Schwann Cell-Like Cells: Origin and Usability for Repair and Regeneration of the Peripheral and Central Nervous System

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

(2020) Jarred M Griffin et al.   EMBO Molecular Medicine

Five Decades Later, Are Mesenchymal Stem Cells Still Relevant?

(2020) Mario Gomez-Salazar et al.   Frontiers in Bioengineering and Biotechnology

Transplantation of Skin Precursor-Derived Schwann Cells Yields Better Locomotor Outcomes and Reduces Bladder Pathology in Rats with Chronic Spinal Cord Injury

(2020) Peggy Assinck et al.   Stem Cell Reports

The Success and Failure of the Schwann Cell Response to Nerve Injury

(2019) Kristjan R. Jessen et al.   Frontiers in Cellular Neuroscience

Immunosuppressive mechanisms for stem cell transplant survival in spinal cord injury

(2019) Joseph P. Antonios et al.   Neurosurgical Focus

First decade of clinical trials and published studies with mesenchymal stromal cells from umbilical cord tissue

(2019) Pedro S Couto et al.   Regenerative Medicine

Engineered substrates with imprinted cell-like topographies induce direct differentiation of adipose-derived mesenchymal stem cells into Schwann cells

(2019) Mehrdad Moosazadeh Moghaddam et al.   Artificial Cells Nanomedicine and Biotechnology

Differentiated human adipose-derived stromal cells exhibit the phenotypic and functional characteristics of mature Schwann cells through a modified approach

(2019) YU KANG et al.   CYTOTHERAPY

The Effect of Wharton Jelly-Derived Mesenchymal Stromal Cells and Their Conditioned Media in the Treatment of a Rat Spinal Cord Injury

(2019) Milada Chudickova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation

(2018) Ana Patricia Ayala-Cuellar et al.   Biomolecules & Therapeutics

The Effect of Human Mesenchymal Stem Cells Derived from Wharton’s Jelly in Spinal Cord Injury Treatment Is Dose-Dependent and Can Be Facilitated by Repeated Application

(2018) Petr Krupa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regenerative effects of human embryonic stem cell-derived neural crest cells for treatment of peripheral nerve injury

(2018) Iwan Jones et al.   Journal of Tissue Engineering and Regenerative Medicine

Differentiation of adipose-derived stem cells into Schwann cell-like cells through intermittent induction: potential advantage of cellular transient memory function

(2018) Xun Sun et al.   Stem Cell Research & Therapy

The Human Skin-Derived Precursors for Regenerative Medicine: Current State, Challenges, and Perspectives

(2018) Ru Dai et al.   Stem Cells International

Regeneration of peripheral nerves by nerve guidance conduits: Influence of design, biopolymers, cells, growth factors, and physical stimuli

(2018) M.D. Sarker et al.   PROGRESS IN NEUROBIOLOGY

Stem cells purified from human induced pluripotent stem cell-derived neural crest-like cells promote peripheral nerve regeneration

(2018) Hiroo Kimura et al.   Scientific Reports

Injury-induced perivascular niche supports alternative differentiation of adult rodent CNS progenitor cells

(2018) Justyna Ulanska-Poutanen et al.   eLife

Role of bone marrow derived mesenchymal stromal cells and Schwann-like cells transplantation on spinal cord injury in adult male albino rats

(2018) Rania A. Galhom et al.   BIOMEDICINE & PHARMACOTHERAPY

Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury

(2017) Peggy Assinck et al.   JOURNAL OF NEUROSCIENCE

Safety of Autologous Human Schwann Cell Transplantation in Subacute Thoracic Spinal Cord Injury

(2017) Kim D. Anderson et al.   JOURNAL OF NEUROTRAUMA

Quantitative Multimodal Evaluation of Passaging Human Neural Crest Stem Cells for Peripheral Nerve Regeneration

(2017) Jian Du et al.   Stem Cell Reviews and Reports

Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells

(2017) Pietro Giuseppe Mazzara et al.   Nature Communications

Electrical Differentiation of Mesenchymal Stem Cells into Schwann-Cell-Like Phenotypes Using Inkjet-Printed Graphene Circuits

(2017) Suprem R. Das et al.   Advanced Healthcare Materials

Direct Conversion of Human Fibroblasts into Schwann Cells that Facilitate Regeneration of Injured Peripheral Nerve In Vivo

(2017) Yoshihiro Sowa et al.   Stem Cells Translational Medicine

Quantitative Multimodal Evaluation of Passaging Human Neural Crest Stem Cells for Peripheral Nerve Regeneration

(2017) Jian Du et al.   Stem Cell Reviews and Reports

Roles of Mesenchymal Stem Cells in Spinal Cord Injury

(2017) Jing Qu et al.   Stem Cells International

Directed Differentiation of Human Bone Marrow Stromal Cells to Fate-Committed Schwann Cells

(2017) Sa Cai et al.   Stem Cell Reports

Schwann Cell Precursors from Human Pluripotent Stem Cells as a Potential Therapeutic Target for Myelin Repair

(2017) Han-Seop Kim et al.   Stem Cell Reports

Oriented growth and transdifferentiation of mesenchymal stem cells towards a Schwann cell fate on micropatterned substrates

(2016) Anup D. Sharma et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Efficacy of Schwann cell transplantation for spinal cord repair is improved with combinatorial strategies

(2016) Mary Bartlett Bunge   JOURNAL OF PHYSIOLOGY-LONDON

A Phase III Clinical Trial Showing Limited Efficacy of Autologous Mesenchymal Stem Cell Therapy for Spinal Cord Injury

(2016) Sun Kyu Oh et al.   NEUROSURGERY

A Modified Approach to Inducing Bone Marrow Stromal Cells to Differentiate into Cells with Mature Schwann Cell Phenotypes

(2016) Yutian Liu et al.   STEM CELLS AND DEVELOPMENT

A rapid and versatile method for the isolation, purification and cryogenic storage of Schwann cells from adult rodent nerves

(2016) Natalia D. Andersen et al.   Scientific Reports

Astrocyte Activation via Stat3 Signaling Determines the Balance of Oligodendrocyte versus Schwann Cell Remyelination

(2015) Glaucia Monteiro de Castro et al.   AMERICAN JOURNAL OF PATHOLOGY

Neural stem cell differentiation by electrical stimulation using a cross-linked PEDOT substrate: Expanding the use of biocompatible conjugated conductive polymers for neural tissue engineering

(2015) Filipa Pires et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve

(2015) Melanie Georgiou et al.   BIOMATERIALS

Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves

(2015) Anne-Laure Cattin et al.   CELL

Human epidermal neural crest stem cells as a source of Schwann cells

(2015) M. Sakaue et al.   DEVELOPMENT

Human Schwann-like cells derived from adipose-derived mesenchymal stem cells rapidly de-differentiate in the absence of stimulating medium

(2015) Alessandro Faroni et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Schwann Cells Generated from Neonatal Skin-Derived Precursors or Neonatal Peripheral Nerve Improve Functional Recovery after Acute Transplantation into the Partially Injured Cervical Spinal Cord of the Rat

(2015) J. S. Sparling et al.   JOURNAL OF NEUROSCIENCE

Direct conversion of human fibroblasts into functional osteoblasts by defined factors

(2015) Kenta Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrical Stimulation Using Conductive Polymer Polypyrrole Promotes Differentiation of Human Neural Stem Cells: A Biocompatible Platform for Translational Neural Tissue Engineering

(2015) Elise Stewart et al.   TISSUE ENGINEERING PART C-METHODS

Schwann Cells: Development and Role in Nerve Repair

(2015) Kristján R. Jessen et al.   Cold Spring Harbor Perspectives in Biology

Wharton’s Jelly Derived Mesenchymal Stem Cells: Future of Regenerative Medicine? Recent Findings and Clinical Significance

(2015) Ilona Kalaszczynska et al.   Biomed Research International

Intermittent electrical stimuli for guidance of human mesenchymal stem cell lineage commitment towards neural-like cells on electroconductive substrates

(2014) Greeshma Thrivikraman et al.   BIOMATERIALS

Skin derived precursor Schwann cells improve behavioral recovery for acute and delayed nerve repair

(2014) Helene T. Khuong et al.   EXPERIMENTAL NEUROLOGY

Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury

(2014) Hongbin Cheng et al.   Journal of Translational Medicine

Differentiation of Schwann-like cells from human umbilical cord blood mesenchymal stem cells in vitro

(2014) YU-ZHOU XIAO et al.   Molecular Medicine Reports

Peripheral Nerve Injury Modulates Neurotrophin Signaling in the Peripheral and Central Nervous System

(2014) Mette Richner et al.   MOLECULAR NEUROBIOLOGY

miR-21 promotes the differentiation of hair follicle-derived neural crest stem cells into Schwann cells

(2014) Yanmin Zhou et al.   Neural Regeneration Research

Pluripotent Stem Cells for Schwann Cell Engineering

(2014) Ming-San Ma et al.   Stem Cell Reviews and Reports

Human umbilical cord blood-derived mesenchymal stem cell transplantation for the treatment of spinal cord injury

(2014) BINGZHOU CUI et al.   Experimental and Therapeutic Medicine

Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury

(2014) Marcus Vinícius Mendonça et al.   Stem Cell Research & Therapy

Direct Genesis of Functional Rodent and Human Schwann Cells from Skin Mesenchymal Precursors

(2014) Matthew P. Krause et al.   Stem Cell Reports

Combining Neurotrophin-Transduced Schwann Cells and Rolipram to Promote Functional Recovery from Subacute Spinal Cord Injury

(2013) Govinder Flora et al.   CELL TRANSPLANTATION

Tissue engineered constructs for peripheral nerve surgery

(2013) P. J. Johnson et al.   European Surgery-Acta Chirurgica Austriaca

Schwann cells differentiated from adipose-derived stem cells for the treatment of brain contusion

(2013) LIANG YANG et al.   Molecular Medicine Reports

Electromagnetic fields induce neural differentiation of human bone marrow derived mesenchymal stem cells via ROS mediated EGFR activation

(2013) Jeong-Eun Park et al.   NEUROCHEMISTRY INTERNATIONAL

Glial differentiation of human adipose-derived stem cells: Implications for cell-based transplantation therapy

(2013) K. Tomita et al.   NEUROSCIENCE

Stimulating the Neurotrophic and Angiogenic Properties of Human Adipose-Derived Stem Cells Enhances Nerve Repair

(2013) Paul J. Kingham et al.   STEM CELLS AND DEVELOPMENT

Differentiation of adipose-derived stem cells into Schwann cell phenotype induces expression of P2X receptors that control cell death

(2013) A Faroni et al.   Cell Death & Disease

Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles

(2013) Ruifeng Yang et al.   Jove-Journal of Visualized Experiments

Multipotent stem cells are effectively collected from adult human cheek skin

(2012) Katsuhiro Yoshikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel niche for skin derived precursors in non-follicular skin

(2012) Martin Ruetze et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Expression of Functional γ-Aminobutyric Acid Type A Receptors in Schwann-Like Adult Stem Cells

(2012) Alessandro Faroni et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Differentiated adipose-derived stem cells promote myelination and enhance functional recovery in a rat model of chronic denervation

(2012) Koichi Tomita et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cartilage graft engineering by co-culturing primary human articular chondrocytes with human bone marrow stromal cells

(2012) Maria Antonietta Sabatino et al.   Journal of Tissue Engineering and Regenerative Medicine

Extracellular Matrix Molecules Enhance the Neurotrophic Effect of Schwann Cell-Like Differentiated Adipose-Derived Stem Cells and Increase Cell Survival Under Stress Conditions

(2012) Pietro G. di Summa et al.   TISSUE ENGINEERING PART A

Human Neural Crest Stem Cells Derived from Human ESCs and Induced Pluripotent Stem Cells: Induction, Maintenance, and Differentiation into Functional Schwann Cells

(2012) Qiuyue Liu et al.   Stem Cells Translational Medicine

Schwann-like mesenchymal stem cells within vein graft facilitate facial nerve regeneration and remyelination

(2011) Xuemei Wang et al.   BRAIN RESEARCH

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53

(2011) G Melino   CELL DEATH AND DIFFERENTIATION

Anatomical site influences the differentiation of adipose-derived stem cells for Schwann-cell phenotype and function

(2011) Rossukon Kaewkhaw et al.   GLIA

Differentiated and undifferentiated adipose-derived stem cells improve function in rats with peripheral nerve gaps

(2011) Hakan Orbay et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Long-term in vivo regeneration of peripheral nerves through bioengineered nerve grafts

(2011) P.G. di Summa et al.   NEUROSCIENCE

Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors

(2011) W. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Epidermal Neural Crest Stem Cells (hEPI-NCSC)—Characterization and Directed Differentiation into Osteocytes and Melanocytes

(2011) Oliver Clewes et al.   Stem Cell Reviews and Reports

Safety of Intravenous Infusion of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Animals and Humans

(2011) Jeong Chan Ra et al.   STEM CELLS AND DEVELOPMENT

Anti-Nogo on the go: from animal models to a clinical trial

(2010) Björn Zörner et al.   Annals of the New York Academy of Sciences

In vitro effects of direct current electric fields on adipose-derived stromal cells

(2010) Kyle E. Hammerick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human umbilical cord Wharton's jelly-derived mesenchymal stem cells differentiate into a Schwann-cell phenotype and promote neurite outgrowth in vitro

(2010) Jiang Peng et al.   BRAIN RESEARCH BULLETIN

Directed Stem Cell Differentiation: The Role of Physical Forces

(2010) Kelly C. Clause et al.   CELL COMMUNICATION AND ADHESION

Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function

(2010) Yasuyuki Amoh et al.   CELL CYCLE

CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

(2010) Malgorzata Zawadzka et al.   Cell Stem Cell

Bone marrow-derived Schwann cells achieve fate commitment – a prerequisite for remyelination therapy

(2010) Graham K.H. Shea et al.   EXPERIMENTAL NEUROLOGY

Emerging functions of myelin-associated proteins during development, neuronal plasticity, and neurodegeneration

(2010) Franc Llorens et al.   FASEB JOURNAL

Human mesenchymal stem cell-derived Schwann cell-like cells exhibit neurotrophic effects, via distinct growth factor production, in a model of spinal cord injury

(2010) Hwan-Woo Park et al.   GLIA

Human Hair Follicles: “Bulging” with Neural Crest–Like Stem Cells

(2010) Jeff Biernaskie   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Human Umbilical Cord-Derived Mesenchymal Stromal Cells Differentiate Into Functional Schwann Cells That Sustain Peripheral Nerve Regeneration

(2010) Dai Matsuse et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury

(2010) Wolfram Tetzlaff et al.   JOURNAL OF NEUROTRAUMA

The Influence of Electric Fields on Hippocampal Neural Progenitor Cells

(2010) Carlos Atico Ariza et al.   Stem Cell Reviews and Reports

Epidermal Neural Crest Stem Cell (EPI-NCSC)—Mediated Recovery of Sensory Function in a Mouse Model of Spinal Cord Injury

(2010) Yao Fei Hu et al.   Stem Cell Reviews and Reports

Efficient Generation of Schwann Cells from Human Embryonic Stem Cell-Derived Neurospheres

(2010) Lina Ziegler et al.   Stem Cell Reviews and Reports

Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion

(2009) Isabelle Pineau et al.   BRAIN BEHAVIOR AND IMMUNITY

SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

(2009) Jeffrey Biernaskie et al.   Cell Stem Cell

Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral-nerve injury: An advantageous alternative to ES and iPS cells

(2009) Yasuyuki Amoh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Multipotent nestin-expressing hair follicle stem cells

(2009) Yasuyuki AMOH et al.   JOURNAL OF DERMATOLOGY

Adipose-derived stem cells enhance peripheral nerve regeneration

(2009) P.G. di Summa et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Epidermal homeostasis: a balancing act of stem cells in the skin

(2009) Cédric Blanpain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Umbilical cord blood cell-derived neurospheres differentiate into Schwann-like cells

(2009) Hong-Tian Zhang et al.   NEUROREPORT

Combinatorial strategies with Schwann cell transplantation to improve repair of the injured spinal cord

(2009) Jenny Fortun et al.   NEUROSCIENCE LETTERS

Characterisation of human mesenchymal stem cells following differentiation into Schwann cell-like cells

(2009) Maria Brohlin et al.   NEUROSCIENCE RESEARCH

ROLE OF CHRONIC SCHWANN CELL DENERVATION IN POOR FUNCTIONAL RECOVERY AFTER NERVE INJURIES AND EXPERIMENTAL STRATEGIES TO COMBAT IT

(2009) Olawale A.R. Sulaiman et al.   NEUROSURGERY

PA6-induced human embryonic stem cell-derived neurospheres: a new source of human peripheral sensory neurons and neural crest cells

(2008) Oz Pomp et al.   BRAIN RESEARCH

Schwann Cell Transplantation for CNS Repair

(2008) R. Matsas et al.   CURRENT MEDICINAL CHEMISTRY

Bridging Critical Nerve Defects through an Acellular Homograft Seeded with Autologous Schwann Cells Obtained from a Regeneration Neuroma of the Proximal Stump

(2008) Oskar Aszmann et al.   JOURNAL OF RECONSTRUCTIVE MICROSURGERY

Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation

(2008) Rhona Mirsky et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

(2008) A. Buffo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical issues of clinical human embryonic stem cell therapy for brain repair

(2008) Jia-Yi Li et al.   TRENDS IN NEUROSCIENCES

Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm

(2007) Joseph R. Smith et al.   DEVELOPMENTAL BIOLOGY