Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells

(2017) Roberta Gonnella et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

(2017) Marisa Granato et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells

(2017) Maria Saveria Gilardini Montani et al.   CELLULAR ONCOLOGY

In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma

(2017) Laura Masuelli et al.   Frontiers in Pharmacology

Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

(2016) Sonja M. Wörmann et al.   GASTROENTEROLOGY

Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt’s lymphoma

(2016) Marisa Granato et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Reactivation of mutant p53 by capsaicin, the major constituent of peppers

(2016) Alessia Garufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

(2016) Lorenzo Galluzzi et al.   Nature Reviews Clinical Oncology

Autophagy Beyond Intracellular MHC Class II Antigen Presentation

(2016) Christian Münz   TRENDS IN IMMUNOLOGY

Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma

(2016) Hui-Hui Cao et al.   Scientific Reports

Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells

(2015) Marisa Granato et al.   CANCER LETTERS

HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL

(2015) R. Carson et al.   CLINICAL CANCER RESEARCH

Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future

(2015) Marisa Granato et al.   Biomed Research International

Chemopreventive and Therapeutic Potential of “Naringenin,” a Flavanone Present in Citrus Fruits

(2014) Irfan Ahmad Mir et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells

(2014) Roberta Santarelli et al.   Scientific Reports

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

(2013) Xin Tong et al.   Anti-Cancer Agents in Medicinal Chemistry

Autophagy-dependent ATP release from dying cells via lysosomal exocytosis

(2013) Yidan Wang et al.   Autophagy

Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells

(2013) Ding-Guo Wu et al.   TOXICOLOGY LETTERS

The critical role of catalase in prooxidant and antioxidant function of p53

(2012) M Y Kang et al.   CELL DEATH AND DIFFERENTIATION

The effects of dietary flavonoids on the regulation of redox inflammatory networks

(2012) Valerio Izzi   Frontiers in Bioscience-Landmark

Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells

(2012) Hye-Sook Seo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Primary Effusion Lymphoma Cell Death Induced by Bortezomib and AG 490 Activates Dendritic Cells through CD91

(2012) Mara Cirone et al.   PLoS One

Activation of dendritic cells by tumor cell death

(2012) Mara Cirone et al.   OncoImmunology

Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

(2011) Ahmad R. Safa et al.   Cancers

Apigenin induces apoptosisviadownregulation of S-phase kinase-associated protein 2-mediated induction of p27Kip1 in primary effusion lymphoma cells

(2010) A. R. Hussain et al.   CELL PROLIFERATION

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Apigenin induces apoptosis and impairs head and neck carcinomas EGFR/ErbB2 signaling

(2010) Laura Masuelli   Frontiers in Bioscience-Landmark

FLIP-mediated autophagy regulation in cell death control

(2009) Jong-Soo Lee et al.   NATURE CELL BIOLOGY

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell

(2008) J. C. O'Connor et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE