Brain Organoids: Filling the Need for a Human Model of Neurological Disorder

Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs

(2021) Carlo Brighi et al.   Cell Death & Disease

Cell stress in cortical organoids impairs molecular subtype specification

(2020) Aparna Bhaduri et al.   NATURE

Potassium channel dysfunction in human neuronal models of Angelman syndrome

(2020) Alfred Xuyang Sun et al.   SCIENCE

Replacing what’s lost: a new era of stem cell therapy for Parkinson’s disease

(2020) Yong Fan et al.   Translational Neurodegeneration

Cystatin B is essential for proliferation and interneuron migration in individuals with EPM 1 epilepsy

(2020) Francesco Di Matteo et al.   EMBO Molecular Medicine

Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms

(2020) Angélica María Sabogal-Guáqueta et al.   PROGRESS IN NEUROBIOLOGY

Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder

(2020) Annie Kathuria et al.   Genome Medicine

The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus

(2020) Carolina da S. G. Pedrosa et al.   PLoS Neglected Tropical Diseases

Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease

(2020) Sarah Louise Nickels et al.   Stem Cell Research

Dual SMAD inhibition and Wnt inhibition enable efficient and reproducible differentiations of induced pluripotent stem cells into retinal ganglion cells

(2020) Venkata R. M. Chavali et al.   Scientific Reports

Patient-Derived Midbrain Organoids to Explore the Molecular Basis of Parkinson's Disease

(2020) Benjamin Galet et al.   Frontiers in Neurology

Brain Organoids as Model Systems for Genetic Neurodevelopmental Disorders

(2020) Simona Baldassari et al.   Frontiers in Cell and Developmental Biology

Neural Stem Cells and Methods for Their Generation From Induced Pluripotent Stem Cells in vitro

(2020) Adelya A. Galiakberova et al.   Frontiers in Cell and Developmental Biology

Generation of Functional Human 3D Cortico-Motor Assembloids

(2020) Jimena Andersen et al.   CELL

Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells

(2020) Yuki Miura et al.   NATURE BIOTECHNOLOGY

Impact of Traumatic Brain Injury on Neurogenesis

(2019) Laura B. Ngwenya et al.   Frontiers in Neuroscience

Modeling Human Brain Circuitry Using Pluripotent Stem Cell Platforms

(2019) Annalisa M. Hartlaub et al.   Frontiers in Pediatrics

Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

(2019) Hongwon Kim et al.   Stem Cell Reports

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

(2019) Katharina Meyer et al.   Cell Reports

Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia

(2019) Johannes Klaus et al.   NATURE MEDICINE

Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain

(2019) Kirsten Obernier et al.   DEVELOPMENT

OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

(2019) Ranjie Xu et al.   Cell Stem Cell

Brain organoids: advances, applications and challenges

(2019) Xuyu Qian et al.   DEVELOPMENT

Robust Generation of Person-Specific, Synchronously Active Neuronal Networks Using Purely Isogenic Human iPSC-3D Neural Aggregate Cultures

(2019) Julia Izsak et al.   Frontiers in Neuroscience

Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications

(2019) Michael Xavier Doss et al.   Cells

Drug efficacy testing of targeted therapies in endometrial cancer organoids is partially predicted by cancer gene mutation data (Correct)

(2019) H. Chen et al.   GYNECOLOGIC ONCOLOGY

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids

(2019) Bradley R. Groveman et al.   Acta Neuropathologica Communications

Building Complex Life Through Self-Organization

(2019) Mireille M.J.P.E. Sthijns et al.   TISSUE ENGINEERING PART A

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells

(2019) Philipp Wörsdörfer et al.   Scientific Reports

Automated Design of Pluripotent Stem Cell Self-Organization

(2019) Ashley R.G. Libby et al.   Cell Systems

Toward the formation of neural circuits in human brain organoids

(2019) Yusuke Seto et al.   CURRENT OPINION IN CELL BIOLOGY

Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration

(2019) Anna M. Speicher et al.   Molecular Neurodegeneration

Organoid and Assembloid Technologies for Investigating Cellular Crosstalk in Human Brain Development and Disease

(2019) Rebecca M. Marton et al.   TRENDS IN CELL BIOLOGY

Genetic Modification of Brain Organoids

(2019) Jan Fischer et al.   Frontiers in Cellular Neuroscience

Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation

(2018) Maria L. Allende et al.   JOURNAL OF LIPID RESEARCH

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Generation of human brain region–specific organoids using a miniaturized spinning bioreactor

(2018) Xuyu Qian et al.   Nature Protocols

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Generation of human vascularized brain organoids

(2018) Missy T. Pham et al.   NEUROREPORT

Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes

(2018) P. Conforti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells

(2018) Yuanwei Yan et al.   TISSUE ENGINEERING PART A

Glioblastoma Model Using Human Cerebral Organoids

(2018) Junko Ogawa et al.   Cell Reports

Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients

(2018) Wen-Li Deng et al.   Stem Cell Reports

Organoids for Drug Discovery and Personalized Medicine

(2018) Toshio Takahashi   Annual Review of Pharmacology and Toxicology

Living inside the box: environmental effects on mouse models of human disease

(2018) John P. Sundberg et al.   Disease Models & Mechanisms

Modeling amyloid beta and tau pathology in human cerebral organoids

(2018) Cesar Gonzalez et al.   MOLECULAR PSYCHIATRY

Genetically engineered human cortical spheroid models of tuberous sclerosis

(2018) John D. Blair et al.   NATURE MEDICINE

Induction of myelinating oligodendrocytes in human cortical spheroids

(2018) Mayur Madhavan et al.   NATURE METHODS

Patterning factors during neural progenitor induction determine regional identity and differentiation potential in vitro

(2018) Aishwarya G. Nadadhur et al.   Stem Cell Research

Human SPG11 cerebral organoids reveal cortical neurogenesis impairment

(2018) Francesc Pérez-Brangulí et al.   HUMAN MOLECULAR GENETICS

Stem cell models of human synapse development and degeneration

(2018) Emily S. Wilson et al.   MOLECULAR BIOLOGY OF THE CELL

Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

(2018) Mandy Johnstone et al.   MOLECULAR PSYCHIATRY

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres

(2018) Celina Monteiro Abreu et al.   Frontiers in Microbiology

Mechanisms of radial glia progenitor cell lineage progression

(2017) Robert Beattie et al.   FEBS LETTERS

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

(2017) Jinsoo Seo et al.   JOURNAL OF NEUROSCIENCE

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling

(2017) N Mellios et al.   MOLECULAR PSYCHIATRY

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

(2017) Vira Iefremova et al.   Cell Reports

A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates

(2017) Jean-Louis Plouhinec et al.   PLOS BIOLOGY

Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1

(2017) E. K. Stachowiak et al.   Translational Psychiatry

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups

(2016) David A. Parfitt et al.   Cell Stem Cell

Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection

(2016) Michael F. Wells et al.   Cell Stem Cell

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

(2016) Jason Dang et al.   Cell Stem Cell

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Personalized genome sequencing coupled with iPSC technology identifies GTDC1 as a gene involved in neurodevelopmental disorders

(2016) Irene Aksoy et al.   HUMAN MOLECULAR GENETICS

Brain Aggregates: An EffectiveIn VitroCell Culture System Modeling Neurodegenerative Diseases

(2016) Misol Ahn et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The promises and challenges of human brain organoids as models of neuropsychiatric disease

(2016) Giorgia Quadrato et al.   NATURE MEDICINE

Building brains in a dish: Prospects for growing cerebral organoids from stem cells

(2016) John O. Mason et al.   NEUROSCIENCE

Neural Stem Cell Therapy and Rehabilitation in the Central Nervous System: Emerging Partnerships

(2016) H. H. Ross et al.   PHYSICAL THERAPY

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Generating patient-specific induced pluripotent stem cells-derived cardiomyocytes for the treatment of cardiac diseases

(2015) Dorota Jeziorowska et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Somatic cell nuclear transfer: origins, the present position and future opportunities

(2015) Ian Wilmut et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Transmigration of Neural Stem Cells across the Blood Brain Barrier Induced by Glioma Cells

(2013) Mónica Díaz-Coránguez et al.   PLoS One

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transplantation of induced pluripotent stem cell-derived neurospheres for peripheral nerve repair

(2012) Takuya Uemura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stem cells in ectodermal development

(2012) Salvador Aznar Benitah et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Investigating synapse formation and function using human pluripotent stem cell-derived neurons

(2011) J.-E. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Environmental Exposures in Neurodegeneration and Neurodegenerative Diseases

(2011) Jason R. Cannon et al.   TOXICOLOGICAL SCIENCES

Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells

(2010) Christopher A. Fasano et al.   Cell Stem Cell

Long-term culture and differentiation of CNS precursors derived from anterior human neural rosettes following exposure to ventralizing factors

(2010) Silvia Colleoni et al.   EXPERIMENTAL CELL RESEARCH

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Adult neural stem cells in the mammalian central nervous system

(2009) Dengke K Ma et al.   CELL RESEARCH

Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells

(2009) X.-J. Li et al.   DEVELOPMENT

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Blood-Brain Barrier Promotes Differentiation of Human Fetal Neural Precursor Cells

(2009) Satyan Chintawar et al.   STEM CELLS

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage

(2008) Y. Elkabetz et al.   GENES & DEVELOPMENT

Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation

(2008) T. Wataya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neurosphere assay, a method under scrutiny

(2007) Loic P. Deleyrolle et al.   ACTA NEUROPSYCHIATRICA

Neural stem cell self-renewal

(2007) Yanhong Shi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY