Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids

Modeling Causality for Pairs of Phenotypes in System Genetics

(2013) E. C. Neto et al.   GENETICS

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

(2012) Johannes Kettunen et al.   NATURE GENETICS

Genetic variation in metabolic phenotypes: study designs and applications

(2012) Karsten Suhre et al.   NATURE REVIEWS GENETICS

Improving bias and coverage in instrumental variable analysis with weak instruments for continuous and binary outcomes

(2012) Stephen Burgess et al.   STATISTICS IN MEDICINE

Metabolomics: the final frontier?

(2012) Timothy D Veenstra   Genome Medicine

Stitching together Multiple Data Dimensions Reveals Interacting Metabolomic and Transcriptomic Networks That Modulate Cell Regulation

(2012) Jun Zhu et al.   PLOS BIOLOGY

What Can Causal Networks Tell Us about Metabolic Pathways?

(2012) Rachael Hageman Blair et al.   PLoS Computational Biology

Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations

(2012) Ayşe Demirkan et al.   PLoS Genetics

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data

(2011) Jan Krumsiek et al.   BMC Systems Biology

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

(2011) Abbas Dehghan et al.   CIRCULATION

Avoiding bias from weak instruments in Mendelian randomization studies

(2011) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

A genome-wide association study of metabolic traits in human urine

(2011) Karsten Suhre et al.   NATURE GENETICS

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

OpenMx: An Open Source Extended Structural Equation Modeling Framework

(2011) Steven Boker et al.   PSYCHOMETRIKA

A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

(2011) George Nicholson et al.   PLoS Genetics

Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

(2010) N. Soranzo et al.   DIABETES

Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study

(2010) Mary K. Wojczynski et al.   JOURNAL OF LIPID RESEARCH

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

New loci associated with kidney function and chronic kidney disease

(2010) Anna Köttgen et al.   NATURE GENETICS

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

(2010) Christopher T Johansen et al.   NATURE GENETICS

Genome-wide association study of hematological and biochemical traits in a Japanese population

(2010) Yoichiro Kamatani et al.   NATURE GENETICS

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Predicting causal effects in large-scale systems from observational data

(2010) Marloes H Maathuis et al.   NATURE METHODS

The Pharmacology and Off-Target Effects of Some Cholesterol Ester Transfer Protein Inhibitors

(2009) Menno Vergeer et al.   AMERICAN JOURNAL OF CARDIOLOGY

Metabolomics: Unraveling the chemical individuality of common human diseases

(2009) Sander M. Houten   ANNALS OF MEDICINE

Do FADS genotypes enhance our knowledge about fatty acid related phenotypes?

(2009) Eva Lattka et al.   CLINICAL NUTRITION

Effects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitus

(2009) Fabio Galvano et al.   EXPERT OPINION ON PHARMACOTHERAPY

Effects of Genetic and Environmental Factors on Trait Network Predictions From Quantitative Trait Locus Data

(2009) D. L. Remington   GENETICS

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations

(2009) Andrew A. Hicks et al.   PLoS Genetics

Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study

(2009) Toshiko Tanaka et al.   PLoS Genetics

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics

Using genetic markers to orient the edges in quantitative trait networks: The NEO software

(2008) Jason E Aten et al.   BMC Systems Biology

Bioinformatics Analysis of Targeted Metabolomics—Uncovering Old and New Tales of Diabetic Mice under Medication

(2008) Elisabeth Altmaier et al.   ENDOCRINOLOGY

Human metabolic phenotype diversity and its association with diet and blood pressure

(2008) Elaine Holmes et al.   NATURE

Reverse engineering the genotype–phenotype map with natural genetic variation

(2008) Matthew V. Rockman   NATURE

Systems biology: Metabonomics

(2008) Jeremy K. Nicholson et al.   NATURE

Common variants at 30 loci contribute to polygenic dyslipidemia

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

(2008) John C Chambers et al.   NATURE GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

Metabolic Profiling Reveals Distinct Variations Linked to Nicotine Consumption in Humans — First Results from the KORA Study

(2008) Rui Wang-Sattler et al.   PLoS One

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

(2008) Christian Gieger et al.   PLoS Genetics

Mendelian Randomisation and Causal Inference in Observational Epidemiology

(2008) Nuala A Sheehan et al.   PLOS MEDICINE