Nanomedicines in B cell-targeting therapies

Combination treatment with immunogenic and anti-PD-L1 polymer-drug conjugates of advanced tumors in a transgenic MMTV-PyMT mouse model of breast cancer

(2021) Lian Li et al.   JOURNAL OF CONTROLLED RELEASE

Crosslinking of CD38 Receptors Triggers Apoptosis of Malignant B Cells

(2021) M. Tommy Gambles et al.   MOLECULES

B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches

(2020) Nina Shah et al.   LEUKEMIA

Tumor-targeted delivery of silibinin and IPI-549 synergistically inhibit breast cancer by remodeling the microenvironment

(2020) Min Jiang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

State of the art in CAR T cell therapy for CD19+ B cell malignancies

(2020) Matthew J. Frigault et al.   JOURNAL OF CLINICAL INVESTIGATION

Exploration and Evaluation of Therapeutic Efficacy of Drug‐Free Macromolecular Therapeutics in Collagen‐Induced Rheumatoid Arthritis Mouse Model

(2020) Jiawei Wang et al.   MACROMOLECULAR BIOSCIENCE

Stealth Coating of Nanoparticles in Drug-Delivery Systems

(2020) See Yee Fam et al.   Nanomaterials

Systematic Review of Safety and Efficacy of Atacicept in Treating Immune-Mediated Disorders

(2020) Celine Kaegi et al.   Frontiers in Immunology

Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence

(2020) Raju K. Vaddepally et al.   Cancers

Transmembrane Activator and CAML Interactor (TACI): Another Potential Target for Immunotherapy of Multiple Myeloma?

(2020) Shengli Xu et al.   Cancers

Polymer nanomedicines

(2020) Jindřich Kopeček et al.   ADVANCED DRUG DELIVERY REVIEWS

Rapid Assembly and Screening of Multivalent Immune Cell-Redirecting Therapies for Leukemia

(2020) Priscilla Do et al.   ACS Combinatorial Science

Inotuzumab ozogamicin for relapsed/refractory acute lymphoblastic leukemia: outcomes by disease burden

(2020) Daniel J. DeAngelo et al.   Blood Cancer Journal

Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

(2020) Duhyeong Hwang et al.   ADVANCED DRUG DELIVERY REVIEWS

The BAFF / APRIL system as therapeutic target in multiple sclerosis

(2020) Roberta Magliozzi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

B cell depletion therapies in autoimmune disease: advances and mechanistic insights

(2020) Dennis S. W. Lee et al.   NATURE REVIEWS DRUG DISCOVERY

Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives

(2019) Diego Tesauro et al.   MOLECULES

Drug-free macromolecular therapeutics induce apoptosis in cells isolated from patients with B cell malignancies with enhanced apoptosis induction by pretreatment with gemcitabine

(2019) Jiawei Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Decoration of Anti-CD38 on Nanoparticles Carrying a STAT3 Inhibitor Can Improve the Therapeutic Efficacy Against Myeloma

(2019) Yung-Hsing Huang et al.   Cancers

Neuromuscular adverse events associated with anti-PD-1 monoclonal antibodies

(2019) Annette Johansen et al.   NEUROLOGY

Silencing PD-1 and PD-L1 with nanoparticle-delivered small interfering RNA increases cytotoxicity of tumor-infiltrating lymphocytes

(2019) Yanheng Wu et al.   Nanomedicine

Doxorubicin and Anti-PD-L1 Antibody Conjugated Gold Nanoparticles for Colorectal Cancer Photochemotherapy

(2019) Fakhrossadat Emami et al.   MOLECULAR PHARMACEUTICS

Targeting PI3K in cancer: mechanisms and advances in clinical trials

(2019) Jing Yang et al.   Molecular Cancer

Selective targeting of multiple myeloma by B cell maturation antigen (BCMA)-specific central memory CD8+ cytotoxic T lymphocytes: immunotherapeutic application in vaccination and adoptive immunotherapy

(2019) Jooeun Bae et al.   LEUKEMIA

Apoptosis-promoting effect of rituximab-conjugated magnetic nanoprobes on malignant lymphoma cells with CD20 overexpression

(2019) Lina Song et al.   International Journal of Nanomedicine

The Role of Ligands in the Chemical Synthesis and Applications of Inorganic Nanoparticles

(2019) Amelie Heuer-Jungemann et al.   CHEMICAL REVIEWS

Fostamatinib for the treatment of chronic immune thrombocytopenia

(2019) Nathan T. Connell et al.   BLOOD

Development of BTK inhibitors for the treatment of B-cell malignancies

(2019) Hyung-Ook Kim   ARCHIVES OF PHARMACAL RESEARCH

Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo Using Layer‐by‐Layer Nanoparticles

(2019) Ki Young Choi et al.   ADVANCED FUNCTIONAL MATERIALS

MiR155 sensitized B-lymphoma cells to anti-PD-L1 antibody via PD-1/PD-L1-mediated lymphoma cell interaction with CD8+T cells

(2019) Zhong Zheng et al.   Molecular Cancer

The B-side of Cancer Immunity: The Underrated Tune

(2019) Largeot et al.   Cells

CD40 Agonist Antibodies in Cancer Immunotherapy

(2019) Robert H. Vonderheide   Annual Review of Medicine

Inhibiting PI3 kinase-γ in both myeloid and plasma cells remodels the suppressive tumor microenvironment in desmoplastic tumors

(2019) Xueqiong Zhang et al.   JOURNAL OF CONTROLLED RELEASE

BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications

(2019) Jooeun Bae et al.   LEUKEMIA

CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies

(2019) Hong Qin et al.   Science Translational Medicine

Broadening and Enhancing Functions of Antibodies by Self-Assembling Multimerization at Cell Surface

(2019) Lian Li et al.   ACS Nano

Dual‐Locking Nanoparticles Disrupt the PD‐1/PD‐L1 Pathway for Efficient Cancer Immunotherapy

(2019) Zhanzhan Zhang et al.   ADVANCED MATERIALS

Polatuzumab Vedotin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma

(2019) Laurie H. Sehn et al.   JOURNAL OF CLINICAL ONCOLOGY

Chitosan/Sulfobutylether-β-Cyclodextrin Nanoparticles for Ibrutinib Delivery: A Potential Nanoformulation of Novel Kinase Inhibitor

(2019) Ludan Zhao et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Synergy between B cell receptor/antigen uptake and MHCII peptide editing relies on HLA-DO tuning

(2019) Wei Jiang et al.   Scientific Reports

A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer

(2019) Braicu et al.   Cancers

CD19-targeted, Raman tagged gold nanourchins as theranostic agents against acute lymphoblastic leukemia

(2019) Andra-Sorina Tatar et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Multivalent HER2-binding polymer conjugates facilitate rapid endocytosis and enhance intracellular drug delivery

(2019) D. Christopher Radford et al.   JOURNAL OF CONTROLLED RELEASE

Applications of Nanomaterials in Leishmaniasis: A Focus on Recent Advances and Challenges

(2019) Kiran Saleem et al.   Nanomaterials

Amplification of CD20 Cross-Linking in Rituximab-Resistant B-Lymphoma Cells Enhances Apoptosis Induction by Drug-Free Macromolecular Therapeutics

(2018) Lian Li et al.   ACS Nano

Tumor targeting via EPR: Strategies to enhance patient responses

(2018) Susanne K. Golombek et al.   ADVANCED DRUG DELIVERY REVIEWS

A CD19/CD3 bispecific antibody for effective immunotherapy of chronic lymphocytic leukemia in the ibrutinib era

(2018) Hannah R. Robinson et al.   BLOOD

New insights in Type I and II CD20 antibody mechanisms-of-action with a panel of novel CD20 antibodies

(2018) Saskia Meyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Block Copolymer Micelles in Nanomedicine Applications

(2018) Horacio Cabral et al.   CHEMICAL REVIEWS

Inflammatory and Cholesterol Risk in the FOURIER Trial

(2018) Erin A. Bohula et al.   CIRCULATION

Characterization of liposome-containing SPIONs conjugated with anti-CD20 developed as a novel theranostic agent for central nervous system lymphoma

(2018) S. Saesoo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Rituximab in combination with chemotherapy for the treatment of chronic lymphocytic leukaemia in clinical practice

(2018) Marcel Reiser et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Epratuzumab for the treatment of systemic lupus erythematosus

(2018) Daniel Geh et al.   Expert Review of Clinical Immunology

Sequential loss of tumor surface antigens following chimeric antigen receptor T-cell therapies in diffuse large B-cell lymphoma

(2018) Haneen Shalabi et al.   HAEMATOLOGICA

Enhancing proteasome-inhibitory activity and specificity of bortezomib by CD38 targeted nanoparticles in multiple myeloma

(2018) Pilar de la Puente et al.   JOURNAL OF CONTROLLED RELEASE

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

(2018) Tom T.P. Seijkens et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A novel phosphoester-based cationic co-polymer nanocarrier delivers chimeric antigen receptor plasmid and exhibits anti-tumor effect

(2018) Jing Fan et al.   RSC Advances

Sequential loss of tumor surface antigens following chimeric antigen receptor T-cell therapies in diffuse large B-cell lymphoma

(2018) Haneen Shalabi et al.   HAEMATOLOGICA

Targeting B Cells and Plasma Cells in Autoimmune Diseases

(2018) Katharina Hofmann et al.   Frontiers in Immunology

Formulation, Development, and In Vitro Evaluation of a CD22 Targeted Liposomal System Containing a Non-Cardiotoxic Anthracycline for B Cell Malignancies

(2018) Nivesh Mittal et al.   Pharmaceutics

APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications

(2018) Yu-Tzu Tai et al.   LEUKEMIA

Human Serum Albumin-Based Drug-Free Macromolecular Therapeutics: Apoptosis Induction by Coiled-Coil-Mediated Cross-Linking of CD20 Antigens on Lymphoma B Cell Surface

(2018) Libin Zhang et al.   MACROMOLECULAR BIOSCIENCE

Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide-Generating Agents Improves the Therapeutic Effects of Nanomedicines

(2018) Waliul Islam et al.   MOLECULAR CANCER THERAPEUTICS

Optimized nanoparticle-mediated delivery of CRISPR-Cas9 system for B cell intervention

(2018) Min Li et al.   Nano Research

Tumor Antigen Escape from CAR T-cell Therapy

(2018) Robbie G. Majzner et al.   Cancer Discovery

Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells

(2018) Muhammad U. Farooq et al.   Scientific Reports

Anti-CD20 monoclonal antibodies: reviewing a revolution

(2018) J. M. L. Casan et al.   Human Vaccines & Immunotherapeutics

Targeting B Cell Maturation Antigen (BCMA) in Multiple Myeloma: Potential Uses of BCMA-Based Immunotherapy

(2018) Shih-Feng Cho et al.   Frontiers in Immunology

Interactions Between Nanoparticles and Dendritic Cells: From the Perspective of Cancer Immunotherapy

(2018) Jianbo Jia et al.   Frontiers in Oncology

Moxetumomab Pasudotox: First Global Approval

(2018) Sohita Dhillon   DRUGS

Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release

(2018) Aldemar Gordillo-Galeano et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Drug-free albumin-triggered sensitization of cancer cells to anticancer drugs

(2018) Lian Li et al.   JOURNAL OF CONTROLLED RELEASE

Biomaterials for vaccine-based cancer immunotherapy

(2018) Rui Zhang et al.   JOURNAL OF CONTROLLED RELEASE

CD38: A Target for Immunotherapeutic Approaches in Multiple Myeloma

(2018) Fabio Morandi et al.   Frontiers in Immunology

BAFF and BAFF-Receptor in B Cell Selection and Survival

(2018) Cristian R. Smulski et al.   Frontiers in Immunology

A new construct of antibody-drug conjugates for treatment of B-cell non-Hodgkin's lymphomas

(2017) Libin Zhang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Silibinin inhibits the fibrotic responses induced by cigarette smoke via suppression of TGF-β1/Smad 2/3 signaling

(2017) Je-Won Ko et al.   FOOD AND CHEMICAL TOXICOLOGY

Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases

(2017) Eileen Samy et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Pretargeting with bispecific fusion proteins facilitates delivery of nanoparticles to tumor cells with distinct surface antigens

(2017) Qi Yang et al.   JOURNAL OF CONTROLLED RELEASE

Syk inhibitors in clinical development for hematological malignancies

(2017) Delong Liu et al.   Journal of Hematology & Oncology

CD22 Ligands on a Natural N-Glycan Scaffold Efficiently Deliver Toxins to B-Lymphoma Cells

(2017) Wenjie Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway

(2017) Lian Li et al.   MACROMOLECULAR BIOSCIENCE

Nuclear and Fluorescent Labeled PD-1-Liposome-DOX-64Cu/IRDye800CW Allows Improved Breast Tumor Targeted Imaging and Therapy

(2017) Yang Du et al.   MOLECULAR PHARMACEUTICS

An Anti-Programmed Death-1 Antibody (αPD-1) Fusion Protein That Self-Assembles into a Multivalent and Functional αPD-1 Nanoparticle

(2017) Peng Zhao et al.   MOLECULAR PHARMACEUTICS

Therapeutic targeting in nanomedicine: the future lies in recombinant antibodies

(2017) Geoffrey A Pietersz et al.   Nanomedicine

Overexpression of the Cytokine BAFF and Autoimmunity Risk

(2017) Maristella Steri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modulating Cytotoxic Effector Functions by Fc Engineering to Improve Cancer Therapy

(2017) Christian Kellner et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Anti-CD22-conjugated CdTe QDs co-loaded with doxorubicin and gambogic acid: a novel platform for lymphoma treatment

(2017) Peipei Xu et al.   RSC Advances

Phase I clinical trial of idiotypic DNA vaccine administered as a complex with polyethylenimine to patients with B-cell lymphoma

(2017) A. N. Meleshko et al.   Human Vaccines & Immunotherapeutics

Antibody-targeted paclitaxel loaded nanoparticles for the treatment of CD20+ B-cell lymphoma

(2017) Wendy K. Nevala et al.   Scientific Reports

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

A Review of Obinutuzumab (GA101), a Novel Type II Anti-CD20 Monoclonal Antibody, for the Treatment of Patients with B-Cell Malignancies

(2016) Kensei Tobinai et al.   ADVANCES IN THERAPY

Dual stimulation of antigen presenting cells using carbon nanotube-based vaccine delivery system for cancer immunotherapy

(2016) Hatem A.F.M. Hassan et al.   BIOMATERIALS

APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

(2016) Y.-T. Tai et al.   BLOOD

Gemcitabine enhances rituximab-mediated complement-dependent cytotoxicity to B cell lymphoma by CD20 upregulation

(2016) Kazumi Hayashi et al.   CANCER SCIENCE

A molecular perspective on rituximab: A monoclonal antibody for B cell non Hodgkin lymphoma and other affections

(2016) Narges Seyfizadeh et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4 + T Cell Immunity

(2016) Deshapriya S. Karunarathne et al.   IMMUNITY

CD20-targeting in B-cell malignancies: novel prospects for antibodies and combination therapies

(2016) Yaghoub Safdari et al.   INVESTIGATIONAL NEW DRUGS

Human immune cell targeting of protein nanoparticles – caveospheres

(2016) Joshua J. Glass et al.   Nanoscale

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

(2016) Olivier De Henau et al.   NATURE

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

PD-1–PD-L1 immune-checkpoint blockade in B-cell lymphomas

(2016) Aaron Goodman et al.   Nature Reviews Clinical Oncology

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate

(2016) Catherine A. Evans et al.   ACS Medicinal Chemistry Letters

Antigen-specific T cell Redirectors: a nanoparticle based approach for redirecting T cells

(2016) Christian Schütz et al.   Oncotarget

Inebilizumab, a B Cell-Depleting Anti-CD19 Antibody for the Treatment of Autoimmune Neurological Diseases: Insights from Preclinical Studies

(2016) Ding Chen et al.   Journal of Clinical Medicine

Iron-Based Superparamagnetic Nanoparticle Contrast Agents for MRI of Infection and Inflammation

(2015) Alexander Neuwelt et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Blocking of the PD-1/PD-L1 Interaction by aD-Peptide Antagonist for Cancer Immunotherapy

(2015) Hao-Nan Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Potential applications for sigma receptor ligands in cancer diagnosis and therapy

(2015) Aren van Waarde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses

(2015) Rodney A. Rosalia et al.   BIOMATERIALS

Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma

(2015) Q. Yang et al.   CLINICAL CANCER RESEARCH

CD38 Monoclonal Antibody Therapies for Multiple Myeloma

(2015) Sandy W. Wong et al.   Clinical Lymphoma Myeloma & Leukemia

B cells responses and cytokine production are regulated by their immune microenvironment

(2015) Monica I. Vazquez et al.   CYTOKINE

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

(2015) Edgar Pérez-Herrero et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Investigating the potential of employing bilosomes as a novel vesicular carrier for transdermal delivery of tenoxicam

(2015) Abdulaziz M. Al-mahallawi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

(2015) Lieping Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

FRET-trackable biodegradable HPMA copolymer-epirubicin conjugates for ovarian carcinoma therapy

(2015) Jiyuan Yang et al.   JOURNAL OF CONTROLLED RELEASE

Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia

(2015) Jingjing Wu et al.   Journal of Hematology & Oncology

Enhancing Accumulation and Penetration of HPMA Copolymer–Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer

(2015) Zheng-Hong Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Water-soluble nanoconjugates of quantum dot-chitosan-antibody for in vitro detection of cancer cells based on “enzyme-free” fluoroimmunoassay

(2015) Herman S. Mansur et al.   Materials Science & Engineering C-Materials for Biological Applications

Selective Delivery of PEGylated Compounds to Tumor Cells by Anti-PEG Hybrid Antibodies

(2015) H.-Y. Tung et al.   MOLECULAR CANCER THERAPEUTICS

CD19-Targeted Nanodelivery of Doxorubicin Enhances Therapeutic Efficacy in B-Cell Acute Lymphoblastic Leukemia

(2015) Vinu Krishnan et al.   MOLECULAR PHARMACEUTICS

Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes

(2015) Paul R Moody et al.   MOLECULAR THERAPY

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab

(2015) Te-Wei Chu et al.   Theranostics

Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superior Survival Outcomes in Mice

(2015) Fatih M. Uckun et al.   EBioMedicine

A Hybrid Protein–Polymer Nanoworm Potentiates Apoptosis Better than a Monoclonal Antibody

(2014) Suhaas Rayudu Aluri et al.   ACS Nano

Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia

(2014) Noriko Satake et al.   BRITISH JOURNAL OF HAEMATOLOGY

B-cell inhibition by cross-linking CD79b is superior to B-cell depletion with anti-CD20 antibodies in treating murine collagen-induced arthritis

(2014) Hilke Brühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells

(2014) Dorothea E. Myers et al.   Integrative Biology

Sensitizing B- and T- cell Lymphoma Cells to Paclitaxel/Abraxane–Induced Death by AS101 via Inhibition of the VLA-4–IL10–Survivin Axis

(2014) Hila Danoch et al.   MOLECULAR CANCER RESEARCH

Drug-free macromolecular therapeutics induce apoptosis of patient chronic lymphocytic leukemia cells

(2014) Te-Wei Chu et al.   Drug Delivery and Translational Research

Blinatumomab, a Bi-Specific Anti-CD19/CD3 BiTE® Antibody for the Treatment of Acute Lymphoblastic Leukemia: Perspectives and Current Pediatric Applications

(2014) Lindsey M. Hoffman et al.   Frontiers in Oncology

Cell Surface Self-Assembly of Hybrid Nanoconjugates via Oligonucleotide Hybridization Induces Apoptosis

(2013) Te-Wei Chu et al.   ACS Nano

Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells

(2013) Bo Yu et al.   BIOMATERIALS

Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia

(2013) F. M. Uckun et al.   BLOOD

Enhanced anticancer efficacy of snake venom combined with silica nanoparticles in a murine model of human multiple myeloma: Molecular targets for cell cycle arrest and apoptosis induction

(2013) Mohamed K. Al-Sadoon et al.   CELLULAR IMMUNOLOGY

B cells and their mediators as targets for therapy in solid tumors

(2013) Andrew J. Gunderson et al.   EXPERIMENTAL CELL RESEARCH

Targeting of Antigens to B Lymphocytes via CD19 as a Means for Tumor Vaccine Development

(2013) Y. Ma et al.   JOURNAL OF IMMUNOLOGY

Mcl-1 is essential for the survival of plasma cells

(2013) Victor Peperzak et al.   NATURE IMMUNOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

(2013) Omid Hamid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

(2013) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells

(2013) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

BAFF Receptor mAb Treatment Ameliorates Development and Progression of Atherosclerosis in Hyperlipidemic ApoE−/− Mice

(2013) Tin Kyaw et al.   PLoS One

New Potential Therapeutic Approach for the Treatment of B-Cell Malignancies Using Chlorambucil/Hydroxychloroquine-Loaded Anti-CD20 Nanoparticles

(2013) Nelly Mezzaroba et al.   PLoS One

Expression of the B-Cell Receptor Component CD79a on Immature Myeloid Cells Contributes to Their Tumor Promoting Effects

(2013) Dror Luger et al.   PLoS One

PDL241, a novel humanized monoclonal antibody, reveals CD319 as a therapeutic target for rheumatoid arthritis

(2013) Jacky Woo et al.   ARTHRITIS RESEARCH & THERAPY

Gemcitabine-mediated tumour regression and p53-dependent gene expression: implications for colon and pancreatic cancer therapy

(2013) R Hill et al.   Cell Death & Disease

Quantum dots as a platform for nanoparticle drug delivery vehicle design

(2012) Christine E. Probst et al.   ADVANCED DRUG DELIVERY REVIEWS

Multivalent Porous Silicon Nanoparticles Enhance the Immune Activation Potency of Agonistic CD40 Antibody

(2012) Luo Gu et al.   ADVANCED MATERIALS

Simultaneous gene transduction and silencing using stimuli-responsive viral/nonviral chimeric nanoparticles

(2012) Soo Kyung Cho et al.   BIOMATERIALS

The B-cell receptor signaling pathway as a therapeutic target in CLL

(2012) J. A. Woyach et al.   BLOOD

The Akt signaling pathway

(2012) SubbaRao V. Madhunapantula et al.   CANCER BIOLOGY & THERAPY

Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation

(2012) Willemijn Hobo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A

(2012) Nikolaos Patsoukis et al.   CELL CYCLE

Mesoporous silica nanoparticles in biomedical applications

(2012) Zongxi Li et al.   CHEMICAL SOCIETY REVIEWS

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

(2012) Wahajuddin et al.   International Journal of Nanomedicine

Walterinnesia aegyptia venom combined with silica nanoparticles enhances the functioning of normal lymphocytes through PI3K/AKT, NFkappaB and ERK signaling

(2012) Gamal Badr et al.   Lipids in Health and Disease

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rituximab resistance

(2011) Andrew R. Rezvani et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies

(2011) W. Alduaij et al.   BLOOD

Recombinant human CD19-ligand protein as a potent anti-leukaemic agent

(2011) Fatih M. Uckun et al.   BRITISH JOURNAL OF HAEMATOLOGY

Current understanding of the role of B cell subsets and intimal and adventitial B cells in atherosclerosis

(2011) Tin Kyaw et al.   CURRENT OPINION IN LIPIDOLOGY

Therapeutic effects of TACI-Ig on collagen-induced arthritis by regulating T and B lymphocytes function in DBA/1 mice

(2011) Yunjie Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Downregulation of the B-cell receptor signaling component CD79b in plasma cell myeloma: A possible post transcriptional regulation

(2011) Xingang Huang et al.   PATHOLOGY INTERNATIONAL

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Co-stimulation and T cells as therapeutic targets

(2010) Alison M. Gizinski et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects

(2010) Hiroshi Maeda   BIOCONJUGATE CHEMISTRY

The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the E - TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling

(2010) M. Suljagic et al.   BLOOD

Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications

(2010) J. Löfblom et al.   FEBS LETTERS

B cell depletion reduces the development of atherosclerosis in mice

(2010) Hafid Ait-Oufella et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic Equilibrium of B7-1 Dimers and Monomers Differentially Affects Immunological Synapse Formation and T Cell Activation in Response to TCR/CD28 Stimulation

(2010) Sumeena Bhatia et al.   JOURNAL OF IMMUNOLOGY

Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis

(2010) T. Kyaw et al.   JOURNAL OF IMMUNOLOGY

CD22 Is a Recycling Receptor That Can Shuttle Cargo between the Cell Surface and Endosomal Compartments of B Cells

(2010) M. K. O'Reilly et al.   JOURNAL OF IMMUNOLOGY

The Complex Role of Multivalency in Nanoparticles Targeting the Transferrin Receptor for Cancer Therapies

(2010) Jin Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A pretargeted nanoparticle system for tumor cell labeling

(2010) Jonathan Gunn et al.   Molecular BioSystems

STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

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