Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

(2020) Matthias Arnold et al.   Nature Communications

Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease

(2020) Noam D. Beckmann et al.   Nature Communications

Circulating Metabolites as Potential Biomarkers for Neurological Disorders—Metabolites in Neurological Disorders

(2020) Amanda Donatti et al.   Metabolites

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

(2020) Minghui Wang et al.   NEURON

Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk

(2019) Amanda McQuade et al.   JOURNAL OF MOLECULAR BIOLOGY

Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons

(2019) Pierre Theurey et al.   AGING CELL

Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming

(2019) James Spyrou et al.   Stem Cells International

Three plasma metabolites in elderly patients differentiate mild cognitive impairment and Alzheimer’s disease: a pilot study

(2019) Alana C. Costa et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Modeling Alzheimer’s disease with iPSC-derived brain cells

(2019) Jay Penney et al.   MOLECULAR PSYCHIATRY

Systematic identification of metabolites controlling gene expression in E. coli

(2019) Martin Lempp et al.   Nature Communications

Bile acids targeted metabolomics and medication classification data in the ADNI1 and ADNIGO/2 cohorts

(2019) Lisa St. John-Williams et al.   Scientific Data

Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes

(2019) Ahmed T. Ahmed et al.   JOURNAL OF AFFECTIVE DISORDERS

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

(2018) Kelly Street et al.   BMC GENOMICS

Religious Orders Study and Rush Memory and Aging Project

(2018) David A. Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

(2018) Yang Wu et al.   Nature Communications

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

(2018) Ting Qi et al.   Nature Communications

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations

(2018) Roddy S. O’Connor et al.   Scientific Reports

Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C

(2018) Zhaoyu Lin et al.   Stem Cell Research & Therapy

Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites

(2018) Shiho Fujisaka et al.   Cell Reports

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

(2018) Vijay R. Varma et al.   PLOS MEDICINE

Response of Gut Microbiota to Metabolite Changes Induced by Endurance Exercise

(2018) Xia Zhao et al.   Frontiers in Microbiology

Application of Metabolomics in Alzheimer’s Disease

(2018) Jordan Maximillian Wilkins et al.   Frontiers in Neurology

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

(2018) Minghui Wang et al.   Scientific Data

A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research

(2018) Philip L. De Jager et al.   Scientific Data

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

(2018) Dallas P. Veitch et al.   Alzheimers & Dementia

Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden

(2018) Jean-Vianney Haure-Mirande et al.   MOLECULAR PSYCHIATRY

The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia

(2018) Shinya Tasaki et al.   Frontiers in Neuroscience

Generation and quality control of lipidomics data for the alzheimer’s disease neuroimaging initiative cohort

(2018) Dinesh Kumar Barupal et al.   Scientific Data

Polygenic hazard score, amyloid deposition and Alzheimer’s neurodegeneration

(2018) Chin Hong Tan et al.   BRAIN

Adiponectin and sporadic Alzheimer’s disease: Clinical and molecular links

(2017) Liliana Letra et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Causal Genetic Variation Underlying Metabolome Differences

(2017) Devjanee Swain-Lenz et al.   GENETICS

Plasma metabolite profiles, cellular cholesterol efflux, and non-traditional cardiovascular risk in patients with CKD

(2017) Anjali Ganda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

(2017) Kuan-lin Huang et al.   NATURE NEUROSCIENCE

Using induced pluripotent stem cells derived neurons to model brain diseases

(2017) CindyE McKinney   Neural Regeneration Research

Metabolomic biomarkers as strong correlates of Parkinson disease progression

(2017) Peter A. LeWitt et al.   NEUROLOGY

Blocking of carnitine palmitoyl transferase 1 potently reduces stress-induced depression in rat highlighting a pivotal role of lipid metabolism

(2017) Anne Skøttrup Mørkholt et al.   Scientific Reports

Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study

(2017) Stuart G. Snowden et al.   PLOS MEDICINE

Causal Genetic Variation Underlying Metabolome Differences

(2017) Devjanee Swain-Lenz et al.   GENETICS

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

(2017) Lisa St John-Williams et al.   Scientific Data

Increased ATP-Binding Cassette Transporter A1 Expression in Alzheimer's Disease Hippocampal Neurons

(2017) Woojin Scott Kim et al.   JOURNAL OF ALZHEIMERS DISEASE

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Local and global regulation of transcription initiation in bacteria

(2016) Douglas F. Browning et al.   NATURE REVIEWS MICROBIOLOGY

Metabolic Biomarkers and Neurodegeneration: A Pathway Enrichment Analysis of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis

(2016) Medi Kori et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

(2016) Minghui Wang et al.   Genome Medicine

Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

(2016) Mariet Allen et al.   Scientific Data

Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia

(2016) Adriana Cristofano et al.   PLoS One

Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

(2015) Andrew J. Saykin et al.   Alzheimers & Dementia

Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease

(2015) Liv Tybjærg Nordestgaard et al.   Alzheimers & Dementia

A Heme Oxygenase-1 Transducer Model of Degenerative and Developmental Brain Disorders

(2015) Hyman Schipper et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions

(2015) Ashraf Virmani et al.   MOLECULAR NEUROBIOLOGY

Multiscale Embedded Gene Co-expression Network Analysis

(2015) Won-Min Song et al.   PLoS Computational Biology

Relationship between the Montreal Cognitive Assessment and Mini-mental State Examination for assessment of mild cognitive impairment in older adults

(2015) Paula T. Trzepacz et al.   BMC Geriatrics

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism

(2014) Andrew C. Shin et al.   Cell Metabolism

ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity

(2014) Willeke de Haan et al.   JOURNAL OF LIPID RESEARCH

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Coordination of microbial metabolism

(2014) Victor Chubukov et al.   NATURE REVIEWS MICROBIOLOGY

Alzheimer’s and ABC transporters — new opportunities for diagnostics and treatment

(2014) Jens Pahnke et al.   NEUROBIOLOGY OF DISEASE

ATP-binding cassette transporter A1: From metabolism to neurodegeneration

(2014) Radosveta Koldamova et al.   NEUROBIOLOGY OF DISEASE

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers

(2013) Li Shen et al.   Brain Imaging and Behavior

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Overview and Findings from the Religious Orders Study

(2013) David A. Bennett et al.   Current Alzheimer Research

Overview and Findings from the Rush Memory and Aging Project

(2013) David A. Bennett et al.   Current Alzheimer Research

Effect of Allium macrostemon on a rat model of depression studied by using plasma lipid and acylcarnitine profiles from liquid chromatography/mass spectrometry

(2013) Shili Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Influence of Genetic Variation on Plasma Protein Levels in Older Adults Using a Multi-Analyte Panel

(2013) Sungeun Kim et al.   PLoS One

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) I. Tesseur et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) K. Veeraraghavalu et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) A. R. Price et al.   SCIENCE

Genome-Wide Haplotype Analysis of Cis Expression Quantitative Trait Loci in Monocytes

(2013) Sophie Garnier et al.   PLoS Genetics

Longitudinal change in neuropsychological performance using latent growth models: a study of mild cognitive impairment

(2012) Julene K. Johnson et al.   Brain Imaging and Behavior

Development and assessment of a composite score for memory in the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

(2012) Paul K. Crane et al.   Brain Imaging and Behavior

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Acylcarnitines

(2012) Marieke G. Schooneman et al.   DIABETES

Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

(2012) I.-M. Wang et al.   Molecular Systems Biology

ABC Transporters B1, C1 and G2 Differentially Regulate Neuroregeneration in Mice

(2012) Toni Schumacher et al.   PLoS One

Adiponectin is Protective against Oxidative Stress Induced Cytotoxicity in Amyloid-Beta Neurotoxicity

(2012) Koon-Ho Chan et al.   PLoS One

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

ABC Transporters and the Alzheimer’s Disease Enigma

(2012) Andrea Wolf et al.   Frontiers in Psychiatry

Developing predictive CSF biomarkers—A challenge critical to success in Alzheimer's disease and neuropsychiatric translational medicine

(2011) Dorothy G. Flood et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of ABCA1 functions by signaling pathways

(2011) Yuhua Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Detection and interpretation of metabolite–transcript coresponses using combined profiling data

(2011) Henning Redestig et al.   BIOINFORMATICS

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

(2011) Xianlin Han et al.   PLoS One

Metabolome in progression to Alzheimer's disease

(2011) M Orešič et al.   Translational Psychiatry

Metabolomic and transcriptomic stress response of Escherichia coli

(2010) Szymon Jozefczuk et al.   Molecular Systems Biology

Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity

(2010) Stephanie J. Mihalik et al.   Obesity

ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

(2010) L. Yvan-Charvet et al.   SCIENCE

Characterizing Dynamic Changes in the Human Blood Transcriptional Network

(2010) Jun Zhu et al.   PLoS Computational Biology

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

(2009) Xia Yang et al.   NATURE GENETICS

Increased expression of Annexin A2 in oral squamous cell carcinoma

(2008) Lai-ping Zhong et al.   ARCHIVES OF ORAL BIOLOGY

Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks

(2008) Jun Zhu et al.   NATURE GENETICS