Methodological Challenges in Mendelian Randomization

Commentary: Building an evidence base for mendelian randomization studies: assessing the validity and strength of proposed genetic instrumental variables

(2013) Eric J Tchetgen Tchetgen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

(2013) Karani S. Vimaleswaran et al.   PLOS MEDICINE

Re: "Credible Mendelian Randomization Studies: Approaches For Evaluating The Instrumental Variable Assumptions"

(2012) S. Burgess   AMERICAN JOURNAL OF EPIDEMIOLOGY

Genetic Variants on 15q25.1, Smoking, and Lung Cancer: An Assessment of Mediation and Interaction

(2012) Tyler J. VanderWeele et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Credible Mendelian Randomization Studies: Approaches for Evaluating the Instrumental Variable Assumptions

(2012) M. M. Glymour et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses

(2012) Yiqing Song et al.   HUMAN MOLECULAR GENETICS

The effect of non-differential measurement error on bias, precision and power in Mendelian randomization studies

(2012) Brandon L Pierce et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

(2012) Robert A Scott et al.   NATURE GENETICS

Severity of bias of a simple estimator of the causal odds ratio in Mendelian randomization studies

(2012) Roger M. Harbord et al.   STATISTICS IN MEDICINE

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

Odds Ratios for Mediation Analysis for a Dichotomous Outcome

(2010) T. J. VanderWeele et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Bias Formulas for Sensitivity Analysis of Unmeasured Confounding for General Outcomes, Treatments, and Confounders

(2010) Tyler J. VanderWeele et al.   EPIDEMIOLOGY

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

(2010) Brandon L Pierce et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Assumptions of IV Methods for Observational Epidemiology

(2010) Vanessa Didelez et al.   STATISTICAL SCIENCE

Mendelian randomization analysis of case-control data using structural mean models

(2010) Jack Bowden et al.   STATISTICS IN MEDICINE

Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease

(2009) Paul Elliott   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men

(2009) Eric L. Ding et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smokers with the CHRNA Lung Cancer-Associated Variants Are Exposed to Higher Levels of Nicotine Equivalents and a Carcinogenic Tobacco-Specific Nitrosamine

(2008) L. Le Marchand et al.   CANCER RESEARCH

Adjusting for bias and unmeasured confounding in Mendelian randomization studies with binary responses

(2008) Tom M Palmer et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Inflammation, Insulin Resistance, and Diabetes—Mendelian Randomization Using CRP Haplotypes Points Upstream

(2008) Eric J Brunner et al.   PLOS MEDICINE

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE