The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions

Altered energy metabolism in cancer

(2013) Yi Zhang et al.   CANCER BIOLOGY & THERAPY

Hypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin

(2013) S. Ramirez et al.   DIABETES

Relation Between Serum Free Fatty Acids and Adiposity, Insulin Resistance, and Cardiovascular Risk Factors From Adolescence to Adulthood

(2013) Brigitte I. Frohnert et al.   DIABETES

Hippocampal calcium dysregulation at the nexus of diabetes and brain aging

(2013) Olivier Thibault et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities

(2013) Anna Hernández-Aguilera et al.   MEDIATORS OF INFLAMMATION

Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!

(2013) Ashraf Virmani et al.   MOLECULAR NEUROBIOLOGY

Histone Modifications in Senescence-Associated Resistance to Apoptosis by Oxidative Stress

(2013) Yan Y. Sanders et al.   Redox Biology

Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism

(2012) Jieun Lee et al.   BMC BIOCHEMISTRY

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Molecular Pathways: Tumor Cells Co-opt the Brain-Specific Metabolism Gene CPT1C to Promote Survival

(2012) P. T. Reilly et al.   CLINICAL CANCER RESEARCH

Mitochondrion-Specific Antioxidants as Drug Treatments for Alzheimer Disease

(2012) Hector H. Palacios et al.   CNS & Neurological Disorders-Drug Targets

Risk of Parkinson Disease Onset in Patients With Diabetes: A 9-year population-based cohort study with age and sex stratifications

(2012) Y. Sun et al.   DIABETES CARE

Ceramide Levels Regulated by Carnitine Palmitoyltransferase 1C Control Dendritic Spine Maturation and Cognition

(2012) Patricia Carrasco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Endoplasmic Reticulum Stress on Inflammation and Adiponectin Regulation in Human Adipocytes

(2012) Ashis K. Mondal et al.   Metabolic Syndrome and Related Disorders

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

(2012) David N. Hauser et al.   NEUROBIOLOGY OF DISEASE

S6K1 determines the metabolic requirements for BCR-ABL survival

(2012) J F Barger et al.   ONCOGENE

Manifold effects of palmitoylcarnitine on endoplasmic reticulum metabolism: 11β-hydroxysteroid dehydrogenase 1, flux through hexose-6-phosphate dehydrogenase and NADPH concentration

(2011) Xudong Wang et al.   BIOCHEMICAL JOURNAL

Establishing a relationship between prolactin and altered fatty acid β-Oxidation via carnitine palmitoyl transferase 1 in breast cancer cells

(2011) Katja Linher-Melville et al.   BMC CANCER

Kynurenine Pathway in Schizophrenia: Pathophysiological and Therapeutic Aspects

(2011) Norbert Muller et al.   CURRENT PHARMACEUTICAL DESIGN

Insulin resistance impairs nigrostriatal dopamine function

(2011) J.K. Morris et al.   EXPERIMENTAL NEUROLOGY

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

(2011) K. Zaugg et al.   GENES & DEVELOPMENT

Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly

(2011) Amanda A. Reamy et al.   JOURNAL OF NEUROCHEMISTRY

Calorie Restriction: Is AMPK a Key Sensor and Effector?

(2011) Carles Cantó et al.   PHYSIOLOGY

Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding

(2011) S. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis

(2011) Leah P. Shriver et al.   Scientific Reports

Neuroprotective strategies in drug abuse-evoked encephalopathy

(2010) Ashraf Virmani et al.   Annals of the New York Academy of Sciences

Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

(2010) N. Lefort et al.   DIABETES

Diabetes and Cancer: A consensus report

(2010) E. Giovannucci et al.   DIABETES CARE

Evidence for the Involvement of Carnitine-Dependent Long-Chain Acyltransferases in Neuronal Triglyceride and Phospholipid Fatty Acid Turnover

(2010) Arduino Arduini et al.   JOURNAL OF NEUROCHEMISTRY

Carnitine Palmitoyltransferase 2 Deficiency: The Time-Course of Blood and Urinary Acylcarnitine Levels during Initial L-Carnitine Supplementation

(2010) Tomohiro Hori et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders

(2009) Louis A. Profenno et al.   BIOLOGICAL PSYCHIATRY

Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake

(2009) X. F. Gao et al.   DIABETOLOGIA

Diabetes and cancer

(2009) Paolo Vigneri et al.   ENDOCRINE-RELATED CANCER

Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation

(2009) Christopher M. Mayer et al.   ENDOCRINOLOGY

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

(2009) Stephen C. Benoit et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing

(2009) V. Solfrizzi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Regulatory enzymes of mitochondrial β-oxidation as targets for treatment of the metabolic syndrome

(2009) M. Schreurs et al.   Obesity Reviews

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet-Induced Insulin Resistance

(2008) C. R. Bruce et al.   DIABETES

Metabolic Syndrome and Risk for Incident Alzheimer's Disease or Vascular Dementia: The Three-City Study

(2008) C. Raffaitin et al.   DIABETES CARE

CPT1c Is Localized in Endoplasmic Reticulum of Neurons and Has Carnitine Palmitoyltransferase Activity

(2008) Adriana Y. Sierra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight

(2008) Michael J. Wolfgang et al.   JOURNAL OF NEUROCHEMISTRY

Impaired insulin secretion increases the risk of Alzheimer disease

(2008) E. Ronnemaa et al.   NEUROLOGY

Effects of short-term and long-term treatment with medium- and long-chain triglycerides ketogenic diet on cortical spreading depression in young rats

(2008) Marcela de Almeida Rabello Oliveira et al.   NEUROSCIENCE LETTERS

Acetyl l-carnitine (ALC) treatment in elderly patients with fatigue

(2007) Michele Malaguarnera et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS