Challenges and novel approaches for investigating molecular mediation

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

(2016) Philip C Haycock et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

cit: hypothesis testing software for mediation analysis in genomic applications

(2016) Joshua Millstein et al.   BIOINFORMATICS

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia

(2016) Amit V. Khera et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A fatter, healthier but more unequal world

(2016) George Davey Smith   LANCET

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking

(2016) Panagiotis Georgiadis et al.   Scientific Reports

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects

(2015) S. Burgess et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Advances in Mediation Analysis: A Survey and Synthesis of New Developments

(2015) Kristopher J. Preacher   Annual Review of Psychology

DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring

(2015) Leanne K Küpers et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A statistical framework to model the meeting-in-the-middle principle using metabolomic data: application to hepatocellular carcinoma in the EPIC study

(2015) Nada Assi et al.   MUTAGENESIS

An epigenome-wide association study of total serum immunoglobulin E concentration

(2015) Liming Liang et al.   NATURE

The UK10K project identifies rare variants in health and disease

(2015)   NATURE

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

(2015) Norihiro Kato et al.   NATURE GENETICS

The role of regulatory variation in complex traits and disease

(2015) Frank W. Albert et al.   NATURE REVIEWS GENETICS

Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

(2015) Francesca Fasanelli et al.   Nature Communications

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children

(2015) Xiumei Hong et al.   Nature Communications

A Primer Series on -Omic Technologies for the Practice of Epidemiology

(2014) M. J. Khoury   AMERICAN JOURNAL OF EPIDEMIOLOGY

Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer

(2014) Devin C Koestler et al.   BMC Medical Genomics

Methodological Challenges in Mendelian Randomization

(2014) Tyler J. VanderWeele et al.   EPIDEMIOLOGY

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways

(2014) S. Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids

(2014) So-Youn Shin et al.   Genome Medicine

Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators

(2013) B. L. Pierce et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Advancing the application of omics-based biomarkers in environmental epidemiology

(2013) Paolo Vineis et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

A Three-way Decomposition of a Total Effect into Direct, Indirect, and Interactive Effects

(2013) Tyler J. VanderWeele   EPIDEMIOLOGY

Misclassification of the mediator matters when estimating indirect effects

(2013) Tony Blakely et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

(2013) Yun Liu et al.   NATURE BIOTECHNOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Systems genetics approaches to understand complex traits

(2013) Mete Civelek et al.   NATURE REVIEWS GENETICS

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

(2013) Sonja Zeilinger et al.   PLoS One

DNA Hypomethylation, Ambient Particulate Matter, and Increased Blood Pressure: Findings From Controlled Human Exposure Experiments

(2013) Andrea Bellavia et al.   Journal of the American Heart Association

Quantification of Bias in Direct Effects Estimates Due to Different Types of Measurement Error in the Mediator

(2012) Saskia le Cessie et al.   EPIDEMIOLOGY

The Role of Measurement Error and Misclassification in Mediation Analysis

(2012) Tyler J. VanderWeele et al.   EPIDEMIOLOGY

The effect of non-differential measurement error on bias, precision and power in Mendelian randomization studies

(2012) Brandon L Pierce et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

(2012) Caroline L Relton et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease

(2012) Brian A. Ference et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

(2012) Johannes Kettunen et al.   NATURE GENETICS

Prenatal nutrition, epigenetics and schizophrenia risk: can we test causal effects?

(2012) James B Kirkbride et al.   Epigenomics

Quantitative high-throughput metabolomics: a new era in epidemiology and genetics

(2012) Mika Ala-Korpela et al.   Genome Medicine

The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

(2011) Günter P. Wagner et al.   NATURE REVIEWS GENETICS

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

(2010) N J Timpson et al.   INTERNATIONAL JOURNAL OF OBESITY

Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and Treatment

(2010) Caroline L. Relton et al.   PLOS MEDICINE

Disentangling molecular relationships with a causal inference test

(2009) Joshua Millstein et al.   BMC GENETICS

Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach

(2009) Paul Welsh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE