A Novel Progress: Glial Cells and Inflammatory Pain

Docosahexaenoic fatty acid reduces the pro‐inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation

(2021) Emilia Zgórzyńska et al.   BMC NEUROSCIENCE

Neuregulin1-ErbB4 Signaling in Spinal Cord Participates in Electroacupuncture Analgesia in Inflammatory Pain

(2021) Chaofan Wan et al.   Frontiers in Neuroscience

Olig2 regulates p53-mediated apoptosis, migration and invasion of melanoma cells

(2021) Ji Eun Lee et al.   Scientific Reports

Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective

(2021) Patrycja Mulica et al.   Frontiers in Endocrinology

Involvement of Opioid System and TRPM8/TRPA1 Channels in the Antinociceptive Effect of Spirulina platensis

(2021) Mariana A. Freitas et al.   Biomolecules

Immunomodulatory Effect of Microglia-Released Cytokines in Gliomas

(2021) Marika Lanza et al.   Brain Sciences

The Participation of Microglia in Neurogenesis: A Review

(2021) Diego R. Pérez-Rodríguez et al.   Brain Sciences

CY-09 Inhibits NLRP3 Inflammasome Activation to Relieve Pain via TRPA1

(2021) Youjia Fan et al.   Computational and Mathematical Methods in Medicine

HSF1 is involved in suppressing A1 phenotype conversion of astrocytes following spinal cord injury in rats

(2021) Lilan Li et al.   Journal of Neuroinflammation

Microglia, Cytokines, and Neural Activity: Unexpected Interactions in Brain Development and Function

(2021) Austin Ferro et al.   Frontiers in Immunology

Astrocyte-Neuron Signaling in Synaptogenesis

(2021) Lili Shan et al.   Frontiers in Cell and Developmental Biology

Melatonin Ameliorates Axonal Hypomyelination of Periventricular White Matter by Transforming A1 to A2 Astrocyte via JAK2/STAT3 Pathway in Septic Neonatal Rats

(2021) Shuqi Jiang et al.   Journal of Inflammation Research

Silencing of PTX3 alleviates LPS-induced inflammatory pain by regulating TLR4/NF-κB signaling pathway in mice

(2020) Shuang Qi et al.   BIOSCIENCE REPORTS

Glutamate Transporters and Mitochondria: Signaling, Co-compartmentalization, Functional Coupling, and Future Directions

(2020) Michael B. Robinson et al.   NEUROCHEMICAL RESEARCH

Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes

(2020) Abdullah Al Mamun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effects of Leukocyte-Platelet Rich Fibrin (L-PRF) on Suppression of the Expressions of the Pro-Inflammatory Cytokines, and Proliferation of Schwann Cell, and Neurotrophic Factors

(2020) Zhanqi Wang et al.   Scientific Reports

Paricalcitol improves experimental autoimmune encephalomyelitis (EAE) by suppressing inflammation via NF-κB signaling

(2020) Dangfeng Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury

(2020) Gianluigi Nocera et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4/JAK2-STAT3 pathway and NLRP3 inflammasome

(2020) Shanshan Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hemokinin-1 Gene Expression Is Upregulated in Trigeminal Ganglia in an Inflammatory Orofacial Pain Model: Potential Role in Peripheral Sensitization

(2020) Timea Aczél et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Fatal Alliance between Microglia, Inflammasomes, and Central Pain

(2020) Stefanie Hoffmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunomodulatory and anti-oxidative effect of the direct TRPV1 receptor agonist capsaicin on Schwann cells

(2020) Thomas Grüter et al.   Journal of Neuroinflammation

TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain

(2020) Shih-Ping Dai et al.   Journal of Neuroinflammation

Bone marrow mesenchymal stem cells upregulate PI3K/AKT pathway and down-regulate NF-κB pathway by secreting glial cell-derived neurotrophic factors to regulate microglial polarization and alleviate deafferentation pain in rats

(2020) Zhenzhong Zhong et al.   NEUROBIOLOGY OF DISEASE

Interleukin-1 receptor antagonist ameliorates the pain hypersensitivity, spinal inflammation and oxidative stress induced by systemic lipopolysaccharide in neonatal rats

(2020) Cheng-Ta Hsieh et al.   NEUROCHEMISTRY INTERNATIONAL

G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

(2020) Paulo Kofuji et al.   NEUROSCIENCE

Botulinum toxin type A promotes microglial M2 polarization and suppresses chronic constriction injury-induced neuropathic pain through the P2X7 receptor

(2020) Xianwei Gui et al.   Cell and Bioscience

Peripheral Inflammatory Hyperalgesia Depends on P2X7 Receptors in Satellite Glial Cells

(2020) Amanda Ferreira Neves et al.   Frontiers in Physiology

Mitochondrial bioenergetics, glial reactivity and pain-related behavior can be restored by dichloroacetate treatment in rodent pain models

(2020) Valentina Lagos-Rodríguez et al.   PAIN

Luteoloside Exerts Analgesic Effect in a Complete Freund’s Adjuvant-Induced Inflammatory Model via Inhibiting Interleukin-1β Expression and Macrophage/Microglia Activation

(2020) Chun-Yan Shi et al.   Frontiers in Pharmacology

Microglia: sculptors of neuropathic pain?

(2020) Harry Ward et al.   Royal Society Open Science

TLR Antagonism by Sparstolonin B Alters Microbial Signature and Modulates Gastrointestinal and Neuronal Inflammation in Gulf War Illness Preclinical Model

(2020) Dipro Bose et al.   Brain Sciences

Anti-inflammatory signaling through G protein-coupled receptors

(2020) Yun-jun Ge et al.   ACTA PHARMACOLOGICA SINICA

Aquaporin 4 is involved in chronic pain but not acute pain

(2020) Guanyi Lu et al.   BEHAVIOURAL BRAIN RESEARCH

TRPA1 as a therapeutic target for nociceptive pain

(2020) Daniel Souza Monteiro de Araujo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy

(2020) Xinyu Li et al.   Oxidative Medicine and Cellular Longevity

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

Astrocytic Calcium Dynamics Along the Pain Pathway

(2020) Jeiwon Cho et al.   Frontiers in Cellular Neuroscience

Sensory satellite glial Gq-GPCR activation alleviates inflammatory pain via peripheral adenosine 1 receptor activation

(2020) Alison Xiaoqiao Xie et al.   Scientific Reports

Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation

(2020) Yu-Chi Cheng et al.   Cells

Schwann Cell-Like Cells: Origin and Usability for Repair and Regeneration of the Peripheral and Central Nervous System

(2020) Alois Hopf et al.   Cells

The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases

(2020) Tahereh Gharbi et al.   Frontiers in Cell and Developmental Biology

The Role of Satellite Glial Cells, Astrocytes, and Microglia in Oxaliplatin-Induced Neuropathic Pain

(2020) Ji Hwan Lee et al.   Biomedicines

2-Bromopalmitate attenuates inflammatory pain by maintaining mitochondrial fission/fusion balance and function

(2020) Min Xie et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

From astrocytes to satellite glial cells and back: A 25 year-long journey through the purinergic modulation of glial functions in pain and more

(2020) Stefania Ceruti   BIOCHEMICAL PHARMACOLOGY

Morphological and functional characteristics of satellite glial cells in the peripheral nervous system

(2020) A. Milosavljević et al.   FOLIA MORPHOLOGICA

The Neuroimmunology of Chronic Pain: From Rodents to Humans

(2020) Peter M. Grace et al.   JOURNAL OF NEUROSCIENCE

IL-1β Induced Cytokine Expression by Spinal Astrocytes Can Play a Role in the Maintenance of Chronic Inflammatory Pain

(2020) Andrea Gajtkó et al.   Frontiers in Physiology

Neuron-Astrocyte Interactions in Parkinson’s Disease

(2020) Ikuko Miyazaki et al.   Cells

Thymosin Alpha-1 Inhibits Complete Freund’s Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord

(2019) Yunlong Xu et al.   Neuroscience Bulletin

The Success and Failure of the Schwann Cell Response to Nerve Injury

(2019) Kristjan R. Jessen et al.   Frontiers in Cellular Neuroscience

Proteomics analysis of Schwann cell-derived exosomes: a novel therapeutic strategy for central nervous system injury

(2019) Zhijian Wei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Intrathecal triamcinolone acetonide exerts anti-inflammatory effects on Lewis rat experimental autoimmune neuritis and direct anti-oxidative effects on Schwann cells

(2019) Kalliopi Pitarokoili et al.   Journal of Neuroinflammation

Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice

(2019) Norimitsu Morioka et al.   BRAIN BEHAVIOR AND IMMUNITY

Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing

(2019) Annemarie Dedek et al.   BRAIN

Chronic pain: a review of its epidemiology and associated factors in population-based studies

(2019) Sarah E.E. Mills et al.   BRITISH JOURNAL OF ANAESTHESIA

Thymulin treatment attenuates inflammatory pain by modulating spinal cellular and molecular signaling pathways

(2019) Behzad Nasseri et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling

(2019) Takuya Kameda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

P2Y 14 receptor is functionally expressed in satellite glial cells and mediates interleukin‐1β and chemokine CCL2 secretion

(2019) Jiu Lin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anxiolytic effects of Formononetin in an inflammatory pain mouse model

(2019) Xin-shang Wang et al.   Molecular Brain

A Bcr-Abl Inhibitor GNF-2 Attenuates Inflammatory Activation of Glia and Chronic Pain

(2019) Gyun Jee Song et al.   Frontiers in Pharmacology

GABAB receptor activation attenuates inflammatory orofacial pain by modulating interleukin-1β in satellite glial cells: Role of NF-κB and MAPK signaling pathways

(2019) Fei Liu et al.   BRAIN RESEARCH BULLETIN

The CCL2 elevation in primary afferent fibers produces zymosan-induced hyperalgesia through microglia-mediated neuronal activation in the spinal dorsal horn

(2019) Sungkun Chun et al.   BRAIN RESEARCH BULLETIN

Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States

(2019) Seoyon Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An update on reactive astrocytes in chronic pain

(2019) Ting Li et al.   Journal of Neuroinflammation

Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain

(2019) Yanyan Zhang et al.   International Journal of Oral Science

Annexin-1 Mimetic Peptide Ac2-26 Suppresses Inflammatory Mediators in LPS-Induced Astrocytes and Ameliorates Pain Hypersensitivity in a Rat Model of Inflammatory Pain

(2019) Zhenzhao Luo et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Activated spinal astrocytes contribute to the later phase of carrageenan-induced prostatitis pain

(2019) Guo-Chuang Deng et al.   Journal of Neuroinflammation

Oligodendrocytes in Development, Myelin Generation and Beyond

(2019) Sarah Kuhn et al.   Cells

Activated Schwann cells and increased inflammatory cytokines IL‐1β, IL‐6, and TNF‐α in patients' sural nerve are lack of tight relationship with specific sensory disturbances in Parkinson's disease

(2019) Hui Zhang et al.   CNS Neuroscience & Therapeutics

The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain

(2019) Jiu Lin et al.   NEUROCHEMISTRY INTERNATIONAL

Expressions of spinal microglia activation, BDNF, and DREAM proteins correlated with formalin-induced nociceptive responses in painful and painless diabetic neuropathy rats

(2019) Che Aishah Nazariah Ismail et al.   NEUROPEPTIDES

Botulinum toxin type A ameliorates adjuvant-arthritis pain by inhibiting microglial activation-mediated neuroinflammation and intracellular molecular signaling

(2019) Xiaojuan Shi et al.   TOXICON

Human visceral nociception: findings from translational studies in human tissue

(2018) James R F Hockley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Stem cells from human apical papilla decrease neuro-inflammation and stimulate oligodendrocyte progenitor differentiation via activin-A secretion

(2018) Pauline De Berdt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Paeoniflorin Attenuates Inflammatory Pain by Inhibiting Microglial Activation and Akt-NF-κB Signaling in the Central Nervous System

(2018) Bo Hu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Molecular Targets and Natural Compounds in Drug Development for the Treatment of Inflammatory Pain

(2018) Anna Woodbury et al.   CURRENT DRUG TARGETS

Ecto-5′-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice

(2018) Shun Xu et al.   Journal of Neuroinflammation

Characterization of rat primary trigeminal satellite glial cells and associated extracellular vesicles under normal and inflammatory conditions

(2018) Hye Sook Han Vinterhøj et al.   Journal of Proteomics

Long non‑coding RNA BC168687 small interfering RNA reduces high glucose and high free fatty acid‑induced expression of P2X7 receptors in satellite glial cells

(2018) Cheng‑Long Liu et al.   Molecular Medicine Reports

Glial cell type-specific changes in spinal dipeptidyl peptidase 4 expression and effects of its inhibitors in inflammatory and neuropatic pain

(2018) Kornél Király et al.   Scientific Reports

Elevation of the Chemokine Pair CXCL10/CXCR3 Initiates Sequential Glial Activation and Crosstalk During the Development of Bimodal Inflammatory Pain after Spinal Cord Ischemia Reperfusion

(2018) Qian Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Micronized palmitoylethanolamide reduces joint pain and glial cell activation

(2018) Maria Lavinia Bartolucci et al.   INFLAMMATION RESEARCH

Inhibition of lncRNA X inactivate-specific transcript ameliorates inflammatory pain by suppressing satellite glial cell activation and inflammation by acting as a sponge of miR-146a to inhibit Nav 1.7

(2018) Wenbo Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The analgesic effect and possible mechanisms by which koumine alters type II collagen-induced arthritis in rats

(2018) Gui-Lin Jin et al.   Journal of Natural Medicines

CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways

(2018) Yongyang Tian et al.   Molecular Medicine Reports

A model of neuropathic pain in brachial plexus avulsion injury and associated spinal glial cell activation

(2018) Ao-Lin Hou et al.   Journal of Pain Research

Nicotinic acetylcholine receptors in neuropathic and inflammatory pain

(2017) Arik J. Hone et al.   FEBS LETTERS

Regulation of mitochondrial dynamics in astrocytes: Mechanisms, consequences, and unknowns

(2017) Joshua G. Jackson et al.   GLIA

Role of Neuron-Glial Interaction Mediated by IL-1β in Ectopic Tooth Pain

(2017) H. Komiya et al.   JOURNAL OF DENTAL RESEARCH

Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes

(2017) Gang Chen et al.   Neuroscience Bulletin

Neuronal Interleukin-4 as a Modulator of Microglial Pathways and Ischemic Brain Damage

(2015) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice

(2014) Simon Gritsch et al.   Nature Communications

Potassium Channels as a Potential Therapeutic Target for Trigeminal Neuropathic and Inflammatory Pain

(2011) Mamoru Takeda et al.   Molecular Pain