Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain

Single-Cell Transcriptomics and Fate Mapping of Ependymal Cells Reveals an Absence of Neural Stem Cell Function

(2018) Prajay T. Shah et al.   CELL

Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner

(2018) David Petrik et al.   Cell Stem Cell

Human Hippocampal Neurogenesis Persists throughout Aging

(2018) Maura Boldrini et al.   Cell Stem Cell

Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation

(2018) Kirsten Obernier et al.   Cell Stem Cell

Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer’s Disease Adults

(2018) Sara Cipriani et al.   CEREBRAL CORTEX

A Temporal Transcriptional Switch Governs Stem Cell Division, Neuronal Numbers, and Maintenance of Differentiation

(2018) Natalia Mora et al.   DEVELOPMENTAL CELL

Fractone Bulbs Derive from Ependymal Cells and Their Laminin Composition Influence the Stem Cell Niche in the Subventricular Zone

(2018) Marcos Assis Nascimento et al.   JOURNAL OF NEUROSCIENCE

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

(2018) Onur Basak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult-born neurons boost odor–reward association

(2018) Anne Grelat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live imaging of neurogenesis in the adult mouse hippocampus

(2018) Gregor-Alexander Pilz et al.   SCIENCE

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

(2018) Dena S. Leeman et al.   SCIENCE

Adult-born neurons facilitate olfactory bulb pattern separation during task engagement

(2018) Wankun L Li et al.   eLife

Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron

(2018) Elisa Galliano et al.   eLife

Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone

(2017) Hiroki Kawai et al.   JOURNAL OF NEUROSCIENCE

Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice

(2017) Mingke Song et al.   NEUROBIOLOGY OF DISEASE

Diazepam Binding Inhibitor Promotes Stem Cell Expansion Controlling Environment-Dependent Neurogenesis

(2017) Ionut Dumitru et al.   NEURON

Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells

(2017) Xiao-Ling Hu et al.   NEURON

Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis

(2017) Alex Paul et al.   SCIENCE

Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling

(2017) Scott A. Yuzwa et al.   Cell Reports

Single-Cell Transcriptomic Analysis Defines Heterogeneity and Transcriptional Dynamics in the Adult Neural Stem Cell Lineage

(2017) Ben W. Dulken et al.   Cell Reports

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

(2017) Benedetta Artegiani et al.   Cell Reports

Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells

(2017) Arantxa Cebrián-Silla et al.   Stem Cell Reports

Strategies targeting endogenous neurogenic cell response to improve recovery following traumatic brain injury

(2016) Kaushal Patel et al.   BRAIN RESEARCH

Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions

(2016) Jeffrey M. Bernitz et al.   CELL

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

(2016) J. Tiago Gonçalves et al.   CELL

Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells

(2016) Violeta Silva-Vargas et al.   Cell Stem Cell

Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury

(2016) Dong Sun   EXPERIMENTAL NEUROLOGY

Human adult neurogenesis across the ages: An immunohistochemical study

(2016) C. V. Dennis et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Fine processes of Nestin-GFP–positive radial glia-like stem cells in the adult dentate gyrus ensheathe local synapses and vasculature

(2016) Jonathan Moss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extensive migration of young neurons into the infant human frontal lobe

(2016) M. F. Paredes et al.   SCIENCE

Spatiotemporal coordination of stem cell commitment during epidermal homeostasis

(2016) P. Rompolas et al.   SCIENCE

Heterogeneity of Radial Glia-Like Cells in the Adult Hippocampus

(2016) Elias Gebara et al.   STEM CELLS

Neuronal Circuitry Mechanisms Regulating Adult Mammalian Neurogenesis

(2016) Juan Song et al.   Cold Spring Harbor Perspectives in Biology

The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis

(2016) Daniel A. Lim et al.   Cold Spring Harbor Perspectives in Biology

A mosaic world: puzzles revealed by adult neural stem cell heterogeneity

(2016) Zayna Chaker et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche

(2016) Eun Hyuk Chang et al.   Frontiers in Neuroscience

Embryonic Origin of Postnatal Neural Stem Cells

(2015) Luis C. Fuentealba et al.   CELL

Molecular Identity of Human Outer Radial Glia during Cortical Development

(2015) Alex A. Pollen et al.   CELL

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis

(2015) Jaehoon Shin et al.   Cell Stem Cell

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

(2015) Allison M. Bond et al.   Cell Stem Cell

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

(2015) Enric Llorens-Bobadilla et al.   Cell Stem Cell

Embryonic Nkx2.1-expressing neural precursor cells contribute to the regional heterogeneity of adult V–SVZ neural stem cells

(2015) Ryan N. Delgado et al.   DEVELOPMENTAL BIOLOGY

Brain size and limits to adult neurogenesis

(2015) Mercedes F. Paredes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

(2015) A. L. Ribeiro Xavier et al.   JOURNAL OF NEUROSCIENCE

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

(2015) Filippo Calzolari et al.   NATURE NEUROSCIENCE

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

(2015) Shohei Furutachi et al.   NATURE NEUROSCIENCE

Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain

(2015) Gerald J. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hopx distinguishes hippocampal from lateral ventricle neural stem cells

(2015) Deqiang Li et al.   Stem Cell Research

A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain

(2015) Cheuk Ka Tong et al.   Stem Cell Reports

Axonal Control of the Adult Neural Stem Cell Niche

(2014) Cheuk Ka Tong et al.   Cell Stem Cell

Age-related changes in astrocytic and ependymal cells of the subventricular zone

(2014) Vivian Capilla-Gonzalez et al.   GLIA

Bone morphogenetic protein-4 inhibits adult neurogenesis and is regulated by fractone-associated heparan sulfates in the subventricular zone

(2014) Frederic Mercier et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

Direct cell–cell contact with the vascular niche maintains quiescent neural stem cells

(2014) Cristina Ottone et al.   NATURE CELL BIOLOGY

Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis

(2014) Patricia Paez-Gonzalez et al.   NATURE NEUROSCIENCE

A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells

(2014) Jimena Andersen et al.   NEURON

Prospective Identification and Purification of Quiescent Adult Neural Stem Cells from Their In Vivo Niche

(2014) Paolo Codega et al.   NEURON

Opposing Effects of α2- and β-Adrenergic Receptor Stimulation on Quiescent Neural Precursor Cell Activity and Adult Hippocampal Neurogenesis

(2014) Dhanisha J. Jhaveri et al.   PLoS One

Primary cilia are required in a unique subpopulation of neural progenitors

(2014) C. K. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity

(2014) Stephanie Z. Young et al.   Frontiers in Cellular Neuroscience

Proliferation and cilia dynamics in neural stem cells prospectively isolated from the SEZ

(2014) Priti Khatri et al.   Scientific Reports

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Fractone-heparan sulphates mediate FGF-2 stimulation of cell proliferation in the adult subventricular zone

(2013) V. Douet et al.   CELL PROLIFERATION

Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain

(2013) D. A. Berg et al.   DEVELOPMENT

Stem cell population asymmetry can reduce rate of replicative aging

(2013) Sahand Hormoz   JOURNAL OF THEORETICAL BIOLOGY

Adult neural stem cells in distinct microdomains generate previously unknown interneuron types

(2013) Florian T Merkle et al.   NATURE NEUROSCIENCE

Parvalbumin interneurons mediate neuronal circuitry–neurogenesis coupling in the adult hippocampus

(2013) Juan Song et al.   NATURE NEUROSCIENCE

Symmetric vs. Asymmetric Stem Cell Divisions: An Adaptation against Cancer?

(2013) Leili Shahriyari et al.   PLoS One

Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice

(2013) Giovanna Ponti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis

(2013) Daichi Kawaguchi et al.   Nature Communications

Diazepam Binding Inhibitor Promotes Progenitor Proliferation in the Postnatal SVZ by Reducing GABA Signaling

(2012) Julieta Alfonso et al.   Cell Stem Cell

VCAM1 Is Essential to Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensor to Regulate SVZ Lineage Progression

(2012) Erzsebet Kokovay et al.   Cell Stem Cell

The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond

(2012) Mauro W. Zappaterra et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NKCC1 Knockdown Decreases Neuron Production through GABAA-Regulated Neural Progenitor Proliferation and Delays Dendrite Development

(2012) S. Z. Young et al.   JOURNAL OF NEUROSCIENCE

Neurogenic Subventricular Zone Stem/Progenitor Cells Are Notch1-Dependent in Their Active But Not Quiescent State

(2012) O. Basak et al.   JOURNAL OF NEUROSCIENCE

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

(2012) Juan Song et al.   NATURE

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

miR-7a regulation of Pax6 controls spatial origin of forebrain dopaminergic neurons

(2012) Antoine de Chevigny et al.   NATURE NEUROSCIENCE

Neural progenitor cells regulate microglia functions and activity

(2012) Kira I Mosher et al.   NATURE NEUROSCIENCE

Fractone-heparan sulfates mediate BMP-7 inhibition of cell proliferation in the adult subventricular zone

(2012) Vanessa Douet et al.   NEUROSCIENCE LETTERS

Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis

(2012) M. V. Gomez-Gaviro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1high intermediate progenitors

(2012) Sebastian Lugert et al.   Nature Communications

Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain

(2011) Congmin Wang et al.   CELL RESEARCH

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

(2011) Juan M. Encinas et al.   Cell Stem Cell

Gap junction-mediated calcium waves define communication networks among murine postnatal neural progenitor cells

(2011) Benjamin Lacar et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Midbrain Dopamine Neurons Associated with Reward Processing Innervate the Neurogenic Subventricular Zone

(2011) J. B. Lennington et al.   JOURNAL OF NEUROSCIENCE

The Timing for Neuronal Maturation in the Adult Hippocampus Is Modulated by Local Network Activity

(2011) V. C. Piatti et al.   JOURNAL OF NEUROSCIENCE

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Corridors of migrating neurons in the human brain and their decline during infancy

(2011) Nader Sanai et al.   NATURE

The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells

(2011) Maria K. Lehtinen et al.   NEURON

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity

(2011) Rebecca A. Ihrie et al.   NEURON

Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells

(2011) R. N. Fernando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Adult SVZ Lineage Cells Home to and Leave the Vascular Niche via Differential Responses to SDF1/CXCR4 Signaling

(2010) Erzsebet Kokovay et al.   Cell Stem Cell

In Vivo Fate Mapping and Expression Analysis Reveals Molecular Hallmarks of Prospectively Isolated Adult Neural Stem Cells

(2010) Ruth Beckervordersandforth et al.   Cell Stem Cell

Norepinephrine Directly Activates Adult Hippocampal Precursors via  3-Adrenergic Receptors

(2010) D. J. Jhaveri et al.   JOURNAL OF NEUROSCIENCE

Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains

(2010) I. Imayoshi et al.   JOURNAL OF NEUROSCIENCE

Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal

(2010) Adan Aguirre et al.   NATURE

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years

(2010) Rolf Knoth et al.   PLoS One

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Vasculature Guides Migrating Neuronal Precursors in the Adult Mammalian Forebrain via Brain-Derived Neurotrophic Factor Signaling

(2009) M. Snapyan et al.   JOURNAL OF NEUROSCIENCE

Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone

(2009) Celia Andreu-Agulló et al.   NATURE NEUROSCIENCE

Agonist-induced restoration of hippocampal neurogenesis and cognitive improvement in a model of cholinergic denervation

(2009) Jackalina M. Van Kampen et al.   NEUROPHARMACOLOGY

Developmental forebrain cholinergic lesion and environmental enrichment: Behaviour, CA1 cytoarchitecture and neurogenesis

(2008) Mylène Fréchette et al.   BRAIN RESEARCH

Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain

(2008) Zaman Mirzadeh et al.   Cell Stem Cell

A Specialized Vascular Niche for Adult Neural Stem Cells

(2008) Masoud Tavazoie et al.   Cell Stem Cell

Adult SVZ Stem Cells Lie in a Vascular Niche: A Quantitative Analysis of Niche Cell-Cell Interactions

(2008) Qin Shen et al.   Cell Stem Cell

The Distinct Temporal Origins of Olfactory Bulb Interneuron Subtypes

(2008) R. Batista-Brito et al.   JOURNAL OF NEUROSCIENCE

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain

(2008) Itaru Imayoshi et al.   NATURE NEUROSCIENCE

Directed differentiation of hippocampal stem/progenitor cells in the adult brain

(2008) Sebastian Jessberger et al.   NATURE NEUROSCIENCE