Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

Milk intake is not associated with low risk of diabetes or overweight-obesity: a Mendelian randomization study in 97,811 Danish individuals

(2015) Helle KM Bergholdt et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mendelian Randomization Studies for a Continuous Exposure Under Case-Control Sampling

(2015) J. Y. Dai et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors

(2015) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

The support of human genetic evidence for approved drug indications

(2015) Matthew R Nelson et al.   NATURE GENETICS

Methodological Challenges in Mendelian Randomization

(2014) Tyler J. VanderWeele et al.   EPIDEMIOLOGY

Mendelian randomization of blood lipids for coronary heart disease

(2014) Michael V. Holmes et al.   EUROPEAN HEART JOURNAL

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome

(2014) S. Burgess   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways

(2014) S. Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117 411 patients

(2014) D. Keene et al.   BMJ-British Medical Journal

Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators

(2013) B. L. Pierce et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Mendelian randomization in health research: Using appropriate genetic variants and avoiding biased estimates

(2013) Amy E. Taylor et al.   Economics & Human Biology

Misclassification of the mediator matters when estimating indirect effects

(2013) Tony Blakely et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Causal inference of gene regulation with subnetwork assembly from genetical genomics data

(2013) Chien-Hua Peng et al.   NUCLEIC ACIDS RESEARCH

Identifying the odds ratio estimated by a two-stage instrumental variable analysis with a logistic regression model

(2013) Stephen Burgess et al.   STATISTICS IN MEDICINE

Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials

(2013) S.-K. Myung et al.   BMJ-British Medical Journal

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

(2013) T. M. Palmer et al.   BMJ-British Medical Journal

Invited Commentary: Structural Equation Models and Epidemiologic Analysis

(2012) T. J. VanderWeele   AMERICAN JOURNAL OF EPIDEMIOLOGY

Credible Mendelian Randomization Studies: Approaches for Evaluating the Instrumental Variable Assumptions

(2012) M. M. Glymour et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Quantification of Bias in Direct Effects Estimates Due to Different Types of Measurement Error in the Mediator

(2012) Saskia le Cessie et al.   EPIDEMIOLOGY

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

(2012) Caroline L Relton et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Effect of a Monoclonal Antibody to PCSK9 on Low-Density Lipoprotein Cholesterol Levels in Statin-Intolerant Patients

(2012) David Sullivan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease

(2012) Brian A. Ference et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure

(2012) Marcus R. Munafò et al.   JNCI-Journal of the National Cancer Institute

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

(2012)   LANCET

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

(2012)   LANCET

Severity of bias of a simple estimator of the causal odds ratio in Mendelian randomization studies

(2012) Roger M. Harbord et al.   STATISTICS IN MEDICINE

The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

(2011) Günter P. Wagner et al.   NATURE REVIEWS GENETICS

On Instrumental Variables Estimation of Causal Odds Ratios

(2011) Stijn Vansteelandt et al.   STATISTICAL SCIENCE

Bias in causal estimates from Mendelian randomization studies with weak instruments

(2011) Stephen Burgess et al.   STATISTICS IN MEDICINE

Causal graphical models in systems genetics: A unified framework for joint inference of causal network and genetic architecture for correlated phenotypes

(2010) Elias Chaibub Neto et al.   Annals of Applied Statistics

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

(2010) N J Timpson et al.   INTERNATIONAL JOURNAL OF OBESITY

Apolipoprotein(a) Isoforms and the Risk of Vascular Disease

(2010) Sebhat Erqou et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies

(2010)   LANCET

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

(2010) Thorgeir E Thorgeirsson et al.   NATURE GENETICS

Mendelian randomization analysis of case-control data using structural mean models

(2010) Jack Bowden et al.   STATISTICS IN MEDICINE

Illustrating bias due to conditioning on a collider

(2009) Stephen R Cole et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction

(2009) Pia R. Kamstrup   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lipoprotein(a) Concentration and the Risk of Coronary Heart Disease, Stroke, and Nonvascular Mortality

(2009)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Major Lipids, Apolipoproteins, and Risk of Vascular Disease

(2009) The Emerging Risk Factors Collaboration*   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

(2009) Robert Clarke et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity

(2008) Sotirios Tsimikas et al.   CURRENT OPINION IN LIPIDOLOGY

Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease

(2008) Jeppe Zacho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization Approach

(2008) Lina Chen et al.   PLOS MEDICINE

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE