Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils

Steady-state and time-resolved Thioflavin-T fluorescence can report on morphological differences in amyloid fibrils formed by Aβ(1-40) and Aβ(1-42)

(2015) David J. Lindberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Formation of Amyloid Fibers by Monomeric Light Chain Variable Domains

(2014) Boris Brumshtein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Effects on Light Chain Amyloid Formation Depend on Mutations and Type of Glycosaminoglycans

(2014) Luis M. Blancas-Mejía et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Amyloidoses

(2013) Luis M. Blancas-Mejía et al.   Annual Review of Biochemistry

Kinetic Control in Protein Folding for Light Chain Amyloidosis and the Differential Effects of Somatic Mutations

(2013) Luis.M. Blancas-Mejía et al.   JOURNAL OF MOLECULAR BIOLOGY

Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency

(2013) Geovanny Rivera-Hernández et al.   mAbs

Tyrosine Residues Mediate Fibril Formation in a Dynamic Light Chain Dimer Interface

(2012) Ara Celi DiCostanzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An anti-Aβ (amyloid β) single-chain variable fragment prevents amyloid fibril formation and cytotoxicity by withdrawing Aβ oligomers from the amyloid pathway

(2011) Marta Marín-Argany et al.   BIOCHEMICAL JOURNAL

Structural Evolution of Iowa Mutant β-Amyloid Fibrils from Polymorphic to Homogeneous States under Repeated Seeded Growth

(2011) Wei Qiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light Chain Amyloidosis – Current Findings and Future Prospects

(2009) Elizabeth Baden et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Structural Alterations within Native Amyloidogenic Immunoglobulin Light Chains

(2009) Edward G. Randles et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutations in Specific Structural Regions of Immunoglobulin Light Chains Are Associated with Free Light Chain Levels in Patients with AL Amyloidosis

(2009) Tanya L. Poshusta et al.   PLoS One

Salts enhance both protein stability and amyloid formation of an immunoglobulin light chain

(2008) Laura A. Sikkink et al.   BIOPHYSICAL CHEMISTRY

Altered Dimer Interface Decreases Stability in an Amyloidogenic Protein

(2008) Elizabeth M. Baden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into the Role of Mutations in Amyloidogenesis

(2008) Elizabeth M. Baden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity

(2007) Mark R. Wilson et al.   Molecular BioSystems