NMR illuminates intrinsic disorder

Optimization of sortase A ligation for flexible engineering of complex protein systems

(2020) Jess Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The (un)structural biology of biomolecular liquid-liquid phase separation using NMR spectroscopy

(2020) Anastasia C. Murthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMR Experiments for Studies of Dilute and Condensed Protein Phases: Application to the Phase-Separating Protein CAPRIN1

(2020) Leo E. Wong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I

(2020) Alberto Ceccon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitivity‐Enhanced 13 C‐NMR Spectroscopy for Monitoring Multisite Phosphorylation at Physiological Temperature and pH

(2020) Ania Alik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Description of the Nipah Virus Phosphoprotein and Its Interaction with STAT1

(2020) Malene Ringkjøbing Jensen et al.   BIOPHYSICAL JOURNAL

Confronting the Invisible: Assignment of Protein 1HN Chemical Shifts in Cases of Extreme Broadening

(2020) Leo E. Wong et al.   Journal of Physical Chemistry Letters

Flanking Regions Determine the Structure of the Poly-Glutamine in Huntingtin through Mechanisms Common among Glutamine-Rich Human Proteins

(2020) Annika Urbanek et al.   STRUCTURE

NMR Structure and Dynamics of TonB Investigated by Scar-Less Segmental Isotopic Labeling Using a Salt-Inducible Split Intein

(2020) Annika Ciragan et al.   Frontiers in Chemistry

Measles virus nucleo- and phosphoproteins form liquid-like phase-separated compartments that promote nucleocapsid assembly

(2020) Serafima Guseva et al.   Science Advances

The mechanism of Hsp90-induced oligomerizaton of Tau

(2020) S. Weickert et al.   Science Advances

The methyl 13C-edited/13C-filtered transferred NOE for studying protein interactions with short linear motifs

(2020) Suresh Kumar et al.   JOURNAL OF BIOMOLECULAR NMR

Conformational Ensembles of an Intrinsically Disordered Protein Consistent with NMR, SAXS, and Single-Molecule FRET

(2020) Gregory-Neal W. Gomes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids

(2020) Ruben D. Elias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust Cell-Free Expression of Sub-Pathological and Pathological Huntingtin Exon-1 for NMR Studies. General Approaches for the Isotopic Labeling of Low-Complexity Proteins

(2020) Anna Morató et al.   Biomolecules

A lowly populated, transient β-sheet structure in monomeric Aβ1-42 identified by multinuclear NMR of chemical denaturation

(2020) Tayeb Kakeshpour et al.   BIOPHYSICAL CHEMISTRY

Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR

(2019) Samuel A. Kotler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Backbone Dynamics in Modulating the Interactions of Disordered Ligands with the TAZ1 Domain of the CREB-Binding Protein

(2019) Rebecca B. Berlow et al.   BIOCHEMISTRY

Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

(2019) Fan He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C

(2019) Miranda P. Collier et al.   Science Advances

NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins

(2019) Christoph Hartlmüller et al.   JOURNAL OF BIOMOLECULAR NMR

Solvent-dependent segmental dynamics in intrinsically disordered proteins

(2019) Nicola Salvi et al.   Science Advances

Observation of β-Amyloid Peptide Oligomerization by Pressure-Jump NMR Spectroscopy

(2019) C. Ashley Barnes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation

(2019) Tae Hun Kim et al.   SCIENCE

Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins

(2019) H. Jane Dyson et al.   JOURNAL OF BIOMOLECULAR NMR

The Ambivalent Role of Proline Residues in an Intrinsically Disordered Protein: From Disorder Promoters to Compaction Facilitators

(2019) Borja Mateos et al.   JOURNAL OF MOLECULAR BIOLOGY

A Unified Description of Intrinsically Disordered Protein Dynamics under Physiological Conditions Using NMR Spectroscopy

(2019) Wiktor Adamski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mapping Hidden Residual Structure within the Myc bHLH-LZ Domain Using Chemical Denaturant Titration

(2019) Stanislava Panova et al.   STRUCTURE

Histone chaperone exploits intrinsic disorder to switch acetylation specificity

(2019) Nataliya Danilenko et al.   Nature Communications

Characterization of the dynamics and the conformational entropy in the binding between TAZ1 and CTAD-HIF-1α

(2019) Ida Nyqvist et al.   Scientific Reports

Regulation of α-synuclein by chaperones in mammalian cells

(2019) Björn M. Burmann et al.   NATURE

A General Strategy to Access Structural Information at Atomic Resolution in Polyglutamine Homorepeats

(2018) Annika Urbanek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

How Do Intrinsically Disordered Viral Proteins Hijack the Cell?

(2018) H. Jane Dyson et al.   BIOCHEMISTRY

Proline Fingerprint in Intrinsically Disordered Proteins

(2018) Maria Grazia Murrali et al.   CHEMBIOCHEM

Conformational flexibility within the nascent polypeptide–associated complex enables its interactions with structurally diverse client proteins

(2018) Esther M. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Sampling of Interdomain Motion Using Map-Restrained Langevin Dynamics and NMR: Application to Pin1

(2018) Jill J. Bouchard et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryptic Disorder Out of Disorder: Encounter between Conditionally Disordered CP12 and Glyceraldehyde-3-Phosphate Dehydrogenase

(2018) Hélène Launay et al.   JOURNAL OF MOLECULAR BIOLOGY

The Mechanism of HdeA Unfolding and Chaperone Activation

(2018) Loïc Salmon et al.   JOURNAL OF MOLECULAR BIOLOGY

Interaction of Huntingtin Exon-1 Peptides with Lipid-Based Micellar Nanoparticles Probed by Solution NMR and Q-Band Pulsed EPR

(2018) Alberto Ceccon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing Conformational Exchange in Weakly Interacting, Slowly Exchanging Protein Systems via Off-Resonance R1ρ Experiments: Application to Studies of Protein Phase Separation

(2018) Tairan Yuwen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deciphering the Dynamic Interaction Profile of an Intrinsically Disordered Protein by NMR Exchange Spectroscopy

(2018) Elise Delaforge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins

(2018) Sandeep Chhabra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCF Fbw7 Ubiquitin Ligase

(2018) Veronika Csizmok et al.   STRUCTURE

Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions

(2018) Ashok Sekhar et al.   eLife

Local and Global Dynamics in Intrinsically Disordered Synuclein

(2018) Nasrollah Rezaei-Ghaleh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conformational Ensemble of Disordered Proteins Probed by Solvent Paramagnetic Relaxation Enhancement (sPRE)

(2018) Hamed Kooshapur et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formation of a Secretion-Competent Protein Complex by a Dynamic Wrap-around Binding Mechanism

(2018) Arun A. Gupta et al.   JOURNAL OF MOLECULAR BIOLOGY

Measuring Solvent Hydrogen Exchange Rates by Multifrequency Excitation 15N CEST: Application to Protein Phase Separation

(2018) Tairan Yuwen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Extreme disorder in an ultrahigh-affinity protein complex

(2018) Alessandro Borgia et al.   NATURE

Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain

(2018) Ke Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FBP21’s C-Terminal Domain Remains Dynamic when Wrapped around the c-Sec63 Unit of Brr2 Helicase

(2018) Jana Sticht et al.   BIOPHYSICAL JOURNAL

Structural basis and mechanism of the unfolding-induced activation of HdeA, a bacterial acid response chaperone

(2018) Xing-Chi Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

15N transverse relaxation measurements for the characterization of µs–ms dynamics are deteriorated by the deuterium isotope effect on 15N resulting from solvent exchange

(2018) Pratibha Kumari et al.   JOURNAL OF BIOMOLECULAR NMR

A CON-based NMR assignment strategy for pro-rich intrinsically disordered proteins with low signal dispersion: the C-terminal domain of histone H1.0 as a case study

(2018) Belén Chaves-Arquero et al.   JOURNAL OF BIOMOLECULAR NMR

Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain

(2018) Alexander S. Krois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypersensitive termination of the hypoxic response by a disordered protein switch

(2017) Rebecca B. Berlow et al.   NATURE

Identification of Dynamic Modes in an Intrinsically Disordered Protein Using Temperature-Dependent NMR Relaxation

(2016) Anton Abyzov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Mapping the interactions of adenoviral E1A proteins with the p160 nuclear receptor coactivator binding domain of CBP

(2016) Peter Haberz et al.   PROTEIN SCIENCE

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NMR Spectroscopic Studies of Intrinsically Disordered Proteins at Near-Physiological Conditions

(2013) Sergio Gil et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modulation of allostery by protein intrinsic disorder

(2013) Allan Chris M. Ferreon et al.   NATURE

D2P2: database of disordered protein predictions

(2012) Matt E. Oates et al.   NUCLEIC ACIDS RESEARCH

Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES