Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden

Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau

(2018) Mickael Audrain et al.   MOLECULAR PSYCHIATRY

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data

(2017) Charles C. White et al.   PLOS MEDICINE

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

(2016) Taylor R. Jay et al.   JOURNAL OF NEUROSCIENCE

Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer’s disease

(2016) T Roostaei et al.   MOLECULAR PSYCHIATRY

Genetic variants in Alzheimer disease — molecular and brain network approaches

(2016) Chris Gaiteri et al.   Nature Reviews Neurology

TYROBP genetic variants in early-onset Alzheimer's disease

(2016) Cyril Pottier et al.   NEUROBIOLOGY OF AGING

Relation of genomic variants for Alzheimer disease dementia to common neuropathologies

(2016) Jose M. Farfel et al.   NEUROLOGY

Polygenic risk of Alzheimer disease is associated with early- and late-life processes

(2016) Elizabeth C. Mormino et al.   NEUROLOGY

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1

(2016) Elysse M. Knight et al.   Acta Neuropathologica Communications

Convergent genetic and expression data implicate immunity in Alzheimer's disease

(2015) Lesley Jones et al.   Alzheimers & Dementia

Molecular systems evaluation of oligomerogenic APP E693Q and fibrillogenic APP KM670/671NL /PSEN1 Δexon9 mouse models identifies shared features with human Alzheimer’s brain molecular pathology

(2015) B Readhead et al.   MOLECULAR PSYCHIATRY

CD33 modulates TREM2: convergence of Alzheimer loci

(2015) Gail Chan et al.   NATURE NEUROSCIENCE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

(2015) Peng Liu et al.   Cell Reports

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

(2015) Tomas Fanutza et al.   eLife

Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease

(2014) David A. Bennett et al.   BIOCHEMICAL PHARMACOLOGY

Siglec functions of microglia

(2014) B. Linnartz-Gerlach et al.   GLYCOBIOLOGY

Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse

(2014) S H Kim et al.   MOLECULAR PSYCHIATRY

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

(2014) M. Narayanan et al.   Molecular Systems Biology

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

(2014) Takahiro Masuda et al.   Nature Communications

Toward the Treatment and Prevention of Alzheimer's Disease: Rational Strategies and Recent Progress

(2013) Sam Gandy et al.   Annual Review of Medicine

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Overview and Findings from the Religious Orders Study

(2013) David A. Bennett et al.   Current Alzheimer Research

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

(2012) Takahiro Masuda et al.   Cell Reports

Histological and Direct Evidence for the Role of Complement in the Neuroinflammation of AD

(2011) Robert Veerhuis   Current Alzheimer Research

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

(2011) Cristina Marchetti et al.   REVIEWS IN THE NEUROSCIENCES

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Disentangling molecular relationships with a causal inference test

(2009) Joshua Millstein et al.   BMC GENETICS

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

(2009) Jennifer L. Tomic et al.   NEUROBIOLOGY OF DISEASE

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

(2008) Karla L Lightfield et al.   NATURE IMMUNOLOGY

Transcriptional vulnerability of brain regions in Alzheimer's disease and dementia

(2007) Vahram Haroutunian et al.   NEUROBIOLOGY OF AGING