Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift
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Title
Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift
Authors
Keywords
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Journal
Frontiers in Behavioral Neuroscience
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2015-02-20
DOI
10.3389/fnbeh.2015.00025
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- (2015) Olivia F. O’Leary et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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- (2014) Ting Du et al. CELL CALCIUM
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- (2014) Andres M. Kanner EPILEPSY & BEHAVIOR
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- (2014) Ursula Sonnewald JOURNAL OF NEUROCHEMISTRY
- Glutamate and Choline Levels Predict Individual Differences in Reading Ability in Emergent Readers
- (2014) K. R. Pugh et al. JOURNAL OF NEUROSCIENCE
- Roles of astrocytic Na+,K+-ATPase and glycogenolysis for K+homeostasis in mammalian brain
- (2014) Leif Hertz et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Astrocytic glycogenolysis: mechanisms and functions
- (2014) Leif Hertz et al. METABOLIC BRAIN DISEASE
- Why are Astrocytes Important?
- (2014) Alexei Verkhratsky et al. NEUROCHEMICAL RESEARCH
- Basic Mechanism Leading to Stimulation of Glycogenolysis by Isoproterenol, EGF, Elevated Extracellular K+ Concentrations, or GABA
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- (2014) Chadi G. Abdallah et al. PSYCHOTHERAPY AND PSYCHOSOMATICS
- Serotonin mediation of early memory formation via 5-HT2B receptor-induced glycogenolysis in the day-old chick
- (2014) Marie E. Gibbs et al. Frontiers in Pharmacology
- High impact child abuse may predict risk of elevated suicidality during antidepressant initiation
- (2013) Ajeet B Singh et al. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
- From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders
- (2013) Gerard Sanacora et al. BIOLOGICAL PSYCHIATRY
- Postnatal Fluoxetine-Evoked Anxiety Is Prevented by Concomitant 5-HT2A/C Receptor Blockade and Mimicked by Postnatal 5-HT2A/C Receptor Stimulation
- (2013) Ambalika Sarkar et al. BIOLOGICAL PSYCHIATRY
- Mechanisms for L-channel-mediated increase in [Ca2+]i and its reduction by anti-bipolar drugs in cultured astrocytes combined with its mRNA expression in freshly isolated cells support the importance of astrocytic L-channels
- (2013) Enzhi Yan et al. CELL CALCIUM
- Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue
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- Impairment in Long-Term Memory Formation and Learning-Dependent Synaptic Plasticity in Mice Lacking Glycogen Synthase in the Brain
- (2013) Jordi Duran et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Glutamatergic and GABAergic energy metabolism measured in the rat brain by13C NMR spectroscopy at 14.1 T
- (2013) João M. N. Duarte et al. JOURNAL OF NEUROCHEMISTRY
- NMDA Receptor Activation and Calpain Contribute to Disruption of Dendritic Spines by the Stress Neuropeptide CRH
- (2013) Adrienne L. Andres et al. JOURNAL OF NEUROSCIENCE
- Glutamine deficiency in the prefrontal cortex increases depressive-like behaviours in male mice
- (2013) Younghyurk Lee et al. JOURNAL OF PSYCHIATRY & NEUROSCIENCE
- K+ Homeostasis in the Brain: A New Role for Glycogenolysis
- (2013) S. Mangia et al. NEUROCHEMICAL RESEARCH
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- (2013) B. Li et al. NEUROCHEMICAL RESEARCH
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- (2012) L. Descarries et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
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- (2012) Clarrisa A. Bradley et al. Frontiers in Molecular Neuroscience
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- (2011) Golam M.I. Chowdhury et al. BIOLOGICAL PSYCHIATRY
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- (2011) Atsushi Oyagi et al. BRAIN RESEARCH
- Effects of chronic treatment with fluoxetine on receptor-stimulated increase of [Ca2+]i in astrocytes mimic those of acute inhibition of TRPC1 channel activity
- (2011) Baoman Li et al. CELL CALCIUM
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- (2011) Abigail M. Polter et al. CELLULAR SIGNALLING
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- (2011) Maosheng Xia et al. GLIA
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- (2011) Madhukar H. Trivedi et al. JOURNAL OF CLINICAL PSYCHIATRY
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- (2011) Baoman Li JOURNAL OF PSYCHIATRY & NEUROSCIENCE
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- (2011) S L Diaz et al. MOLECULAR PSYCHIATRY
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- (2011) E Beurel et al. MOLECULAR PSYCHIATRY
- Chronic antidepressant treatments induce a time-dependent up-regulation of AMPA receptor subunit protein levels
- (2011) Alessandro Barbon et al. NEUROCHEMISTRY INTERNATIONAL
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- (2011) Igor Allaman et al. PSYCHOPHARMACOLOGY
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- (2010) Carola G. Schipke et al. JOURNAL OF PSYCHIATRIC RESEARCH
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- (2010) C. Schmauss et al. RNA
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- (2009) Tae-Yeon Eom et al. BIOLOGICAL PSYCHIATRY
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- (2009) Graziano Pinna et al. CURRENT OPINION IN PHARMACOLOGY
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- (2009) John E. Kraus et al. JOURNAL OF AFFECTIVE DISORDERS
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- (2008) B Li et al. BRITISH JOURNAL OF PHARMACOLOGY
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- (2008) M Banasr et al. MOLECULAR PSYCHIATRY
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- (2008) G Shaltiel et al. MOLECULAR PSYCHIATRY
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