A Mechanistic approach of Peroxisome Proliferator-Activated Receptors and its subtypes on Clinical and preclinical model of Neurodegenerative disorders

Role of PPAR receptor in different diseases and their ligands: Physiological importance and clinical implications

(2019) Agha Zeeshan Mirza et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation of PPAR δ suppresses BACE 1 expression by upregulating SOCS 1 in a JAK 2/ STAT 1‐dependent manner

(2019) Won Jin Lee et al.   JOURNAL OF NEUROCHEMISTRY

PPAR-δ Activation Ameliorates Diabetes-Induced Cognitive Dysfunction by Modulating Integrin-linked Kinase and AMPA Receptor Function

(2019) Engy A. Abdel-Rahman et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Phytohormone abscisic acid ameliorates cognitive impairments in streptozotocin-induced rat model of Alzheimer's disease through PPARβ/δ and PKA signaling

(2019) Ali Khorasani et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer’s disease by restoring microglial function via a PPAR-γ-dependent mechanism

(2019) Elisa Medrano-Jiménez et al.   Journal of Neuroinflammation

An Exploratory Phase IIa Study of the PPAR delta/gamma Agonist T3D-959 Assessing Metabolic and Cognitive Function in Subjects with Mild to Moderate Alzheimer’s Disease

(2019) Stanley Chamberlain et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting PPARalpha in Alzheimer's Disease

(2018) Barbara D'Orio et al.   Current Alzheimer Research

Pioglitazone reduces mortality, prevents depressive-like behavior, and impacts hippocampal neurogenesis in the 6-OHDA model of Parkinson's disease in rats

(2018) Jéssica Mendes Bonato et al.   EXPERIMENTAL NEUROLOGY

Honokiol ameliorates cognitive impairment by attenuating amyloidosis and neuroinflammation in a transgenic mouse model of Alzheimer's disease

(2018) DONGMEI WANG et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1α deacetylation

(2018) Mijung Lee et al.   PLoS One

Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation

(2018) Ling Wang et al.   Cell Death & Disease

Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway

(2018) Mu Zhang et al.   Theranostics

MicroRNA-128 knockout inhibits the development of Alzheimer's disease by targeting PPARγ in mouse models

(2018) Yanqiu Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes

(2018) Henna Konttinen et al.   GLIA

PPAR-γ agonist pioglitazone reduces microglial proliferation and NF-κB activation in the substantia nigra in the 6-hydroxydopamine model of Parkinson’s disease

(2018) Meira Maria Forcelini Machado et al.   Pharmacological Reports

Glitazone use associated with reduced risk of Parkinson's disease

(2017) Brage Brakedal et al.   MOVEMENT DISORDERS

PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

(2017) Audrey S. Dickey et al.   Science Translational Medicine

Fatty acids, eicosanoids and PPAR gamma

(2016) Rachel Marion-Letellier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pioglitazone for the treatment of Alzheimer’s disease

(2016) Daniela Galimberti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

PPARδ agonist GW0742 ameliorates Aβ1–42-induced hippocampal neurotoxicity in mice

(2016) Yun-Qi An et al.   METABOLIC BRAIN DISEASE

The retina as an early biomarker of neurodegeneration in a rotenone-induced model of Parkinson’s disease: evidence for a neuroprotective effect of rosiglitazone in the eye and brain

(2016) Eduardo Maria Normando et al.   Acta Neuropathologica Communications

Localization of PPAR isotypes in the adult mouse and human brain

(2016) Anna Warden et al.   Scientific Reports

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

(2015) Avik Roy et al.   Cell Metabolism

A step ahead of PPARγ full agonists to PPARγ partial agonists: Therapeutic perspectives in the management of diabetic insulin resistance

(2015) Sridevi Chigurupati et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The PPARβ/δ Agonist GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons: Role of PPARβ/δ in Neuronal Maturation

(2015) Elisabetta Benedetti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation

(2015) Tarja Malm et al.   Journal of Neuroinflammation

PPAR-α agonist regulates amyloid-β generation via inhibiting BACE-1 activity in human neuroblastoma SH-SY5Y cells transfected with APPswe gene

(2015) Hua Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PPARβ/δ Agonist Provides Neuroprotection by Suppression of IRE1α–Caspase-12-Mediated Endoplasmic Reticulum Stress Pathway in the Rotenone Rat Model of Parkinson’s Disease

(2015) Qiang Tong et al.   MOLECULAR NEUROBIOLOGY

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

(2015) Audrey S Dickey et al.   NATURE MEDICINE

Transcriptional dysregulation in Huntington’s disease: The role of histone deacetylases

(2015) Sorabh Sharma et al.   PHARMACOLOGICAL RESEARCH

Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP

(2015) Grant T. Corbett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A PPAR-β/δ Agonist is Neuroprotective and Decreases Cognitive Impairment in a Rodent Model of Parkinson’s Disease

(2014) Nihar Das et al.   CURRENT NEUROVASCULAR RESEARCH

PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1

(2014) Juan Carlos Corona et al.   EXPERIMENTAL NEUROLOGY

Fenofibrate reduces amyloidogenic processing of APP in APP/PS1 transgenic mice via PPAR-α/PI3-K pathway

(2014) Hua Zhang et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

PPAR-α agonist fenofibrate protects against the damaging effects of MPTP in a rat model of Parkinson's disease

(2014) Janaína K. Barbiero et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice

(2013) Emma Barroso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease

(2013) Jing Jin et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNAs with a role in gene regulation and in human diseases

(2013) Sami Ullah et al.   MOLECULAR BIOLOGY REPORTS

Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease

(2013) J Xu et al.   Cell Death & Disease

Regulation of Cyclic AMP Response Element Binding and Hippocampal Plasticity-Related Genes by Peroxisome Proliferator-Activated Receptor α

(2013) Avik Roy et al.   Cell Reports

Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease

(2012) Mark P. Mattson   Cell Metabolism

The Peroxisome Proliferator-activated Receptor γ (PPARγ) Controls Natural Protective Mechanisms against Lipid Peroxidation in Amyotrophic Lateral Sclerosis

(2012) Valeria Benedusi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated Virtual Screening for the Identification of Novel and Selective Peroxisome Proliferator-Activated Receptor (PPAR) Scaffolds

(2012) Daniel K. Nevin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α

(2012) Caterina Scuderi et al.   Journal of Neuroinflammation

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis

(2012) Luc Dupuis et al.   PLoS One

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

Effects of pioglitazone and retinoic acid in a rotenone model of Parkinson's disease

(2011) Gokhan K. Ulusoy et al.   BRAIN RESEARCH BULLETIN

Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease

(2011) Ashu Johri et al.   HUMAN MOLECULAR GENETICS

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

(2011) Yuhai Zhao et al.   PLoS One

PPARδ deficient mice develop elevated Th1/Th17 responses and prolonged experimental autoimmune encephalomyelitis

(2010) Saravanan Kanakasabai et al.   BRAIN RESEARCH

Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma

(2010) Ming-Chang Chiang et al.   HUMAN MOLECULAR GENETICS

Peroxisome proliferator-activated receptor δ agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis

(2010) Saravanan Kanakasabai et al.   IMMUNOLOGY

The Role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in Alzheimer’s Disease

(2009) Qingguang Jiang et al.   CNS DRUGS

A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease

(2009) Sergey Kalinin et al.   Current Alzheimer Research

Cognitive Deficit in Amyloid-β–Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-γ Activation

(2009) Kana Tsukuda et al.   HYPERTENSION

Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer’s disease mouse model

(2008) Luis Escribano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rosiglitazone Treatment Prevents Mitochondrial Dysfunction in Mutant Huntingtin-expressing Cells

(2008) Rodrigo A. Quintanilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPAR: a therapeutic target in Parkinsons disease

(2008) Rajnish K. Chaturvedi et al.   JOURNAL OF NEUROCHEMISTRY

Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt

(2008) Bin Xing et al.   Journal of Neuroinflammation

Effects of the PPARγ activator pioglitazone on p38 MAP kinase and IκBα in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis

(2008) Noriyuki Shibata et al.   NEUROPATHOLOGY