Review
Biochemistry & Molecular Biology
Luciana Baroni, Anna Rita Sarni, Cristina Zuliani
Summary: The intake of plant foods rich in antioxidants may have a protective effect on cognition and improve cognitive abilities. While results varied, most studies showed a positive association between dietary plant antioxidants and cognitive functions.
Review
Endocrinology & Metabolism
Dipak Kumar Sahoo, Romy M. Heilmann, Biswaranjan Paital, Ashish Patel, Virendra Kumar Yadav, David Wong, Albert E. Jergens
Summary: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder characterized by intestinal inflammation. The causes of IBD are multifactorial, involving mucosal immunity, environmental factors, and host genetics. Understanding the cellular and molecular mechanisms mediated by reactive oxygen species (ROS) is crucial for the development of future therapies for IBD, which are driven by oxidative stress. This review discusses various natural antioxidant compounds and phytochemicals that target cellular signaling pathways to reduce intestinal inflammation in IBD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sandra Rojas-Lema, Sergio Torres-Giner, Luis Quiles-Carrillo, Jaume Gomez-Caturla, Daniel Garcia-Garcia, Rafael Balart
Summary: This study investigates the use of phenolic compounds such as naringin, gallic acid, caffeic acid, and quercetin as natural antioxidants for bio-based high-density polyethylene. The results show that these compounds significantly enhance the thermo-oxidative stability of bio-HDPE, while maintaining mechanical performance and transparency. Additionally, films containing these compounds exhibit high antioxidant activity in alcoholic solutions.
Review
Nutrition & Dietetics
Anamaria Jurcau
Summary: Research has shown the significance of oxidative stress in the pathogenesis and progression of dementia, highlighting the limitations of drugs targeting single pathways. Natural antioxidants offer potential in combating dementia by affecting multiple pathways involved in neurodegeneration and neuroinflammation, but face challenges in human trials related to bioavailability and treatment timing.
Review
Biochemistry & Molecular Biology
Kim S. Stote, Gracie Burns, Kim Mears, Marva Sweeney, Cynthia Blanton
Summary: Bioactive compounds in berries protect DNA, proteins, and lipids from oxidative damage by scavenging reactive oxygen and nitrogen species. This study reviewed randomized controlled trials (RCTs) to examine the effects of non-acute berry consumption on biomarkers of oxidative stress. Out of the 28 RCTs evaluated, 32% of the biomarkers showed statistically significant beneficial results, while 68% showed no significant differences. Further well-designed and longer-term trials are needed to assess biomarkers of oxidative stress.
Review
Nutrition & Dietetics
Sen-Yuan Hong, Bao-Long Qin
Summary: Urolithiasis is a common urological disease with increasing prevalence and high recurrence rates worldwide. Reactive oxygen species (ROS) and oxidative stress (OS) play crucial roles in stone formation. Dietary polyphenols, which are natural antioxidant compounds found in plant-based foods and beverages, have been shown to be effective in preventing and treating stone formation. This review discusses the antioxidant potential of polyphenols and their mechanisms in ameliorating oxidative stress and preventing stone formation. Dietary polyphenols offer promising applications in the treatment and prevention of urolithiasis.
Review
Food Science & Technology
Hiba N. Rajha, Armelle Paule, Gerard Aragones, Mariana Barbosa, Carla Caddeo, Esperance Debs, Rada Dinkova, Gunter P. Eckert, Ariel Fontana, Prisca Gebrayel, Richard G. Maroun, Alessandra Napolitano, Lucia Panzella, Giulio Maria Pasinetti, Jan F. Stevens, Andreas Schieber, Marvin Edeas
Summary: Polyphenols have attracted researchers from various disciplines due to their diverse biological activities. The latest scientific research has focused on polyphenol interactions with the microbiome and mitochondria, as well as their potential applications in cosmetics, dietary supplements, and functional foods. Polyphenols may play a key role in disease prevention and have promising prospects in future food and nutrition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ana L. Becerril-Sanchez, Baciliza Quintero-Salazar, Octavio Dublan-Garcia, Hector B. Escalona-Buendia
Summary: Honey has been used since ancient times for its sensory, nutritional, and therapeutic properties, which are related to its physical and chemical composition. Phenolic compounds play a significant role in honey, influencing its antioxidant activity, botanical-geographical origin, and sensory characteristics. Researchers are increasingly interested in the study of phenolic compounds and their impact on honey's biological and functional activity.
Article
Engineering, Environmental
Jozef Kovacik, Slawomir Dresler, Maciej Strzemski, Ireneusz Sowa, Petr Babula, Magdalena Wojciak-Kosior
Summary: The study found that in the medicinal plant Hypericum perforatum L., strontium can be mitigated by organic nitrogen forms, and even have a stimulatory effect. Additionally, the effects of strontium on the plant mainly manifest in changes in primary and secondary metabolites, as well as in mineral elements.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Eleonora Cremonini, Elena Daveri, Dario E. Iglesias, Jiye Kang, Ziwei Wang, Russell Gray, Angela Mastaloudis, Colin D. Kay, Shelly N. Hester, Steven M. Wood, Cesar G. Fraga, Patricia Oteiza
Summary: This study investigated the effects of a cyanidin-and delphinidin-rich extract on the postprandial dysmetabolism, inflammation, and insulin signaling triggered by a high fat meal. The results showed that the extract reduced the negative effects associated with postprandial dysmetabolism and regulated glycemia and lipidemia.
Article
Biochemistry & Molecular Biology
Jurga Andreja Kazlauskaite, Liudas Ivanauskas, Mindaugas Marksa, Jurga Bernatoniene
Summary: This study investigated and compared the effects of different extraction methods on the total phenolic content, flavonoid content, and antioxidant activity of red clover. The results showed that cyclodextrins significantly increased the total phenolic content, with beta-cyclodextrin being the most effective in aqueous samples and gamma-cyclodextrin being the most effective in ethanolic samples. The study also found a strong relationship between total phenolic content and DPPH assay. These findings suggest that cyclodextrins are a valuable tool for obtaining red clover extracts high in antioxidant activity.
Article
Food Science & Technology
Kirinde Gedara Isuru Sandanuwan Kirindage, Ilekuttige Priyan Shanura Fernando, Arachchige Maheshika Kumari Jayasinghe, Eui-Jeong Han, Mawalle Kankanamge Hasitha Madhawa Dias, Kyung-Pil Kang, Sung-Ig Moon, Tai-Sun Shin, Ayeong Ma, Ginnae Ahn
Summary: The present study identified phenolic compounds in Moringa oleifera hot water extract (MOH) and evaluated its antioxidant activity on H2O2-induced oxidative stress in Vero cells. Results showed that MOH exhibited strong radical scavenging and antioxidant properties, reduced ROS generation, increased cell viability, suppressed mitochondrial depolarization and apoptosis, and activated the Nrf2/HO-1 signaling pathway.
Review
Biochemistry & Molecular Biology
Maochao Luo, Li Zhou, Zhao Huang, Bowen Li, Edouard C. Nice, Jia Xu, Canhua Huang
Summary: Cancer is associated with oxidative stress, and targeting this imbalance between reactive oxygen species (ROS) and antioxidants may have therapeutic potential. However, the clinical efficacy of antioxidants in cancer treatment remains uncertain. This review discusses the rationale and recent advances in antioxidant therapy for cancer, as well as potential strategies for improving its effectiveness.
Review
Endocrinology & Metabolism
Dharmsheel Shrivastav, Pradeep Kumar Dabla, Jitender Sharma, Aroop Viswas, Rashid Mir
Summary: Antioxidant supplements can be an effective treatment approach for type 2 diabetes mellitus, resulting in significant reductions in blood glucose and glycated hemoglobin, as well as decreased oxidative stress and increased antioxidant capacity.
WORLD JOURNAL OF DIABETES
(2023)
Review
Plant Sciences
Georgiana Dretcanu, Ioana Stirbu, Nicolae Leoplold, Daniel Cruceriu, Corina Danciu, Andreea Stanila, Anca Farcas, Ileana Monica Borda, Cristian Iuhas, Zorita Diaconeasa
Summary: There has been a significant shift in the global collective mindset towards prevention rather than treatment, leading to the popularity of plant-based diets among consumers. Flavonoids, a type of bioactive compound, have garnered attention from researchers for their potential in preventing and treating various types of cancers. This review aims to inform readers about the diversity, accessibility, and importance of flavonoids as biomolecules essential for optimal health, with a focus on their potential in cancer prevention. Additionally, the review discusses alternative methods, such as genetic manipulation, for obtaining higher amounts of flavonoids.
Review
Spectroscopy
Khalil Mallah, Kazem Zibara, Coline Kerbaj, Ali Eid, Nour Khoshman, Zahraa Ousseily, Abir Kobeissy, Tristan Cardon, Dasa Cizkova, Firas Kobeissy, Isabelle Fournier, Michel Salzet
Summary: Traumatic brain injury (TBI) is a major public health concern worldwide, and the use of proteomic and lipidomic platforms has broadened our understanding of TBI-related mechanisms and neuropathological complications. This study provides an updated overview of spatially resolved microproteomics and microlipidomics approaches guided by mass spectrometry imaging in TBI studies and discusses their applications in neurotrauma research. The accurate and precise techniques of microproteomic sampling, such as laser capture microdissection, parafilm assisted microdissection, and liquid microjunction extraction, are evaluated. The potential of lipid profiling, particularly in phospholipid metabolism and proinflammatory molecules, is highlighted.
