The Link between Type 2 Diabetes Mellitus and the Polymorphisms of Glutathione-Metabolizing Genes Suggests a New Hypothesis Explaining Disease Initiation and Progression

Aggregating multiple expression prediction models improves the power of transcriptome wide association studies

(2021) Ping Zeng et al.   HUMAN MOLECULAR GENETICS

Polymorphic Variants in gamma-glutamyltransferase 6 as New Genetic Markers of Type 2 Diabetes Mellitus

(2021) Iuliia Azarova et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Changes in Glutathione Content in Liver Diseases: An Update

(2021) Mariapia Vairetti et al.   Antioxidants

Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes

(2021) Zhongying Wang et al.   Communications Biology

Diabetes and global ageing among 65–99-year-old adults: Findings from the International Diabetes Federation Diabetes Atlas, 9th edition

(2020) Alan Sinclair et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The Dose-Response Relationship between Gamma-Glutamyl Transferase and Risk of Diabetes Mellitus Using Publicly Available Data: A Longitudinal Study in Japan

(2020) Wei Zhao et al.   International Journal of Endocrinology

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

(2020) Alexey Polonikov   ACS Infectious Diseases

Genetic variants in glutamate cysteine ligase confer protection against type 2 diabetes

(2020) Iuliia Azarova et al.   MOLECULAR BIOLOGY REPORTS

The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19

(2020) Francesca Silvagno et al.   Antioxidants

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets

(2020) Qiong Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Role of Glutathione in Cancer: From Mechanisms to Therapies

(2020) Luke Kennedy et al.   Biomolecules

The pharmacogenetics of hypoglycemia and the glycemic variability at the patients ith type 2 diabetes mellitus

(2020) N. A. Chernikova et al.   TERAPEVTICHESKII ARKHIV

Circulating Oxidative Stress Biomarkers in Clinical Studies on Type 2 Diabetes and Its Complications

(2019) Elisabetta Bigagli et al.   Oxidative Medicine and Cellular Longevity

Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure

(2019) Jitai Zhang et al.   Cell Death & Disease

Identification of core genes and pathways in type 2 diabetes mellitus by bioinformatics analysis

(2019) Linchao Ding et al.   Molecular Medicine Reports

Proinsulin misfolding is an early event in the progression to type 2 diabetes

(2019) Anoop Arunagiri et al.   eLife

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

QTLbase: an integrative resource for quantitative trait loci across multiple human molecular phenotypes

(2019) Zhanye Zheng et al.   NUCLEIC ACIDS RESEARCH

Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program

(2019) Jacklyn N. Hellwege et al.   Nature Communications

Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high-fat diet-fed obese mice

(2019) Rajesh Parsanathan et al.   Scientific Reports

Sexual dimorphism in glutathione metabolism and glutathione-dependent responses

(2019) Luxi Wang et al.   Redox Biology

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

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(2018) Po-Ru Loh et al.   NATURE GENETICS

Glycine Increases Insulin Sensitivity and Glutathione Biosynthesis and Protects against Oxidative Stress in a Model of Sucrose-Induced Insulin Resistance

(2018) Mohammed El-Hafidi et al.   Oxidative Medicine and Cellular Longevity

Glutathione metabolism in type 2 diabetes and its relationship with microvascular complications and glycemia

(2018) Fallon K. Lutchmansingh et al.   PLoS One

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(2018) Caroline Maria Oliveira Volpe et al.   Cell Death & Disease

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes

(2018) Beibei Xu et al.   Cell Reports

Glutathione S-transferase genes and the risk of type 2 diabetes mellitus: Role of sexual dimorphism, gene-gene and gene-smoking interactions in disease susceptibility

(2018) Iuliia Azarova et al.   Journal of Diabetes

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(2018) Ming Liu et al.   DIABETES OBESITY & METABOLISM

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Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine

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Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors

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Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked?

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Combined effect of serum gamma-glutamyltransferase and uric acid on incidence of diabetes mellitus

(2017) Seok-Hoon Lee et al.   MEDICINE

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

(2017) Xinjian Li et al.   MOLECULAR CELL

Type-2 diabetes-associated variants with cross-trait relevance: Post-GWAs strategies for biological function interpretation

(2017) Francesca Frau et al.   MOLECULAR GENETICS AND METABOLISM

Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding

(2017) I Moreno-Gonzalez et al.   MOLECULAR PSYCHIATRY

A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility

(2017) Alexey V. Polonikov et al.   Pharmacogenetics and Genomics

Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

(2017) Mariaelisa Graff et al.   PLoS Genetics

Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties

(2017) Marina Diotallevi et al.   Frontiers in Immunology

The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo

(2017) Karilyn E. Sant et al.   Redox Biology

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

Novel insight into streptozotocin-induced diabetic rats from the protein misfolding perspective

(2017) Edgar Leyva-García et al.   Scientific Reports

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum

(2016) Leena Haataja et al.   DIABETES

Prevalence of type 2 diabetes mellitus (T2DM) in the adult Russian population (NATION study)

(2016) Ivan Dedov et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet

(2016) Neus Martínez-Micaelo et al.   Disease Models & Mechanisms

Assessment of causality between serum gamma-glutamyltransferase and type 2 diabetes mellitus using publicly available data: a Mendelian randomization study

(2016) Raymond Noordam et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Nineteen-year follow-up of a patient with severe glutathione synthetase deficiency

(2016) Paldeep S Atwal et al.   JOURNAL OF HUMAN GENETICS

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(2016) L. Lattenist et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

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(2016) Christian Fuchsberger et al.   NATURE

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(2016) Alexander Gusev et al.   NATURE GENETICS

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(2015) Federico Pietrocola et al.   Cell Metabolism

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(2015) Feng Gu et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes☆

(2015) Jinhong Sun et al.   MOLECULAR ASPECTS OF MEDICINE

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(2014) L. V. Mohan Rao et al.   BLOOD

Oxidative stress in susceptibility to breast cancer: study in Spanish population

(2014) Patricia Rodrigues et al.   BMC CANCER

Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

(2014) Tobias Eisenberg et al.   Cell Metabolism

Targeted Allelic Expression Profiling in Human Islets Identifiescis-Regulatory Effects for Multiple Variants Identified by Type 2 Diabetes Genome-Wide Association Studies

(2014) Jonathan M. Locke et al.   DIABETES

Switching from singlet-oxygen-mediated oxidation to free-radical-mediated oxidation in the pathogenesis of type 2 diabetes in model mouse

(2014) K. Murotomi et al.   FREE RADICAL RESEARCH

Association ofSuperoxide dismutases(SOD1 and SOD2) andGlutathione peroxidase 1 (GPx1)gene polymorphisms with Type 2 diabetes mellitus

(2014) P. Vats et al.   FREE RADICAL RESEARCH

Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome

(2014) Emma Raitoharju et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

(2014) Satoshi Tsunoda et al.   eLife

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(2014) José L. García-Giménez et al.   Frontiers in Pharmacology

 -Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?

(2013) S. Costes et al.   DIABETES

Evaluation of Glutathione S-Transferase GSTM1 and GSTT1 Deletion Polymorphisms on Type-2 Diabetes Mellitus Risk

(2013) Denise S. Pinheiro et al.   PLoS One

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(2013) I. Braakman et al.   Cold Spring Harbor Perspectives in Biology

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(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

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Genetic Variation in Glutathione S-Transferase Genes and Risk of Nonfatal Cerebral Stroke in Patients Suffering from Essential Hypertension

(2012) Alexey Polonikov et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53

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(2012) K. A. Dill et al.   SCIENCE

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Polymorphic variations in manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1), and catalase (CAT) contribute to elevated plasma triglyceride levels in Chinese patients with type 2 diabetes or diabetic cardiovascular disease

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(2011) Stella Koutros et al.   Pharmacogenetics and Genomics

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(2010) Carrie V. Breton et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

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Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

(2010) N. Soranzo et al.   DIABETES

Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine

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(2010) Erik J. Henriksen et al.   FREE RADICAL BIOLOGY AND MEDICINE

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(2010) Peter Kraft et al.   STATISTICAL SCIENCE

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(2009) Charumathi Sabanayagam et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

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(2009) Federico V. Pallardó et al.   MOLECULAR ASPECTS OF MEDICINE

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(2009) Zongli Xu et al.   NUCLEIC ACIDS RESEARCH

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