Article
Biochemistry & Molecular Biology
Tomoka Yoda, Masateru Furuta, Tomohiko Tsutsumi, Seiki Ikeda, Shunsuke Yukizawa, Satoshi Arai, Akinori Morita, Kenji Yamatoya, Kazuya Nakata, Shusuke Tomoshige, Kenji Ohgane, Yuuki Furuyama, Kengo Sakaguchi, Fumio Sugawara, Susumu Kobayashi, Masahiko Ikekita, Kouji Kuramochi
Summary: Epo-C12, a synthetic derivative of epolactaene isolated from Penicillium sp. BM 1689-P, induces apoptosis in BALL-1 cells. The study reveals that Epo-C12 inhibits peroxidase activity of Prx 1 without affecting its chaperone activity. Epo-C12 binds to Cys52 and Cys83 in Prx 1, indicating Prx 1 as a target protein for Epo-C12-induced apoptotic effect in BALL-1 cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Qian Zhang, Piao Luo, Liuhai Zheng, Jiayun Chen, Junzhe Zhang, Huan Tang, Dandan Liu, Xueling He, Qiaoli Shi, Liwei Gu, Jiahao Li, Qiuyan Guo, Chuanbin Yang, Yin Kwan Wong, Fei Xia, Jigang Wang
Summary: 18beta-glycyrrhetinic acid (18 beta-GA) decreases hepatic fibrosis by inducing the apoptosis of activated hepatic stellate cells (HSCs). It targets peroxiredoxin proteins (PRDX1 and PRDX2) by binding to active cysteine residues, inhibiting their enzymatic activities. This leads to an increase in reactive oxygen species (ROS) and subsequent apoptosis of activated HSCs. The study highlights the potential of 18 beta-GA as a novel therapeutic drug for hepatic fibrosis.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Nutrition & Dietetics
Zhixiang Xu, Yue Jia, Jun Liu, Xiaomin Ren, Xiaoxia Yang, Xueshan Xia, Xuejun Pan
Summary: This study aimed to investigate the synergistic antitumor effects of tamoxifen and naringenin/quercetin on human hepatic carcinoma, and to explore the potential molecular mechanisms involved. The results demonstrated that a combination of tamoxifen and higher concentrations of naringenin or quercetin significantly inhibited cell growth and migration, stimulated apoptosis, and resulted in loss of mitochondrial membrane potential. These effects were regulated by ROS-mediated p53 signaling cascades. On the other hand, lower concentrations of naringenin and quercetin regulated cell migration, invasion, cycle, and apoptosis, thereby inhibiting the tamoxifen-induced antiproliferative effects.
Article
Biochemistry & Molecular Biology
Yuhui Liu, Chengjian Shi, Zheng He, Feng Zhu, Min Wang, Ruizhi He, Chunle Zhao, Xiuhui Shi, Min Zhou, Shutao Pan, Yang Gao, Xu Li, Renyi Qin
Summary: Rhein, a component of Chinese herb rhubarb, has been shown to inhibit pancreatic cancer cell growth by inducing apoptosis and arresting the cell cycle. When combined with oxaliplatin, Rhein synergistically enhances apoptosis in pancreatic cancer cells through increased ROS levels and inactivation of the PI3K/AKT pathway, suggesting it may be an effective strategy to overcome drug resistance.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Olena Odnokoz, Noah Earland, Marziyeh Badinloo, Vladimir I. Klichko, Judith Benes, William C. Orr, Svetlana N. Radyuk
Summary: Aberrant immune responses and chronic inflammation can increase health risks and promote premature aging. Peroxiredoxins (Prxs) play a critical role in maintaining cellular redox homeostasis and regulating the immune response. The activity of mitochondrial Prxs in the intestinal epithelium is important for preventing intestinal barrier dysfunction, systemic inflammation, and premature aging.
Article
Biochemistry & Molecular Biology
Sin Ri Kim, Ji Won Park, Byung-Hoon Lee, Kyung Min Lim, Tong-Shin Chang
Summary: Ultraviolet B (UVB) irradiation induces the production of reactive oxygen species (ROS), leading to damage in exposed skin cells. Mitochondria and NADPH oxidase are two major sources of ROS in UVB-irradiated keratinocytes. Peroxiredoxin V (PrxV) is a cysteine-dependent peroxidase enzyme found in mitochondria and cytosol, which effectively removes H2O2. We investigated the role of PrxV in protecting epidermal keratinocytes against UVB-induced ROS damage.
Article
Biochemistry & Molecular Biology
Ying Zhang, Jiyoung Park, Seong-Jeong Han, Iha Park, Thang Nguyen Huu, Jong-Suk Kim, Hyun Ae Woo, Seung-Rock Lee
Summary: This study investigates the roles of peroxiredoxin III and redox regulation of phosphatase and tension homolog deleted on chromosome 10 (PTEN) in alcoholic fatty liver disease. It found that alcohol-induced mitochondrial oxidative stress contributes to reversible oxidation of PTEN, leading to hyperactivation of Akt and MAPK with elevated levels of lipogenesis regulators. Peroxiredoxin III in mitochondria was found to have antagonistic effects on lipogenesis by removing ROS, highlighting the crucial roles of redox regulation of PTEN and peroxiredoxin III in the development of AFLD.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cell Biology
Florenci Serras
Summary: One of the main topics in regeneration biology is understanding the early signals that drive the damage response. Recent studies in Drosophila have identified the MAP3 kinase Ask1 as a key regulator that integrates multiple signals at the onset of regeneration. This research reveals the activation of Ask1 by reactive oxygen species (ROS) produced in damaged tissues, and highlights the dual function of Ask1 in promoting cell survival and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Shuxin Sun, Yang Liu, Chaobin He, Wanming Hu, Wenfeng Liu, Xin Huang, Jiali Wu, Fengxiao Xie, Chen Chen, Jun Wang, Yuan Lin, Wenbo Zhu, Guangmei Yan, Jing Cai, Shengping Li
Summary: NanoKnife, a nonthermal ablation technique, combined with M1 virus shows synergistic therapeutic efficacy in treating locally advanced pancreatic cancer, enhancing tumor inhibition and prolonging survival in immunocompetent mice. The combination promotes M1 infection, converting immune-silent tumors into immune-inflamed tumors and potentially improving prognosis for LAPC patients.
Article
Oncology
Jie Du, Fan Jiang, Shen-Sheng Xu, Zi-Feng Huang, Li-Li Chen, Li Li
Summary: Tephrosin exhibits potent anticancer activity against pancreatic cancer cells by suppressing cell viability and promoting apoptosis through increased ROS production and DNA damage. Additionally, it demonstrates strong antitumor activity with low toxicity in a mouse model.
Article
Pharmacology & Pharmacy
Piao Luo, Dandan Liu, Qian Zhang, Fan Yang, Yin-Kwan Wong, Fei Xia, Junzhe Zhang, Jiayun Chen, Ya Tian, Chuanbin Yang, Lingyun Dai, Han-Ming Shen, Jigang Wang
Summary: Celastrol exerts anti-fibrotic effects by inducing ferroptosis and promoting the production of ROS. It directly binds to PRDXs and HO-1, inhibiting their antioxidant activities and increasing ROS levels, thereby inducing ferroptosis.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Da Eun Lee, Hyeon Woong Kang, So Yi Kim, Myeong Jin Kim, Jae Woong Jeong, Woosol Chris Hong, Sungsoon Fang, Hyung Sun Kim, Yun Sun Lee, Hyo Jung Kim, Joon Seong Park
Summary: This study demonstrates that the combination of ivermectin and gemcitabine effectively suppresses pancreatic cancer by inhibiting cell proliferation and inducing cell apoptosis through cell cycle arrest and mitochondrial dysfunction. In vivo experiments also support the tumor-inhibiting effect of this combination treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Eun-Kyung Kim, Yosup Kim, Jun Young Yang, Ho Hee Jang
Summary: Prx1 overexpression inhibits nuclear localization of XBP-1 and CHOP expression, reducing apoptosis and ROS production during ER stress. While ROS scavenger inhibits ER stress-induced apoptosis, it does not affect XBP-1 activation and CHOP expression. The biological role of Prx1 in ER stress may have important implications for ER stress-related diseases.
Review
Biochemistry & Molecular Biology
Inna L. Karpenko, Vladimir T. Valuev-Elliston, Olga N. Ivanova, Olga A. Smirnova, Alexander V. Ivanov
Summary: Viral infections lead to increased ROS production, causing oxidative stress and disrupting the antioxidant capacity of cells, while Prdx, the most effective peroxide scavengers, have been largely overlooked. Prdx can scavenge peroxides at physiological concentrations in various cell compartments, showcasing important antioxidant functions that warrant further attention.
Article
Oncology
Yong-Zhe Jin, Yi-Xi Gong, Yue Liu, Dan-Ping Xie, Chen-Xi Ren, Seung-Jae Lee, Hu-Nan Sun, Taeho Kwon, Dong-Yuan Xu
Summary: The study suggests that Prx V knockdown may significantly increase DOX-induced apoptosis by aggravating intracellular ROS accumulation, and also activates mitochondria-dependent apoptotic signaling pathways.
ANTICANCER RESEARCH
(2021)
Article
Clinical Neurology
Min-Seok Kang, Hyun-Jin Park, Ki-Han You, Dae-Jung Choi, Chang-Won Park, Hoon-Jae Chung
Summary: This study compared the clinical outcomes of biportal endoscopic technique for primary and revision lumbar discectomy. The results showed that there were no significant differences in pain improvement between the two groups, and revision surgery had favorable clinical outcomes with less postoperative pain.
GLOBAL SPINE JOURNAL
(2023)
Article
Orthopedics
Hyun-Jin Park, Ki-Han You, Bingzhe Huang, Joon Hyeok Yoon, Hyong Nyun Kim
Summary: We investigated if 3D printed models can reduce operation time and improve the quality of reduction for calcaneal fractures. The study included 48 patients with unilateral intra-articular calcaneal fractures. The use of 3D printed models significantly reduced operation time and did not affect the radiological parameters or quality of fracture reduction compared to standard techniques.
JOURNAL OF FOOT & ANKLE SURGERY
(2023)
Article
Horticulture
Hyun-Jin Park, Gyu-Bin Lee, Young-Eun Park, Yong-Ik Jin, Jang-Gyu Choi, Jin-Hee Seo, Chung-Gi Cheon, Dong Chil Chang, Ji-Hong Cho, Jin-Ho Kang
Summary: The size of seed tubers affects the dormancy characteristics and yield of potatoes. Larger seed tubers have shorter dormancy periods, higher sprouting rates, better quality, and higher yields. Therefore, medium and large seed tubers are ideal choices for double-cropping in potato cultivation.
HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY
(2023)
Article
Microbiology
Yeon-Sook Kim, Seng-Ho Jeon, Junghee Kim, Jong Hoon Koh, Seung Won Ra, Ji Won Kim, Yeonjae Kim, Choon Kwan Kim, Yun Chul Shin, Beo Deul Kang, Seung ji Kang, Chul Hee Park, Boyoung Lee, Ji Yeon Lee, Chung Hoon Lee, Jae-phil Choi, Jin Yong Kim, Shi Nae Yu, Kyong Ran Peck, Sung-Han Kim, Jung Yeon Heo, Hyun ah Kim, Hyun-jin Park, JoungWon Choi, Jumi Han, JooHyun Kim, Hyoung jun Kim, Se Hee Han, Aeri Yoon, MiHee Park, SuJung Park, YuKyung Kim, Minji Jung, Myoung-don Oh
Summary: This study evaluated the efficacy of oral drug Camostat mesylate in treating mild to moderate COVID-19 patients. The results showed that patients in the Camostat group had a shorter time to symptom improvement compared to the placebo group, and it may be more effective in high-risk patients. Further clinical studies are needed to assess the efficacy of Camostat mesylate in high-risk patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Mechanics
Dongik Yoon, Hyun Jin Park, Yuji Tasaka, Yuichi Murai
Summary: This study experimentally investigates bubbles sliding near inclined walls to understand their behavior within turbulent boundary layers. The shape of the bubbles is found to vary with changes in channel inclination. A measurement technique involving optoacoustic and ultrasound pulsed Doppler methods is utilized to determine the sliding motion, diameter, advection velocity, liquid velocity profiles, and maximum distance of the bubbles. The results confirm that buoyancy has an enhanced effect on the slip velocity of the bubble with increased inclination, and drag and buoyancy determine the bubble's shape in inclined conditions. The measured drag coefficient increases with the inclination angle up to 35 degrees, and a modeling equation for the drag coefficient is proposed based on the Weber number, inclination angle, and ellipticity of the bubble. This equation is applicable to bubbles within turbulent boundary layers.
INTERNATIONAL JOURNAL OF MULTIPHASE FLOW
(2023)
Article
Polymer Science
Li Jun Ren, Hui Yun Zhou, Pei Yan Hao, Hui Jie Zheng, Jia Nan Tong, Ya Wei Chen, Hyun Jin Park
Summary: In this study, l-lysine (Lys), l-glutamate (Glu), and l-glutamine (Gln) grafted-chitosan (CS) polymers (AA-g-CS) were prepared using EDC/NHS as coupling agents. AA-g-CS/GP hydrogel showed improved thermosensitivity and had a dense three-dimensional network structure. The hydrogel loaded with berberine hydrochloride (BBH) demonstrated sustained release, with BBH@Lys-g-CS/GP hydrogel showing the best sustained release effect.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Haishan Wu, Jian Nan, Liu Yang, Hyun Jin Park, Jinglei Li
Summary: Compared to subcutaneous injections, oral administration of insulin is preferred for diabetic patients. However, challenges such as early drug release and poor absorption hinder the effectiveness of liposomes and alginate hydrogels for oral delivery. This study presents a liposome-in-alginate hydrogel loaded with arginine-insulin complexes, demonstrating improved intestinal permeation and retention, controlled release, and hypoglycemic effects. Therefore, this strategy holds promise for oral insulin delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Food Science & Technology
Yaxin Wen, Chhychhy Chao, Quang Tuan Che, Hyun Woo Kim, Hyun Jin Park
Summary: Plant-based meat analog production is a strategy to replace animal meat consumption, but faces challenges in terms of texture, nutrition, and sensory properties. 3D food printing can be used to produce customized food with different characteristics. Therefore, 3D-printed plant-based meat analogs have technical and commercial potential, but require further research.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Orthopedics
Hyun-Jin Park, Jun-Young Choi, Woo Myung Lee, Sang-Min Park
Summary: This study examined the prevalence and associated factors of chronic low back pain in the South Korean population. The results showed that chronic low back pain was most common in the elderly and women. Age, gender, physical activity level, depressive symptoms, and comorbidities were found to be associated with chronic low back pain.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Food Science & Technology
Byungchan Cho, Korakot Charoensri, Hansol Doh, Hyun Jin Park
Summary: The colorimetric sensor array (CSA) system is used in food science to assess food quality by identifying undesirable volatile organic compounds. In this study, the quality of edible-coated food products was evaluated using both conventional and CSA methods, demonstrating that the CSA approach is a feasible alternative to conventional methods.
Article
Orthopedics
Woo-Myung Lee, Ki-Han You, Min-Seok Kang, Jun-Hyun Kim, Hyun-Jin Park
Summary: Oblique lumbar interbody fusion is a minimally invasive technique that can correct spinal alignment and achieve indirect neural decompression. However, it may be limited in patients with central canal lesions who require direct decompression. By combining it with biportal endoscopic spinal surgery, both alignment correction and direct decompression can be achieved.
ASIAN SPINE JOURNAL
(2023)
Article
Engineering, Marine
Taiji Tanaka, Yoshihiko Oishi, Hyun Jin Park, Yuji Tasaka, Yuichi Murai, Chiharu Kawakita
Summary: Frictional drag reduction using repetitive bubble injection in a turbulent boundary layer beneath a towing model ship was studied. The drag reduction ratio reached 24%, which was a 5% improvement compared to continuous bubble injection. The transition of bubble dispersion status was found to cause the streamwise decay of local drag reduction. Repetitive bubble injection improved the downstream persistence of the drag-reduction effect by a factor of 15. The estimation of full-scale performance indicated that repetitive bubble injection provided approximately 7 times the drag reduction of continuous bubble injection for long ship hulls exceeding 130m.
Article
Orthopedics
Min-Seok Kang, Hyun-Jin Park, Sang-Min Park, Ki-Han You, Won-Jik Ju
Summary: The study aimed to determine the learning curve for biportal full-endoscopic posterior cervical foraminotomy (BE-PCF). The learning curve was evaluated using a learning curve cumulative summation test (LC-CUSUM). The study found that the surgeon became competent after performing 20 operations, and there were no significant differences in operation time and clinical outcomes.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Orthopedics
Woo-Myung Lee, Ki-Han You, Min-Seok Kang, Jun-Hyun Kim, Hyun-Jin Park
Summary: Oblique lumbar interbody fusion (OLIF) is a minimally invasive procedure for degenerative lumbar disease, providing advantages of spinal alignment correction and indirect neural decompression. However, direct decompression is needed for some patients with central canal lesions, which can be achieved through biportal endoscopic spinal surgery. The combination of OLIF and biportal endoscopic spinal surgery allows for both alignment correction and direct decompression in multilevel lumbar lesions.
ASIAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Byung-Taek Kwon, Ho-Joong Kim, Sanghoon Lee, Sang-Min Park, Dae-Woong Ham, Hyun-Jin Park, Ohsang Kwon, Jin S. Yeom
Summary: This study compared the radiographic and clinical efficacy and safety between the BGS-7 spacer and PEEK cage in PLIF surgery. The results showed similar fusion rates and clinicoradiographic outcomes between the two groups, but the non-inferiority of the BGS-7 spacer was inconclusive. Safety concerns regarding fracture and migration of the BGS-7 spacer must be considered.
ACTA NEUROCHIRURGICA
(2023)
