Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy

GDNF, A Neuron-Derived Factor Upregulated in Glial Cells during Disease

(2020) Marcelo Duarte Azevedo et al.   Journal of Clinical Medicine

Exogenous activation of cannabinoid-2 receptor modulates TLR4/MMP9 expression in a spinal cord ischemia reperfusion rat model

(2020) Na Jing et al.   Journal of Neuroinflammation

Sonic hedgehog signaling is negatively regulated in reactive astrocytes after forebrain stab injury

(2019) R. Vivian Allahyari et al.   Scientific Reports

Silencing miR-21 induces polarization of astrocytes to the A2 phenotype and improves the formation of synapses by targeting glypican 6 via the signal transducer and activator of transcription-3 pathway after acute ischemic spinal cord injury

(2019) Yanlin Su et al.   FASEB JOURNAL

An update on reactive astrocytes in chronic pain

(2019) Ting Li et al.   Journal of Neuroinflammation

Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma

(2019) Dieter Henrik Heiland et al.   Nature Communications

The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A

(2019) Yuan Huang et al.   Frontiers in Neuroscience

Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma

(2019) Julian Wurm et al.   Cancers

Selective Modulation of A1 Astrocytes by Drug-Loaded Nano-Structured Gel in Spinal Cord Injury

(2019) Irma Vismara et al.   ACS Nano

Bestrophin1‐mediated tonic GABA release from reactive astrocytes prevents the development of seizure‐prone network in kainate‐injected hippocampi

(2019) Sudip Pandit et al.   GLIA

Polarization of Reactive Astrocytes in Response to Spinal Cord Injury is Enhanced by M2 Macrophage–Mediated Activation of Wnt/β-Catenin Pathway

(2019) Iki Sonn et al.   MOLECULAR NEUROBIOLOGY

microRNA-21 regulates astrocytic reaction post-acute phase of spinal cord injury through modulating TGF-β signaling

(2018) Ronghan Liu et al.   Aging-US

Astrocytes in primary cultures express serine racemase, synthesize d -serine and acquire A1 reactive astrocyte features

(2018) Suyan Li et al.   BIOCHEMICAL PHARMACOLOGY

Comparison of subacute and chronic scar tissues after complete spinal cord transection

(2018) Xing Li et al.   EXPERIMENTAL NEUROLOGY

Astrocyte truncated-TrkB mediates BDNF antiapoptotic effect leading to neuroprotection

(2018) Julieta Saba et al.   JOURNAL OF NEUROCHEMISTRY

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

(2018) Neibla Priego et al.   NATURE MEDICINE

Astrocyte reactivity and astrogliosis after spinal cord injury

(2018) Seiji Okada et al.   NEUROSCIENCE RESEARCH

The Biology of Regeneration Failure and Success After Spinal Cord Injury

(2018) Amanda Phuong Tran et al.   PHYSIOLOGICAL REVIEWS

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive Astrocytes as Drug Target in Alzheimer’s Disease

(2018) Brhane Teklebrhan Assefa et al.   Biomed Research International

Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

(2018) Atsushi Fujita et al.   Journal of Neuroinflammation

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Cell biology of spinal cord injury and repair

(2017) Timothy M. O’Shea et al.   JOURNAL OF CLINICAL INVESTIGATION

Astrocyte dysfunction in Alzheimer disease

(2017) Crystal Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Central Nervous System Injury and Nicotinamide Adenine Dinucleotide Phosphate Oxidase: Oxidative Stress and Therapeutic Targets

(2017) Ramona E. von Leden et al.   JOURNAL OF NEUROTRAUMA

Dissociation of nNOS from PSD-95 promotes functional recovery after cerebral ischaemia in mice through reducing excessive tonic GABA release from reactive astrocytes

(2017) Yu-Hui Lin et al.   JOURNAL OF PATHOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury

(2017) Masamitsu Hara et al.   NATURE MEDICINE

The diversity and disparity of the glial scar

(2017) Katrina L. Adams et al.   NATURE NEUROSCIENCE

IL-17 induces reactive astrocytes and up-regulation of vascular endothelial growth factor (VEGF) through JAK/STAT signaling

(2017) Tao You et al.   Scientific Reports

The glial scar is more than just astrocytes

(2016) Jerry Silver   EXPERIMENTAL NEUROLOGY

Nucleolin inhibitor GroA triggers reduction in epidermal growth factor receptor activation: Pharmacological implication for glial scarring after spinal cord injury

(2016) Yona Goldshmit et al.   JOURNAL OF NEUROCHEMISTRY

Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury

(2016) Hong Fan et al.   Molecular Neurodegeneration

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Lipocalin-2 as a therapeutic target for brain injury: An astrocentric perspective

(2016) Kyoungho Suk   PROGRESS IN NEUROBIOLOGY

Elusive roles for reactive astrocytes in neurodegenerative diseases

(2015) Lucile Ben Haim et al.   Frontiers in Cellular Neuroscience

Functional regeneration beyond the glial scar

(2014) Jared M. Cregg et al.   EXPERIMENTAL NEUROLOGY

MicroRNA-145 as one negative regulator of astrogliosis

(2014) Chih-Yen Wang et al.   GLIA

Functional requirement of dicer1 and miR-17-5p in reactive astrocyte proliferation after spinal cord injury in the mouse

(2014) Peiwei Hong et al.   GLIA

Targeted inhibition of KCa3.1 attenuates TGF-β-induced reactive astrogliosis through the Smad2/3 signaling pathway

(2014) Zhihua Yu et al.   JOURNAL OF NEUROCHEMISTRY

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

(2014) Bradley T. Lang et al.   NATURE

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Astrocytic control of neural circuit formation: Highlights on TGF-beta signaling

(2014) Luan Pereira Diniz et al.   NEUROCHEMISTRY INTERNATIONAL

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation

(2014) Timothy R. Hammond et al.   NEURON

Illness experience of adults with cervical spinal cord injury in Japan: a qualitative investigation

(2013) Ayako Ide-Okochi et al.   BMC PUBLIC HEALTH

Spinal cord regeneration: Lessons for mammals from non-mammalian vertebrates

(2013) Dasfne Lee-Liu et al.   GENESIS

Absence of post-lesion reactive gliosis in elasmobranchs and turtles and its bearing on the evolution of astroglia

(2013) M. Kálmán et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

(2013) Sophia Bardehle et al.   NATURE NEUROSCIENCE

Reactive Oxygen Species from Human Astrocytes Induced Functional Impairment and Oxidative Damage

(2013) Wen S. Sheng et al.   NEUROCHEMICAL RESEARCH

Clonal Astrocytic Response to Cortical Injury

(2013) Eduardo Martín-López et al.   PLoS One

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

(2012) Andrew W. Kraft et al.   FASEB JOURNAL

S-Nitrosoglutathione Induces Ciliary Neurotrophic Factor Expression in Astrocytes, Which Has Implications to Protect the Central Nervous System under Pathological Conditions

(2012) Manjeet K. Paintlia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD36 is Involved in Astrocyte Activation and Astroglial Scar Formation

(2012) Yi Bao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-Protein-Coupled Receptors

(2012) M. E. Hamby et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Reactive Astrogliosis after Spinal Cord Injury—Beneficial and Detrimental Effects

(2012) Soheila Karimi-Abdolrezaee et al.   MOLECULAR NEUROBIOLOGY

Protease Activated Receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis

(2012) Soo-Jin Oh et al.   Molecular Brain

Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   BRAIN

GDNF modifies reactive astrogliosis allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury

(2011) Ling-Xiao Deng et al.   EXPERIMENTAL NEUROLOGY

Delayed treatment with Chondroitinase ABC reverses chronic atrophy of rubrospinal neurons following spinal cord injury

(2011) Lucy M. Carter et al.   EXPERIMENTAL NEUROLOGY

Chondroitinase treatment following spinal contusion injury increases migration of oligodendrocyte progenitor cells

(2011) Justin R. Siebert et al.   EXPERIMENTAL NEUROLOGY

Stab wound injury of the zebrafish telencephalon: A model for comparative analysis of reactive gliosis

(2011) Emily Violette Baumgart et al.   GLIA

The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes

(2011) Justin R. Siebert et al.   JOURNAL OF NEUROCHEMISTRY

Astrocytes from the Contused Spinal Cord Inhibit Oligodendrocyte Differentiation of Adult Oligodendrocyte Precursor Cells by Increasing the Expression of Bone Morphogenetic Proteins

(2011) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

The Role of Attenuated Astrocyte Activation in Infantile Neuronal Ceroid Lipofuscinosis

(2011) S. L. Macauley et al.   JOURNAL OF NEUROSCIENCE

Signaling Pathways in Reactive Astrocytes, a Genetic Perspective

(2011) Wenfei Kang et al.   MOLECULAR NEUROBIOLOGY

The stem cell potential of glia: lessons from reactive gliosis

(2011) Stefanie Robel et al.   NATURE REVIEWS NEUROSCIENCE

Structural Remodeling of Astrocytes in the Injured CNS

(2011) Daniel Sun et al.   NEUROSCIENTIST

Discovery and development of avotermin (recombinant human transforming growth factor beta 3): A new class of prophylactic therapeutic for the improvement of scarring

(2011) Nick L. Occleston et al.   WOUND REPAIR AND REGENERATION

Manipulating the glial scar: Chondroitinase ABC as a therapy for spinal cord injury

(2010) Elizabeth J. Bradbury et al.   BRAIN RESEARCH BULLETIN

Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-  after Vascular Damage

(2010) C. Schachtrup et al.   JOURNAL OF NEUROSCIENCE

Structural Remodeling of Fibrous Astrocytes after Axonal Injury

(2010) D. Sun et al.   JOURNAL OF NEUROSCIENCE

STAT3 inhibitors attenuate interferon-γ-induced neurotoxicity and inflammatory molecule production by human astrocytes

(2010) Sadayuki Hashioka et al.   NEUROBIOLOGY OF DISEASE

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Astrocytes in the damaged brain: Molecular and cellular insights into their reactive response and healing potential

(2009) Annalisa Buffo et al.   BIOCHEMICAL PHARMACOLOGY

Regional heterogeneity in astrocyte responses following contusive spinal cord injury in mice

(2009) Robin E. White et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Transgenic Inhibition of Astroglial NF- B Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation

(2009) R. Brambilla et al.   JOURNAL OF IMMUNOLOGY

Transgenic inhibition of astroglial NF-κB leads to increased axonal sparing and sprouting following spinal cord injury

(2009) Roberta Brambilla et al.   JOURNAL OF NEUROCHEMISTRY

The Rheb-mTOR Pathway Is Upregulated in Reactive Astrocytes of the Injured Spinal Cord

(2009) S. Codeluppi et al.   JOURNAL OF NEUROSCIENCE

Lipocalin-2 Is an Autocrine Mediator of Reactive Astrocytosis

(2009) S. Lee et al.   JOURNAL OF NEUROSCIENCE

The bright side of the glial scar in CNS repair

(2009) Asya Rolls et al.   NATURE REVIEWS NEUROSCIENCE

Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury

(2009) Hyunjung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Locus Coeruleus α-Adrenergic–Mediated Activation of Cortical Astrocytes In Vivo

(2008) Lane K. Bekar et al.   CEREBRAL CORTEX

Photothrombosis ischemia stimulates a sustained astrocytic Ca2+signalingin vivo

(2008) Shinghua Ding et al.   GLIA

Endothelin-1 Regulates Astrocyte Proliferation and Reactive Gliosis via a JNK/c-Jun Signaling Pathway

(2008) A. Gadea et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloproteinase-9 Facilitates Glial Scar Formation in the Injured Spinal Cord

(2008) J.-Y. C. Hsu et al.   JOURNAL OF NEUROSCIENCE

The Basic Helix-Loop-Helix Transcription Factor Olig2 Is Critical for Reactive Astrocyte Proliferation after Cortical Injury

(2008) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON

Spinal glial activation contributes to pathological pain states

(2008) Hong Cao et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure

(2007) Michael T. Fitch et al.   EXPERIMENTAL NEUROLOGY

Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders

(2007) Jacques De Keyser et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES