A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis

Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension

(2018) Toshio Suzuki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Twist1 in Hypoxia-induced Pulmonary Hypertension through Transforming Growth Factor-β–Smad Signaling

(2018) Tadanori Mammoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of mTOR ameliorates bleomycin-induced pulmonary fibrosis by regulating epithelial-mesenchymal transition

(2018) Qian Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium

(2018) Thomas J. Lynch et al.   Cell Stem Cell

Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury

(2018) Aleksandra Tata et al.   Cell Stem Cell

NLRP3 Inflammasome Activation Contributes to Mechanical Stretch–Induced Endothelial-Mesenchymal Transition and Pulmonary Fibrosis

(2018) Zhou Lv et al.   CRITICAL CARE MEDICINE

NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy

(2018) Kishore Reddy Katikireddy et al.   FREE RADICAL BIOLOGY AND MEDICINE

NADPH oxidase, oxidative stress and fibrosis in systemic sclerosis

(2018) Silvia Svegliati et al.   FREE RADICAL BIOLOGY AND MEDICINE

MicroRNA-148b Targets the TGF-β Pathway to Regulate Angiogenesis and Endothelial-to-Mesenchymal Transition during Skin Wound Healing

(2018) Vladislav Miscianinov et al.   MOLECULAR THERAPY

circHECTD1 promotes the silica-induced pulmonary endothelial–mesenchymal transition via HECTD1

(2018) Shencun Fang et al.   Cell Death & Disease

Hedgehog Interacting Protein Promotes Fibrosis and Apoptosis in Glomerular Endothelial Cells in Murine Diabetes

(2018) Xin-Ping Zhao et al.   Scientific Reports

Endothelial to Mesenchymal Transition Represents a Key Link in the Interaction between Inflammation and Endothelial Dysfunction

(2018) Jin Gu Cho et al.   Frontiers in Immunology

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

(2018) William J. Zacharias et al.   NATURE

NF-κB mediated miR-130a modulation in lung microvascular cell remodeling: Implication in pulmonary hypertension

(2017) Li Li et al.   EXPERIMENTAL CELL RESEARCH

Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol

(2017) Yucai Chen et al.   International Journal of Biological Sciences

Endothelial cell-specific activation of transforming growth factor-β signaling in mice induces cutaneous, visceral, and microvascular fibrosis

(2017) Peter J Wermuth et al.   LABORATORY INVESTIGATION

Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties

(2017) Giacomo Donati et al.   NATURE CELL BIOLOGY

Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts

(2017) Hannah Murphy-Marshman et al.   PLoS One

Reactive oxygen species as signaling molecules in the development of lung fibrosis

(2017) Francisco J. Gonzalez-Gonzalez et al.   Translational Research

TGF-β1 Signaling and Tissue Fibrosis

(2017) Kevin K. Kim et al.   Cold Spring Harbor Perspectives in Biology

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Premature senescence of cardiac fibroblasts and atrial fibrosis in patients with atrial fibrillation

(2017) Jun Xie et al.   Oncotarget

Lovastatin Alleviates Endothelial-to-Mesenchymal Transition in Glomeruli via Suppression of Oxidative Stress and TGF-β1 Signaling

(2017) Zejun Ma et al.   Frontiers in Pharmacology

Extracellular matrix remodeling in idiopathic pulmonary fibrosis. It is the ‘bed’ that counts and not ‘the sleepers’

(2017) Ioannis P. Tomos et al.   Expert Review of Respiratory Medicine

Agonistic Anti-PDGF Receptor Autoantibodies from Patients with Systemic Sclerosis Impact Human Pulmonary Artery Smooth Muscle Cells Function In Vitro

(2017) Silvia Svegliati et al.   Frontiers in Immunology

Response to Letter Regarding Article, “MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis”

(2016) Varun Nagpal et al.   CIRCULATION

Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis

(2016) Heba Dosoki et al.   EXPERIMENTAL DERMATOLOGY

Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells

(2016) Andrea Aguado et al.   JOURNAL OF HYPERTENSION

Tamibarotene Ameliorates Bleomycin-Induced Dermal Fibrosis by Modulating Phenotypes of Fibroblasts, Endothelial Cells, and Immune Cells

(2016) Tetsuo Toyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality?

(2016) Sergio A. Jimenez et al.   MATRIX BIOLOGY

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

(2016) Kaname Akamata et al.   Oncotarget

Raynaud’s Phenomenon: A Brief Review of the Underlying Mechanisms

(2016) Manal M. Fardoun et al.   Frontiers in Pharmacology

Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases

(2016) Sonsoles Piera-Velazquez et al.   Journal of Clinical Medicine

Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1

(2016) Peter J. Wermuth et al.   PLoS One

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2015) Robert B. Good et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

Kallistatin inhibits TGF-β-induced endothelial–mesenchymal transition by differential regulation of microRNA-21 and eNOS expression

(2015) Youming Guo et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β

(2015) Akihiro Katsura et al.   GENES TO CELLS

Critical roles of microRNAs in the pathogenesis of systemic sclerosis: New advances, challenges and potential directions

(2015) Cheng-gui Miao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-  and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist

(2015) P. Cipriani et al.   JOURNAL OF RHEUMATOLOGY

Diverse origins of the myofibroblast—implications for kidney fibrosis

(2015) Lucas L. Falke et al.   Nature Reviews Nephrology

Cellular and molecular mechanisms in the pathophysiology of systemic sclerosis

(2015) T. Hua-Huy et al.   PATHOLOGIE BIOLOGIE

Partially Evoked Epithelial-Mesenchymal Transition (EMT) Is Associated with Increased TGFβ Signaling within Lesional Scleroderma Skin

(2015) Joanna Nikitorowicz-Buniak et al.   PLoS One

Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease

(2015) Fabian A. Mendoza et al.   Arthritis & Rheumatology

Fibrosis, Vascular Activation, and Immune Abnormalities Resembling Systemic Sclerosis in Bleomycin-Treated Fli-1-Haploinsufficient Mice

(2015) Takashi Taniguchi et al.   Arthritis & Rheumatology

A Reactive Oxygen Species-Mediated Loop Maintains Increased Expression of NADPH Oxidases 2 and 4 in Skin Fibroblasts From Patients With Systemic Sclerosis

(2015) Tatiana Spadoni et al.   Arthritis & Rheumatology

Pathogenesis of Systemic Sclerosis

(2015) Debendra Pattanaik et al.   Frontiers in Immunology

Role of Flow-Sensitive microRNAs in Endothelial Dysfunction and Atherosclerosis

(2014) Sandeep Kumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen

(2014) Keizo Kanasaki et al.   DIABETES

Reversal of myofibroblast differentiation: A review

(2014) XiaoHong Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Endotoxin-Induced Endothelial Fibrosis Is Dependent on Expression of Transforming Growth Factors β1 and β2

(2014) César Echeverría et al.   INFECTION AND IMMUNITY

Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway

(2014) Ignacio Montorfano et al.   LABORATORY INVESTIGATION

Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis

(2014) Bogna Grygiel-Górniak et al.   MEDIATORS OF INFLAMMATION

Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension

(2014) Francesco Boin et al.   Orphanet Journal of Rare Diseases

Pathophysiology of systemic sclerosis: State of the art in 2014

(2014) Nicolas Dumoitier et al.   PRESSE MEDICALE

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

N-acetyl-seryl-aspartyl-lysyl-proline Inhibits Diabetes-Associated Kidney Fibrosis and Endothelial-Mesenchymal Transition

(2014) Takako Nagai et al.   Biomed Research International

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

(2014) Fan Jiang et al.   Redox Biology

Reversal of Myofibroblast Differentiation by Prostaglandin E2

(2013) Garth Garrison et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An Inhibitor of NADPH Oxidase-4 Attenuates Established Pulmonary Fibrosis in a Rodent Disease Model

(2013) Elizabeth R Jarman et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Myofibroblast Differentiation: Main Features, Biomedical Relevance, and the Role of Reactive Oxygen Species

(2013) Alessandro Siani et al.   ANTIOXIDANTS & REDOX SIGNALING

Review: Evidence That Systemic Sclerosis Is a Vascular Disease

(2013) Marco Matucci-Cerinic et al.   ARTHRITIS AND RHEUMATISM

Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease

(2013) Jianhua He et al.   Clinical and Experimental Nephrology

Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition

(2013) David Balli et al.   EMBO JOURNAL

Apoptosis and angiogenesis: an evolving mechanism for fibrosis

(2013) Ariel Johnson et al.   FASEB JOURNAL

Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells

(2013) César Echeverría et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Interferon-γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2

(2013) Izabela Chrobak et al.   JOURNAL OF CELLULAR PHYSIOLOGY

microRNA 126 Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells via the PIK3R2-PI3K/Akt Signalling Pathway

(2013) Junfeng Zhang et al.   PLoS One

Simvastatin attenuates the development of pulmonary and cutaneous fibrosis in a murine model of systemic sclerosis

(2013) G. Bagnato et al.   RHEUMATOLOGY

Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis

(2013) Patricia Almudéver et al.   THORAX

Epithelial–mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells

(2013) Song-Ze Ding et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Simvastatin inhibits transforming growth factor-β1-induced expression of type I collagen, CTGF, and α-SMA in keloid fibroblasts

(2013) Je-Ho Mun et al.   WOUND REPAIR AND REGENERATION

Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis

(2013) Gianluca Bagnato et al.   ARTHRITIS RESEARCH & THERAPY

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

(2012) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): Differential expression of microRNAs during EndMT

(2012) Asish K. Ghosh et al.   CELLULAR SIGNALLING

Epithelial-to-Mesenchymal and Endothelial-to-Mesenchymal Transition

(2012) Jason C. Kovacic et al.   CIRCULATION

Reactive oxygen species stimulates epithelial mesenchymal transition in normal human epidermal keratinocytes via TGF-beta secretion

(2012) Teruhisa Fukawa et al.   EXPERIMENTAL CELL RESEARCH

NADPH oxidase 4 is required for interleukin-1β-mediated activation of protein kinase Cδ and downstream activation of c-jun N-terminal kinase signaling in smooth muscle

(2012) Roman Ginnan et al.   FREE RADICAL BIOLOGY AND MEDICINE

IL-1β and TGFβ2 synergistically induce endothelial to mesenchymal transition in an NFκB-dependent manner

(2012) Monika Maleszewska et al.   IMMUNOBIOLOGY

The role of endothelial-mesenchymal transition in development and pathological process

(2012) Feng Lin et al.   IUBMB LIFE

Mitochondrial Reactive Oxygen Species Regulate Transforming Growth Factor-β Signaling

(2012) Manu Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin II induces skin fibrosis: a novel mouse model of dermal fibrosis

(2012) Lukasz Stawski et al.   ARTHRITIS RESEARCH & THERAPY

FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression

(2012) Pei-Yu Chen et al.   Cell Reports

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Peripheral blood mononuclear cells from patients with systemic sclerosis spontaneously secrete increased amounts of vascular endothelial growth factor (VEGF) already in the early stage of the disease

(2011) M Bielecki et al.   Advances in Medical Sciences

Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders

(2011) Sonsoles Piera-Velazquez et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation-Induced Endothelial-to-Mesenchymal Transition

(2011) Florian Rieder et al.   AMERICAN JOURNAL OF PATHOLOGY

Cardiac pressure overload hypertrophy is differentially regulated by β-adrenergic receptor subtypes

(2011) Mingming Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

(2011) Harold A. Chapman   Annual Review of Physiology

Transforming Growth Factor-β–Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21

(2011) Regalla Kumarswamy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro

(2011) Zhaodong Li et al.   ARTHRITIS AND RHEUMATISM

Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling

(2011) Damian Medici et al.   BIOCHEMICAL JOURNAL

Regulation of endothelial cell plasticity by TGF-β

(2011) Laurens A. van Meeteren et al.   CELL AND TISSUE RESEARCH

New insights on chemically induced animal models of systemic sclerosis

(2011) Frédéric Batteux et al.   CURRENT OPINION IN RHEUMATOLOGY

Myofibroblast differentiation and survival in fibrotic disease

(2011) Kornelia Kis et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A

(2011) Hajime Mihira et al.   JOURNAL OF BIOCHEMISTRY

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

(2011) Swati Bhattacharyya et al.   Nature Reviews Rheumatology

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis

(2010) Hao Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model

(2010) Niloufar Kavian et al.   ARTHRITIS AND RHEUMATISM

Transcriptional regulation of NADPH oxidase isoforms, Nox1 and Nox4, by nuclear factor-κB in human aortic smooth muscle cells

(2010) Adrian Manea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression of SNAI1 and TWIST1 in the eccrine glands of patients with systemic sclerosis: possible involvement of epithelial-mesenchymal transition in the pathogenesis

(2010) M. Nakamura et al.   BRITISH JOURNAL OF DERMATOLOGY

miR-200a Prevents Renal Fibrogenesis Through Repression of TGF- 2 Expression

(2010) B. Wang et al.   DIABETES

Cellular and molecular aspects of vascular dysfunction in systemic sclerosis

(2010) Maria Trojanowska   Nature Reviews Rheumatology

Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate

(2010) A. Dooley et al.   RHEUMATOLOGY

Endothelial–Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis

(2009) Naozumi Hashimoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

JAK/STAT Signaling Pathway Regulates Nox1 and Nox4-Based NADPH Oxidase in Human Aortic Smooth Muscle Cells

(2009) Adrian Manea et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

α-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: Melanocortin peptides as a novel treatment strategy for scleroderma?

(2009) Agatha Kokot et al.   ARTHRITIS AND RHEUMATISM

Oxidative stress and glutathione in TGF-β-mediated fibrogenesis

(2009) R.-M. Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selective Oxidation of DNA Topoisomerase 1 Induces Systemic Sclerosis in the Mouse

(2009) A. Servettaz et al.   JOURNAL OF IMMUNOLOGY

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle α2C-adrenoceptors

(2008) A. H. Eid et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis

(2008) Francesco Del Galdo et al.   ARTHRITIS AND RHEUMATISM

TNF-α upregulates the A 2B adenosine receptor gene: The role of NAD(P)H oxidase 4

(2008) Cynthia St. Hilaire et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

Caveolin-1, transforming growth factor-β receptor internalization, and the pathogenesis of systemic sclerosis

(2008) Francesco Del Galdo et al.   CURRENT OPINION IN RHEUMATOLOGY

Oxidative stress and the pathogenesis of scleroderma: the Murrell’s hypothesis revisited

(2008) Armando Gabrielli et al.   Seminars in Immunopathology