Advantages of proteins being disordered

Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes

(2013) Alexander Cumberworth et al.   BIOCHEMICAL JOURNAL

Inherent Relationships among Different Biophysical Prediction Methods for Intrinsically Disordered Proteins

(2013) Fan Jin et al.   BIOPHYSICAL JOURNAL

Analysis and consensus of currently available intrinsic protein disorder annotation sources in the MobiDB database

(2013) Tomás Di Domenico et al.   BMC BIOINFORMATICS

Do Intrinsically Disordered Proteins Possess High Specificity in Protein-Protein Interactions?

(2013) Yongqi Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Regulated unfolding of proteins in signaling

(2013) Diana M. Mitrea et al.   FEBS LETTERS

Rapid Evolutionary Dynamics of Structural Disorder as a Potential Driving Force for Biological Divergence in Flaviviruses

(2013) Juan F. Ortiz et al.   Genome Biology and Evolution

Polyproline-II Helix in Proteins: Structure and Function

(2013) Alexei A. Adzhubei et al.   JOURNAL OF MOLECULAR BIOLOGY

Energetic Basis of Uncoupling Folding from Binding for an Intrinsically Disordered Protein

(2013) Igor Drobnak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A comprehensive analysis of the influence of drug binding kinetics on drug action at molecular and systems levels

(2013) Ning Yin et al.   Molecular BioSystems

The C-terminal linker ofEscherichia coli FtsZ functions as an intrinsically disordered peptide

(2013) Kiani A. J. Arkus Gardner et al.   MOLECULAR MICROBIOLOGY

Marked Variability in the Extent of Protein Disorder within and between Viral Families

(2013) Ravindra Pushker et al.   PLoS One

A decade and a half of protein intrinsic disorder: Biology still waits for physics

(2013) Vladimir N. Uversky   PROTEIN SCIENCE

Design Principles of the Yeast G1/S Switch

(2013) Xiaojing Yang et al.   PLOS BIOLOGY

Exploring Protein-Peptide Binding Specificity through Computational Peptide Screening

(2013) Arnab Bhattacherjee et al.   PLoS Computational Biology

On the Importance of Polar Interactions for Complexes Containing Intrinsically Disordered Proteins

(2013) Eric T. C. Wong et al.   PLoS Computational Biology

Electrostatically Accelerated Encounter and Folding for Facile Recognition of Intrinsically Disordered Proteins

(2013) Debabani Ganguly et al.   PLoS Computational Biology

Phosphorylation Variation during the Cell Cycle Scales with Structural Propensities of Proteins

(2013) Stefka Tyanova et al.   PLoS Computational Biology

Ligand Clouds around Protein Clouds: A Scenario of Ligand Binding with Intrinsically Disordered Proteins

(2013) Fan Jin et al.   PLoS Computational Biology

Mechanism of Cell Cycle Entry Mediated by the Intrinsically Disordered Protein p27Kip1

(2012) Li Ou et al.   ACS Chemical Biology

Towards structure-based protein drug design

(2012) Changsheng Zhang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Sweeping Away Protein Aggregation with Entropic Bristles: Intrinsically Disordered Protein Fusions Enhance Soluble Expression

(2012) Aaron A. Santner et al.   BIOCHEMISTRY

Unusual biophysics of intrinsically disordered proteins

(2012) Vladimir N. Uversky   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

On the functional and structural characterization of hubs in protein–protein interaction networks

(2012) Paola Bertolazzi et al.   BIOTECHNOLOGY ADVANCES

Intrinsically disordered proteins and conformational noise

(2012) Gita Mahmoudabadi et al.   CELL CYCLE

Intrinsically disordered proteins in human mitochondria

(2012) Masahiro Ito et al.   GENES TO CELLS

Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life

(2012) Bin Xue et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Electrostatically Accelerated Coupled Binding and Folding of Intrinsically Disordered Proteins

(2012) Debabani Ganguly et al.   JOURNAL OF MOLECULAR BIOLOGY

Kinetic Basis for the Competitive Recruitment of TolB by the Intrinsically Disordered Translocation Domain of Colicin E9

(2012) Grigorios Papadakos et al.   JOURNAL OF MOLECULAR BIOLOGY

Long-Range Interactions in Nonsense-Mediated mRNA Decay Are Mediated by Intrinsically Disordered Protein Regions

(2012) Lajos Kalmar et al.   JOURNAL OF MOLECULAR BIOLOGY

An Intrinsically Disordered Domain Has a Dual Function Coupled to Compartment-Dependent Redox Control

(2012) Lucia Banci et al.   JOURNAL OF MOLECULAR BIOLOGY

D2P2: database of disordered protein predictions

(2012) Matt E. Oates et al.   NUCLEIC ACIDS RESEARCH

Rate constants and mechanisms of intrinsically disordered proteins binding to structured targets

(2012) Huan-Xiang Zhou et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Prediction of protein-protein binding free energies

(2012) Thom Vreven et al.   PROTEIN SCIENCE

Phosphoproteomic analysis reveals major default phosphorylation sites outside long intrinsically disordered regions of Arabidopsis plasma membrane proteins

(2012) Claude Nespoulous et al.   Proteome Science

Conditional disorder in chaperone action

(2012) James C.A. Bardwell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Intrinsically disordered proteins: a 10-year recap

(2012) Peter Tompa   TRENDS IN BIOCHEMICAL SCIENCES

Binding of Two Intrinsically Disordered Peptides to a Multi-Specific Protein: A Combined Monte Carlo and Molecular Dynamics Study

(2012) Iskra Staneva et al.   PLoS Computational Biology

A Preformed Binding Interface in the Unbound Ensemble of an Intrinsically Disordered Protein: Evidence from Molecular Simulations

(2012) Michael Knott et al.   PLoS Computational Biology

Cooperativity, Local-Nonlocal Coupling, and Nonnative Interactions: Principles of Protein Folding from Coarse-Grained Models

(2011) Hue Sun Chan et al.   Annual Review of Physical Chemistry

Constructing ensembles for intrinsically disordered proteins

(2011) Charles K Fisher et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intrinsically disordered proteins: regulation and disease

(2011) M Madan Babu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intrinsically disordered proteins from A to Z

(2011) Vladimir N. Uversky   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Anchoring Intrinsically Disordered Proteins to Multiple Targets: Lessons from N-Terminus of the p53 Protein

(2011) Yongqi Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thermo-resistant intrinsically disordered proteins are efficient 20S proteasome substrates

(2011) Peter Tsvetkov et al.   Molecular BioSystems

Meta-structure correlation in protein space unveils different selection rules for folded and intrinsically disordered proteins

(2011) Yandi Naranjo et al.   Molecular BioSystems

Fuzziness: linking regulation to protein dynamics

(2011) Monika Fuxreiter   Molecular BioSystems

A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance

(2011) Meng Zhang et al.   Nature Chemical Biology

Context-dependent resistance to proteolysis of intrinsically disordered proteins

(2011) Marcin J. Suskiewicz et al.   PROTEIN SCIENCE

Ensemble modeling of protein disordered states: Experimental restraint contributions and validation

(2011) Joseph A. Marsh et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Evaluation of disorder predictions in CASP9

(2011) Bohdan Monastyrskyy et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Expanding the proteome: disordered and alternatively folded proteins

(2011) H. Jane Dyson   QUARTERLY REVIEWS OF BIOPHYSICS

Intrinsic disorder: signaling via highly specific but short-lived association

(2011) Huan-Xiang Zhou   TRENDS IN BIOCHEMICAL SCIENCES

Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database

(2011) George A. Khoury et al.   Scientific Reports

Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes

(2010) Vladimir N. Uversky   CHEMICAL SOCIETY REVIEWS

Intrinsically disordered proteins are potential drug targets

(2010) Steven J Metallo   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein binding specificity versus promiscuity

(2010) Gideon Schreiber et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Nonnative Interactions in Coupled Folding and Binding Processes of Intrinsically Disordered Proteins

(2010) Yongqi Huang et al.   PLoS One

Catalytic and chaperone-like functions in an intrinsically disordered protein associated with desiccation tolerance

(2010) S. Chakrabortee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoothing molecular interactions: The “kinetic buffer” effect of intrinsically disordered proteins

(2010) Yongqi Huang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Protein disorder in the human diseasome: unfoldomics of human genetic diseases

(2009) Uros Midic et al.   BMC GENOMICS

Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

(2009) Tanya Vavouri et al.   CELL

Fundamental Aspects of Protein−Protein Association Kinetics

(2009) G. Schreiber et al.   CHEMICAL REVIEWS

Cold stability of intrinsically disordered proteins

(2009) Agnes Tantos et al.   FEBS LETTERS

Kinetic Advantage of Intrinsically Disordered Proteins in Coupled Folding–Binding Process: A Critical Assessment of the “Fly-Casting” Mechanism

(2009) Yongqi Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Compositional Determinants of Prion Formation in Yeast

(2009) J. A. Toombs et al.   MOLECULAR AND CELLULAR BIOLOGY

Rejuvenation of CcdB-Poisoned Gyrase by an Intrinsically Disordered Protein Domain

(2009) Natalie De Jonge et al.   MOLECULAR CELL

The nanny model for IDPs

(2009) Peter Tsvetkov et al.   Nature Chemical Biology

Toward a quantitative theory of intrinsically disordered proteins and their function

(2009) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsically Disordered Proteins and Their Environment: Effects of Strong Denaturants, Temperature, pH, Counter Ions, Membranes, Binding Partners, Osmolytes, and Macromolecular Crowding

(2009) Vladimir N. Uversky   PROTEIN JOURNAL

Identification, analysis, and prediction of protein ubiquitination sites

(2009) Predrag Radivojac et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data

(2009) Yvonne JK Edwards et al.   GENOME BIOLOGY

The Intrinsically Disordered Cytoplasmic Domain of the T Cell Receptor ζ Chain Binds to the Nef Protein of Simian Immunodeficiency Virus without a Disorder-to-Order Transition†

(2008) Alexander B. Sigalov et al.   BIOCHEMISTRY

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

LEA (Late Embryogenesis Abundant) proteins and their encoding genes in Arabidopsis thaliana

(2008) Michaela Hundertmark et al.   BMC GENOMICS

Calcium-induced tripartite binding of intrinsically disordered calpastatin to its cognate enzyme, calpain

(2008) Róbert Kiss et al.   FEBS LETTERS

Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor

(2008) T. Mittag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

(2008) J. Gsponer et al.   SCIENCE

Disordered Flanks Prevent Peptide Aggregation

(2008) Sanne Abeln et al.   PLoS Computational Biology

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES