The BAFF / APRIL system as therapeutic target in multiple sclerosis

Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis

(2019) Hans Lassmann   Frontiers in Immunology

B cell depletion with ublituximab reshapes the T cell profile in multiple sclerosis patients

(2019) Amy E. Lovett-Racke et al.   JOURNAL OF NEUROIMMUNOLOGY

Increase of CSF inflammatory profile in a case of highly active multiple sclerosis

(2019) R. Magliozzi et al.   BMC Neurology

Failed B cell survival factor trials support the importance of memory B cells in multiple sclerosis

(2019) D. Baker et al.   EUROPEAN JOURNAL OF NEUROLOGY

The predictive value of CSF multiple assay in multiple sclerosis: A single center experience

(2019) C. De Fino et al.   Multiple Sclerosis and Related Disorders

Iron homeostasis, complement, and coagulation cascade as CSF signature of cortical lesions in early multiple sclerosis

(2019) Roberta Magliozzi et al.   Annals of Clinical and Translational Neurology

Inflammatory intrathecal profiles and cortical damage in multiple sclerosis

(2018) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

(2018) Joana Machado-Santos et al.   BRAIN

MRI of cortical lesions and its use in studying their role in MS pathogenesis and disease course

(2018) R Magliozzi et al.   BRAIN PATHOLOGY

Reassessing B cell contributions in multiple sclerosis

(2018) Rui Li et al.   NATURE IMMUNOLOGY

The cortical damage, early relapses, and onset of the progressive phase in multiple sclerosis

(2018) Antonio Scalfari et al.   NEUROLOGY

Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus

(2018) David González-Serna et al.   Scientific Reports

B-Cell Therapies in Multiple Sclerosis

(2018) Joseph J. Sabatino et al.   Cold Spring Harbor Perspectives in Medicine

Learning from other autoimmunities to understand targeting of B cells to control multiple sclerosis

(2018) David Baker et al.   BRAIN

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis

(2018) Ivan Jelcic et al.   CELL

APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications

(2018) Yu-Tzu Tai et al.   LEUKEMIA

Shedding of BAFF/APRIL Receptors Controls B Cells

(2018) Edgar Meinl et al.   TRENDS IN IMMUNOLOGY

The role of APRIL - A proliferation inducing ligand - In autoimmune diseases and expectations from its targeting

(2018) Laurie Baert et al.   JOURNAL OF AUTOIMMUNITY

Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement

(2017) Elisabeth Schuh et al.   JOURNAL OF IMMUNOLOGY

B cells from patients with multiple sclerosis induce cell death via apoptosis in neurons in vitro

(2017) Robert P. Lisak et al.   JOURNAL OF NEUROIMMUNOLOGY

BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset

(2017) M. Puthenparampil et al.   Journal of Neuroinflammation

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis

(2017) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

(2017) Xavier Montalban et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overexpression of the Cytokine BAFF and Autoimmunity Risk

(2017) Maristella Steri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis

(2017) David Baker et al.   EBioMedicine

The chronically inflamed central nervous system provides niches for long-lived plasma cells

(2017) Karolin Pollok et al.   Acta Neuropathologica Communications

Effect of Treatment With Tabalumab, a B Cell-Activating Factor Inhibitor, on Highly Sensitized Patients With End-Stage Renal Disease Awaiting Transplantation

(2016) M. A. Mujtaba et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A proliferation inducing ligand (APRIL) promotes IL-10 production and regulatory functions of human B cells

(2016) Charlotte Hua et al.   JOURNAL OF AUTOIMMUNITY

Soluble BAFF Level Is Not Correlated to Mycobacterium avium Subspecies Paratuberculosis Antibodies and Increases After Interferon-β Therapy in Multiple Sclerosis Patients

(2016) Giuseppe Mameli et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

BAFF is decreased in the cerebrospinal fluid of multiple sclerosis at clinical onset

(2016) M. Puthenparampil et al.   JOURNAL OF NEUROIMMUNOLOGY

B Cell, Th17, and Neutrophil Related Cerebrospinal Fluid Cytokine/Chemokines Are Elevated in MOG Antibody Associated Demyelination

(2016) Kavitha Kothur et al.   PLoS One

Serum BAFF levels, Methypredsinolone therapy, Epstein-Barr Virus and Mycobacterium avium subsp. paratuberculosis infection in Multiple Sclerosis patients

(2016) Giuseppe Mameli et al.   Scientific Reports

Efficacy and safety of subcutaneous tabalumab in patients with systemic lupus erythematosus: results from ILLUMINATE-1, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study

(2015) D A Isenberg et al.   ANNALS OF THE RHEUMATIC DISEASES

ATON: Results from a Phase II randomized trial of the B-cell-targeting agent atacicept in patients with optic neuritis

(2015) Robert C. Sergott et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

BAFF Suppresses IL-15 Expression in B Cells

(2014) N. Ma et al.   JOURNAL OF IMMUNOLOGY

Atacicept in multiple sclerosis (ATAMS): a randomised, placebo-controlled, double-blind, phase 2 trial

(2014) Ludwig Kappos et al.   LANCET NEUROLOGY

The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity

(2013) Fabien B. Vincent et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cortical lesion load associates with progression of disability in multiple sclerosis

(2012) M. Calabrese et al.   BRAIN

BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosus

(2012) Fabien B Vincent et al.   IMMUNOLOGY AND CELL BIOLOGY

Cerebrospinal Fluid BAFF and APRIL Levels in Neuromyelitis Optica and Multiple Sclerosis Patients During Relapse

(2012) Honghao Wang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Antibodies Against Human BLyS and APRIL Attenuate EAE Development in Marmoset Monkeys

(2012) S. Anwar Jagessar et al.   Journal of Neuroimmune Pharmacology

The discovery and development of belimumab: the anti-BLyS–lupus connection

(2012) William Stohl et al.   NATURE BIOTECHNOLOGY

ANCA-stimulated neutrophils release BLyS and promote B cell survival: a clinically relevant cellular process

(2011) N. J. Holden et al.   ANNALS OF THE RHEUMATIC DISEASES

Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase II, randomized, placebo-controlled trial

(2011) R. F. van Vollenhoven et al.   ARTHRITIS AND RHEUMATISM

Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

(2011) Owain W. Howell et al.   BRAIN

Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid

(2011) Samia Ragheb et al.   Multiple Sclerosis Journal

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

Aberrant Expression of Functional BAFF-System Receptors by Malignant B-Cell Precursors Impacts Leukemia Cell Survival

(2011) Sara Maia et al.   PLoS One

Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4+ T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein

(2010) Christopher T. Harp et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses

(2010) Claudia Bossen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: Novel Function of B Cell-Activating Factor in the Induction of IL-10-Producing Regulatory B Cells

(2010) M. Yang et al.   JOURNAL OF IMMUNOLOGY

Cerebrospinal fluid levels of BAFF and APRIL in untreated multiple sclerosis

(2010) F. Piazza et al.   JOURNAL OF NEUROIMMUNOLOGY

B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B cell maturation antigen-immunoglobulin

(2010) Stacey R Dillon et al.   ARTHRITIS RESEARCH & THERAPY

Atacicept: targeting B cells in multiple sclerosis

(2010) Hans-Peter Hartung et al.   Therapeutic Advances in Neurological Disorders

Effect of interleukin-2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells

(2008) Katsuya Suzuki et al.   CYTOKINE

hsBAFF enhances activity of NK cells by regulation of CD4+ T lymphocyte function

(2008) W ZHANG et al.   IMMUNOLOGY LETTERS

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET