The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

Identification and Characterization of Small Molecules as Potent and Specific EPAC2 Antagonists

(2013) Haijun Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

PADI4 and HLA-DRB1 Are Genetic Risks for Radiographic Progression in RA Patients, Independent of ACPA Status: Results from the IORRA Cohort Study

(2013) Taku Suzuki et al.   PLoS One

PLD4as a novel susceptibility gene for systemic sclerosis in a Japanese population

(2012) Chikashi Terao et al.   ARTHRITIS AND RHEUMATISM

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

(2012) Mark E. Schnute et al.   BIOCHEMICAL JOURNAL

Identification of Biologically Active PDE11-Selective Inhibitors Using a Yeast-Based High-Throughput Screen

(2012) Ozge Ceyhan et al.   CHEMISTRY & BIOLOGY

A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation

(2012) Giovanna Bergamini et al.   Nature Chemical Biology

Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population

(2012) Yukinori Okada et al.   NATURE GENETICS

A Role for Phospholipase D3 in Myotube Formation

(2012) Mary Osisami et al.   PLoS One

A homogeneous and nonisotopic assay for phosphatidylinositol 4-kinases

(2011) Andrew W. Tai et al.   ANALYTICAL BIOCHEMISTRY

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics

(2011) David J. Rawson et al.   BIOORGANIC & MEDICINAL CHEMISTRY

(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells

(2011) Keng Gat Lim et al.   CELLULAR SIGNALLING

Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration

(2011) Lin Huo et al.   EMBO JOURNAL

Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage

(2011) Sandrine Lépine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral type of choline acetyltransferase: Biological and evolutionary implications for novel mechanisms in cholinergic system

(2011) J.-P. Bellier et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Dihydroceramide desaturase and dihydrosphingolipids: Debutant players in the sphingolipid arena

(2011) Gemma Fabrias et al.   PROGRESS IN LIPID RESEARCH

Leukotriene A4Hydrolase Inhibition Attenuates Allergic Airway Inflammation and Hyperresponsiveness

(2010) Navin L. Rao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tyrosine hydroxylase and regulation of dopamine synthesis

(2010) S. Colette Daubner et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Human MRCKα is regulated by cellular iron levels and interferes with transferrin iron uptake

(2010) Radek Cmejla et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inactivation of Lipid Glyceryl Ester Metabolism in Human THP1 Monocytes/Macrophages by Activated Organophosphorus Insecticides: Role of Carboxylesterases 1 and 2

(2010) Shuqi Xie et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structural Basis for the Growth Factor Activity of Human Adenosine Deaminase ADA2

(2010) Anton V. Zavialov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of HalogenatedN-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: Discovery of an Isoform-Selective Small Molecule Phospholipase D2 Inhibitor

(2010) Robert R. Lavieri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

(2010) K. J. French et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo

(2010) Gabriel M. Simon et al.   Molecular BioSystems

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

Oxidation of the Endogenous Cannabinoid Arachidonoyl Ethanolamide by the Cytochrome P450 Monooxygenases: Physiological and Pharmacological Implications

(2010) N. T. Snider et al.   PHARMACOLOGICAL REVIEWS

Phospholipase D Family Member 4, a Transmembrane Glycoprotein with No Phospholipase D Activity, Expression in Spleen and Early Postnatal Microglia

(2010) Fumio Yoshikawa et al.   PLoS One

LC–MS/MS analysis of epoxyalcohols and epoxides of arachidonic acid and their oxygenation by recombinant CYP4F8 and CYP4F22

(2009) T. Nilsson et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes

(2009) Motohiro Tani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

N-Myristoylation targets dihydroceramide Δ4-desaturase 1 to mitochondria: Partial involvement in the apoptotic effect of myristic acid

(2009) Erwan Beauchamp et al.   BIOCHIMIE

Pharmacologic Inhibition of Squalene Synthase and Other Downstream Enzymes of the Cholesterol Synthesis Pathway

(2009) Stephanie Seiki et al.   Cardiology in Review

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Expression and Characterization of CYP4V2 as a Fatty Acid  -Hydroxylase

(2009) M. Nakano et al.   DRUG METABOLISM AND DISPOSITION

In vivo inactivation of MASTL kinase results in thrombocytopenia

(2009) H. Jan Johnson et al.   EXPERIMENTAL HEMATOLOGY

M-Type Phospholipase A2Receptor as Target Antigen in Idiopathic Membranous Nephropathy

(2009) Laurence H. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase

(2009) S. Philipp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation

(2009) C. Solorzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities

(2009) G. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

(2008) John M. Keith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

(2008) S. W. Paugh et al.   BLOOD

Myotonic dystrophy protein kinase (DMPK) and its role in the pathogenesis of myotonic dystrophy 1

(2008) Perla Kaliman et al.   CELLULAR SIGNALLING

AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids

(2008) Lucie Škarydová et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide

(2008) Katarina Stark et al.   FEBS Journal

MAST3: a novel IBD risk factor that modulates TLR4 signaling

(2008) C Labbé et al.   GENES AND IMMUNITY

Ribosomal S6 Kinase 2 Directly Phosphorylates the 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptor, Thereby Modulating 5-HT2ASignaling

(2008) Ryan T. Strachan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac Regulates Its Effector Phospholipase Cγ2through Interaction with a Split Pleckstrin Homology Domain

(2008) Claudia Walliser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Male Germ Cells Require Polyenoic Sphingolipids with Complex Glycosylation for Completion of Meiosis

(2008) Mariona Rabionet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-Chromosome Inactivation and Skin Disease

(2008) Bryan K. Sun et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism

(2008) Maude Fer et al.   JOURNAL OF LIPID RESEARCH

Pirinixic Acid Derivatives as Novel Dual Inhibitors of Microsomal Prostaglandin E2Synthase-1 and 5-Lipoxygenase

(2008) Andreas Koeberle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase

(2008) Dirk A. Heerding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor

(2008) C. Graf et al.   MOLECULAR PHARMACOLOGY

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Structural basis for induced formation of the inflammatory mediator prostaglandin E2

(2008) C. Jegerschold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The contribution of cyclooxygenase-2 to endocannabinoid metabolism and action

(2007) C J Fowler   BRITISH JOURNAL OF PHARMACOLOGY

The complications of promiscuity: endocannabinoid action and metabolism

(2007) S P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY