Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis

(2017) Fei Ye et al.   NEURON

The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484

(2017) Nicholas J. Bradshaw et al.   Open Biology

NDE1 and GSK3β Associate with TRAK1 and Regulate Axonal Mitochondrial Motility: Identification of Cyclic AMP as a Novel Modulator of Axonal Mitochondrial Trafficking

(2016) Fumiaki Ogawa et al.   ACS Chemical Neuroscience

Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports

(2016) Catherine A. Brownstein et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

NDE1 and NDEL1 from genes to (mal)functions: parallel but distinct roles impacting on neurodevelopmental disorders and psychiatric illness

(2016) Nicholas J. Bradshaw et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The NF-κB signaling pathway: an important therapeutic target in psychiatric disorders

(2016) M A Altinoz et al.   MOLECULAR PSYCHIATRY

Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages

(2016) David J. Doobin et al.   Nature Communications

A maternally inherited 16p13.11-p12.3 duplication concomitant with a de novoSOX5deletion in a male patient with global developmental delay, disruptive and obsessive behaviors and minor dysmorphic features

(2015) Ines Quintela et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

miRWalk2.0: a comprehensive atlas of microRNA-target interactions

(2015) Harsh Dweep et al.   NATURE METHODS

The Poly(I:C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery

(2015) Sonali Reisinger et al.   PHARMACOLOGY & THERAPEUTICS

Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity

(2014) Ki-Jun Yoon et al.   Cell Stem Cell

Realizing the Promise of Reverse Phase Protein Arrays for Clinical, Translational, and Basic Research: A Workshop Report

(2014) Rehan Akbani et al.   MOLECULAR & CELLULAR PROTEOMICS

Synaptic dysregulation in a human iPS cell model of mental disorders

(2014) Zhexing Wen et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility

(2014) Hiroki Kimura et al.   SCHIZOPHRENIA BULLETIN

The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation

(2014) Shauna L Houlihan et al.   eLife

SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients

(2013) Aleksandr Shcheglovitov et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex

(2013) Bridget E. LaMonica et al.   Nature Communications

NF-κB signalling requirement for brain myelin formation is shown by genotype/MRI phenotype correlations in patients with Xq28 duplications

(2012) Orianne Philippe et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Regrowing the Adult Brain: NF-κB Controls Functional Circuit Formation and Tissue Homeostasis in the Dentate Gyrus

(2012) Yvonne Imielski et al.   PLoS One

The Essential Role of Centrosomal NDE1 in Human Cerebral Cortex Neurogenesis

(2011) Mehmet Bakircioglu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human Mutations in NDE1 Cause Extreme Microcephaly with Lissencephaly

(2011) Fowzan S. Alkuraya et al.   AMERICAN JOURNAL OF HUMAN GENETICS

IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system

(2011) Jenni Raasch et al.   BRAIN

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

(2011) Sergiu P Paşca et al.   NATURE MEDICINE

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Variants of the RELA Gene are Associated with Schizophrenia and their Startle Responses

(2011) Ryota Hashimoto et al.   NEUROPSYCHOPHARMACOLOGY

Nuclear Factor Kappa B Signaling Initiates Early Differentiation of Neural Stem Cells

(2011) Yonggang Zhang et al.   STEM CELLS

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning

(2010) C. Lam et al.   JOURNAL OF CELL SCIENCE

Identification of novel small molecule activators of nuclear factor-κb with neuroprotective action via high-throughput screening

(2010) Marina S. Manuvakhova et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Nuclear factor- B is a critical mediator of stress-impaired neurogenesis and depressive behavior

(2010) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Generation of functional human hepatic endoderm from human induced pluripotent stem cells

(2009) Gareth J. Sullivan et al.   HEPATOLOGY

Support for the involvement of large copy number variants in the pathogenesis of schizophrenia

(2009) George Kirov et al.   HUMAN MOLECULAR GENETICS

Copy number variations of chromosome 16p13.1 region associated with schizophrenia

(2009) A Ingason et al.   MOLECULAR PSYCHIATRY

DISC1, PDE4B, and NDE1 at the centrosome and synapse

(2008) Nicholas J. Bradshaw et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: Evidence of epistasis and competitive binding

(2008) K. E. Burdick et al.   HUMAN MOLECULAR GENETICS

Recurrent reciprocal deletions and duplications of 16p13.11: the deletion is a risk factor for MR/MCA while the duplication may be a rare benign variant

(2008) F D Hannes et al.   JOURNAL OF MEDICAL GENETICS

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE

NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction

(2008) Nicholas J. Bradshaw et al.   NEUROSCIENCE LETTERS