Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

Epigenesis for epidemiologists: does evo-devo have implications for population health research and practice?

(2012) George Davey Smith   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Confounding of Indirect Effects: A Sensitivity Analysis Exploring the Range of Bias Due to a Cause Common to Both the Mediator and the Outcome

(2011) Danella M. Hafeman   AMERICAN JOURNAL OF EPIDEMIOLOGY

Tobacco-Smoking-Related Differential DNA Methylation: 27K Discovery and Replication

(2011) Lutz P. Breitling et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Unified Approach to the Evolutionary Consequences of Genetic and Nongenetic Inheritance

(2011) Troy Day et al.   AMERICAN NATURALIST

Genetic Polymorphisms in 15q25 and 19q13 Loci, Cotinine Levels, and Risk of Lung Cancer in EPIC

(2011) M. N. Timofeeva et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Genome-wide association studies may be misinterpreted: genes versus heritability

(2011) P. Vineis et al.   CARCINOGENESIS

Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change

(2011) Ki-Hyeon Seong et al.   CELL

Mendelian Randomization: Application to Cardiovascular Disease

(2011) Nicholas J. Timpson et al.   CURRENT HYPERTENSION REPORTS

Long non-coding RNAs and enhancers

(2011) Ulf Andersson Ørom et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Postnatal Growth and DNA Methylation Are Associated With Differential Gene Expression of the TACSTD2 Gene and Childhood Fat Mass

(2011) A. Groom et al.   DIABETES

Epigenetic Gene Promoter Methylation at Birth Is Associated With Child's Later Adiposity

(2011) K. M. Godfrey et al.   DIABETES

The impact of epigenomics on future drug design and new therapies

(2011) Christopher A. Hamm et al.   DRUG DISCOVERY TODAY

Global Methylation in Exposure Biology and Translational Medical Science

(2011) Heather H. Nelson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Random Allocation in Observational Data

(2011) George Davey Smith   EPIDEMIOLOGY

Allele-specific methylation in the human genome

(2011) Emma L. Meaburn et al.   Epigenetics

DNA methylation in white blood cells

(2011) Mary Beth Terry et al.   Epigenetics

Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability

(2011)   Epigenetics

Transgenerational inheritance of stress pathology

(2011) Stephen G. Matthews et al.   EXPERIMENTAL NEUROLOGY

Distinct DNA methylation changes highly correlated with chronological age in the human brain

(2011) Dena G. Hernandez et al.   HUMAN MOLECULAR GENETICS

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

(2011) Louise N. Reynard et al.   HUMAN MOLECULAR GENETICS

Evidence of constitutional MLH1 epimutation associated to transgenerational inheritance of cancer susceptibility

(2011) Michel Crépin et al.   HUMAN MUTATION

Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

(2011) R. M. Freathy et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Bookmarking the Genome: Maintenance of Epigenetic Information

(2011) Sayyed K. Zaidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Methylation Array Analysis Identifies Profiles of Blood-Derived DNA Methylation Associated With Bladder Cancer

(2011) Carmen J. Marsit et al.   JOURNAL OF CLINICAL ONCOLOGY

Low-Density Lipoprotein Cholesterol and the Risk of Cancer: A Mendelian Randomization Study

(2011) Marianne Benn et al.   JNCI-Journal of the National Cancer Institute

SHOX2 DNA Methylation Is a Biomarker for the Diagnosis of Lung Cancer in Plasma

(2011) Christoph Kneip et al.   Journal of Thoracic Oncology

Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study

(2011) J Anthony G Scott et al.   LANCET

A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder

(2011) Z Kaminsky et al.   MOLECULAR PSYCHIATRY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Increased methylation variation in epigenetic domains across cancer types

(2011) Kasper Daniel Hansen et al.   NATURE GENETICS

Epigenome-wide association studies for common human diseases

(2011) Vardhman K. Rakyan et al.   NATURE REVIEWS GENETICS

Integration of genomic and epigenomic DNA methylation data in common complex diseases by haplotype-specific methylation analysis

(2011) Christopher G Bell   Personalized Medicine

Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats

(2011) Patrick O. McGowan et al.   PLoS One

DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing

(2011) Fabienne Brenet et al.   PLoS One

A Genome-Wide Study of DNA Methylation Patterns and Gene Expression Levels in Multiple Human and Chimpanzee Tissues

(2011) Athma A. Pai et al.   PLoS Genetics

A Sustained Dietary Change Increases Epigenetic Variation in Isogenic Mice

(2011) Cheryl C. Y. Li et al.   PLoS Genetics

Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development

(2011) Ulla Sovio et al.   PLoS Genetics

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

(2011) Jordana T Bell et al.   GENOME BIOLOGY

Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain

(2010) Dandan Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Assessing Intrauterine Influences on Offspring Health Outcomes: Can Epidemiological Studies Yield Robust Findings?

