Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-00588-w
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- Uppsala University
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AA amyloidosis can be transmitted between different species, even through consumption of meat containing amyloid seeds. Research shows that meat from Swedish and Italian cattle often contains AA amyloid, and bovine AA fibrils can efficiently cross-seed human amyloid beta peptide.
AA amyloidosis can be transmitted experimentally in several mammalian and avian species as well as spontaneously between captive animals, even by oral intake of amyloid seeds. Amyloid seeding can cross species boundaries, and fibrils of one kind of amyloid protein may also seed other types. Here we show that meat from Swedish and Italian cattle for consumption by humans often contains AA amyloid and that bovine AA fibrils efficiently cross-seed human amyloid beta peptide, associated with Alzheimer's disease.
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