Crosslinking of CD38 Receptors Triggers Apoptosis of Malignant B Cells

Inhibition of Immunosuppressive Tumors by Polymer‐Assisted Inductions of Immunogenic Cell Death and Multivalent PD‐L1 Crosslinking

(2020) Lian Li et al.   ADVANCED FUNCTIONAL MATERIALS

Therapeutic potential of isatuximab in the treatment of multiple myeloma: Evidence to date

(2020) Joshua Richter et al.   SEMINARS IN ONCOLOGY

Overcoming resistance to rituximab in relapsed non-Hodgkin lymphomas by antibody-polymer drug conjugates actively targeted by anti-CD38 daratumumab

(2020) Ondřej Lidický et al.   JOURNAL OF CONTROLLED RELEASE

Say no to drugs: Bioactive macromolecular therapeutics without conventional drugs

(2020) Marie Rütter et al.   JOURNAL OF CONTROLLED RELEASE

Bioconjugated oligonucleotides: recent developments and therapeutic applications

(2019) sebastien benizri et al.   BIOCONJUGATE CHEMISTRY

Drug-free macromolecular therapeutics induce apoptosis in cells isolated from patients with B cell malignancies with enhanced apoptosis induction by pretreatment with gemcitabine

(2019) Jiawei Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

The Mechanism Of Action Of The Anti-CD38 Monoclonal Antibody Isatuximab In Multiple Myelmoa

(2019) Laura Moreno et al.   CLINICAL CANCER RESEARCH

Broadening and Enhancing Functions of Antibodies by Self-Assembling Multimerization at Cell Surface

(2019) Lian Li et al.   ACS Nano

Multivalent HER2-binding polymer conjugates facilitate rapid endocytosis and enhance intracellular drug delivery

(2019) D. Christopher Radford et al.   JOURNAL OF CONTROLLED RELEASE

Amplification of CD20 Cross-Linking in Rituximab-Resistant B-Lymphoma Cells Enhances Apoptosis Induction by Drug-Free Macromolecular Therapeutics

(2018) Lian Li et al.   ACS Nano

New insights in Type I and II CD20 antibody mechanisms-of-action with a panel of novel CD20 antibodies

(2018) Saskia Meyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Novel Immunoliposome Technology for Enhancing the Activity of the Agonistic Antibody against the Tumor Necrosis Factor Receptor Superfamily

(2018) Takako Niwa et al.   MOLECULAR PHARMACEUTICS

CD38 Antibodies in Multiple Myeloma: Mechanisms of Action and Modes of Resistance

(2018) Niels W.C.J. van de Donk et al.   Frontiers in Immunology

Daratumumab induces CD38 internalization and impairs myeloma cell adhesion

(2018) Jayeeta Ghose et al.   OncoImmunology

Biorecognition: A key to drug-free macromolecular therapeutics

(2018) Jiyuan Yang et al.   BIOMATERIALS

Drug-free albumin-triggered sensitization of cancer cells to anticancer drugs

(2018) Lian Li et al.   JOURNAL OF CONTROLLED RELEASE

Drug-free macromolecular therapeutics: Impact of structure on induction of apoptosis in Raji B cells

(2017) Libin Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Immunotherapy in hematologic malignancies: past, present, and future

(2017) Annie Im et al.   Journal of Hematology & Oncology

Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway

(2017) Lian Li et al.   MACROMOLECULAR BIOSCIENCE

FDA Approval Summary: Daratumumab for Treatment of Multiple Myeloma After One Prior Therapy

(2017) Vishal Bhatnagar et al.   ONCOLOGIST

A molecular perspective on rituximab: A monoclonal antibody for B cell non Hodgkin lymphoma and other affections

(2016) Narges Seyfizadeh et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Daratumumab: a first-in-class CD38 monoclonal antibody for the treatment of multiple myeloma

(2016) Larysa Sanchez et al.   Journal of Hematology & Oncology

The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor–Mediated Cross-Linking

(2016) Marije B. Overdijk et al.   JOURNAL OF IMMUNOLOGY

Super-Resolution Imaging and Quantitative Analysis of Membrane Protein/Lipid Raft Clustering Mediated by Cell-Surface Self-Assembly of Hybrid Nanoconjugates

(2015) Jonathan M. Hartley et al.   CHEMBIOCHEM

SAR650984 directly induces multiple myeloma cell death via lysosomal-associated and apoptotic pathways, which is further enhanced by pomalidomide

(2015) H Jiang et al.   LEUKEMIA

Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes

(2015) Paul R Moody et al.   MOLECULAR THERAPY

A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab

(2015) Te-Wei Chu et al.   Theranostics

Drug-free macromolecular therapeutics – a new paradigm in polymeric nanomedicines

(2015) Te-Wei Chu et al.   Biomaterials Science

Immunogenicity of coiled-coil based drug-free macromolecular therapeutics

(2014) Miloslav Kverka et al.   BIOMATERIALS

SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies

(2014) J. Deckert et al.   CLINICAL CANCER RESEARCH

Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies

(2011) W. Alduaij et al.   BLOOD

Coiled-coil based drug-free macromolecular therapeutics: In vivo efficacy

(2011) Kuangshi Wu et al.   JOURNAL OF CONTROLLED RELEASE

Drug-Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled-Coil-Mediated Cross-Linking of Antigens on the Cell Surface

(2010) Kuangshi Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An experimental and theoretical evaluation of the influence of pretargeting antibody on the tumor accumulation of effector

(2008) G. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

(2008) J. I. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA