Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers

Comparative Functional Evolution of Human and Mouse CR1 and CR2

(2014) A. C. Jacobson et al.   JOURNAL OF IMMUNOLOGY

Fast Identification of Biological Pathways Associated with a Quantitative Trait Using Group Lasso with Overlaps

(2014) Matt Silver et al.   Statistical Applications in Genetics and Molecular Biology

The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI)

(2014) Shannon Risacher   Frontiers in Aging Neuroscience

Initial Assessment of the Pathogenic Mechanisms of the Recently Identified Alzheimer Risk Loci

(2013) Patrick Holton et al.   ANNALS OF HUMAN GENETICS

Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment

(2013) K Nho et al.   MOLECULAR PSYCHIATRY

Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics

(2013) K Nho et al.   MOLECULAR PSYCHIATRY

Meta-analysis methods for genome-wide association studies and beyond

(2013) Evangelos Evangelou et al.   NATURE REVIEWS GENETICS

GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease

(2013) Carlos Cruchaga et al.   NEURON

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Discovery and replication of gene influences on brain structure using LASSO regression

(2013) Omid Kohannim   Frontiers in Neuroscience

Structural, functional and molecular imaging as intermediate phenotypes for studies of candidate genes, pathways and GWAS in Alzheimer's disease

(2012) Andrew Saykin et al.   Alzheimers & Dementia

The Effect of Subsyndromal Symptoms of Depression and White Matter Lesions on Disability for Individuals With Mild Cognitive Impairment

(2012) R. Scott Mackin et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Linkage-Disequilibrium-Based Binning Affects the Interpretation of GWASs

(2012) Andrea Christoforou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Multiple loci influencing hippocampal degeneration identified by genome scan

(2012) Scott A. Melville et al.   ANNALS OF NEUROLOGY

Comprehensive Search for Alzheimer Disease Susceptibility Loci in the APOE Region

(2012) Gyungah Jun et al.   ARCHIVES OF NEUROLOGY

Identifying disease sensitive and quantitative trait-relevant biomarkers from multidimensional heterogeneous imaging genetics data via sparse multimodal multitask learning

(2012) H. Wang et al.   BIOINFORMATICS

From phenotype to genotype: an association study of longitudinal phenotypic markers to Alzheimer's disease relevant SNPs

(2012) H. Wang et al.   BIOINFORMATICS

Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing

(2012) Saurabh Gombar et al.   BMC GENOMICS

Sparse learning and stability selection for predicting MCI to AD conversion using baseline ADNI data

(2012) Jieping Ye et al.   BMC Neurology

Dysexecutive and amnesic AD subtypes defined by single indicator and modern psychometric approaches: relationships with SNPs in ADNI

(2012) Shubhabrata Mukherjee et al.   Brain Imaging and Behavior

Genetic architecture of resilience of executive functioning

(2012) Shubhabrata Mukherjee et al.   Brain Imaging and Behavior

Genome-wide pathway analysis of memory impairment in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical pathways, and networks

(2012) Vijay K. Ramanan et al.   Brain Imaging and Behavior

Analysis of Copy Number Variation in Alzheimer’s Disease: The NIALOAD/ NCRAD Family Study

(2012) Shanker Swaminathan et al.   Current Alzheimer Research

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

(2012) Carlos Cruchaga et al.   HUMAN MOLECULAR GENETICS

A coding variant in CR1 interacts with APOE-ɛ4 to influence cognitive decline

(2012) Brendan T. Keenan et al.   HUMAN MOLECULAR GENETICS

Identification of cis-regulatory variation influencing protein abundance levels in human plasma

(2012) Anbarasu Lourdusamy et al.   HUMAN MOLECULAR GENETICS

Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis

(2012) Qingli Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Network Effects on Brain Microstructure and Intellectual Performance Identified in 472 Twins

(2012) M.-C. Chiang et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E, Not Fibrillar  -Amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging

(2012) W. J. Jagust et al.   JOURNAL OF NEUROSCIENCE

Gender Modulates the APOE  4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels

(2012) J. S. Damoiseaux et al.   JOURNAL OF NEUROSCIENCE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Common variants at 12q14 and 12q24 are associated with hippocampal volume

(2012) et al.   NATURE GENETICS

Identification of common variants associated with human hippocampal and intracranial volumes

(2012) Jason L Stein et al.   NATURE GENETICS

A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort

(2012) Shashwath A. Meda et al.   NEUROIMAGE

Increasing power for voxel-wise genome-wide association studies: The random field theory, least square kernel machines and fast permutation procedures

(2012) Tian Ge et al.   NEUROIMAGE

Identification of gene pathways implicated in Alzheimer's disease using longitudinal imaging phenotypes with sparse regression

(2012) Matt Silver et al.   NEUROIMAGE

Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease

(2012) W. T. Hu et al.   NEUROLOGY

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasma Based Markers of [11C] PiB-PET Brain Amyloid Burden

(2012) Steven John Kiddle et al.   PLoS One

Analysis of Copy Number Variation in Alzheimer’s Disease in a Cohort of Clinically Characterized and Neuropathologically Verified Individuals

(2012) Shanker Swaminathan et al.   PLoS One

Genetic Variants in the Fat and Obesity Associated (FTO) Gene and Risk of Alzheimer's Disease

(2012) Christiane Reitz et al.   PLoS One

The Interleukin 3 Gene (IL3) Contributes to Human Brain Volume Variation by Regulating Proliferation and Survival of Neural Progenitors

(2012) Xiong-jian Luo et al.   PLoS One

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans

(2012) T. E. Bakken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathway analysis of genomic data: concepts, methods, and prospects for future development

(2012) Vijay K. Ramanan et al.   TRENDS IN GENETICS

Genome-wide association study of Alzheimer's disease

(2012) M I Kamboh et al.   Translational Psychiatry

Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment

(2012) Priya Rajagopalan et al.   NeuroImage-Clinical

Genetic association of complement receptor 1 polymorphism rs3818361 in Alzheimer’s disease

(2011) Carmen Antúnez et al.   Alzheimers & Dementia

The Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception

(2011) Michael W. Weiner et al.   Alzheimers & Dementia

Circadian Clock Gene Polymorphisms and Sleep–Wake Disturbance in Alzheimer Disease

(2011) Jerome A. Yesavage et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Apolipoprotein E ɛ2 and Functional Decline in Amnestic Mild Cognitive Impairment and Alzheimer Disease

(2011) Aaron Bonner-Jackson et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Association and Expression Analyses With Single-Nucleotide Polymorphisms in TOMM40 in Alzheimer Disease

(2011) Carlos Cruchaga   ARCHIVES OF NEUROLOGY

Identifying quantitative trait loci via group-sparse multitask regression and feature selection: an imaging genetics study of the ADNI cohort

(2011) Hua Wang et al.   BIOINFORMATICS

CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer’s disease risk in an APOE-dependent manner

(2011) Elizabeth A. Murphy et al.   Brain Imaging and Behavior

Amyloid pathway-based candidate gene analysis of [11C]PiB-PET in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort

(2011) Shanker Swaminathan et al.   Brain Imaging and Behavior

The Association between a Polygenic Alzheimer Score and Cortical Thickness in Clinically Normal Subjects

(2011) Mert R. Sabuncu et al.   CEREBRAL CORTEX

Impact of SORL1 Single Nucleotide Polymorphisms on Alzheimer’s Disease Cerebrospinal Fluid Markers

(2011) Panagiotis Alexopoulos et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

A Geographic Cline of Skull and Brain Morphology among Individuals of European Ancestry

(2011) Trygve E. Bakken et al.   HUMAN HEREDITY

Genome-wide and gene-based association implicates FRMD6 in alzheimer disease

(2011) Mun-Gwan Hong et al.   HUMAN MUTATION

Design and Application of a Generic Clinical Decision Support System for Multiscale Data

(2011) J. Mattila et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

An Improved Model for Disease Progression in Patients From the Alzheimer's Disease Neuroimaging Initiative

(2011) Mahesh N. Samtani et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Cell adhesion molecules contribute to Alzheimer’s disease: multiple pathway analyses of two genome-wide association studies

(2011) Guiyou Liu et al.   JOURNAL OF NEUROCHEMISTRY

Nonlinear dimensionality reduction combining MR imaging with non-imaging information

(2011) Robin Wolz et al.   MEDICAL IMAGE ANALYSIS

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

(2011) N Brouwers et al.   MOLECULAR PSYCHIATRY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Voxelwise gene-wide association study (vGeneWAS): Multivariate gene-based association testing in 731 elderly subjects

(2011) Derrek P. Hibar et al.   NEUROIMAGE

Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer's disease

(2011) Maria Vounou et al.   NEUROIMAGE

Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease

(2011) Xiaolan Hu et al.   PLoS One

Fine Mapping of Genetic Variants in BIN1, CLU, CR1 and PICALM for Association with Cerebrospinal Fluid Biomarkers for Alzheimer's Disease

(2011) John S. K. Kauwe et al.   PLoS One

A Blood-Based Screening Tool for Alzheimer's Disease That Spans Serum and Plasma: Findings from TARC and ADNI

(2011) Sid E. O'Bryant et al.   PLoS One

Can medical genetics and evolutionary biology inspire drug target identification?

(2011) Zhong-Yi Wang et al.   TRENDS IN MOLECULAR MEDICINE

Systems genetics for drug target discovery

(2011) Nadia M. Penrod et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

For debate: substituting placebo controls in long-term Alzheimer's prevention trials

(2011) René Spiegel et al.   Alzheimers Research & Therapy

The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease

(2011) Carmen Antúnez et al.   Genome Medicine

Genome-wide association study identifies multiple novel loci associated with disease progression in subjects with mild cognitive impairment

(2011) X Hu et al.   Translational Psychiatry

Multilocus Genetic Analysis of Brain Images

(2011) Derrek P. Hibar et al.   Frontiers in Genetics

Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans

(2010) Andrew J. Saykin et al.   Alzheimers & Dementia

Prioritizing GWAS Results: A Review of Statistical Methods and Recommendations for Their Application

(2010) Rita M. Cantor et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes

(2010) Chantel D. Sloan et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Genetic Variation and Neuroimaging Measures in Alzheimer Disease

(2010) Alessandro Biffi   ARCHIVES OF NEUROLOGY

Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

(2010) Gyungah Jun   ARCHIVES OF NEUROLOGY

Genome-wide association reveals genetic effects on human Aβ 42 and τ protein levels in cerebrospinal fluids: a case control study

(2010) Mi-Ryung Han et al.   BMC Neurology

Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics

(2010) B. C. Dickerson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Distribution and Expression of Picalm in Alzheimer Disease

(2010) Shabnam Baig et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease

(2010) S J Furney et al.   MOLECULAR PSYCHIATRY

Analysing biological pathways in genome-wide association studies

(2010) Kai Wang et al.   NATURE REVIEWS GENETICS

Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study

(2010) Duygu Tosun et al.   NEUROBIOLOGY OF AGING

3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects

(2010) Liana G. Apostolova et al.   NEUROBIOLOGY OF AGING

The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort

(2010) A. Caroli et al.   NEUROBIOLOGY OF AGING

Longitudinal MRI atrophy biomarkers: Relationship to conversion in the ADNI cohort

(2010) Shannon L. Risacher et al.   NEUROBIOLOGY OF AGING

Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans

(2010) Xue Hua et al.   NEUROBIOLOGY OF AGING

Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort

(2010) Anita Lakatos et al.   NEUROBIOLOGY OF AGING

Effects of ApoE4 and maternal history of dementia on hippocampal atrophy

(2010) John P. Andrawis et al.   NEUROBIOLOGY OF AGING

Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort

(2010) Li Shen et al.   NEUROIMAGE

Discovering genetic associations with high-dimensional neuroimaging phenotypes: A sparse reduced-rank regression approach

(2010) Maria Vounou et al.   NEUROIMAGE

Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease

(2010) Jason L. Stein et al.   NEUROIMAGE

Voxelwise genome-wide association study (vGWAS)

(2010) Jason L. Stein et al.   NEUROIMAGE

False positives in neuroimaging genetics using voxel-based morphometry data

(2010) Matt Silver et al.   NEUROIMAGE

Genome-wide association study of CSF biomarkers A 1-42, t-tau, and p-tau181p in the ADNI cohort

(2010) S. Kim et al.   NEUROLOGY

Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimerʼs disease

(2010) Cunlu Xu et al.   NEUROREPORT

Cortical thickness is associated with different apolipoprotein E genotypes in healthy elderly adults

(2010) Ming Fan et al.   NEUROSCIENCE LETTERS

GSA-SNP: a general approach for gene set analysis of polymorphisms

(2010) Dougu Nam et al.   NUCLEIC ACIDS RESEARCH

Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease

(2010) D. A. Wolk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly

(2010) A. J. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities

(2010) Adam C. Naj et al.   PLoS Genetics

SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease

(2010) Carlos Cruchaga et al.   PLoS Genetics

Gene Ontology Analysis of GWA Study Data Sets Provides Insights into the Biology of Bipolar Disorder

(2009) Peter Holmans et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn Disease

(2009) Kai Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease

(2009) J.S.K. Kauwe et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The SNP ratio test: pathway analysis of genome-wide association datasets

(2009) Colm O'Dushlaine et al.   BIOINFORMATICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)

(2009) Jessica B.S. Langbaum et al.   NEUROIMAGE

Genomewide Association Studies — Illuminating Biologic Pathways

(2009) Joel N. Hirschhorn   NEW ENGLAND JOURNAL OF MEDICINE

ApoE genotyping as a progression-rate biomarker in phase II disease-modification trials for Alzheimer's disease

(2009) D J Stone et al.   PHARMACOGENOMICS JOURNAL

A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

(2009) A D Roses et al.   PHARMACOGENOMICS JOURNAL

Hippocampal Atrophy as a Quantitative Trait in a Genome-Wide Association Study Identifying Novel Susceptibility Genes for Alzheimer's Disease

(2009) Steven G. Potkin et al.   PLoS One

Sex-dependent association of common variants of microcephaly genes with brain structure

(2009) L. M. Rimol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide strategies for discovering genetic influences on cognition and cognitive disorders: Methodological considerations

(2009) Steven G. Potkin et al.   Cognitive Neuropsychiatry

Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions

(2009) Soumya Raychaudhuri et al.   PLoS Genetics

Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia

(2008) S G Potkin et al.   MOLECULAR PSYCHIATRY

A Genome-Wide Association Study of Schizophrenia Using Brain Activation as a Quantitative Phenotype

(2008) Steven G. Potkin et al.   SCHIZOPHRENIA BULLETIN

Working memory and DLPFC inefficiency in schizophrenia: The FBIRN study

(2008) S. G. Potkin et al.   SCHIZOPHRENIA BULLETIN