MASS SPECTROMETRY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Khalil Hamze, Rola H. Abdallah, Nour K. Younis, Manal Fardoun, Nadine Darwiche, Firas Kobeissy, Rabah Iratni, Kamal Bouhadir, Ali H. Eid
Summary: In this study, we synthesized four novel nucleobase analogs and investigated their effects on CRC cells. The results showed that these analogs significantly inhibited cell viability, attenuated cell migration and adhesion, and promoted cell-cell interaction. Additionally, these compounds exhibited anti-angiogenic activity in vivo.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Stanley Ibeh, Nour-Mounira Z. Bakkar, Fatima Ahmad, Judith Nwaiwu, Chloe Barsa, Sarine Mekhjian, Mohammad Amine Reslan, Ali H. Eid, Hayat Harati, Sanaa Nabha, Yehia Mechref, Ahmed F. El-Yazbi, Firas Kobeissy
Summary: This study suggests that chronic high-fat diet worsens the outcomes of traumatic brain injury, leading to neurodegeneration and impaired brain recovery.
Letter
Medicine, General & Internal
Hiam Chemaitelly, Patrick Tang, Peter Coyle, Hadi M. Yassine, Hebah A. Al-Khatib, Maria K. Smatti, Mohammad R. Hasan, Houssein H. Ayoub, Heba N. Altarawneh, Zaina Al-Kanaani, Einas Al-Kuwari, Andrew Jeremijenko, Anvar H. Kaleeckal, Ali N. Latif, Riyazuddin M. Shaik, Hanan F. Abdul-Rahim, Gheyath K. Nasrallah, Mohamed G. Al-Kuwari, Adeel A. Butt, Hamad E. Al-Romaihi, Mohamed H. Al-Thani, Abdullatif Al-Khal, Roberto Bertollini, Laith J. Abu-Raddad
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Surgery
Sara Jangjoo, Nima Emami, Mehrdad Sahranavard, Najeeb Z. Shah, Mona Alidadi, Fatemeh Baratzadeh, Thozhukat Sathyapalan, Ali H. Eid, Ali Jangjoo, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: This study aimed to determine the diagnostic accuracy of non-invasive liver function tests in liver fibrosis and assess their changes after metabolic surgery. The results showed that AST/ALT (AAR) was the most sensitive pre-operative serological marker, while NAFLD Fibrosis Score (NFS) was the most specific. Additionally, APRI showed a positive correlation with 2D-SWE post-metabolic surgery.
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Pharmacology & Pharmacy
Hasan Slika, Hadi Mansour, Suzanne A. Nasser, Abdullah Shaito, Firas Kobeissy, Alexander N. Orekhov, Gianfranco Pintus, Ali H. Eid
Summary: In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the cAMP-protein kinase A (PKA) pathway was discovered as the first signaling cascade. Recently, a new cAMP effector called exchange protein directly activated by cAMP (Epac) has emerged as a critical mediator of cAMP's actions, playing a role in various diseases and offering potential as a therapeutic target. This paper provides a comprehensive analysis of Epac's structure, distribution, compartmentalization, and signaling mechanisms, discussing the development of specific Epac modulators for future pharmacotherapeutics.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jignesh D. Pandya, Sudeep Musyaju, Hiren R. Modi, Ying Cao, William J. Flerlage, Linda Huynh, Brittany Kociuba, Nishant P. Visavadiya, Firas Kobeissy, Kevin Wang, Janice S. Gilsdorf, Anke H. Scultetus, Deborah A. Shear
Summary: Traumatic Brain Injury (TBI) is a heterogeneous disorder caused by external physical assaults that damages the brain. Mitochondrial dysfunction plays a pivotal role in long-term injury progression through cellular excitotoxicity. This study provides an in-depth evaluation of mitochondrial endpoints with respect to redox and calcium homeostasis, and cell death responses following penetrating TBI (PTBI).
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nader Al-Dewik, Muthanna Samara, Salma Younes, Rana Al-jurf, Gheyath Nasrallah, Sawsan Al-Obaidly, Husam Salama, Tawa Olukade, Sara Hammuda, Neil Marlow, Mohamed Ismail, Taghreed Abu Nada, M. Walid Qoronfleh, Binny Thomas, Ghassan Abdoh, Palli Valapila Abdulrouf, Thomas Farrell, Mai Al Qubaisi, Hilal Al Rifai
Summary: This study aimed to assess the incidence, risk factors, and outcomes of major congenital anomalies (CAs) in Qatar. The study found that the incidence of any CA among live births in Qatar was 1.3%, with cardiovascular system (CVS) anomalies being the most common. Multiple pregnancies, parity, and maternal BMI were associated with specific CAs. CAs were significantly associated with high rates of caesarean deliveries, low Apgar scores, in-hospital mortality, and neonatal intensive care unit admission.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Aysha Alneyadi, Zohra Nausheen Nizami, Hanan E. E. Aburawi, Soleiman Hisaindee, Muhammad Nawaz, Samir Attoub, Gaber Ramadan, Nehla Benhalilou, Mazoun Al Azzani, Yassine Elmahi, Aysha Almeqbali, Khalid Muhammad, Ali H. H. Eid, Ranjit Vijayan, Rabah Iratni
Summary: This study synthesized two new chromene compounds and tested their activity against hormone-responsive and TNBC cells. The compounds specifically inhibited the proliferation of TNBC cells and disrupted the polymerization of microtubules within the cytoskeleton. Additionally, the compounds efficiently blocked TNBC migration and inhibited the formation of blood vessels. These findings highlight the therapeutic potential of these compounds against TNBC.
Article
Genetics & Heredity
Dalal Al-Sharshani, Dinesh Velayutham, Muthanna Samara, Reham Gazal, Ayman Al Haj Zen, Mohamed A. Ismail, Mahmoud Ahmed, Gheyath Nasrallah, Salma Younes, Nasser Rizk, Sara Hammuda, M. Walid Qoronfleh, Thomas Farrell, Hatem Zayed, Palli Valapila Abdulrouf, Manar AlDweik, John Paul Ben Silang, Alaa Rahhal, Rana Al-Jurf, Ahmed Mahfouz, Amar Salam, Hilal Al Rifai, Nader I. Al-Dewik
Summary: This study aimed to investigate the association between selected single nucleotide polymorphisms (SNPs) and dyslipidemia, as well as the increased susceptibility risks of cardiovascular diseases, type 2 diabetes mellitus, and non-alcoholic fatty liver disease. The results showed significant differences in genotypic frequencies of six SNPs between dyslipidemia patients and control individuals. These differences were found to be associated with gender, obesity, hypertension, and diabetes.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Article
Immunology
Abdul Rasheed Palakkott, Aysha Alneyadi, Khalid Muhammad, Ali Hussein Eid, Khaled M. A. Amiri, Mohammed Akli Ayoub, Rabah Iratni
Summary: The novel coronavirus, SARS-CoV-2, uses its spike S protein to bind with the ACE2 receptor in lung cells and cause COVID-19. This study reveals the potential involvement of the epidermal growth factor receptor (EGFR) and its signaling pathway in SARS-CoV-2 infectivity. Targeting EGFR could be a new approach for treating COVID-19.
Article
Biochemistry & Molecular Biology
Chirine El-Baba, Zeinab Ayache, Mona Goli, Berthe Hayar, Zeinab Kawtharani, Claudio Pisano, Firas Kobeissy, Yehia Mechref, Nadine Darwiche
Summary: The study shows that ST1926 is effective in reducing cell viability and inducing apoptosis in GBM cells, and it also reduces the level of POLA1 protein. Additionally, proteomics analysis reveals that ST1926 affects multiple cellular processes related to GBM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Salma Younes, Eleonora Nicolai, Duaa W. Al-Sadeq, Nadin Younes, Nader Al-Dewik, Haissam Abou-Saleh, Bushra Y. Abo-Halawa, Ali Hussein Eid, Massimo Pieri, Na Liu, Hanin I. Daas, Hadi M. Yassine, Parveen B. Nizamuddin, Laith J. Abu-Raddad, Gheyath K. Nasrallah
Summary: This study compared antibody responses between vaccinated individuals and naturally infected individuals over a 10-month period. The vaccinated individuals showed significantly higher antibody responses in the first 6 months compared to the naturally infected individuals. However, antibody responses started to decline after the 7th month in the vaccinated group. These findings have important implications for the development of long-lasting protection strategies.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Hasan Slika, Ziya Karimov, Paolo Alimonti, Tatiana Abou-Mrad, Emerson De Fazio, Safwan Alomari, Betty Tyler
Summary: Glioblastoma is a common and debilitating malignant tumor of the central nervous system. The prognosis for patients with glioblastoma remains poor, and current management methods are not optimal. This review explores the evolution of preclinical models for glioblastoma and discusses commonly used in vitro and in vivo models, as well as advancements in humanized mouse models, genetically engineered animal models, 3D in vitro models, and microfluidics. The review highlights the importance of developing suitable preclinical models to advance glioblastoma research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
