancer Journal

The expanding amyloid family: Structure, stability, function, and pathogenesis

(2021) Michael R. Sawaya et al.   CELL

Protease‐sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation

(2021) Giulia Mazzini et al.   FEBS Journal

Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment (LARKS) structural motif in amyloid-like fibrils

(2021) Michael P. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution structure and strain comparison of infectious mammalian prions

(2021) Allison Kraus et al.   MOLECULAR CELL

Barriers to Small Molecule Drug Discovery for Systemic Amyloidosis

(2021) Gareth J. Morgan   MOLECULES

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Accurate prediction of protein structures and interactions using a three-track neural network

(2021) Minkyung Baek et al.   SCIENCE

NMR illuminates intrinsic disorder

(2021) H. Jane Dyson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure-based classification of tauopathies

(2021) Yang Shi et al.   NATURE

AA amyloid in human food chain is a possible biohazard

(2021) Anna Rising et al.   Scientific Reports

Proteome-wide observation of the phenomenon of life on the edge of solubility

(2020) Giulia Vecchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

(2020) Timothy R Sampson et al.   eLife

Small-Molecule Inhibitor Prevents Insulin Fibrillogenesis and Preserves Activity

(2020) Anirban Das et al.   MOLECULAR PHARMACEUTICS

Disruption of the CD Loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway

(2020) Anvesh K. R. Dasari et al.   BIOCHEMISTRY

Cryo-EM structure of an amyloid fibril formed by full-length human prion protein

(2020) Li-Qiang Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve

(2020) Olga Gursky   Current Atherosclerosis Reports

Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis:insights into the timing of proteolysis

(2020) Francesca Lavatelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Amyloids Are the Rule Rather Than the Exception in Cellular Biology

(2020) Anthony Balistreri et al.   Microorganisms

Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis

(2019) Lynn Radamaker et al.   Nature Communications

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

(2019) Paolo Swuec et al.   Nature Communications

Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

(2019) Falk Liberta et al.   Nature Communications

Stabilization of amyloidogenic immunoglobulin light chains by small molecules

(2019) Gareth J. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unfolded states under folding conditions accommodate sequence-specific conformational preferences with random coil-like dimensions

(2019) Ivan Peran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins

(2019) H. Jane Dyson et al.   JOURNAL OF BIOMOLECULAR NMR

The molecular principles governing the activity and functional diversity of AAA+ proteins

(2019) Cristina Puchades et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-EM structure of a transthyretin-derived amyloid fibril from a patient with hereditary ATTR amyloidosis

(2019) Matthias Schmidt et al.   Nature Communications

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

(2019) Ricardo Guerrero-Ferreira et al.   eLife

Adaptive antibody diversification throughN-linked glycosylation of the immunoglobulin variable region

(2018) Fleur S. van de Bovenkamp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease

(2018) Elena S. Klimtchuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition

(2018) Lorena Saelices et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

(2018) Michael P. Hughes et al.   SCIENCE

MASS-FIX may allow identification of patients at risk for light chain amyloidosis before the onset of symptoms

(2018) Taxiarchis Kourelis et al.   AMERICAN JOURNAL OF HEMATOLOGY

Extreme disorder in an ultrahigh-affinity protein complex

(2018) Alessandro Borgia et al.   NATURE

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

(2018) Mathew S. Maurer et al.   NEW ENGLAND JOURNAL OF MEDICINE

The structure of a β2-microglobulin fibril suggests a molecular basis for its amyloid polymorphism

(2018) Matthew G. Iadanza et al.   Nature Communications

Systemic immunoglobulin light chain amyloidosis

(2018) Giampaolo Merlini et al.   Nature Reviews Disease Primers

Oxidative post-translational modifications of an amyloidogenic immunoglobulin light chain protein

(2017) Yanyan Lu et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS)

(2017) Smriti Sangwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competition between crystal and fibril formation in molecular mutations of amyloidogenic peptides

(2017) Nicholas P. Reynolds et al.   Nature Communications

Recruitment of Light Chains by Homologous and Heterologous Fibrils Shows Distinctive Kinetic and Conformational Specificity

(2016) Luis M. Blancas-Mejía et al.   BIOCHEMISTRY

Revisiting supersaturation as a factor determining amyloid fibrillation

(2016) Masatomo So et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable Domains

(2016) Gareth J. Morgan et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

AA Amyloidosis: Pathogenesis and Targeted Therapy

(2015) Gunilla T. Westermark et al.   Annual Review of Pathology-Mechanisms of Disease

Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils

(2015) Marta Marin-Argany et al.   PROTEIN SCIENCE

Repurposing Diflunisal for Familial Amyloid Polyneuropathy

(2015) John L. Berk et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Structural Characterization of IgG1 mAb Aggregates and Particles Generated Under Various Stress Conditions

(2014) Srivalli N. Telikepalli et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

(2014) Gergely Tóth et al.   PLoS One

Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis

(2014) P. P. Mangione et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin

(2013) S. C. Penchala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug

(2012) Steven M. Johnson et al.   JOURNAL OF MOLECULAR BIOLOGY

Tafamidis for transthyretin familial amyloid polyneuropathy: A randomized, controlled trial

(2012) T. Coelho et al.   NEUROLOGY

Opposing Effects of Glutamine and Asparagine Govern Prion Formation by Intrinsically Disordered Proteins

(2011) Randal Halfmann et al.   MOLECULAR CELL

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

(2011) Stuart A. Sievers et al.   NATURE

Protein Native-State Stabilization by Placing Aromatic Side Chains in N-Glycosylated Reverse Turns

(2011) E. K. Culyba et al.   SCIENCE

Protein kinetic stability

(2010) Jose M. Sanchez-Ruiz   BIOPHYSICAL CHEMISTRY

Dissecting the Alternatively Folded State of the Antibody Fab Fragment

(2010) Matthias Johannes Feige et al.   JOURNAL OF MOLECULAR BIOLOGY

Folding of glycoproteins: toward understanding the biophysics of the glycosylation code

(2009) Dalit Shental-Bechor et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

(2009) Matthias J. Feige et al.   MOLECULAR CELL

Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins

(2009) Jianmin Gao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability

(2009) S. R. Hanson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

The Protein Folding Problem

(2008) Ken A. Dill et al.   Annual Review of Biophysics

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

(2008) Wei-Feng Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unfolding and aggregation of transthyretin by the truncation of 50 N-terminal amino acids

(2008) Mineyuki Mizuguchi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Bacterial Inclusion Bodies Contain Amyloid-Like Structure

(2008) Lei Wang et al.   PLOS BIOLOGY

Exclusion of the Native α-Helix from the Amyloid Fibrils of a Mixed α/β Protein

(2007) Gareth J. Morgan et al.   JOURNAL OF MOLECULAR BIOLOGY