Article
Pharmacology & Pharmacy
Jiu Lin, Xinyi Fang, Fei Liu, Yanyan Zhang, Yueling Li, Zhonghan Fang, Qingfeng Tang, Chunjie Li, Cheng Zhou, Jeifei Shen
Summary: This study revealed that increased expression of P2Y(14)R in the trigeminal ganglion was associated with trigeminal neuropathic pain. P2Y(14)R promotes this pain by enhancing neuroinflammation, which can be alleviated by a P2Y(14)R antagonist to reduce mechanical hypersensitivity and pro-inflammatory cytokines production.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Yanhao Chu, Shilin Jia, Ke Xu, Qing Liu, Lijia Mai, Jiawei Liu, Wenguo Fan, Fang Huang
Summary: This study reveals the transcript characteristics and heterogeneity of satellite glial cells (SGCs) in trigeminal ganglion (TG) and investigates the interactions between SGCs and neurons. The results show that TG consists of various cell clusters including neurons, SGCs, myeloid Schwann cells, non-myeloid Schwann cells, and immune cells, with corresponding markers identified. The findings provide valuable insights into studying SGCs in the TG.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Riffat Mehboob, Maher Kurdi, Ahmed Bamaga, Njoud Aldardeir, Hisham Nasief, Leena H. Moshref, Taghreed Alsinani, Almotasimbellah O. Rayes, Reem H. Jabbad
Summary: SARS-CoV-2 infection induces inflammation possibly through the release of Substance P in the trigeminal ganglion, which can be treated with neurokinin-1 receptor antagonists and glucocorticoids.
FRONTIERS IN MEDICINE
(2021)
Article
Neurosciences
Lin-Xia Zhao, Ming Jiang, Xue-Qiang Bai, De-Li Cao, Xiao-Bo Wu, Jing Zhang, Jian-Shuang Guo, Tong-Tong Chen, Juan Wang, Hao Wu, Yong-Jing Gao, Zhi-Jun Zhang
Summary: TLR8 expression is increased in trigeminal neuropathic pain, and targeting TLR8 signaling may be effective in reducing pain and neuroinflammation.
NEUROSCIENCE BULLETIN
(2021)
Review
Pharmacology & Pharmacy
Stefania Ceruti
Summary: Progress in pain research has focused on the role of glial cells and purinergic receptors in pain modulation. Understanding the purinergic system's involvement in pain conditions may lead to the development of new and effective analgesics.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kjeld Morten Mohr, Lone Tjener Pallesen, Mette Richner, Christian Bjerggaard Vaegter
Summary: Satellite glial cells (SGCs) surrounding neuronal somas are sensitive to neuronal stressors and exhibit induced gliosis, however, GFAP may not be a universally suitable marker for SGC reactivity across species and experimental models.
Article
Clinical Neurology
Momoko Koizumi, Sayaka Asano, Akihiko Furukawa, Yoshinori Hayashi, Suzuro Hitomi, Ikuko Shibuta, Katsuhiko Hayashi, Fusao Kato, Koichi Iwata, Masamichi Shinoda
Summary: Trigeminal neuralgia is a characteristic disease characterized by severe pain triggered by innocuous stimulations, and the study found that TNFα released from activated macrophages in the trigeminal ganglion may lead to upregulation of P2X(3) receptors, resulting in persistent orofacial mechanical allodynia.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Endocrinology & Metabolism
Ran Yang, Shanzi Yu, Lu Chen, Jiahui Ma, Zhenxing Li, Dong Huang
Summary: This study aimed to investigate the role and mechanism of action of Alkbh5 on trigeminal neuralgia. The results showed that the relative expression level of Alkbh5 was negatively correlated with the mechanical pain threshold in rats. Alkbh5 alleviated the mechanical hyperalgesia of the trigeminal neuralgia rat model by negatively regulating the expression of p-ERK.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Jean Kwon, Young In Choi, Hang Joon Jo, Sang Hoon Lee, Han Kyu Lee, Heesoo Kim, Jee Youn Moon, Sung Jun Jung
Summary: The study confirms that PGE1 can induce pain in mice and enhances the excitability of trigeminal ganglion neurons through HCN channel facilitation. The research also identifies the target mechanism of PGE1 in nociceptive neurons, suggesting its potential as a therapeutic target for pain management under inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Rachel Feldman-Goriachnik, Menachem Hanani
Summary: Neuronal excitation leads to NO release, inducing SGCs activation, with ATP potentially playing a role in NO's action.
Article
Medicine, Research & Experimental
Ailin Cao, Weiqi Gao, Takeshi Sawada, Reiko U. Yoshimoto, Reona Aijima, Yasuyoshi Ohsaki, Mizuho A. Kido
Summary: Allergic inflammation in the bronchi can cause hypersensitive skin in the facial skin, potentially leading to mechanical hypersensitivity. This hypersensitivity may be the result of TRPV1-mediated neuronal plasticity and glial activation in the trigeminal ganglion.
LABORATORY INVESTIGATION
(2023)
Article
Agronomy
Tingzhen Wang, Mingjia Liu, Yufeng Tian, Yingyan Han, Chaojie Liu, Jinghong Hao, Shuangxi Fan
Summary: This study investigates the important role of mitogen-activated protein kinase 6 (MAPK6) in high temperature bolting of lettuce. The researchers amplified the full-length coding sequence of the LsMAPK6 gene and analyzed its expression using real-time polymerase chain reaction. The results demonstrate that LsMAPK6 is mainly expressed in the stem, stem apex, and taproot, and its expression is significantly promoted by high temperatures.
Article
Neurosciences
Yi-Ke Li, Yan-Yan Zhang, Jiu Lin, Ya-Jing Liu, Yue-Ling Li, Yu-Heng Feng, Jia-Shuo Zhao, Cheng Zhou, Fei Liu, Jie-Fei Shen
Summary: By regulating K+ homeostasis in neurons and glia, Kir4.1 and mGluR5 play a critical role in neuropathic pain. Activation of mGluR5 in the trigeminal ganglion contributes to orofacial ectopic mechanical allodynia by suppressing Kir4.1 via the PKC signaling pathway.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Benno Traub, Aileen Roth, Marko Kornmann, Uwe Knippschild, Joachim Bischof
Summary: Pancreatic cancer is a devastating disease with poor survival rates, prompting the need for new therapeutic approaches. Protein kinases play crucial roles in development and pathogenesis, making them potential targets for precision medicine in patients with deregulated kinase pathways.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Plant Sciences
Xi Zhu, Ning Zhang, Xue Liu, Shigui Li, Jiangwei Yang, Xusheng Hong, Fangfang Wang, Huaijun Si
Summary: The study demonstrates that overexpression of StMAPK11 can promote potato growth, physiological activities, and photosynthesis under drought conditions, indicating its crucial role in enhancing potato drought resistance. The up-regulation of StMAPK11 intensifies drought resistance by elevating antioxidant activities and photosynthesis, providing new insights into its function in drought response.
PLANT CELL REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ning Song, Da-Qing Liao, Fei Liu, Yan-Yan Zhang, Jiu Lin, Hang Wang, Jie-Fei Shen
Article
Cell Biology
Jiu Lin, Fei Liu, Yan-yan Zhang, Ning Song, Meng-ke Liu, Xin-yi Fang, Da-qing Liao, Cheng Zhou, Hang Wang, Jie-fei Shen
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Neurosciences
Yan-yan Zhang, Ning Song, Fei Liu, Jiu Lin, Meng-ke Liu, Chao-lan Huang, Da-qing Liao, Cheng Zhou, Hang Wang, Jie-fei Shen
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Dentistry, Oral Surgery & Medicine
Jiu Lin, Xinyi Fang, Pin Ha, Min Fu, Hang Wang
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2020)
Article
Neurosciences
Chao-Lan Huang, Fei Liu, Yan-Yan Zhang, Jiu Lin, Min Fu, Yue-Ling Li, Cheng Zhou, Chun-Jie Li, Jie-Fei Shen
Summary: This study demonstrates that activation of OXTR in the trigeminal ganglion relieves orofacial ectopic pain and inhibits the upregulated expression of CGRP, IL-1 beta, and TNF-alpha in rats with inferior alveolar nerve transection.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Yue-ling Li, Fei Liu, Yan-yan Zhang, Jiu Lin, Chao-lan Huang, Min Fu, Cheng Zhou, Chun-jie Li, Jie-fei Shen
Summary: The study investigated the interactions of NR1, Src, and Panx1 in the trigeminal ganglion, revealing their roles in orofacial ectopic pain induced by inferior alveolar nerve transection. It was found that these proteins contributed to mechanical allodynia, composing a signaling pathway involved in the condition.
Article
Neurosciences
Min Fu, Fei Liu, Yan-Yan Zhang, Jiu Lin, Chao-Lan Huang, Yue-Ling Li, Hang Wang, Cheng Zhou, Chun-Jie Li, Jie-Fei Shen
Summary: The study investigated the role of alpha 2 delta-1-NMDAR1 interaction in orofacial ectopic pain induced by trigeminal nerve injury in a rat model. Results showed that the physical and functional interaction between alpha 2 delta-1 and NMDAR1 is critical for the development of orofacial ectopic pain, suggesting potential targets for treatment.
BRAIN RESEARCH BULLETIN
(2021)
Article
Dentistry, Oral Surgery & Medicine
X. Y. Fang, Y. X. Zhan, X. M. Zhou, L. N. Wu, J. Lin, Y. T. Yi, C. M. Jiang, J. Wang, J. Liu
Summary: Mechanical force-induced CXCL12/CXCR4 axis is involved in promoting orthodontic root resorption (ORR) by attracting Ly6C(hi) inflammatory monocytes and modulating macrophage polarization, leading to an increased M1/M2 ratio in periodontal tissues. Blockage of the CXCL12/CXCR4 axis using AMD3100 may potentially inhibit root resorption.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jie Yang, Fei Liu, Yan-Yan Zhang, Jiu Lin, Yue-Ling Li, Cheng Zhou, Chun-Jie Li, Jie-Fei Shen
Summary: Our study demonstrated that CXCR2 participates in orofacial ectopic mechanical allodynia by downregulating Kv1.4 and Kv1.1 through the PKC signaling pathway, which may serve as a potential target for developing treatment strategies for orofacial ectopic pain.
JOURNAL OF ORAL REHABILITATION
(2022)
Article
Neurosciences
Yan-Yan Zhang, Fei Liu, Jiu Lin, Yue-Ling Li, Zhong-Han Fang, Cheng Zhou, Chun-Jie Li, Jie-Fei Shen
Summary: Neuropathic and inflammatory pain pose major challenges in clinical practice. This study explores the roles of NMDAR and CaMKII in orofacial pain and reveals new molecular signaling pathways involved in peripheral and central sensitization. The findings suggest that targeting NR2B and CaMKII may be beneficial for the treatment of orofacial allodynia.
BRAIN RESEARCH BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Jiu Lin, Xinyi Fang, Fei Liu, Yanyan Zhang, Yueling Li, Zhonghan Fang, Qingfeng Tang, Chunjie Li, Cheng Zhou, Jeifei Shen
Summary: This study revealed that increased expression of P2Y(14)R in the trigeminal ganglion was associated with trigeminal neuropathic pain. P2Y(14)R promotes this pain by enhancing neuroinflammation, which can be alleviated by a P2Y(14)R antagonist to reduce mechanical hypersensitivity and pro-inflammatory cytokines production.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Correction
Pharmacology & Pharmacy
Jiu Lin, Xinyi Fang, Fei Liu, Yanyan Zhang, Yueling Li, Zhonghan Fang, Qingfeng Tang, Chunjie Li, Cheng Zhou, Jiefei Shen
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Neurosciences
Ya-Jing Liu, Yue-Ling Li, Zhong-Han Fang, Hong-Lin Liao, Yan-Yan Zhang, Jiu Lin, Fei Liu, Jie-Fei Shen
Summary: This review focuses on the pivotal roles and mechanisms of NMDARs in the trigeminal nervous system under orofacial neuropathic and inflammatory pain conditions. The types, components, and distribution of NMDARs in the trigeminal nervous system are summarized. The regulatory roles of NMDARs in the peripheral mechanisms of chronic orofacial pain following neuropathic injury and inflammation, as well as their functional roles and mechanisms in the ascending and descending circuits, are discussed.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Zhong-Han Fang, Hong-Lin Liao, Qing-Feng Tang, Ya-Jing Liu, Yan-Yan Zhang, Jiu Lin, Hao-Peng Yu, Cheng Zhou, Chun-Jie Li, Fei Liu, Jie-Fei Shen
Summary: This study reveals the expression profile and regulatory mechanism of non-coding RNAs in trigeminal neuropathic pain using RNA sequencing and bioinformatics analysis. The results indicate the involvement of multiple pain-related genes and pathways in the development of pain.
JOURNAL OF PAIN RESEARCH
(2022)