Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin

Induction of apoptosis by quercetin is mediated through AMPKα1/ASK1/p38 pathway

(2010) Yun-Kyoung Lee et al.   CANCER LETTERS

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quercetin enhances TRAIL-induced apoptosis in prostate cancer cells via increased protein stability of death receptor 5

(2010) Young-Hwa Jung et al.   LIFE SCIENCES

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

(2010) Laura Bravo   NUTRITION REVIEWS

Thioredoxins and Glutaredoxins: Unifying Elements in Redox Biology

(2009) Yves Meyer et al.   Annual Review of Genetics

Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1and Survivin Expression through Wnt/β-Catenin Signaling Pathway

(2009) Bao-En Shan et al.   CANCER INVESTIGATION

NADPH Oxidase 4 Contributes to Transformation Phenotype of Melanoma Cells by Regulating G2-M Cell Cycle Progression

(2009) M. Yamaura et al.   CANCER RESEARCH

Metabolic transformation in cancer

(2009) D. A. Tennant et al.   CARCINOGENESIS

The roles of ASK family proteins in stress responses and diseases

(2009) Kazuki Hattori et al.   Cell Communication and Signaling

Regulation of Survivin and Bcl-2 in HepG2 Cell Apoptosis Induced by Quercetin

(2009) Jun Tan et al.   CHEMISTRY & BIODIVERSITY

FoxM1, a critical regulator of oxidative stress during oncogenesis

(2009) Hyun Jung Park et al.   EMBO JOURNAL

AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin

(2009) Yun-Kyoung Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

BRCA1 down-regulates cellular levels of reactive oxygen species

(2009) Tapas Saha et al.   FEBS LETTERS

Lipid peroxidation: Physiological levels and dual biological effects

(2009) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells

(2009) Su-Yu Chien et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Reactive Oxygen Generated by NADPH Oxidase 1 (Nox1) Contributes to Cell Invasion by Regulating Matrix Metalloprotease-9 Production and Cell Migration

(2009) Masahiro Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant/antioxidant activity: molecular and histological evidences

(2009) AlaaEddeen M Seufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Simultaneous analysis of reactive oxygen species and reduced glutathione content in living cells by polychromatic flow cytometry

(2009) Andrea Cossarizza et al.   Nature Protocols

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2

(2008) Marcelo G. Binker et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines

(2008) Adrián M. Ramos et al.   BIOCHEMICAL PHARMACOLOGY

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

(2008) Atsushi Matsuzawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

(2008) D. Trachootham et al.   BLOOD

The xc− cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance

(2008) M Lo et al.   BRITISH JOURNAL OF CANCER

The x c − cystine/glutamate antiporter as a potential therapeutic target for small-cell lung cancer: use of sulfasalazine

(2008) Jun Guan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells

(2008) Yee-Man Lee et al.   CANCER LETTERS

Altered Detoxification Status and Increased Resistance to Oxidative Stress by K-Ras Transformation

(2008) C. V. Recktenwald et al.   CANCER RESEARCH

Tumor Protein 53-Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function

(2008) C. E. Cano et al.   CANCER RESEARCH

Expression of β-F1-ATPase and mitochondrial transcription factor A and the change in mitochondrial DNA content in colorectal cancer: clinical data analysis and evidence from an in vitro study

(2008) Pei-Ching Lin et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPSdown-regulation

(2008) Jin Yeop Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression

(2008) Jae-Hoon Jeong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The xc− cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases

(2008) Maisie Lo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells

(2008) Young-Hee Kang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism

(2008) H Zhang et al.   LEUKEMIA

Quercetin inhibits lymphocyte activation and proliferation without inducing apoptosis in peripheral mononuclear cells

(2008) Enrico Lugli et al.   LEUKEMIA RESEARCH

Quercetin promotes degradation of survivin and thereby enhances death-receptor–mediated apoptosis in glioma cells

(2008) Markus D. Siegelin et al.   NEURO-ONCOLOGY

The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90

(2008) Ravikumar Aalinkeel et al.   PROSTATE

2-Methoxyestradiol Mediates Apoptosis Through Caspase-Dependent and Independent Mechanisms in Ovarian Cancer Cells But Not in Normal Counterparts

(2008) Sumie Kato et al.   Reproductive Sciences

Chloroquine-induced nitric oxide increase and cell death is dependent on cellular GSH depletion in A172 human glioblastoma cells

(2008) Byung Chul Park et al.   TOXICOLOGY LETTERS