Liquid-liquid phase separation as a common organizing principle of intracellular space and biomembranes providing dynamic adaptive responses

Self-Organization of Cellular Units

(2021) Timothy J. Mitchison et al.   Annual Review of Cell and Developmental Biology

Phase separation of Epstein-Barr Virus EBNA2 and Its Coactivator EBNALP controls gene expression

(2020) Qiu Peng et al.   JOURNAL OF VIROLOGY

Phase separation organizes the site of autophagosome formation

(2020) Yuko Fujioka et al.   NATURE

Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation

(2020) Matthew R. King et al.   Nature Communications

DNA repair by Rad52 liquid droplets

(2020) Roxanne Oshidari et al.   Nature Communications

Annexin-V stabilizes membrane defects by inducing lipid phase transition

(2020) Yi-Chih Lin et al.   Nature Communications

Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains

(2020) Kiyoto Kamagata et al.   Scientific Reports

Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

(2020) Christiane Iserman et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

BR-Bodies Provide Selectively Permeable Condensates that Stimulate mRNA Decay and Prevent Release of Decay Intermediates

(2020) Nadra Al-Husini et al.   MOLECULAR CELL

Lipid rafts come of age

(2020) Ilya Levental   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia

(2020) Gregory G Fuller et al.   eLife

Nuclear microenvironment in cancer: Control through liquid‐liquid phase separation

(2020) Ryu‐Suke Nozawa et al.   CANCER SCIENCE

Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid–liquid phase separation

(2020) Anne-Marie Ladouceur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid Phase Separation Controlled by pH

(2020) Omar Adame-Arana et al.   BIOPHYSICAL JOURNAL

Filament formation by metabolic enzymes—A new twist on regulation

(2020) Eric M. Lynch et al.   CURRENT OPINION IN CELL BIOLOGY

Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics

(2020) Timo Rey et al.   NATURE CELL BIOLOGY

Tunable multiphase dynamics of arginine and lysine liquid condensates

(2020) Rachel S. Fisher et al.   Nature Communications

From start to end: Phase separation and transcriptional regulation

(2020) Liu Peng et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Complex Interactions Between Membrane-Bound Organelles, Biomolecular Condensates and the Cytoskeleton

(2020) Max Koppers et al.   Frontiers in Cell and Developmental Biology

More than just a phase: the search for membraneless organelles in the bacterial cytoplasm

(2019) Elio A. Abbondanzieri et al.   CURRENT GENETICS

Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows

(2019) Thorsten B. Blum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular sensing by phase separation: Using the process, not just the products

(2019) Haneul Yoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleosome Crowding in Chromatin Slows the Diffusion but Can Promote Target Search of Proteins

(2019) Ryo Kanada et al.   BIOPHYSICAL JOURNAL

On the existence of endocytosis driven by membrane phase separations

(2019) Donald W. Hilgemann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

(2019) Sinan Kilic et al.   EMBO JOURNAL

The synergic effect of water and biomolecules in intracellular phase separation

(2019) Sara S. Ribeiro et al.   Nature Reviews Chemistry

Lipid Raft Phase Modulation by Membrane-Anchored Proteins with Inherent Phase Separation Properties

(2019) Il-Hyung Lee et al.   ACS Omega

Liquid–Liquid Phase Separation in Disease

(2019) Simon Alberti et al.   Annual Review of Genetics

Two distinct nuclear stress bodies containing different sets of RNA-binding proteins are formed with HSATIII architectural noncoding RNAs upon thermal stress exposure

(2019) Mahmoud Khamis Aly et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

(2019) Fabio Pessina et al.   NATURE CELL BIOLOGY

Microtubules gate tau condensation to spatially regulate microtubule functions

(2019) Ruensern Tan et al.   NATURE CELL BIOLOGY

Shaping membranes with disordered proteins

(2019) Mohammad A.A. Fakhree et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Flipping the dogma – phosphatidylserine in non-apoptotic cell death

(2019) Inbar Shlomovitz et al.   Cell Communication and Signaling

The Significance of the Intrinsically Disordered Regions for the Functions of the bHLH Transcription Factors

(2019) Aneta Tarczewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation

(2019) Wilton T. Snead et al.   MOLECULAR CELL

High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

(2019) Kristian Parey et al.   Science Advances

In Aqua Veritas: The Indispensable yet Mostly Ignored Role of Water in Phase Separation and Membrane-less Organelles

(2018) Boris Y. Zaslavsky et al.   BIOCHEMISTRY

P-Bodies: Composition, Properties, and Functions

(2018) Yang Luo et al.   BIOCHEMISTRY

Non-bilayer structures in mitochondrial membranes regulate ATP synthase activity

(2018) Sardar E. Gasanov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Phase Separation of Mitochondrial DNA in the Premature Aging Disease Hutchinson-Gilford Progeria Syndrome

(2018) Marina Mahynski et al.   BIOPHYSICAL JOURNAL

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

(2018) Briana Van Treeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Entropic effect of macromolecular crowding enhances binding between nucleosome clutches in heterochromatin, but not in euchromatin

(2018) Inrok Oh et al.   Scientific Reports

α-Proteobacterial RNA Degradosomes Assemble Liquid-Liquid Phase-Separated RNP Bodies

(2018) Nadra Al-Husini et al.   MOLECULAR CELL

Liquid–liquid phase separation in artificial cells

(2018) Charles D. Crowe et al.   Interface Focus

Regulation of Phagocytosis in Macrophages by Membrane Ethanolamine Plasmalogens

(2018) Julio M. Rubio et al.   Frontiers in Immunology

From Active Sites to Machines: A Challenge for Enzyme Chemists

(2018) Chaitan Khosla   ISRAEL JOURNAL OF CHEMISTRY

The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure

(2017) Hakjoo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The glycolytic enzyme phosphofructokinase-1 assembles into filaments

(2017) Bradley A. Webb et al.   JOURNAL OF CELL BIOLOGY

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity

(2017) Manoël Prouteau et al.   NATURE

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear speckles: molecular organization, biological function and role in disease

(2017) Lukasz Galganski et al.   NUCLEIC ACIDS RESEARCH

Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body

(2017) Robert J. Duronio et al.   RNA Biology

Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1

(2017) Danilo Faccenda et al.   Cell Reports

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

(2017) Amayra Hernández-Vega et al.   Cell Reports

Chaos and beauty in a beaker: The early history of the Belousov-Zhabotinsky reaction

(2016) Konstantin S. Kiprijanov   ANNALEN DER PHYSIK

Membrane re-arrangements and rippled phase stabilisation by the cell penetrating peptide penetratin

(2016) Claudia Almeida et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

Imaging plasma membrane phase behaviour in live cells using a thiophene-based molecular rotor

(2016) Michael R. Dent et al.   CHEMICAL COMMUNICATIONS

Intracellular pH Modulates Autophagy and Mitophagy

(2016) Alexey V. Berezhnov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular recognition features (MoRFs) in three domains of life

(2016) Jing Yan et al.   Molecular BioSystems

Generalized crystallography and bound-water modular structures determining morphogenesis and size of biosystems

(2016) N. A. Bulienkov et al.   STRUCTURAL CHEMISTRY

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D

(2016) E. Nicholas Petersen et al.   Nature Communications

Membrane curvature modulation of protein activity determined by NMR

(2015) Richard M. Epand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cytoskeletal Pinning Controls Phase Separation in Multicomponent Lipid Membranes

(2015) Senthil Arumugam et al.   BIOPHYSICAL JOURNAL

PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening

(2015) S. Osterwald et al.   JOURNAL OF CELL SCIENCE

Membrane curvature at a glance

(2015) H. T. McMahon et al.   JOURNAL OF CELL SCIENCE

Live Cell Plasma Membranes Do Not Exhibit a Miscibility Phase Transition over a Wide Range of Temperatures

(2015) Il-Hyung Lee et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

(2015) Matthias Altmeyer et al.   Nature Communications

Rafting through traffic: Membrane domains in cellular logistics

(2014) Blanca Diaz-Rohrer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Electron Transfer from Plant Phenolates to Carotenoid Radical Cations. Antioxidant Interaction Entering the Marcus Theory Inverted Region

(2014) Hong Cheng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Spatial trigger waves: positive feedback gets you a long way

(2014) Lendert Gelens et al.   MOLECULAR BIOLOGY OF THE CELL

Centrosomes are autocatalytic droplets of pericentriolar material organized by centrioles

(2014) David Zwicker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular-crowding effects on single-molecule RNA folding/unfolding thermodynamics and kinetics

(2014) N. F. Dupuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advantages of proteins being disordered

(2014) Zhirong Liu et al.   PROTEIN SCIENCE

Modifying Lipid Rafts Promotes Regeneration and Functional Recovery

(2014) Nardos G. Tassew et al.   Cell Reports

Phase transitions of multivalent proteins can promote clustering of membrane receptors

(2014) Sudeep Banjade et al.   eLife

Interaction of membrane/lipid rafts with the cytoskeleton: Impact on signaling and function

(2013) Brian P. Head et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Organization and function of membrane contact sites

(2013) Sebastian C.J. Helle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

Intrinsic Structural Disorder in Cytoskeletal Proteins

(2013) Mainak Guharoy et al.   Cytoskeleton

Stochastic machines as a colocalization mechanism for scaffold protein function

(2013) Bin Xue et al.   FEBS LETTERS

Large effect of membrane tension on the fluid-solid phase transitions of two-component phosphatidylcholine vesicles

(2013) D. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytochrome c causes pore formation in cardiolipin-containing membranes

(2013) C. L. Bergstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monolayer curvature stabilizes nanoscale raft domains in mixed lipid bilayers

(2013) S. Meinhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Structure and Interconnections with Other Organelles

(2013) A. R. English et al.   Cold Spring Harbor Perspectives in Biology

Cardiolipin binding in bacterial respiratory complexes: Structural and functional implications

(2012) Rodrigo Arias-Cartin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress

(2012) Saori Morino-Koga et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human mitochondrial RNA decay mediated by PNPase–hSuv3 complex takes place in distinct foci

(2012) Lukasz S. Borowski et al.   NUCLEIC ACIDS RESEARCH

PML body meets telomere

(2012) Inn Chung et al.   Nucleus

Lipid raft involvement in yeast cell growth and death

(2012) Faustino Mollinedo   Frontiers in Oncology

Membrane Restructuring by Phospholipase A2 Is Regulated by the Presence of Lipid Domains

(2011) Chad Leidy et al.   BIOPHYSICAL JOURNAL

U bodies respond to nutrient stress in Drosophila

(2011) Mickey Buckingham et al.   EXPERIMENTAL CELL RESEARCH

Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

(2011) Mee-Sup Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains

(2011) X. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis and function of nuclear bodies

(2011) Yuntao S. Mao et al.   TRENDS IN GENETICS

The effect of membrane domains on the G protein–phospholipase Cβ signaling pathway

(2010) Urszula Golebiewska et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Caveolae at a glance

(2010) M. Bastiani et al.   JOURNAL OF CELL SCIENCE

Low-frequency spectroscopy of four-photon scattering of laser radiation in aqueous solutions of biopolymers

(2010) A. F. Bunkin et al.   OPTICS AND SPECTROSCOPY

The Perinucleolar Compartment

(2010) C. Pollock et al.   Cold Spring Harbor Perspectives in Biology

Nuclear Stress Bodies

(2010) G. Biamonti et al.   Cold Spring Harbor Perspectives in Biology

The Cajal Body and Histone Locus Body

(2010) Z. Nizami et al.   Cold Spring Harbor Perspectives in Biology

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

Effect of Macromolecular Crowding on Reaction Rates: A Computational and Theoretical Study

(2009) Jun Soo Kim et al.   BIOPHYSICAL JOURNAL

Paraspeckles: nuclear bodies built on long noncoding RNA

(2009) Charles S. Bond et al.   JOURNAL OF CELL BIOLOGY

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

The inhomogeneous structure of water at ambient conditions

(2009) C. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Guiding Protein Aggregation with Macromolecular Crowding†

(2008) Larissa A. Munishkina et al.   BIOCHEMISTRY

Lipid lateral diffusion and membrane heterogeneity

(2008) Göran Lindblom et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Compartmentalization of Phosphatidylinositol 4,5-Bisphosphate Signaling Evidenced Using Targeted Phosphatases

(2008) Corey M. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress induces the assembly of RNA granules in the chloroplast ofChlamydomonas reinhardtii

(2008) James Uniacke et al.   JOURNAL OF CELL BIOLOGY

A Role for DEAD Box 1 at DNA Double-Strand Breaks

(2008) L. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Ultrastructural characterization of spermatogenesis and its evolutionary conservation in the germline: Germinal granules in mammals☆

(2008) Shinichiro Chuma et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Spatiotemporal Analysis of Differential Akt Regulation in Plasma Membrane Microdomains

(2008) Xinxin Gao et al.   MOLECULAR BIOLOGY OF THE CELL