Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease

Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis

(2012) Shunxing Rong et al.   JOURNAL OF LIPID RESEARCH

Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α

(2012) Emanuela Esposito et al.   Journal of Neuroinflammation

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

(2012) Jack van Horssen et al.   Journal of Neuroinflammation

The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function

(2012) Elizabeth Gray et al.   Journal of Neuroinflammation

Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases

(2012) Li Tian et al.   Journal of Neuroinflammation

PPARs: Fatty acid sensors controlling metabolism

(2012) Lars la Cour Poulsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PPARs at the crossroads of lipid signaling and inflammation

(2012) Walter Wahli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Transcriptional regulation of βsecretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments

(2011) Jin Chu et al.   ANNALS OF NEUROLOGY

Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis

(2011) Bianca Weinstock-Guttman et al.   Journal of Neuroinflammation

Amelioration of the Alzheimer's Disease Phenotype by Absence of 12/15-Lipoxygenase

(2010) Hengxuan Yang et al.   BIOLOGICAL PSYCHIATRY

Immunopharmacological role of the Leukotriene Receptor Antagonists and inhibitors of leukotrienes generating enzymes in Multiple Sclerosis

(2010) Abbas Mirshafiey et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Peroxisome proliferator–activated receptor δ limits the expansion of pathogenic Th cells during central nervous system autoimmunity

(2010) Shannon E. Dunn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional and pathological roles of the 12- and 15-lipoxygenases

(2010) Anca D. Dobrian et al.   PROGRESS IN LIPID RESEARCH

Intracellular trafficking of anandamide: new concepts for signaling

(2010) Mauro Maccarrone et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of Immune Responses and Autoimmune Encephalomyelitis by PPARs

(2010) Yuhong Yang et al.   PPAR Research

12/15-Lipoxygenase inhibitor baicalein suppresses PPARγ expression and nuclear translocation induced by cerebral ischemia/reperfusion

(2009) Yan-Wei Xu et al.   BRAIN RESEARCH

Dual 12/15- and 5-Lipoxygenase Deficiency in Macrophages Alters Arachidonic Acid Metabolism and Attenuates Peritonitis and Atherosclerosis in ApoE Knock-out Mice

(2009) Daniel Poeckel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Th17 Differentiation by Epidermal Fatty Acid-Binding Protein

(2009) B. Li et al.   JOURNAL OF IMMUNOLOGY

Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination

(2009) Antoinette Defaux et al.   Journal of Neuroinflammation

Mice Lacking 12/15-Lipoxygenase Have Attenuated Airway Allergic Inflammation and Remodeling

(2008) Cecilia K. Andersson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

(2008) David Wheeler et al.   BRAIN

Activation of Peroxisome Proliferator-Activated Receptor  /  Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor- B Activity via Extracellular Signal-Related Kinase 1/2

(2008) R. Rodriguez-Calvo et al.   DIABETES

Inflammatory Pathways Are Activated during Cardiomyocyte Hypertrophy and Attenuated by Peroxisome Proliferator-activated Receptors PPARα and PPARδ

(2008) Pascal J. H. Smeets et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic deletion of Fatty Acid Amide Hydrolase results in improved long-term outcome in chronic autoimmune encephalitis

(2008) Michael Webb et al.   NEUROSCIENCE LETTERS

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

(2008) Satoshi Serada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer’s disease

(2007) Omidreza Firuzi et al.   FASEB JOURNAL