(2010) George Davey Smith   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Epigenetics and parental effects

(2010) Laurent Kappeler et al.   BIOESSAYS

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

(2010) Christopher G Bell et al.   BMC Medical Genomics

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Cardiovascular Epigenetics

(2010) Andrea Baccarelli et al.   Circulation-Cardiovascular Genetics

The hunt for the epiallele

(2010) Sarah Finer et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome

(2010) R. Shoemaker et al.   GENOME RESEARCH

Transgenerational epigenetic inheritance: More questions than answers

(2010) L. Daxinger et al.   GENOME RESEARCH

Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis

(2010) Stuart F. W. Kendrick et al.   HEPATOLOGY

Allele-specific DNA methylation: beyond imprinting

(2010) B. Tycko   HUMAN MOLECULAR GENETICS

The disappointments of the double helix: a master theory

(2010) James Le Fanu   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE

Comprehensive methylome map of lineage commitment from haematopoietic progenitors

(2010) Hong Ji et al.   NATURE

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

(2010)   NATURE GENETICS

Principles and challenges of genome-wide DNA methylation analysis

(2010) Peter W. Laird   NATURE REVIEWS GENETICS

Genomic Medicine — An Updated Primer

(2010) W. Gregory Feero et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

(2010) Christopher G. Bell et al.   PLoS One

Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index

(2010) A. P. Feinberg et al.   Science Translational Medicine

Extensive sequence-influenced DNA methylation polymorphism in the human genome

(2010) Asaf Hellman et al.   Epigenetics & Chromatin

Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles

(2010) Robert A. Waterland et al.   PLoS Genetics

Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain

(2010) J. Raphael Gibbs et al.   PLoS Genetics

Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and Treatment

(2010) Caroline L. Relton et al.   PLOS MEDICINE

HapMap methylation-associated SNPs, markers of germline DNA methylation, positively correlate with regional levels of human meiotic recombination

(2009) M. I. Sigurdsson et al.   GENOME RESEARCH

A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women

(2009) Luisa Zuccolo et al.   HUMAN MOLECULAR GENETICS

Does Greater Adiposity Increase Blood Pressure and Hypertension Risk?

(2009) Nicholas J. Timpson et al.   HYPERTENSION

Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype

(2009) P. Brennan et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Illustrating bias due to conditioning on a collider

(2009) Stephen R Cole et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Biomarkers and Cardiovascular Disease

(2009) Svati H. Shah et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction

(2009) Pia R. Kamstrup   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mendelian Randomization

(2009) George Thanassoulis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epigenetics and transgenerational transfer: a physiological perspective

(2009) D. H. Ho et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

Molecular networks as sensors and drivers of common human diseases

(2009) Eric E. Schadt   NATURE

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

(2009) Patrick O McGowan et al.   NATURE NEUROSCIENCE

Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men

(2009) Eric L. Ding et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Epigenetic Signature in Peripheral Blood Predicts Active Ovarian Cancer

(2009) Andrew E. Teschendorff et al.   PLoS One

Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease

(2009) A. P. Feinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

(2009) Eva Jablonka et al.   QUARTERLY REVIEW OF BIOLOGY

Epigenetics: Definition, Mechanisms and Clinical Perspective

(2009) Cathérine Dupont et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Genome-scale approaches to the epigenetics of common human disease

(2009) Andrew P. Feinberg   VIRCHOWS ARCHIV

Methyl donor supplementation prevents transgenerational amplification of obesity

(2008) R A Waterland et al.   INTERNATIONAL JOURNAL OF OBESITY

How Does Body Fat Influence Bone Mass in Childhood? A Mendelian Randomization Approach

(2008) Nicholas J Timpson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Epigenetic Programming of Phenotypic Variations in Reproductive Strategies in the Rat Through Maternal Care

(2008) N. M. Cameron et al.   JOURNAL OF NEUROENDOCRINOLOGY

The case for transgenerational epigenetic inheritance in humans

(2008) Daniel K. Morgan et al.   MAMMALIAN GENOME

Reverse engineering the genotype–phenotype map with natural genetic variation

(2008) Matthew V. Rockman   NATURE

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease

(2008) Jeppe Zacho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mendelian Randomisation and Causal Inference in Observational Epidemiology

(2008) Nuala A Sheehan et al.   PLOS MEDICINE

Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization Approach

(2008) Lina Chen et al.   PLOS MEDICINE

Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts

(2007) Shah Ebrahim et al.   ATHEROSCLEROSIS

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE