High-resolution structure and strain comparison of infectious mammalian prions

Short and sweet: How glycans impact prion conversion, cofactor interactions, and cross-species transmission

(2021) Patricia Aguilar-Calvo et al.   PLoS Pathogens

Scaling analysis reveals the mechanism and rates of prion replication in vivo

(2021) Georg Meisl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models

(2021) Razieh Kamali-Jamil et al.   PLoS Pathogens

Amyloid structure determination in RELION-3.1

(2020) Sjors H. W. Scheres   Acta Crystallographica Section D-Structural Biology

Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core

(2020) Calina Glynn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of an amyloid fibril formed by full-length human prion protein

(2020) Li-Qiang Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns

(2020) David M Asher et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Modeling PrPSc Generation Through Deformed Templating

(2020) Giovanni Spagnolli et al.   Frontiers in Bioengineering and Biotechnology

The Prion 2018 round tables (I): The structure of PrPSc

(2019) Ilia V. Baskakov et al.   Prion

Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro

(2019) Cassandra Terry et al.   Scientific Reports

Full atomistic model of prion structure and conversion

(2019) Giovanni Spagnolli et al.   PLoS Pathogens

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Transmissibility versus Pathogenicity of Self-Propagating Protein Aggregates

(2019) Byron Caughey et al.   Viruses-Basel

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Structural Studies of Amyloid Fibrils by Paramagnetic Solid-State Nuclear Magnetic Resonance Spectroscopy

(2018) Theint Theint et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PrP P102L and Nearby Lysine Mutations Promote Spontaneous In Vitro Formation of Transmissible Prions

(2017) Allison Kraus et al.   JOURNAL OF VIROLOGY

Species-dependent structural polymorphism of Y145Stop prion protein amyloid revealed by solid-state NMR spectroscopy

(2017) Theint Theint et al.   Nature Communications

Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates

(2017) Bradley R. Groveman et al.   PLoS Pathogens

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Altered trafficking of abnormal prion protein in atypical scrapie: prion protein accumulation in oligodendroglial inner mesaxons

(2016) M. Jeffrey et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Amyloid fibrils from the N-terminal prion protein fragment are infectious

(2016) Jin-Kyu Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration

(2016) James Alibhai et al.   PLOS BIOLOGY

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

(2016) Ester Vázquez-Fernández et al.   PLoS Pathogens

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

Glycosylphosphatidylinositol Anchoring Directs the Assembly of Sup35NM Protein into Non-fibrillar, Membrane-bound Aggregates

(2014) Karen E. Marshall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parallel In-register Intermolecular β-Sheet Architectures for Prion-seeded Prion Protein (PrP) Amyloids

(2014) Bradley R. Groveman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Live imaging of prions reveals nascent PrPScin cell-surface, raft-associated amyloid strings and webs

(2014) Alexander Rouvinski et al.   JOURNAL OF CELL BIOLOGY

Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy

(2013) Robert Tycko et al.   ACCOUNTS OF CHEMICAL RESEARCH

Prions and the Potential Transmissibility of Protein Misfolding Diseases

(2013) Allison Kraus et al.   Annual Review of Microbiology

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo

(2013) Susan F. Godsave et al.   NEUROBIOLOGY OF AGING

SAXS structural study of PrPScreveals ~11 nm diameter of basic double intertwined fibers

(2013) Heinz Amenitsch et al.   Prion

Use of knowledge-based restraints inphenix.refineto improve macromolecular refinement at low resolution

(2012) Jeffrey J. Headd et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Review: Membrane-associated misfolded protein propagation in natural transmissible spongiform encephalopathies (TSEs), synthetic prion diseases and Alzheimer's disease

(2012) M. Jeffrey   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Reaction of complement factors varies with prion strains in vitro and in vivo

(2012) Rie Hasebe et al.   VIROLOGY

Effect of Glycans and the Glycophosphatidylinositol Anchor on Strain Dependent Conformations of Scrapie Prion Protein: Improved Purifications and Infrared Spectra

(2011) Gerald S. Baron et al.   BIOCHEMISTRY

Globular Domain of the Prion Protein Needs to Be Unlocked by Domain Swapping to Support Prion Protein Conversion

(2011) Iva Hafner-Bratkovič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange

(2011) Vytautas Smirnovas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The α-Helical C-Terminal Domain of Full-Length Recombinant PrP Converts to an In-Register Parallel β-Sheet Structure in PrP Fibrils: Evidence from Solid State Nuclear Magnetic Resonance

(2010) Robert Tycko et al.   BIOCHEMISTRY

Prion Fibrillization Is Mediated by a Native Structural Element That Comprises Helices H2 and H3

(2010) Miquel Adrover et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Prions Generated from Bacterially Expressed Prion Protein in the Absence of Any Mammalian Cofactors

(2010) Jae-Il Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycosylation of PrPC Determines Timing of Neuroinvasion and Targeting in the Brain following Transmissible Spongiform Encephalopathy Infection by a Peripheral Route

(2010) E. Cancellotti et al.   JOURNAL OF VIROLOGY

Fatal Transmissible Amyloid Encephalopathy: A New Type of Prion Disease Associated with Lack of Prion Protein Membrane Anchoring

(2010) Bruce Chesebro et al.   PLoS Pathogens

Rapid End-Point Quantitation of Prion Seeding Activity with Sensitivity Comparable to Bioassays

(2010) Jason M. Wilham et al.   PLoS Pathogens

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions

(2009) Byron Caughey et al.   Annual Review of Biochemistry

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

Prion Protein Amyloid Formation under Native-like Conditions Involves Refolding of the C-terminal α-Helical Domain

(2008) Nathan J. Cobb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils

(2008) Valerie L. Sim et al.   NEUROBIOLOGY OF AGING

Observing fibrillar assemblies on scrapie-infected cells

(2008) Susanne Wegmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY