Endothelial cell protein C receptor: a multiliganded and multifunctional receptor

EPCR: holy grail of malaria cytoadhesion?

(2014) M. Ho   BLOOD

Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrityin vivo

(2014) J. Sundaram et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria

(2014) Izumi Naka et al.   MALARIA JOURNAL

Organ-Specific Protection Against Lipopolysaccharide-Induced Vascular Leak Is Dependent on the Endothelial Protein C Receptor

(2013) Annette von Drygalski et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

(2013) L. Burnier et al.   BLOOD

The endothelial protein C receptor and malaria

(2013) T. van der Poll   BLOOD

Plasmodium falciparum picks (on) EPCR

(2013) W. C. Aird et al.   BLOOD

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

(2013) C. A. Moxon et al.   BLOOD

Endothelial Cell Protein C Receptor Opposes Mesothelioma Growth Driven by Tissue Factor

(2013) Shiva Keshava et al.   CANCER RESEARCH

Influence of endothelial cell protein C receptor on breast cancer development

(2013) S. Keshava et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway

(2013) E. A. M. Bouwens et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Severe malaria is associated with parasite binding to endothelial protein C receptor

(2013) Louise Turner et al.   NATURE

Rab GTPases Regulate Endothelial Cell Protein C Receptor-Mediated Endocytosis and Trafficking of Factor VIIa

(2013) Ramesh C. Nayak et al.   PLoS One

Mac-1 Directly Binds to the Endothelial Protein C-Receptor: A Link between the Protein C Anticoagulant Pathway and Inflammation?

(2013) Katrin Fink et al.   PLoS One

Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development

(2013) Florence Schaffner et al.   PLoS One

Receptor of Activated Protein C Promotes Metastasis and Correlates with Clinical Outcome in Lung Adenocarcinoma

(2012) Iker Antón et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

(2012) L. O. Mosnier et al.   BLOOD

Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects

(2012) R. A. SCHUEPBACH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa

(2012) C. A. CLARK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

EPCR: a stress trigger for γδ T cells

(2012) Deborah A Witherden et al.   NATURE IMMUNOLOGY

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

(2012) T. Lavstsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is EPCR a multi-ligand receptor? Pros and cons

(2012) Eva Molina et al.   THROMBOSIS AND HAEMOSTASIS

Factor VIIa binding to endothelial cell protein C receptor: Differences between mouse and human systems

(2012) Prosenjit Sen et al.   THROMBOSIS AND HAEMOSTASIS

Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C

(2011) P. Sen et al.   BLOOD

sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove

(2011) J. Lopez-Sagaseta et al.   BLOOD

Control of Plasmodium falciparum erythrocytic cycle:    T cells target the red blood cell-invasive merozoites

(2011) G. Costa et al.   BLOOD

Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection

(2011) P. Sen et al.   BLOOD

Expression and shedding of endothelial protein C receptor in prostate cancer cells

(2011) Mario Menschikowski et al.   Cancer Cell International

Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation

(2011) G.L. van Sluis et al.   CANCER LETTERS

The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling

(2011) Eimear M. Gleeson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases

(2011) Alireza R. Rezaie   IUBMB LIFE

Factor X and factor VII binding to endothelial protein C receptor differs between species

(2011) C. PUY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through  -arrestin and dishevelled-2 scaffolds

(2011) U. J. K. Soh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broken Barriers: A New Take on Sepsis Pathogenesis

(2011) N. M. Goldenberg et al.   Science Translational Medicine

Protein C anticoagulant system—anti-inflammatory effects

(2011) Charles T. Esmon   Seminars in Immunopathology

Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver

(2010) H. Iwasaki et al.   BLOOD

The endothelial cells downregulate the generation of factor VIIa through EPCR binding

(2010) Cristina Puy et al.   BRITISH JOURNAL OF HAEMATOLOGY

Heterogeneity for Stem Cell-Related Markers According to Tumor Subtype and Histologic Stage in Breast Cancer

(2010) S. Y. Park et al.   CLINICAL CANCER RESEARCH

Regulation of the Protein C Anticoagulant and Antiinflammatory Pathways

(2010) A.R. Rezaie   CURRENT MEDICINAL CHEMISTRY

The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors

(2010) Jennifer Disse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Factor X/Xa Elicits Protective Signaling Responses in Endothelial Cells Directly via PAR-2 and Indirectly via Endothelial Protein C Receptor-dependent Recruitment of PAR-1

(2010) Jong-Sup Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice

(2010) Edward Kerschen et al.   JOURNAL OF CLINICAL INVESTIGATION

Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor

(2010) Usha R. Pendurthi et al.   THROMBOSIS RESEARCH

Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications

(2009) R. C. Nayak et al.   BLOOD

Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement

(2009) G. L. Van Sluis et al.   BLOOD

Role of activated protein C and its receptor in inhibition of tumor metastasis

(2009) M. Bezuhly et al.   BLOOD

Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction

(2009) Mark W. Gramling et al.   EXPERIMENTAL CELL RESEARCH

Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function

(2009) Nikita Minhas et al.   FASEB JOURNAL

Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor

(2009) R. A. SCHUEPBACH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Caveolae are required for protease-selective signaling by protease-activated receptor-1

(2009) A. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant expression of biologically active murine soluble EPCR

(2008) Jacinto López-Sagaseta et al.   PROTEIN EXPRESSION AND PURIFICATION