Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
Authors
Keywords
Cancer therapy, Natural polyphenols, Phytomedicine, Flavonoids, Oxidative stress, Antioxidants
Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 146, Issue -, Pages 112442
Publisher
Elsevier BV
Online
2022-01-04
DOI
10.1016/j.biopha.2021.112442
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Ziziphus nummularia Attenuates the Malignant Phenotype of Human Pancreatic Cancer Cells: Role of ROS
- (2021) Joelle Mesmar et al. MOLECULES
- Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway
- (2020) Keitaro Iida et al. CANCER SCIENCE
- Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production
- (2020) Xiangyu Zhang et al. OncoTargets and Therapy
- Flavonoids as Anticancer Agents
- (2020) Dalia M. Kopustinskiene et al. Nutrients
- Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets
- (2020) Manal Muin Fardoun et al. CLINICAL SCIENCE
- The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy
- (2020) Humna Bhagani et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Western diet aggravates neuronal insult in post-traumatic brain injury: Proposed pathways for interplay
- (2020) Abdullah Shaito et al. EBioMedicine
- Repurposing cilostazol for Raynaud's phenomenon
- (2020) Nehme El-Hachem et al. CURRENT MEDICINAL CHEMISTRY
- The Role of Epac in Cancer Progression
- (2020) Nadine Wehbe et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Traumatic Brain Injury: Oxidative Stress and Novel Anti-Oxidants Such as Mitoquinone and Edaravone
- (2020) Helene Ismail et al. Antioxidants
- Reactive Oxygen Species: Modulators of Phenotypic Switch of Vascular Smooth Muscle Cells
- (2020) Adnan Badran et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Recent Advances in the Understanding of the Health Benefits and Molecular Mechanisms Associated with Green Tea Polyphenols
- (2019) Lujuan Xing et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Regulation of the Intracellular ROS Level Is Critical for the Antiproliferative Effect of Quercetin in the Hepatocellular Carcinoma Cell Line HepG2
- (2019) Ji-Sook Jeon et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Comparative evaluation of hesperetin loaded nanoparticles for anticancer activity against C6 glioma cancer cells
- (2019) Melike Ersoz et al. Artificial Cells Nanomedicine and Biotechnology
- Cytotoxic Effects of Some Flavonoids and Imatinib on the K562 Chronic Myeloid Leukemia Cell Line: Data Analysis Using the Combination Index Method
- (2019) Ferdane Danışman Kalındemirtaş et al. Balkan Medical Journal
- Luteolin, a flavonoid, as an anticancer agent: A review
- (2019) Muhammad Imran et al. BIOMEDICINE & PHARMACOTHERAPY
- Flavonoids in hypertension: a brief review of the underlying mechanisms
- (2019) Dina Maaliki et al. CURRENT OPINION IN PHARMACOLOGY
- Impact of ROS Generated by Chemical, Physical, and Plasma Techniques on Cancer Attenuation
- (2019) Sarmistha Mitra et al. Cancers
- Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival
- (2019) Anna Maria Posadino et al. Biomolecules
- Targeting Reactive Oxygen Species in Cancer via Chinese Herbal Medicine
- (2019) Qiaohong Qian et al. Oxidative Medicine and Cellular Longevity
- The Stability and Activity Changes of Apigenin and Luteolin in Human Cervical Cancer Hela Cells in Response to Heat Treatment and Fe2+/Cu2+ Addition
- (2019) Wan-Ning Liu et al. Foods
- Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview
- (2019) Juanjuan Zhao et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling
- (2019) Jhen-Jia Fan et al. Antioxidants
- The ROS-KRAS-Nrf2 axis in the control of the redox homeostasis and the intersection with survival-apoptosis pathways: Implications for photodynamic therapy
- (2019) Annalisa Ferino et al. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
- Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway
- (2018) Qian Sun et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Redox control in cancer development and progression
- (2018) Valeska Helfinger et al. MOLECULAR ASPECTS OF MEDICINE
- Selective Cytotoxicity of Luteolin and Kaempferol on Cancerous Hepatocytes Obtained from Rat Model of Hepatocellular Carcinoma: Involvement of ROS-Mediated Mitochondrial Targeting
- (2018) Enayatollah Seydi et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Nomenclature of flavonoids (IUPAC Recommendations 2017)
- (2018) Amélia P. Rauter et al. PURE AND APPLIED CHEMISTRY
- ROS signalling in the biology of cancer
- (2018) Jennifer N. Moloney et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Different antitumor effects of quercetin, quercetin-3′-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells
- (2018) Qiu Wu et al. Food & Function
- Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells
- (2018) Hung-Sheng Shang et al. ENVIRONMENTAL TOXICOLOGY
- Combinatorial anti-proliferative effects of tamoxifen and naringenin: The role of four estrogen receptor subtypes
- (2018) Zhixiang Xu et al. TOXICOLOGY
- Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies
- (2018) Hui Chang et al. Nutrients
- A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis
- (2018) Duong Thi Bich Thuan et al. Frontiers in Immunology
- Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression
- (2017) Subramaniya Bharathi Raja et al. FOOD AND CHEMICAL TOXICOLOGY
- Naringenin causes ASK1-induced apoptosis via reactive oxygen species in human pancreatic cancer cells
- (2017) Hyun Jin Park et al. FOOD AND CHEMICAL TOXICOLOGY
- Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality—a systematic review and dose-response meta-analysis of prospective studies
- (2017) Dagfinn Aune et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Luteolin induces apoptotic cell death via antioxidant activity in human colon cancer cells
- (2017) Kyoung Ah Kang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Naringenin-Induced Apoptotic Cell Death in Prostate Cancer Cells Is Mediated via the PI3K/AKT and MAPK Signaling Pathways
- (2017) Whasun Lim et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death
- (2017) Marisa Granato et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells
- (2017) Manal Fardoun et al. Oxidative Medicine and Cellular Longevity
- Naringenin suppresses growth of human placental choriocarcinoma via reactive oxygen species-mediated P38 and JNK MAPK pathways
- (2017) Sunwoo Park et al. PHYTOMEDICINE
- The role of quercetin and vitamin C in Nrf2-dependent oxidative stress production in breast cancer cells
- (2017) Zohreh Mostafavi-Pour et al. Oncology Letters
- Dietary Natural Products for Prevention and Treatment of Breast Cancer
- (2017) Ya Li et al. Nutrients
- Selective Toxicity of Apigenin on Cancerous Hepatocytes by Directly Targeting their Mitochondria
- (2016) Enayatollah Seydi et al. Anti-Cancer Agents in Medicinal Chemistry
- Anti-Cancer Effects of Green Tea by Either Anti- or Pro-Oxidative Mechanisms
- (2016) Sumio Hayakawa et al. Asian Pacific Journal of Cancer Prevention
- Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFκB and PCNA expression
- (2016) Lakshmi Narendra Bodduluru et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis
- (2016) Pavida Pittayapruek et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Luteolin induces cholangiocarcinoma cell apoptosis through the mitochondrial-dependent pathway mediated by reactive oxygen species
- (2016) Natthawan Kittiratphatthana et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System
- (2016) Sean M. Bugel et al. TOXICOLOGICAL SCIENCES
- Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update
- (2016) Arif Malik et al. Analytical Cellular Pathology
- Mechanisms underlying the xanthine oxidase inhibitory effects of dietary flavonoids galangin and pinobanksin
- (2016) Yi Dong et al. Journal of Functional Foods
- Natural Polyphenols for Prevention and Treatment of Cancer
- (2016) Yue Zhou et al. Nutrients
- Raynaud’s Phenomenon: A Brief Review of the Underlying Mechanisms
- (2016) Manal M. Fardoun et al. Frontiers in Pharmacology
- The NADPH Oxidase Nox4 mediates tumour angiogenesis
- (2015) V. Helfinger et al. Acta Physiologica
- Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest
- (2015) Yaoxian Wang et al. BMC CANCER
- Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis
- (2015) Ming-Der Shi et al. Cancer Cell International
- Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice
- (2015) Lakshmi Narendra Bodduluru et al. CHEMICO-BIOLOGICAL INTERACTIONS
- 5-Fluorouracil combined with apigenin enhances anticancer activity through mitochondrial membrane potential (ΔΨm)-mediated apoptosis in hepatocellular carcinoma
- (2015) Xiao-Yun Hu et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Health-promoting effects of the citrus flavanone hesperidin
- (2015) Chaoyun Li et al. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- Hesperetin Induces the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by Increasing Reactive Oxygen Species
- (2015) Jixiang Zhang et al. DIGESTIVE DISEASES AND SCIENCES
- Luteolin acts as a radiosensitizer in non-small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade
- (2015) HYUN-JI CHO et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway
- (2015) Shreyasi Palit et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Oxidative stress inhibits distant metastasis by human melanoma cells
- (2015) Elena Piskounova et al. NATURE
- Antioxidants can increase melanoma metastasis in mice
- (2015) Kristell Le Gal et al. Science Translational Medicine
- Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention
- (2015) Akhilendra Kumar Maurya et al. TUMOR BIOLOGY
- Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells
- (2015) Li Zhang et al. Food & Function
- NADPH oxidases: an overview from structure to innate immunity-associated pathologies
- (2014) Arvind Panday et al. Cellular & Molecular Immunology
- ROS Function in Redox Signaling and Oxidative Stress
- (2014) Michael Schieber et al. CURRENT BIOLOGY
- A naringenin–tamoxifen combination impairs cell proliferation and survival of MCF-7 breast cancer cells
- (2014) Talia Hatkevich et al. EXPERIMENTAL CELL RESEARCH
- Induction of Apoptosis and Antiproliferative Activity of Naringenin in Human Epidermoid Carcinoma Cell through ROS Generation and Cell Cycle Arrest
- (2014) Md Sultan Ahamad et al. PLoS One
- Paradoxical Effects of Antioxidants on Cancer
- (2014) Andrew R. Mendelsohn et al. REJUVENATION RESEARCH
- Antioxidants Accelerate Lung Cancer Progression in Mice
- (2014) V. I. Sayin et al. Science Translational Medicine
- (-)-Epigallocatechin-3-gallate inhibits nasopharyngeal cancer stem cell self-renewal and migration and reverses the epithelial–mesenchymal transition via NF-κB p65 inactivation
- (2014) Ya-Jun Li et al. TUMOR BIOLOGY
- Intracellular ROS protection efficiency and free radical-scavenging activity of quercetin and quercetin-encapsulated liposomes
- (2014) Rogaie Rezaei-Sadabady et al. Artificial Cells Nanomedicine and Biotechnology
- Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in rats
- (2013) Duraikannu Arul et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Reactive Oxygen Species Induce Epigenetic Instability through the Formation of 8-Hydroxydeoxyguanosine in Human Hepatocarcinogenesis
- (2013) Naoshi Nishida et al. DIGESTIVE DISEASES
- Simultaneous preparation of naturally abundant and rare catechins by tannase-mediated biotransformation combining high speed counter current chromatography
- (2013) Guobin Xia et al. FOOD CHEMISTRY
- Flavonoids as prospective compounds for anti-cancer therapy
- (2013) Divyashree Ravishankar et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Molecular displacement of warfarin from human serum albumin by flavonoid aglycones
- (2013) Miklós Poór et al. JOURNAL OF LUMINESCENCE
- Teratogenic effect of hydroxyethylrutoside, a flavonoid derivate drug – a population-based case–control study
- (2013) Éva Pósfai et al. Journal of Maternal-Fetal & Neonatal Medicine
- Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
- (2012) Shambhunath Choudhary et al. CARCINOGENESIS
- Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
- (2012) Paul D. Ray et al. CELLULAR SIGNALLING
- The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells
- (2012) Kuo-Ching Liu et al. ENVIRONMENTAL TOXICOLOGY
- Flavonoids as antioxidants in plants: Location and functional significance
- (2012) Giovanni Agati et al. PLANT SCIENCE
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Apigenin affects leptin/leptin receptor pathway and induces cell apoptosis in lung adenocarcinoma cell line
- (2011) Andreina Bruno et al. EUROPEAN JOURNAL OF CANCER
- Antioxidant and prooxidant properties of flavonoids
- (2011) D. Procházková et al. FITOTERAPIA
- Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line – A comparative study
- (2011) Gunasekaran Sivagami et al. FOOD AND CHEMICAL TOXICOLOGY
- The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention
- (2011) Sarah C. Forester et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity
- (2011) Chia-Jui Weng et al. New Biotechnology
- Antioxidant capacity of hesperidin fromCitruspeel using electron spin resonance and cytotoxic activity against human carcinoma cell lines
- (2011) Hanan A. Al-Ashaal et al. PHARMACEUTICAL BIOLOGY
- Synergistic Effects of Apigenin and Paclitaxel on Apoptosis of Cancer Cells
- (2011) Yimiao Xu et al. PLoS One
- Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3-O-gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB
- (2010) Mi Hee Lee et al. APOPTOSIS
- Pro-oxidative activities and dose–response relationship of (−)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro
- (2010) Guang-Xun Li et al. CARCINOGENESIS
- Apigenin induces apoptosis in human lung cancer H460 cells through caspase- and mitochondria-dependent pathways
- (2010) Hsu-Feng Lu et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- Determination of polyphenolic compounds by liquid chromatography–mass spectrometry in Thymus species
- (2010) Borbála Boros et al. JOURNAL OF CHROMATOGRAPHY A
- The flavonoids apigenin and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells
- (2010) Yong Pil Hwang et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Bioavailability of dietary flavonoids and phenolic compounds
- (2010) Alan Crozier et al. MOLECULAR ASPECTS OF MEDICINE
- Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management
- (2010) Ashley J Vargas et al. NUTRITION REVIEWS
- The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells
- (2010) Kuo-Hua Lee et al. TOXICOLOGY LETTERS
- Chemistry and Biochemistry of Dietary Polyphenols
- (2010) Rong Tsao Nutrients
- Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin
- (2010) Lara Gibellini et al. Cancers
- Prevention of oxidative DNA damage in inner organs and lymphocytes of rats by green tea extract
- (2009) Nina Kager et al. EUROPEAN JOURNAL OF NUTRITION
- Phase II Study of Flavopiridol in Relapsed Chronic Lymphocytic Leukemia Demonstrating High Response Rates in Genetically High-Risk Disease
- (2009) Thomas S. Lin et al. JOURNAL OF CLINICAL ONCOLOGY
- Chemoprotective effects of hesperidin against genotoxicity induced by cyclophosphamide in mice bone marrow cells
- (2008) Amirhosein Ahmadi et al. ARCHIVES OF PHARMACAL RESEARCH
- MODULATORY EFFECT OF NARINGENIN ONN-METHYL-N′-NITRO-N-NITROSOGUANIDINE- AND SATURATED SODIUM CHLORIDE-INDUCED GASTRIC CARCINOGENESIS IN MALE WISTAR RATS
- (2008) Ekambaram Ganapathy et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation
- (2008) Sanjeev Shukla et al. FREE RADICAL BIOLOGY AND MEDICINE
- Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice
- (2008) Sattu Kamaraj et al. INVESTIGATIONAL NEW DRUGS
- Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression
- (2008) Jae-Hoon Jeong et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells
- (2008) Ming-Hsien Yeh et al. TOXICOLOGY LETTERS
- Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase
- (2007) Yvonne Steffen et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started